Prognostic Value of Normal Stress Echocardiography in Obese Patients

Background.Chest pain is a common problem in obese patients. Because of the body habitus, the results of noninvasive evaluation for CAD may be limited in this group.Methods.We reviewed the records of 1446 consecutive patients who had undergone clinically indicated stress echocardiography (SE). We compared major adverse cardiac events (MACE; myocardial infarction, cardiac intervention, cardiac death, subsequent hospitalization for cardiac events, and emergency department visits) at 1 year in normal weight, overweight, and obese subjects with normal SE.Results.Excluding patients with an abnormal and indeterminate SE and those who were lost to follow-up, a retrospective analysis of 704 patients was performed. There were 366 obese patients (BMI ≥ 30), 196 overweight patients (BMI 25–29.9), and 142 patients with normal BMI (18.5–24.9). There was no MACE in the groups at 1-year follow-up after a normal SE.Conclusions.In obese patients including those with multiple risk factors and symptoms concerning for cardiac ischemia, stress echocardiography is an effective and reliable noninvasive tool for identifying those with a low 1-year risk of cardiac events.

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Neuromedin Beta: P73t Polymorphism in Overweight and Obese Subjects

Physiological Research ◽

10.33549/physiolres.931488 ◽

2008 ◽

pp. S39-S48

Author(s):

J Spálová ◽

H Zamrazilová ◽

J Včelák ◽

M Vaňková ◽

P Lukášová ◽

...

Keyword(s):

Depression Score ◽

Normal Weight ◽

Genotype Distribution ◽

Obese Patients ◽

Weight Reduction Program ◽

Peptide Family ◽

Reduction Program ◽

Obese Subjects ◽

Baseline Examination

Neuromedin beta (NMB) is a member of the bombesin-like peptide family expressed in brain, gastrointestinal tract, pancreas, adrenals and adipose tissue. The aim of our study was to compare the frequency of P73T polymorphism in overweight and obese patients (37 men: age 50.6+/-11.7 years, BMI 41.1+/-7.8 kg/m(2); 255 women: age 49.0+/-11.9 years, BMI 37.9+/-6.8 kg/m(2)) with that of healthy normal weight subjects (51 men: age 28.2+/-7.1 years, BMI 22.3+/-2.0 kg/m(2); 104 women: age 29.1+/-9.1 years, BMI 21.5+/-1.9 kg/m(2)) and to investigate the polymorphism's influence on anthropometric, nutritional and psychobehavioral parameters in overweight/obese patients both at the baseline examination and at a control visit carried out 2.5 years later, regardless of the patient s compliance with the weight reduction program. No significant differences in the genotype distribution were demonstrated between normal weight and overweight/obese subjects. Male T allele non-carriers compared to T allele carriers had higher energy (p=0.009), protein (p=0.018) and fat (p=0.002) intakes and hunger score (p=0.015) at the beginning of treatment. Male T allele non-carriers had a more favorable response to weight management at the follow-up, as they exhibited a significant reduction in waist circumference, energy intake and depression score as well as a significant increase in dietary restraint. No significant differences between carriers and non-carriers were demonstrated in women at the baseline examination. Both female T allele carriers and non-carriers demonstrated similar significant changes in nutritional parameters and in restraint score at the follow-up. Nevertheless, only female non-carriers showed a significant decrease in the hunger score.

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Relation of Plasma Obestatin Levels with BMI and HOMA-IR in Syrian Obese Patients with Type 2 Diabetes

The Open Public Health Journal ◽

10.2174/1874944501710010132 ◽

2017 ◽

Vol 10 (1) ◽

pp. 132-139

Author(s):

Hiba Alhalbouni ◽

Youns Kabalan ◽

Faizeh Alquobaili

Keyword(s):

