scholarly journals Listeriosis during Pregnancy: A Public Health Concern

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Teresa Mateus ◽  
Joana Silva ◽  
Rui L. Maia ◽  
Paula Teixeira
Keyword(s):  
Pregnant Women ◽  
Fetal Death ◽  
Foodborne Pathogen ◽  
Neonatal Morbidity ◽  
Health Concern ◽  
Prevention Measures ◽  
High Fatality Rate ◽  
The Usa ◽  
Low Incidence

Listeria was first described in 1926 by Murray, Webb, and Swann, who discovered it while investigating an epidemic infection among laboratory rabbits and guinea pigs. The role of Listeria monocytogenes as a foodborne pathogen was definitively recognized during the 1980s. This recognition was the consequence of a number of epidemic human outbreaks due to the consumption of contaminated foods, in Canada, in the USA and in Europe. Listeriosis is especially severe in immunocompromised individuals such as pregnant women. The disease has a low incidence of infection, although this is undeniably increasing, with a high fatality rate amongst those infected. In pregnant women listeriosis may cause abortion, fetal death, or neonatal morbidity in the form of septicemia and meningitis. Improved education concerning the disease, its transmission, and prevention measures for immunocompromised individuals and pregnant women has been identified as a pressing need.

scholarly journals Listeriosis Prevention Knowledge Among Pregnant Women in the USA

2005 ◽  
Vol 13 (1) ◽  
pp. 11-15 ◽  
Author(s):  
Folashade Ogunmodede ◽  
Jeffery L. Jones ◽  
Joni Scheftel ◽  
Elizabeth Kirkland ◽  
Jay Schulkin ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Dairy Products ◽  
Fetal Death ◽  
Severe Infection ◽  
Neonatal Morbidity ◽  
Medical Professional ◽  
Gastrointestinal Illness ◽  
Food Borne ◽  
The Usa ◽  
In Pregnancy

Background:Listeriosis is a food-borne disease often associated with ready-to-eat foods. It usually causes mild febrile gastrointestinal illness in immunocompetent persons. In pregnant women, it may cause more severe infection and often crosses the placenta to infect the fetus, resulting in miscarriage, fetal death or neonatal morbidity. Simple precautions during pregnancy can prevent listeriosis. However, many women are unaware of these precautions and listeriosis education is often omitted from prenatal care.Methods:Volunteer pregnant women were recruited to complete a questionnaire to assess their knowledge of listeriosis and its prevention, in two separate studies. One study was a national survey of 403 women from throughout the USA, and the other survey was limited to 286 Minnesota residents.Results:In the multi-state survey, 74 of 403 respondents (18%) had some knowledge of listeriosis, compared with 43 of 286 (15%) respondents to the Minnesota survey. The majority of respondents reported hearing about listeriosis from a medical professional. In the multi-state survey, 33% of respondents knew listeriosis could be prevented by not eating delicatessen meats, compared with 17% in the Minnesota survey (p= 0.01). Similarly, 31% of respondents to the multi-state survey compared with 19% of Minnesota survey respondents knew listeriosis could be prevented by avoiding unpasteurized dairy products (p = 0.05). As for preventive behaviors, 18% of US and 23% of Minnesota respondents reported avoiding delicatessen meats and ready-to-eat foods during pregnancy, whereas 86% and 88%, respectively, avoided unpasteurized dairy products.Conclusions:Most pregnant women have limited knowledge of listeriosis prevention. Even though most respondents avoided eating unpasteurized dairy products, they were unaware of the risk associated with ready-to-eat foods. Improved education of pregnant women regarding the risk and sources of listeriosis in pregnancy is needed.

scholarly journals Vaginal progesterone in prevention of preterm labour

2020 ◽  
Vol 8 (6) ◽  
pp. 449-454
Author(s):  
Dr. Prativa Sahoo ◽  
◽  
Dr. Nayan Kumar Patel ◽  
Dr. Ojaswini Patel ◽  
Dr. A.K Panigrahi ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Pregnant Women ◽  
Preterm Labour ◽  
Previous History ◽  
Neonatal Morbidity ◽  
Primary Objective ◽  
Vaginal Progesterone ◽  
History Of ◽  
Secondary Objective

