scholarly journals Zirconium-89 Labeled Antibodies: A New Tool for Molecular Imaging in Cancer Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Floor C. J. van de Watering ◽  
Mark Rijpkema ◽  
Lars Perk ◽  
Ulrich Brinkmann ◽  
Wim J. G. Oyen ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Clinical Studies ◽  
Chemical Properties ◽  
Imaging Method ◽  
Positron Emission ◽  
Valuable Method ◽  
Ongoing Development ◽  
The Individual ◽  
Physical And Chemical ◽  
And Chemical Properties

Antibody based positron emission tomography (immuno-PET) imaging is of increasing importance to visualize and characterize tumor lesions. Additionally, it can be used to identify patients who may benefit from a particular therapy and monitor the therapy outcome. In recent years the field is focused on89Zr, a radiometal with near ideal physical and chemical properties for immuno-PET. In this review we will discuss the production of  89Zr, the bioconjugation strategies, and applications in (pre-)clinical studies of  89Zr-based immuno-PET in oncology. To date,89Zr-based PET imaging has been investigated in a wide variety of cancer-related targets. Moreover, clinical studies have shown the feasibility for89Zr-based immuno-PET to predict and monitor treatment, which could be used to tailor treatment for the individual patient. Further research should be directed towards the development of standardized and robust conjugation methods and improved chelators to minimize the amount of released Zr4+from the antibodies. Additionally, further validation of the imaging method is required. The ongoing development of new89Zr-labeled antibodies directed against novel tumor targets is expected to expand applications of  89Zr-labeled immuno-PET to a valuable method in the medical imaging.

scholarly journals In-situ Detection Method for Microplastics in Water by Polarized Light Scattering

2021 ◽  
Vol 8 ◽  
Author(s):  
Tong Liu ◽  
Shijun Yu ◽  
Xiaoshan Zhu ◽  
Ran Liao ◽  
Zepeng Zhuo ◽  
...  
Keyword(s):  
Light Scattering ◽  
Scattered Light ◽  
Polarized Light ◽  
Chemical Properties ◽  
Future Application ◽  
Physical And Chemical Properties ◽  
The Individual ◽  
Physical And Chemical ◽  
And Chemical Properties

Microplastics (MPs) have become the widespread contaminants, which raises concerns on their ecological hazards. In-situ detection of MP in water bodies is essential for clear assessment of the ecological risks of MPs. The present study proposes a method based on polarized light scattering which measures the polarization parameters of the scattered light at 120° to detect MP in water. This method takes the advantage of in-situ measurement of the individual particles and the experimental setup in principle is used. By use of the measured polarization parameters equipped by machine learning, the standard polystyrene (PS) spheres, natural water sample, and lab-cultured microalgae are explicitly discriminated, and MP with different physical and chemical properties can be differentiated. It can also characterize the weathering of different MP and identify the specific type from multiple types of MP. This study explores the capability of the proposed method to detect the physical and chemical properties, weathering state and concentration of MP in water which promises the future application in water quality sensing and monitoring.

scholarly journals MALT90 molecular content on high-mass IR-dark clumps

2018 ◽  
Vol 620 ◽  
pp. A158 ◽  
Author(s):  
Gozde Saral ◽  
Marc Audard ◽  
Yuan Wang
Keyword(s):  
Star Formation ◽  
Initial Conditions ◽  
Chemical Properties ◽  
High Mass ◽  
Mass Star ◽  
Physical And Chemical Properties ◽  
Line Widths ◽  
The Individual ◽  
Physical And Chemical ◽  
And Chemical Properties

Context. High mass stars form in groups or clusters in dense molecular clumps with sizes of 1 pc and masses of 200 M⊙. Infrared-dark clumps and the individual cores within them with sizes < 0.1 pc and masses < 100 M⊙ are important laboratories for high-mass star formation in order to study the initial conditions. Aims. We investigate the physical and chemical properties of high-mass clumps in order to better understand the early evolutionary stages and find targets that show star formation signs such as infall motions or outflows. Methods. We selected the high-mass clumps from ATLASGAL survey that were identified as dark at 8/24 μm wavelengths. We used MALT90 Survey data which provides a molecular line set (HCO+, HNC, HCN, N2H+, H13CO+, HN13C, SiO) to investigate the physical and chemical conditions in early stages of star formation. Results. Eleven sources have significant SiO detection (over 3σ) which usually indicates outflow activity. Thirteen sources are found with blue profiles in both or either HCO+ and/or HNC lines and clump mass infall rates are estimated to be in the range of 0.2 × 10−3 M⊙ yr−1 − 1.8 × 10−2 M⊙ yr−1. The excitation temperature is obtained as < 24 K for all sources. The column densities for optically thin lines of H13CO+ and HN13C are in the range of 0.4–8.8 (×1012) cm−2, and 0.9–11.9 (×1012) cm−2, respectively, while it is in the range of 0.1–7.5 (×1014) cm−2 for HCO+ and HNC lines. The column densities for N2H+ were ranging between 4.4–275.7 (×1012) cm−2 as expected from cold dense regions. Large line widths of N2H+ might indicate turbulence and large line widths of HCO+, HNC, and SiO indicate outflow activities. Mean optical depths are 20.32, and 23.19 for optically thick HCO+ and HCN lines, and 0.39 and 0.45 for their optically thin isotopologues H13CO+ and HN13C, respectively. Conclusions. This study reveals the physical and chemical properties of 30 high-mass IR-dark clumps and the interesting targets among them based on their emission line morphology and kinematics.

