scholarly journals Augmentation Rhinoplasty in Cleft Lip Nasal Deformity: Preliminary Patients’ Perspective

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
William H. C. Tiong ◽  
Mohd Ali Mat Zain ◽  
Normala Hj Basiron
Keyword(s):  
Cleft Lip ◽  
Nasal Deformity ◽  
Main Complaint ◽  
Satisfactory Outcome ◽  
Before And After ◽  
The Common ◽  
One Year ◽  
The One ◽  
Nasal Length ◽  
Patients Perspective

The correction of cleft lip nasal deformity is challenging and there have been numerous methods described in the literature with little demonstrated technical superiority of one over another. The common clinical issues associated with cleft lip nasal deformity are its lack of symmetry, alar collapse on the affected side, obtuse nasal labial angle, short nasal length, loss of tip definition, and altered columella show among others. We carried out augmentation of cleft lip rhinoplasties with rib graft in 16 patients over the one-year study period. Each of these patients was reviewed and given questionnaire before and after surgery to evaluate their response on the outcome to the approach. Preoperatively, nasal asymmetry is the main complaint (14/16, 87.5%) among our series of patients. Postoperatively, 12 (75%) patients out of the 16 reported significant improvement in their nasal symmetry with the other four marginal. All patients reported excellent nasal projection postoperatively with good nasal tip definition. Our series of patients reported overall good satisfaction outcome and will recommend this procedure to other patients with cleft lip nasal deformity. In conclusion, augmentation of cleft lip rhinoplasty can be employed to achieve perceivable and satisfactory outcome in patients with cleft lip nasal deformity.

scholarly journals Evaluation of Modified Unilateral Nasoplasty in Patient with Post Operation of Unilateral Labioplasty at Malahayati Hospital Banda Aceh: Cohort Study from 2017 until 2019

2021 ◽  
Vol 5 (1) ◽  
pp. 23
Author(s):  
Devyana Enggar Taslima ◽  
Muhammad Taufik ◽  
Muhammad Jailani ◽  
Syamsul Rizal ◽  
Mirnasari Amirsyaha
Keyword(s):  
Cohort Study ◽  
Clinical Features ◽  
Cleft Lip ◽  
Nasal Deformity ◽  
Demographic Information ◽  
Nasal Tip ◽  
Post Operation ◽  
The Common ◽  
Nasal Length ◽  
Banda Aceh

Background : Nasal deformity associated with cleft lip has been viewed as one of the most challenging reconstructive problems in rhinoplasty.(1) The common clinical features associated with cleft lip nasal deformity are its lack of symmetry, alar collapse on the affected side, short nasal length, loss of tip definition, obtuse nasal labial angle, and altered columella show among others.(2) The complexity of cleft lip rhinoplasty is demonstrated by the abundance of technique that is available for its correction.(3) In this case we used the technique that modified by Dr. Muhammad Jailani, SpBP-RE in Aceh.Methods: We conducted a retroperspective study involving 139 patients who is done the rhinoplasty unilateral operation at Malahayati Hospital from January 2017 to November 2019. Demographic information was recorded such as ratio between pre – operation and post – operation, gender and age.Results : Our results has shown the result of comparison between cleft nose before rhinoplasty and cleft nose after rhinoplasty is ±0.26 : ±0.58, and the patients who came to the hospital to do the rhinoplasty unilateral surgery are 81% from 139 patients. Woman (61.2%) experience rhinoplasty more dominant compare to man (38.8%), and the highest age average is between 1 years old until 7 years old (71%)Conclusions: Improvement in procedure’s duration and better positioning of both nasal tip and nostril. Expected improvements in terms of aesthetic and functions were observed but further documentations still needed.

scholarly journals Real-World Experience of the One-Year Efficacy of Rifaximin Add-On to Lactulose Is Superior to Lactulose Alone in Patients with Cirrhosis Complicated with Recurrent Hepatic Encephalopathy in Taiwan

2021 ◽  
Vol 11 (6) ◽  
pp. 478
Author(s):  
Ching Chang ◽  
Chien-Hao Huang ◽  
Hsiao-Jung Tseng ◽  
Fang-Chen Yang ◽  
Rong-Nan Chien
Keyword(s):  
Hepatic Encephalopathy ◽  
Real World ◽  
Ammonia Level ◽  
Decompensated Cirrhosis ◽  
Control Group ◽  
Multivariable Logistic Regression Model ◽  
Before And After ◽  
One Year ◽  
The One ◽  
Serum Ammonia