Introduction: Preterm birth, defined as childbirth occurring at less than 37 completed weeks or 259days of gestation since the first day of a woman’s last menstrual period, is one of the leading causesof neonatal morbidity and mortality. Across 184 countries, the rate of preterm birth ranges from 5%to 18% of babies born. Out of 27 million babies born every year (2018 data ) in India, 3.5 millionbabies born are premature. Recent literature review has shown that the use of Progesterone reducesrisk of preterm birth. But there is little information available regarding the role of Progesterone inpreventing preterm labour. Objectives: Primary objective of the study is to find out the incidence ofpreterm labour among pregnant women taking vaginal progesterone. Secondary objective istoassess the safety and efficacy of progesterone in feto-maternal outcome. Methods: This is a crosssectional study where100 prescriptions from IPD of Dept of O&G, VIMSAR, Burla of women who hadrecently undergone labour with singleton gestation and with previous history of preterm labour wereanalysed. Incidence of preterm labour among those taking and not taking vaginal progesterone werecompared. Results: There was decreased incidence of preterm labour as there is prolongation meanGestational age by 9.383 weeks among pregnant women taking vaginal progesterone. Conclusions:In the present study, women taking vaginal progesterone had significantly lowered incidencepreterm birth rate.

scholarly journals Role of sVEGFR1 in the development of complications in pregnant women with antenatal fetal death anamnesis record

2014 ◽  
Author(s):  
Anna Nevolina ◽  
Natalia Safonova ◽  
Maria Proskura
Keyword(s):  
Serum Concentration ◽  
Pregnant Women ◽  
Fetal Death ◽  
Clinical Symptoms ◽  
Statistical Significance ◽  
Control Group ◽  
Study Group ◽  
Prevention Measures ◽  
Physiological Concentration ◽  
Timely Diagnosis

Background sVEGFR1 is a hypoxia influenced growth factor, involved in the endothelial dysfunction characterizing the pregnancy disorder of preeclampsia. Objective Determine correlation between dynamic pattern of sVEGFR1 serum concentration and complications in pregnant women with antenatal fetal death history for timely diagnosis. Materials and Methods A total of 35 women in the second and third trimester of pregnancy were enrolled in the study group and 30 women – in the control group. The study group was divided into 3 subgroups: subgroup #1: pregnant women, with no placental insufficiency (n=21), subgroup #2 - pregnant women with PI (n=8), subgroup #3 - pregnant women with PI resulting in preeclampsia(n=6). The control group comprised 30 pregnant women with uncomplicated childbirth. sVEGFR1 concentration was estimated in maternal serum by means of enzyme multiplied immune assay Quantikine (R and D systems, USA and Canada). Statistical data was assessed by SPSS statistics. Package was used to perform all the statistical analysis. The conventional p≤0,05 was used to assess statistical significance. Results Average age of women in the study group was 28,4±4,7 years, in the control group – 27,7±4,7 years. A physiological sVEGFR1 serum concentration was observed in the subgroup #1. As well as that, this group demonstrated concordant to the healthy pregnant women fluctuations of sVEGRF1 serum concentration. However, sVEGRF1 level was 1,2 fold less than in the control group during 29-32, 33-36 weeks of pregnancy. It was statistically proven, that fluctuations in sVEGRF1 serum concentration in the subgroup #2 were similar to the ones in the control group. No statistically significant changes of sVEGRF1 serum concentration compared to the control group were detected in the subgroup #3 up to the 28th week of pregnancy. However, a 1,5 fold increase of sVEGFR1 concentration was observed in the subgroup #3 (p<0,005) in comparison with the control group (1586±358 pg/ml, 2347±519 pg/ml, 3695±1547 pg/ml during 29-32, 33-36, >37 weeks of pregnancy, respectively). Control group demonstrated physiological concentration of sVEGRF1 throughout the pregnancy. Conclusion Changes in sVEGFR1 serum concentration were statistically significant in the group of pregnant women with PI, resulting in preeclampsia. Moreover, they were detected 3-4 weeks prior to clinical symptoms, providing opportunity for timely diagnosis and prevention measures.

