scholarly journals Promising New Treatments for Psoriasis

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Sarah Dubois Declercq ◽  
Roxane Pouliot
Keyword(s):  
Quality Of Life ◽  
Social Life ◽  
The Body ◽  
Inflammatory Skin Disease ◽  
Biological Drugs ◽  
Immunological Factors ◽  
Traditional Therapies ◽  
New Treatments

Psoriasis is a chronic, proliferative, and inflammatory skin disease affecting 2-3% of the population and is characterized by red plaques with white scales. Psoriasis is a disease that can affect many aspects of professional and social life. Currently, several treatments are available to help control psoriasis such as methotrexate, ciclosporin, and oral retinoids. However, the available treatments are only able to relieve the symptoms and lives of individuals. The discovery of new immunological factors and a better understanding of psoriasis have turned to the use of immunological pathways and could develop new biological drugs against specific immunological elements that cause psoriasis. Biological drugs are less toxic to the body and more effective than traditional therapies. Thus, they should improve the quality of life of patients with psoriasis. This review describes new psoriasis treatments, which are on the market or currently in clinical trials that are being used to treat moderate-to-severe plaque psoriasis. In addition, this paper describes the characteristics and mechanisms in detail. In general, biological drugs are well tolerated and appear to be an effective alternative to conventional therapies. However, their effectiveness and long-term side effects need to be further researched.

scholarly journals Quality of life in patients with mild acute brain injury and their carers’ needs in Greece

2021 ◽  
Vol 9 (1) ◽  
pp. 39
Author(s):  
Evgenia Stasinopoulou ◽  
Margarita Giannakopoulou ◽  
Georgios Fildisis ◽  
Maria Kalafati ◽  
Chryssoula Leomonidou
Keyword(s):  
Quality Of Life ◽  
Brain Injury ◽  
Social Life ◽  
Well Being ◽  
Acute Brain Injury ◽  
Support Network ◽  
Family Needs ◽  
Rehabilitation Centers

Background: Investigating quality of life (QoL) is of crucial importance for the scientific community as it could function not only as an indicator of prognosis and post-traumatic clinical and psychological changes in patients who have suffered from acute brain injury (ABI), but also as an indicator of the effectiveness of their treatment and social rehabilitation. In addition, it can highlight changes in the carer’s health, social life and well-being. This study examined the QoL of patients following ABI and the needs of their carers.Material and methodology: This study was conducted in patients suffering from ABI, who were admitted to the General Hospital of Attica “KAT” and to the National Rehabilitation Center and on their carers. Data collection including demographics and Quality of Life After Brain Injury Questionnaire (QOLIBRI) and the Family Needs Questionnaire (FNQ) was performed during patients’ rehabilitation, while six months after release, a follow-up survey was conducted using the same questionnaires. Statistical analysis of data was performed using SPSS.Results: We analysed 50 patients with mild ABI (GCS ≥ of 13/15) during rehabilitation and six months after release and found that their QoL improves and is positively related to improvement of health status (i.e. in terms of thinking ability, QoL improves from r = 2.33, p < .01 to r = 3.37, p < .001). We also found that “Age” has the greatest impact on the patient’s progress for recovery and the general QoL after ABI (r = -0.423, p < .01). In addition, it was found that carers of patients with ABI are confronted with the burden of care, while they record both fulfilled and unmet needs regarding their individual needs (i.e. only for 30% of the sample the need for help in preparing them for the worst is met).Conclusions: Our study confirms previous findings that underline that ABI has a major impact on QoL of both patients and their carers providing them with long-term daily care. Although it has been found that over time there is an improvement in the QoL of patients with ABI, the absence of an official support network for carers from public health system, hospitals and rehabilitation centers may adversely affect the QoL of patients and their carers. Therefore, more structured, long-term family-wide monitoring and support is needed, focusing on identifying those at risk of social isolation and incomplete social networking.