Background: Hepatic encephalopathy (HE), a neuropsychiatric complication of decompensated cirrhosis, is associated with high mortality and high risk of recurrence. Rifaximin add-on to lactulose for 3 to 6 months is recommended for the prevention of recurrent episodes of HE after the second episode. However, whether the combination for more than 6 months is superior to lactulose alone in the maintenance of HE remission is less evident. Therefore, the aim of this study is to evaluate the one-year efficacy of rifaximin add-on to lactulose for the maintenance of HE remission in Taiwan. Methods: We conducted a real-world single-center retrospective cohort study to compare the long-term efficacy of rifaximin add-on to lactulose (group R + L) versus lactulose alone (group L, control group). Furthermore, the treatment efficacy before and after rifaximin add-on to lactulose was also analyzed. The primary endpoint of our study was time to first HE recurrence (Conn score ≥ 2). All patients were followed up every three months until death, and censored at one year if still alive. Results and Conclusions: 12 patients were enrolled in group R + L. Another 31 patients were stratified into group L. Sex, comorbidity, ammonia level, and ascites grade were matched while age, HE grade, and model for end-stage liver disease (MELD) score were adjusted in the multivariable logistic regression model. Compared with group L, significant improvement in the maintenance of HE remission and decreased episodes and days of HE-related hospitalizations were demonstrated in group R + L. The serum ammonia levels were significantly lower at the 3rd and 6th month in group 1. Concerning changes before and after rifaximin add-on in group R + L, mini-mental status examination (MMSE), episodes of hospitalization, and variceal bleeding also improved at 6 and 12 months. Days of hospitalization, serum ammonia levels also improved at 6th month. Except for concern over price, no patients discontinued rifaximin due to adverse events or complications. The above results provide evidence for the one-year use of rifaximin add-on to lactulose in reducing HE recurrence and HE-related hospitalization for patients with decompensated cirrhosis.

scholarly journals New wavelength calibration of the HARPS spectrograph

2019 ◽  
Vol 629 ◽  
pp. A27 ◽  
Author(s):  
A. Coffinet ◽  
C. Lovis ◽  
X. Dumusque ◽  
F. Pepe
Keyword(s):  
Radial Velocity ◽  
Frequency Comb ◽  
Light Emitting Diode ◽  
Laser Frequency ◽  
Wavelength Calibration ◽  
Light Emitting ◽  
Before And After ◽  
Doppler Spectroscopy ◽  
One Year ◽  
The One

Context. Doppler spectroscopy has been used in astronomy for more than 150 yr. In particular, it has permitted us to detect hundreds of exoplanets over the past 20 yr, and the goal today of detecting Earth-like planets requires a precision around 0.1 m s−1 or better. Doppler spectroscopy has also been and will be of major importance for other studies such as the variability of fundamental constants and cosmological studies. For all these applications, it is crucial to have the best possible wavelength calibration. Despite the fact that the HARPS spectrograph has been operational at the 3.6-m ESO telescope for more than 15 yr, and that it provides among the most precise Doppler measurements, improvements are still possible. One known problem, for instance, is the non-fully regular block-stitching of the charge-coupled devices (CCDs), which in some cases introduces one-year period parasitic signals in the measured radial velocity. Aims. The aim of the presented work is to improve the wavelength calibration of the HARPS spectrograph to push further its planet-detection capabilities. Methods. The properties of the CCD stitching-induced pixel-size anomalies were determined with light-emitting-diode (LED) flat-field frames, and then a physical, gap-corrected map of the CCDs is used for the fitting model of the spectral orders. We also used a new thorium line list, based on much higher-accuracy measurements than the one used up to now. We derive new wavelength solutions for the 15 yr of HARPS data, both before and after the fibre upgrade that took place in 2015. Results. We demonstrate that we do indeed correct the gap anomalies by computing the wavelength solutions of laser frequency comb exposures, known to have a very low dispersion, both with and without taking the gap correction into account. By comparing the rms of the most stable stars of the HARPS sample, we show that we globally decrease the radial velocity (RV) dispersion of the data, especially for the data acquired after the change of fibres of 2015. Finally, the comparative analysis of several individual systems shows that we manage to attenuate the periodogram power at one year in most cases. The analysis of the RVs derived from individual stellar lines also shows that we indeed correct the stitching-induced RV variation. Conclusions. This improved calibration of the HARPS spectrograph allows to go deeper in the search for low-amplitude radial-velocity signals. This new calibration process will be further improved by combining the thorium calibration spectra with laser frequency comb and Fabry–Perot calibration spectra, and this will not only be used for HARPS but notably also for HARPS-N and the new ESPRESSO spectrograph.