Two Pregnant Women Presenting with Umbilical Cord Prolapse

2003 ◽  
Vol 10 (1) ◽  
pp. 43-46
Author(s):  
CY Hung ◽  
P Ng ◽  
HH Yau ◽  
CW Kam
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Cesarean Delivery ◽  
Umbilical Cord ◽  
Neonatal Morbidity ◽  
Obstetric Emergency ◽  
Clinical Presentations ◽  
Cord Prolapse ◽  
Umbilical Cord Prolapse

Cord prolapse is an obstetric emergency as delay in management is associated with significantly increased neonatal morbidity and mortality. If the accident occurred outside the hospital, many babies would be dead or severely asphyxiated upon arrival in the hospital. The role of Accident & Emergency (A&E) department is to arrive at this diagnosis promptly and deliver appropriate intervention. Immediate cesarean delivery is the treatment of choice. The clinical presentations of two cases with umbilical cord prolapse presenting to our A&E department within two weeks were described. The pathophysiology, risk factors, diagnosis, management as well as outcome were discussed.

scholarly journals MMP-9 Level Comparation between Spontaneous Abortion and Normal Pregnancy

2012 ◽  
Vol 4 (3) ◽  
pp. 174
Author(s):  
Aloysius Suryawan ◽  
Johanes C Mose ◽  
Budi Handono
Keyword(s):  
Pregnant Women ◽  
Spontaneous Abortion ◽  
Fetal Death ◽  
Embryo Implantation ◽  
Obstetric Care ◽  
First Trimester ◽  
Normal Pregnancy ◽  
Cross Sectional Study ◽  
Cross Sectional

BACKGROUND: Abortion remains a problem in the obstetric care as it is one of the causes of maternal and fetal death. Bleeding or miscarriage threat in the first trimester comprises 20% to 25% of all pregnant women, and 50% of them will end as spontaneous abortion. The major cause of maternal death in abortion is hemorrhage. Some recent studies have indicated that MMP-9 is important in the process of embryo implantation into the endometrium and spontaneous abortion occurs when there is an overwhelming increase of MMP-9. This data indicate the importance of a further research to elucidate the role of MMP-9 in spontaneous abortion.METHODS: This was a cross sectional study, included 70 pregnant women with gestational age <20 weeks who came for examination and treatment at the Department of Obstetrics and Gynecology, Medical Faculty of Padjadjaran University/Hasan Sadikin Hospital, Bandung. RESULTS: There were differences in the MMP-9 levels in spontaneous abortion compared to normal pregnancy and MMP-9 had a cut-off point >1221.7 with the sensitivity of 48.6% specificity of 80%, and accuracy of 60.9%.SUMMARY: The MMP-9 level in spontaneous abortion was higher than in normal pregnancy.KEYWORDS: MMP-9, spontaneous abortion, normal pregnancy

scholarly journals Role of Cardiac Imaging in the Diagnosis of Immune Checkpoints Inhibitors Related Myocarditis

2021 ◽  
Vol 11 ◽  
Author(s):  
Stéphane Ederhy ◽  
Joe-Elie Salem ◽  
Laurent Dercle ◽  
Abrar Saqif Hasan ◽  
Marion Chauvet-Droit ◽  
...  
Keyword(s):  
Paradigm Shift ◽  
Checkpoint Inhibitors ◽  
Clinical Syndrome ◽  
Immune Checkpoints ◽  
Patients With Cancer ◽  
High Fatality Rate ◽  
Clinical Scenarios ◽  
Low Incidence ◽  
Electrocardiogram Ecg

