The Relationship Between Bacteria and Breast Cancer: Focusing on the Common Staphylococcus aureus
Background: The risk of post-operative infection still accounts for a high proportion among the patients. The peptidoglycan on Staphylococcus aureus promotes cellular invasiveness and adhesiveness of tumor cells by pathways activation, including NF-kB, STAT3 and Smad3. Methods: This study included 132 patients age ranging from 45–55 that have been diagnosed with IIA phase breast cancer based on the TNM classification system in one hospital located in the relatively high-income area. These patients have been scheduled the operations and are distributed into two groups: one group will be given certain dosage of antibiotics on presumed Staphylococcus aureus infections, and another group will not be given any unnecessary antibiotics before surgery. Results: We found that 6 patients present surgical site infection related Staphylococcus aureus, with 1 patient in the antibiotics group and the other 5 patients are in the non-antibiotics group. Within the one-year period after surgery, 4 patients presented with metastasis to adjacent lymph nodes, 3 patients are in the non-antibiotics group and another one in the antibiotics group. Conclusion: Early intervention could be an accessible method to decrease the incidence of surgical site infection, which has been illustrated in this study. We consider to take preventive dosage of antibiotics before surgery, which could improve the prognosis of breast cancer and their quality of life in a larger extent.