Robot-Asssisted Laparoscopic Radical Prostatectomy (Ralp). Oncological and Functional Findings after 90 Cases

2009 ◽  
Vol 76 (2) ◽  
pp. 87-89 ◽  
Author(s):  
C. Giberti ◽  
M. Schenone ◽  
P. Cortese ◽  
F. Gallo ◽  
E Gastaldi ◽  
...  
Keyword(s):  
Disease Free Survival ◽  
Functional Results ◽  
Modern Technology ◽  
Nerve Sparing ◽  
Number Of Patients ◽  
Before And After ◽  
Disease Free Survival Rate ◽  
One Year ◽  
The One

The RALP is the most modern technology available for the treatment of intracapsular prostate cancer (CaP), which can produce a shorter learning curve and better results than the traditional techniques. Methods Between March 2005 and March 2008, 90 patients (64.3 ys, range 52–71) with intracapsular CaP underwent RALP at our institute. Before surgery the patients underwent routine examinations and filled in IIEF, IPSS and EORTC-QLQC30/PR 25 questionnaires. Patients were followed up with PSA assay, physical examination and compilation of the questionnaires. Median follow-up was 12.5 months (range 1–35 months). Results Mean operative time was 230 min. Discharge and catheter removal were at day 7.4 and 8.2, respectively, after surgery. Pathological staging reported pT2 and pT3 in 57 (63%) and 33 patients (37%), respectively. Positive surgical margins were assessed in 30 patients (33%), particularly 8.7% in pT2 tumors. The one-year biochemical disease-free survival rate was 90%. Regarding the functional results, 81 patients (90%) were perfectly continent while a mild and a moderate incontinence were reported in 7 (8%) and 2 (2%) patients, respectively. Mean IPSS score decreased from 8 to 4; among the patients who underwent bilateral nerve sparing RALP and no adjuvant therapy, 31 (70.4%) reported satisfactory sexual intercourses. Concerning postoperative quality of life, mean EORTC-QLQC30/PR 25 questionnaires scores were very similar before and after RALP. Conclusions After 90 cases of RALP the oncological and functional results are definitely promising. However, a wider number of patients and a greater follow-up are needed to confirm these data particularly as regards the functional results.

Collagen metabolites in the prediction of response to GH therapy in short children

1997 ◽  
pp. 621-625 ◽  
Author(s):  
P Tapanainen ◽  
M Knip ◽  
L Risteli ◽  
L Kemppainen ◽  
ML Kaar ◽  
...  
Keyword(s):  
Bone Age ◽  
Type I ◽  
Gh Therapy ◽  
Gh Treatment ◽  
Type I Procollagen ◽  
Short Children ◽  
Before And After ◽  
The Absolute ◽  
One Year ◽  
The One

To evaluate the role of collagen metabolites in the prediction of the response to GH treatment we measured the serum concentrations of the C-terminal propeptide of type I procollagen (PICP) and the N-terminal propeptide of type III procollagen (PIIINP) with specific RIAs in 35 short children (16 boys) before and after 5 days, 5 weeks and 3 months of GH therapy. The mean age of the children was 10.3 years (range 1.9-16.4 years) and the bone age ranged from 1.2 to 12.5 years (mean 7.6 years). The initial mean relative height (RH) was -3.6 SDS (range -6.6 to -2.4 S.D.). Nineteen children were found to have GH deficiency (GHD; peak GH responses in two pharmacological tests < 10 micrograms/l), while the remaining 16 were considered to have undefined short stature (USS). The children were treated with recombinant human GH (0.1 U/kg given subcutaneously at bedtime 6-7 times/week). The increases in RHI over the first 6 and 12 months of therapy were used as response measures. There was already a significant increase (P < 0.001) in both the serum PICP and PIIINP levels at 5 days, and the concentrations continued to rise up to 3 months, PICP levels rising less than the PIIINP levels. In the whole group the RHI over 6 months correlated most strongly with the absolute PICP concentrations at 3 months (rS = 0.59; P < 0.05), while the absolute PIIINP concentrations at 3 months showed the strongest relation to the one year RHI (rS = 0.69; P < 0.001). In the GHD group the 6 month RHI was most strongly related to the absolute PICP concentration at 3 months (rS = 0.59; P < 0.05). In the USS group the absolute PICP concentrations at 3 months correlated most strongly with the one year RHI (rS = 0.82; P < 0.01). Significant correlations were also observed between the absolute PIIINP levels at 3 months and the 6 month RHI (rS = 0.60; P < 0.05) and 12 month RHI (rS = 0.76; P < 0.01) in this group. These results show that GH therapy results in an unequivocal increase in circulating concentrations of PICP and PIIINP. The serum PICP and PIIINP concentrations may be of value in the prediction of the long-term response to GH therapy.