Immune checkpoint inhibitors (ICI) have constituted a paradigm shift in the management of patients with cancer. Their administration is associated with a new spectrum of immune-related toxicities that can affect any organ. In patients treated with ICI, cardiovascular toxicities, particularly myocarditis, occur with a low incidence (&lt;1%) but with a high fatality rate (30−50%). ICI-related myocarditis has been attributed to an immune infiltration, comprising of T-cells that are positive for CD3+, CD4+, CD8+, and macrophages that are positive for CD68. The diagnosis remains challenging and is made based on clinical syndrome, an electrocardiogram (ECG), biomarker data, and imaging criteria. In most clinical scenarios, endomyocardial biopsy plays a pivotal role in diagnosis, while cardiac magnetic resonance imaging (cMRI) has limitations that should be acknowledged. In this review, we discuss the role of medical imaging in optimizing the management of ICI related myocarditis, including diagnosis, prognostication, and treatment decisions.

scholarly journals Enteroviruses and Type 1 Diabetes Mellitus: An Overlooked Relationship in Some Regions

2020 ◽  
Vol 8 (10) ◽  
pp. 1458
Author(s):  
Abdulaziz Alhazmi ◽  
Famara Sane ◽  
Mouna Lazrek ◽  
Magloire Pandoua Nekoua ◽  
Francis Badia-Boungou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
North Africa ◽  
Developed Countries ◽  
The Usa ◽  
Low Incidence ◽  
The Relationship

Enteroviruses (EVs) infect millions of people annually. EV infections can be asymptomatic or symptomatic with conditions ranging from mild illnesses to serious diseases such as dilated cardiomyopathy. A causal relationship between EV infections and type 1 diabetes mellitus (T1DM) has been heavily debated, with some studies suggesting that this relationship is not yet conclusive and requires additional evidence, whereas others strongly argue for this correlation. While this relationship is well investigated in some developed countries like the USA and Finland, it is understudied or neglected in other countries like Russia for many reasons such as the low incidence of T1DM. Although the Middle East and North Africa (MENA) are highly affected by T1DM, the role of EVs in the disease in MENA has not been investigated extensively. Therefore, we aimed to address the relationship between T1DM and EVs in MENA and other regions globally.

scholarly journals Is Antibody-Dependent Enhancement of Trypanosoma cruzi Infection Contributing to Congenital/Neonatal Chagas Disease?

2021 ◽  
Vol 12 ◽  
Author(s):  
Yves Carlier ◽  
Carine Truyens ◽  
Eric Muraille
Keyword(s):  
Trypanosoma Cruzi ◽  
Pregnant Women ◽  
Chagas Disease ◽  
Viral Infections ◽  
Neonatal Morbidity ◽  
Host Cells ◽  
Antibody Dependent Enhancement ◽  
Severe Reduction ◽  
Cruzi Infection

The newborns of women infected with the parasite Trypanosoma cruzi (the agent of Chagas disease) can be infected either before birth (congenitally), or after birth (as e.g., by vector route). Congenital Chagas disease can induce high levels of neonatal morbidity and mortality. Parasite-infected pregnant women transmit antibodies to their fetus. Antibodies, by opsonizing parasites, can promote phagocytosis and killing of T. cruzi by cells expressing FcγR, on the mandatory condition that such cells are sufficiently activated in an inflammatory context. Antibody-dependent enhancement (ADE) is a mechanism well described in viral infections, by which antibodies enhance entry of infectious agents into host cells by exploiting the phagocytic FcγR pathway. Previously reported Chagas disease studies highlighted a severe reduction of the maternal-fetal/neonatal inflammatory context in parasite-transmitting pregnant women and their congenitally infected newborns. Otherwise, experimental observations brought to light ADE of T. cruzi infection (involving FcγR) in mouse pups displaying maternally transferred antibodies, out of an inflammatory context. Herein, based on such data, we discuss the previously unconsidered possibility of a role of ADE in the trans-placental parasite transmission, and/or the development of severe and mortal clinical forms of congenital/neonatal Chagas disease in newborns of T. cruzi-infected mothers.

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