scholarly journals New Cytokines in the Pathogenesis of Atopic Dermatitis—New Therapeutic Targets

2018 ◽  
Vol 19 (10) ◽  
pp. 3086 ◽  
Author(s):  
Jolanta Klonowska ◽  
Jolanta Gleń ◽  
Roman Nowicki ◽  
Magdalena Trzeciak
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Atopic Diseases ◽  
Biologic Therapies ◽  
Inflammatory Skin Disease ◽  
Biological Drugs ◽  
New Era ◽  
To Receive ◽  
Therapeutic Possibilities

Atopic dermatitis (AD) is a recurrent, chronic, and inflammatory skin disease, which processes with severe itchiness. It often coexists with different atopic diseases. The number of people suffering from AD is relatively high. Epidemiological research demonstrates that 15–30% of children and 2–10% adults suffer from AD. The disease has significant negative social and economic impacts, substantially decreasing the quality of life of the patients and their families. Thanks to enormous progress in science and technology, it becomes possible to recognise complex genetic, immunological, and environmental factors and epidermal barrier defects that play a role in the pathogenesis of AD. We hope that the new insight on cytokines in AD will lead to new, individualised therapy and will open different therapeutic possibilities. In this article, we will focus on the cytokines, interleukin (IL)-17, IL-19, IL-33, and TSLP (thymic stromal lymphopoietin), which play a significant role in AD pathogenesis and may become the targets for future biologic therapies in AD. It is believed that the new era of biological drugs in AD will give a chance for patients to receive more successful treatment.

scholarly journals An intravenous biological therapy for psoriasis: Infliximab

2012 ◽  
Vol 7 (1) ◽  
pp. 69-72
Author(s):  
M Mathur ◽  
SK Kedia ◽  
RBK Chimire
Keyword(s):  
Quality Of Life ◽  
Monoclonal Antibody ◽  
Biological Therapy ◽  
Systemic Treatment ◽  
Severe Disease ◽  
Joint Disease ◽  
Inflammatory Skin Disease ◽  
Psychosocial Disability

Psoriasis is a common, chronic inflammatory skin disease which typically follows a relapsing and remitting course and is associated with joint disease. The significant reduction in quality of life and the psychosocial disability suffered by patients underline the need for prompt, effective treatment and long-term disease control. Patients with moderate to severe disease often require systemic treatment with effective & new modalities such as biological-Infliximab. Review will highlight fundamental aspects of infliximab and its use in Psoriasis as well as provide specific comments regarding this monoclonal antibody and its position in of psoriasis in the future treatment. DOI: http://dx.doi.org/10.3126/jcmsn.v7i1.5977 JCMSN 2011; 7(1): 69-72

Long-term impact of childhood-onset type 1 diabetes on social life, quality of life and sexuality

2015 ◽  
Vol 41 (6) ◽  
pp. 489-497 ◽  
Author(s):  
H. Mellerio ◽  
S. Guilmin-Crépon ◽  
P. Jacquin ◽  
M. Labéguerie ◽  
C. Lévy-Marchal ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Type 1 Diabetes ◽  
Social Life ◽  
Life Quality ◽  
Childhood Onset ◽  
Onset Type ◽  
Long Term Impact

scholarly journals Persistent Post-COVID-19 Syndrome in Hemodialyzed Patients—A Longitudinal Cohort Study from the North of Poland

2021 ◽  
Vol 10 (19) ◽  
pp. 4451
Author(s):  
Aleksander Och ◽  
Piotr Tylicki ◽  
Karolina Polewska ◽  
Ewelina Puchalska-Reglińska ◽  
Aleksandra Parczewska ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cohort Study ◽  
The Body ◽  
Longitudinal Cohort Study ◽  
Health Consequences ◽  
Longitudinal Cohort ◽  
Persistent Symptoms ◽  
The North