scholarly journals Reproductive biology and feeding habits of the common dolphinfish Coryphaena hippurus (Linnaeus, 1758) off Saurashtra coast, India

2018 ◽  
Vol 65 (4) ◽  
Author(s):  
Jyoti Saroj ◽  
K. Mohammed Koya ◽  
K.L. Mathew ◽  
Panja Tehseen
Keyword(s):  
Reproductive Biology ◽  
Feeding Habits ◽  
Fork Length ◽  
Reproductive Activity ◽  
Monthly Basis ◽  
Coryphaena Hippurus ◽  
Saurashtra Coast ◽  
The Common ◽  
One Year ◽  
The One

The present study analysed reproductive biology and feeding habits of the common dolphinfish Corphaena hippurus, along the Saurashtra coast of India. The study is based on an investigation of 295 specimens caught using drift gillnet at Veraval. The samples were collected on a monthly basis between March 2015 and February 2016. The sex ratio was 1:1.75 with a significant dominance of females in the population. The size at maturity for females was 593 mm FL (fork length). Absolute fecundity of the individuals ranged from 1,07,813 to 15,50,400 having ova diameter range of 0.3-1.96 mm. C. hippurus spawned throughout the year with its reproductive activity peaking in April and December. Thus the dolphin fish has an extended spawning season; during which it laid eggs almost continuously. A total of 128 stomachs of C. hippurus, whose fork length FL ranged from 380 to 1250 mm were examined during the one year period of this study. Tunas were found to be the common dietary component of the dolphinfish.

Gut Microbiota and Urine Metabonomics Alterations in Constitution after Chinese Medicine and Lifestyle Intervention

2021 ◽  
pp. 1-29
Author(s):  
Yuan Jing ◽  
Shuangshuang Han ◽  
Jieyu Chen ◽  
Yigui Lai ◽  
Jingru Cheng ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Gut Microbiota ◽  
Lifestyle Intervention ◽  
Intervention Group ◽  
Urinary Metabolites ◽  
Control Group ◽  
Human Beings ◽  
Before And After ◽  
One Year ◽  
The One

Traditional Chinese Medicine Constitution (TCMC) divides human beings into balanced (ping-he) constitution (PH) and unbalanced constitution. Yang-deficiency (yang-xu) constitution (YAX) is one of the most common unbalanced constitutions in Chinese general population, and it causes susceptibility to particular diseases. However, unbalanced constitutions can be regulated by Chinese medicine and lifestyle intervention in clinical practice. Gui-fu-di-huang-wan (GFDHW) is a well-known Chinese medicine with yang-invigorating activity and is regarded as improving YAX. In this study, 60 healthy YAX students selected from a prospective population of 5185 were enrolled in a randomized clinical trial and completed the study. We compared the gut microbiota and urinary metabolome between individuals with PH and those with YAX before and after one-month-intervention. Compared with the control group, the health status of the intervention group improved significantly, the YAX symptom score was reduced, and the efficacy remained high at the one-year follow-up. The gut microbiota of the healthy PH exhibited greater diversity, and significantly higher species were identified.[Formula: see text]Compared to PH group, YAX individuals showed increased abundance of Bacteroidetes and Bacteroides,also had higher levels of gut microbial-derived urinary metabolites. After one-month-intervention, both GFDHW treatment and lifestyle intervention enriched the diversity and modulated the structure in YAX. The intervention group also partially restored the microbiome and metabolome to healthy PH-like levels. Further, a microbiota co-occurrence network analysis showed that the metabolites enriched in YAX were correlated with microbial community structure. Taken together, our results suggest that Chinese medicine combined with lifestyle intervention benefits YAX individuals. Gut microbiota/metabolite crosstalk might be involved in the Chinese medicine-mediated effects.