Utilisation de vecteurs tournants pour l'optimisation de la formulation de mélanges de solvants

2002 ◽  
Vol 80 (4) ◽  
pp. 350-361
Author(s):  
Serge Alex
Keyword(s):  
Chemical Composition ◽  
Physical Properties ◽  
Visual Analysis ◽  
Chemical Properties ◽  
New Strategy ◽  
Halogenated Solvents ◽  
Solvent Blends ◽  
The Individual ◽  
Physical And Chemical ◽  
And Chemical Properties

A new strategy is proposed to optimize the design of solvent blends without using complex mathematical models and (or) graphical representations. All calculations are made with standard electronic programs, such as Excel, Lotus, etc. This approach was developed for the cleaning and degreasing industry, which has to find new recipes of solvent blends on a regular basis. The process relies on a visual analysis of the sum of normalized rotating vectors associated with the chemical composition and the physical properties of the individual components. This approach allows for representation of all parameters on a two-dimensional plot, including information about chemical composition, as well as the physical properties to be optimized. The research of a new mixture of halogenated solvents will be used as an example to illustrate the various steps of this technique. This method is not limited to solvent applications; it also applies to all problems that involve comparisons of physical and chemical properties of blends.Key words: solvents, mixtures, components, optimization, cleaning.

Statistical criteria of stellar population types

1966 ◽  
Vol 24 ◽  
pp. 101-110
Author(s):  
W. Iwanowska
Keyword(s):  
Stellar Population ◽  
Chemical Properties ◽  
Spectrophotometric Study ◽  
Physical And Chemical Properties ◽  
Population Type ◽  
The Galaxy ◽  
Distribution Parameters ◽  
Physical And Chemical ◽  
Statistical Criteria ◽  
And Chemical Properties

In connection with the spectrophotometric study of population-type characteristics of various kinds of stars, a statistical analysis of kinematical and distribution parameters of the same stars is performed at the Toruń Observatory. This has a twofold purpose: first, to provide a practical guide in selecting stars for observing programmes, second, to contribute to the understanding of relations existing between the physical and chemical properties of stars and their kinematics and distribution in the Galaxy.

Tailoring microstructures of materials through biomimetics

1993 ◽  
Vol 51 ◽  
pp. 500-501
Author(s):  
Mehmet Sarikaya ◽  
Ilhan A. Aksay
Keyword(s):  
Chemical Properties ◽  
Design And Synthesis ◽  
Structure Sensitive ◽  
Macro Scale ◽  
Methods Of Synthesis ◽  
Successive Level ◽  
Engineering Materials ◽  
Physical And Chemical ◽  
And Chemical Properties ◽  
Synthesis Of Materials

Biomimetics involves investigation of structure, function, and methods of synthesis of biological composite materials. The goal is to apply this information to the design and synthesis of materials for engineering applications.Properties of engineering materials are structure sensitive through the whole spectrum of dimensions from nanometer to macro scale. The goal in designing and processing of technological materials, therefore, is to control microstructural evolution at each of these dimensions so as to achieve predictable physical and chemical properties. Control at each successive level of dimension, however, is a major challenge as is the retention of integrity between successive levels. Engineering materials are rarely fabricated to achieve more than a few of the desired properties and the synthesis techniques usually involve high temperature or low pressure conditions that are energy inefficient and environmentally damaging.In contrast to human-made materials, organisms synthesize composites whose intricate structures are more controlled at each scale and hierarchical order.

Response of corn (Zea mays L.) to various organic-based fertilizers in marginal upland of Sta. Rita, Samar

2017 ◽  
pp. 31-43
Author(s):  
Berta Ratilla ◽  
Loreme Cagande ◽  
Othello Capuno
Keyword(s):  
Block Design ◽  
Management Strategies ◽  
Chemical Properties ◽  
Organic Fertilizers ◽  
Growth And Yield ◽  
Physical And Chemical Properties ◽  
Total N ◽  
Randomized Complete Block Design ◽  
Physical And Chemical ◽  
And Chemical Properties

Organic farming is one of the management strategies that improve productivity of marginal uplands. The study aimed to: (1) evaluate effects of various organic-based fertilizers on the growth and yield of corn; (2) determine the appropriate combination for optimum yield; and (3) assess changes on the soil physical and chemical properties. Experiment was laid out in Randomized Complete Block Design, with 3 replications and 7 treatments, namely; T0=(0-0-0); T1=1t ha-1 Evans + 45-30-30kg N, P2O5, K2O ha-1; T2=t ha-1 Wellgrow + 45-30-30kg N, P2O5, K2O ha-1; T3=15t ha-1 chicken dung; T4=10t ha-1 chicken dung + 45-30-30kg N, P2O5, K2O ha-1; T5=15t ha-1 Vermicast; and T6=10t ha-1 Vermicast + 45-30-30kg N, P2O5, K2O ha-1. Application of organic-based fertilizers with or without inorganic fertilizers promoted growth of corn than the control. But due to high infestation of corn silk beetle(Monolepta bifasciata Horns), its grain yield was greatly affected. In the second cropping, except for Evans, any of these fertilizers applied alone or combined with 45-30-30kg N, P2O5, K2O ha-1 appeared appropriate in increasing corn earyield. Soil physical and chemical properties changed with addition of organic fertilizers. While bulk density decreased irrespective of treatments, pH, total N, available P and exchangeable K generally increased more with chicken dung application.

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