Background: After recovery from COVID-19, patients frequently face so-called “Post-COVID-19 Syndrome” defined by clusters of persistent symptoms lasting for >12 weeks which may arise from any system in the body. The long-term health consequences of COVID-19 in maintenance hemodialyzed (HD) patients remain to be investigated. Methods: In this longitudinal cohort study we described the health consequences in HD patients requiring hospitalization due to COVID-19. They were interviewed three and six months (M3 and M6) after discharge with a series of standardized questionnaires. Results: Of 144 HD patients discharged from the 7th Naval Hospital in Gdansk, 79 participants were enrolled, 39 m (49.4%) and 40 f (50.6%) with a median age of 70.0 (64.0–76.5) and an HD vintage of 40 months (17.5–88). After discharge, 93.7% and 81% reported at least one persistent symptom at M3 and M6, respectively. The most common symptoms were fatigue or muscle weakness (60.76% and 47.04%) and palpitations (40.51% and 30.14%). Dyspnea with an mMRC scale grade of at least 1 was reported by 21.5% before infection, and by 43.03% and 34.25% at M3 and M6, respectively. A decrease in the quality of life was reported in all domains of the EQ-5D-5L questionnaire but mainly in the pain/discomfort and anxiety dimensions. Mean EQ-VAS scores were 69.05, 61.58 and 64.38, respectively. Conclusion: Our study showed that HD patients may still experience persistent symptoms six months after recovery from COVID-19, which can further reduce their already poor health-related quality of life. This study highlights the need for long-term follow-up on these patients for diagnostic and rehabilitation programs.

Study of premenstrual syndrome and premenstrual dysphorik disorder in Azerbaijan

2011 ◽  
Vol 26 (S2) ◽  
pp. 1667-1667
Author(s):  
S. Katibli
Keyword(s):  
Quality Of Life ◽  
Social Life ◽  
Health Program ◽  
Long Term Outcomes ◽  
Premenstrual Symptoms ◽  
Quality Of Life Indicators ◽  
Quality Of Life Scale ◽  
Life Scale

ObjectivesThe study is aimed to investigate clinical and social aspects of premenstrual disorders in Azerbaijan.Methods180 women at the age 20–49 from general population have been included in the research. The study used the Premenstrual Symptoms Screening Tool to assess severity of premenstrual symptoms. The women's quality of life was evaluated with QoLS (Quality of life Scale).ResultsThe most prevalent complaints included sleep disorders, fatigue, irritability and depressed mood. These symptoms affected work efficiency or productivity, relationships with co-workers, relationships with family members, social life activities, and home responsibilities. At the same time short-term presentation of these symptoms had limited impact on quality of life indicators attributed to long-term outcomes.ConclusionsThe activities on increasing awareness on premenstrual disorders are recommended as an important component of reproductive health program.

scholarly journals Long-Term Quality-of-Life Outcomes After Body Contouring Surgery: Phase IV Results for the Body-QoL® Cohort

2017 ◽  
Vol 38 (3) ◽  
pp. 279-288 ◽  
Author(s):  
Jaco Suijker ◽  
Ekaterina Troncoso ◽  
Francisca Pizarro ◽  
Sofia Montecinos ◽  
Galia Villarroel ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Body Contouring ◽  
The Body ◽  
Life Outcomes ◽  
Body Contouring Surgery ◽  
Quality Of Life Outcomes ◽  
Phase Iv

scholarly journals GAMBARAN KUALITAS KEHIDUPAN LANSIA DI GIANYAR BALI

2020 ◽  
Vol 4 (2) ◽  
pp. 383
Author(s):  
Ni Putu Saraswati Wardani ◽  
Fransisca Iriani Roesmala Dewi
Keyword(s):  
Quality Of Life ◽  
Elderly People ◽  
Social Life ◽  
Educational Status ◽  
Well Being ◽  
The Elderly ◽  
Health Care Facilities ◽  
The Body ◽  
Quality Life