The Relationship Between Bacteria and Breast Cancer: Focusing on the Common Staphylococcus aureus

2019 ◽  
Vol 9 (11) ◽  
pp. 1571-1574
Author(s):  
A. Na-Er ◽  
Yunhong Liu ◽  
Yanjun Gan
Keyword(s):  
Breast Cancer ◽  
Staphylococcus Aureus ◽  
Surgical Site Infection ◽  
Tnm Classification ◽  
Site Infection ◽  
The Common ◽  
One Year ◽  
The One ◽  
The Relationship

Background: The risk of post-operative infection still accounts for a high proportion among the patients. The peptidoglycan on Staphylococcus aureus promotes cellular invasiveness and adhesiveness of tumor cells by pathways activation, including NF-kB, STAT3 and Smad3. Methods: This study included 132 patients age ranging from 45–55 that have been diagnosed with IIA phase breast cancer based on the TNM classification system in one hospital located in the relatively high-income area. These patients have been scheduled the operations and are distributed into two groups: one group will be given certain dosage of antibiotics on presumed Staphylococcus aureus infections, and another group will not be given any unnecessary antibiotics before surgery. Results: We found that 6 patients present surgical site infection related Staphylococcus aureus, with 1 patient in the antibiotics group and the other 5 patients are in the non-antibiotics group. Within the one-year period after surgery, 4 patients presented with metastasis to adjacent lymph nodes, 3 patients are in the non-antibiotics group and another one in the antibiotics group. Conclusion: Early intervention could be an accessible method to decrease the incidence of surgical site infection, which has been illustrated in this study. We consider to take preventive dosage of antibiotics before surgery, which could improve the prognosis of breast cancer and their quality of life in a larger extent.

scholarly journals Efficacy of bariatric surgery in a Colombian population

2020 ◽  
Author(s):  
Claudia Y. Obando León ◽  
William Otero Regino ◽  
HERNANDO MARULANDA FERNANDEZ ◽  
Hernán Ballén ◽  
Elder Otero
Keyword(s):  
Bariatric Surgery ◽  
Antihypertensive Drugs ◽  
Adjustable Gastric Band ◽  
Hypertensive Patients ◽  
Risk Of Mortality ◽  
Before And After ◽  
Excess Bmi Loss ◽  
One Year ◽  
The One

Abstract Background Obesity (OB) is defined as having a body mass index (BMI) of ≥ 30 kg/m2. It has a high risk of mortality due to its association with comorbidities. Bariatric surgery (BS) is indicated for a BMI of 40 kg/m2 or of 35 kg/m2 if concurrent with a metabolic disorder. Methods A retrospective observational study of patients subjected to BS, such as Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), and adjustable gastric band (AGB). A survey was applied to determine the BMI and patterns of comorbidities before and after BS. Results The study included 30 patients who underwent 25 RYGB, 4 SG and 1 AGB procedures. A total of 17 patients were evaluated at the one-year follow-up and all showed improvement in comorbidities and weight loss, with a mean excess BMI loss (%EBMIL) of 89.5% At the two-year follow-up, 3 patients reported a %EBMIL of 75%. At the three-year follow-up, 10 patients had a %EBMIL of 70.8%%, but 70% (7/10) still had a BMI > 30 kg/m2. Type 2 diabetes mellitus resolved in all (12/12) and the doses of antihypertensive drugs were reduced in 86.4% of hypertensive patients (11/13). Half of the patients followed a diet. Conclusion In our service, BS was effective one year after the procedure. After three years, BMI > 30 kg/m2 persisted in 70% of patients All diabetics were cured. The doses of antihypertensives were lowered in 86.4% of hypertensive patients. Ultrasound scan detected no fatty liver diseases at the one-year follow-up of 85.7% of patients.

Safety Study of AAV hTert and Klotho Gene Transfer Therapy for Dementia

2021 ◽  
Author(s):  
Patrick E Sewell
Keyword(s):  
Gene Transfer ◽  
Randomized Study ◽  
Control Group ◽  
Response Data ◽  
Cognitive Improvement ◽  
Moderate Dementia ◽  
Before And After ◽  
Transfer Method ◽  
One Year ◽  
The One

A sponsored, interventional, non-randomized study without a control group using a novel and proprietary central nervous system gene transfer method to deliver AAV hTert and Klotho genes to five patients with mild or moderate dementia was performed to primarily evaluate safety. Clinical response data was gathered as a secondary interest. The therapy demonstrated a very high safety profile with no serious adverse effects identified. Clinical evaluation of the patients over the course of the one year follow up yielded significant findings with all five patients demonstrating evident reversal of Dementia symptoms such as sustained cognitive improvement as measured by the Folstein exam. Telomere analysis was performed before and after the therapy. A measurable elongation of the participants telomeres was identified, and biological age was reduced as chronological age increased.

Sign in / Sign up

Export Citation Format

Share Document