Bali as one of the cities with the fourth rank has the largest number of elderly people in Indonesia. Religious, social and cultural life has a very strong influence on the quality of life of the elderly. The purpose of this study was to describe the quality of life of the elderly in Gianyar, Bali. This study uses a phenomenological qualitative approach with data collection techniques, interviews and observations. The subjects involved in this study were eight elderly individuals, eight subjects consisted of 4 men and 4 women, aged 60-70 years, with low educational status. The majority of participants have a partner (married), and still have a job as a daily activity. five out of eight elderly felt that the income they earned was sufficient to meet their daily needs, while three elderly felt that the income they earned could not meet their daily needs. The results of this study illustrate that eight elderly people have been able to achieve a quality life in 6 aspects, namely social relationships (active in social life); psychological well-being (positive feelings, self-worth); spiritual (gratitude), independence (organize and decide on their own activities, be financially independent); self-empowerment (beneficial for others. involved in decision making for family or community); environment (facilities and infrastructure or health care facilities). Meanwhile, one other aspect, namely physical health is defined as a condition of the body that is not fit and visual disturbances are often sick, so that it is perceived that their life is less qualified. Bali sebagai salah satu kota dengan peringkat keempat yang memiliki jumlah penduduk lansia terbanyak di Indonesia. Kehidupan beragama, sosial dan budaya yang sangat kuat mempengaruhi kualitas kehidupan lansia. Tujuan Penelitian ini untuk mendeskripsikan kualitas kehidupan lansia di Gianyar, Bali. Penelitian ini menggunakan pendekatan kualitatif fenomenologi dengan teknik pengumpulan data wawancara dan observasi. Subyek yang terlibat dalam penelitian in adalah delapan individu lansia, delapan subyek terdiri dari 4 orang laki–laki dan 4 perempuan, berusia antara 60-70 tahun, dengan status pendidikan yang rendah. Mayoritas partisipan memiliki pasangan (menikah), serta masih memiliki pekerjaan sebagai aktivitas kesehariannya. Lima dari delapan lansia merasakan bahwa penghasilan yang didapatkan cukup untuk memenuhi kebutuhannya sehari-hari sedangkan tiga lansia merasa bahwa penghasilan yang didapatkan kurang dapat memenuhi kebutuhannya. Hasil penelitian ini menggambarkan bahwa delapan lansia telah mampu mencapai kehidupan yang berkualitas pada 6 aspek yaitu hubungan sosial (aktif dalam kehidupan bermasyarakat); kesejahteraan psikologis (perasasan positif, keberhargaandiri); spiritual (rasa syukur), kemandirian (mengatur dan memutuskan aktivitas sendiri, mandiri secara finansial); pemberdayaan diri (bermanfaat untuk orang lain. dilibatkan dalam pengambilan keputusan untuk keluarga atau masyarakat); lingkungan (sarana dan prasarana atau fasilitas perawatan kesehatan). Sementara satu aspek lainnya, yakni kesehatan fisik dimaknai dengan keadaan tubuh yang kurang fit dan gangguan penglihatan sering sakit, sehingga dipersepsikan kehidupannya kurang berkualitas.

Evaluation of the effectiveness of total knee arthroplasty

2020 ◽  
pp. 26-33
Author(s):  
Dilmurod Ruzibaev ◽  
Saodat Asilova ◽  
Gairat Nurimov
Keyword(s):  
Quality Of Life ◽  
Total Knee Arthroplasty ◽  
Knee Joint ◽  
Total Knee Replacement ◽  
Social Life ◽  
Integrated Approach ◽  
The Body ◽  
Functional Capabilities ◽  
Total Knee

The quality of life of patients after total knee replacement is significantly improved. Endoprosthetics of the knee joint leads to the elimination of pain, improving the physical and functional capabilities of the body, which contributes to the re-adaptation of a person to an active social life. We proposed an integrated approach to rehabilitation measures, both medical, social and psychological to achieve this.

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