Normal Weight ◽

The Body ◽

Diabetic Patients ◽

Model Assessment ◽

Obese Patients ◽

Homeostasis Model Assessment ◽

Insulin Levels ◽

Obese Subjects ◽

The Relationship

Background: Obestatin is a novel hormone derived from preproghrelin, which was reported to inhibit appetite and gastric motility. Study Aim: This study aimed to investigate plasma obestatin levels in obese patients with T2D patients, which had not been studied clearly in last researches. Methods: 23 normal weight subjects, 35 obese subjects and 31 obese patients with T2D participated in the study, the body mass index was calculated. Fasting glucose and insulin levels were measured and the homeostasis model assessment of insulin resistance (HOMA-IR) was determined. Plasma obestatin levels were measured with enzyme-linked immune sorbent assay (ELISA). The relationship between plasma obestatin levels and biochemical parameters was also analyzed. Results: Fasting obestatin was significantly lower in obese patients with T2D, comparing to control subjects (mean=6.35 vs12.38ng/ml) and to the non-patients obese group (mean=6.35 vs 7.76 ng/ml). Obestatin levels correlated significantly and negatively with BMI (R=-0. 451; P=0. 01), basal insulin levels (R=-0.737, P<0.0001) and HOMA-IR (R=-0. 764, P<0.0001) in diabetic patients. Conclusion: Our results suggest that obestatin may contribute to body weight regulation, and insulin sensitivity could be affected by obestatin levels.

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ACLR GRAFT STRAND NUMBER: LONG-TERM FOLLOW-UP ON 400 PATIENTS

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967120s00174 ◽

2020 ◽

Vol 8 (4_suppl3) ◽

pp. 2325967120S0017

Author(s):

Julien T Aoyama ◽

Joshua T Bram ◽

John Todd R. Lawrence ◽

Theodore J Ganley

Keyword(s):

Multivariate Regression ◽

Normal Weight ◽

Obese Patients ◽

Long Term Outcomes ◽

Post Surgery ◽

Graft Rupture ◽

Long Term Follow Up ◽

Graft Diameter

Background: Studies on pediatric anterior cruciate ligament reconstructions (ACLRs) often focus on graft choice, as rates of these injuries have risen in recent years. Large multicenter studies have found younger age and smaller graft size to be risk factors for graft failure and contralateral tears, but despite large sample sizes these studies have not looked specifically at graft strand number. Therefore the purpose of this study was to use a large sample size to ask whether ACLR graft strand number affects long-term outcomes. Hypothesis/Purpose: Examine long-term effects of ACLR graft strand number using a large cohort. Methods: This was a retrospective comparison study of all patients presenting between 1/1/2008 and 12/31/16 for a first-time ACLR at a single pediatric hospital. After querying medical records for all ACLRs using CPT codes, graft strand number, graft diameter, and other variables were abstracted. Long-term outcomes on graft rupture, contralateral ACL tear, and subsequent meniscus injury were collected via phone calls and REDCap emails. Patient groups were compared for differences in graft strand number and diameter using bivariate analyses, and differences in long-term outcomes were analyzed using multivariate regression. Results: 436 patients met the inclusion criteria also completed the long-term follow-up on outcomes. Long-term follow-up ranged from 18 months post surgery to 10 years post surgery. Patients with larger graft diameter were significantly less likely to suffer a complication (graft rupture, contralateral ACL tear, or subsequent meniscus injury) in multivariate regression (p=0.03), while strand number, sex, weight, and age showed no significant difference. Transphyseal reconstructions had larger graft diameters (8.8mm) than partial hybrid (8.6mm) and all-epiphyseal reconstructions (8.3mm) (p<0.001), but had no differences in graft strand number. Males had larger graft diameters (8.9mm) than females (8.6mm) (p=0.03), but also had no differences in graft strand number. Obese patients had larger graft diameters (9.1mm) than overweight (8.9mm) and normal weight patients (8.6mm) (p=0.002). Obese patients also had more graft strands (6.9) than overweight (6.2) or normal weight patients (6.1), but this difference was not significant (p=0.051). Conclusion: This data supports the existing literature that pediatric ACLR patients with larger graft diameters are less likely to suffer long-term complications. Using both a large patient cohort and long-term follow-up, this data also showed that graft strand number was not significantly correlated with outcomes. This suggests that strand number is not important when constructing ACLR grafts, as long as sufficient graft diameter can be achieved.

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Problems of the Irradiation of the Pelvis Cancers in Obese Patients

Tumori Journal ◽

10.1177/030089166605200501 ◽

1966 ◽

Vol 52 (5) ◽

pp. 319-334 ◽

Cited By ~ 1

Author(s):

Lorenzo Magno

Keyword(s):

Gamma Rays ◽

Normal Subjects ◽

Correct Choice ◽

The Body ◽

Treatment Technique ◽

Obese Patients ◽

Obese Women ◽

Moving Beam ◽

Choice Of Treatment ◽

Obese Subjects

The irradiation of the pelvis in obese patients meets biological and technical difficulties sometimes considered insuperable. Chiefly when it is necessary to irradiate a very large volume of tissues (for instance, in the case of the irradiation of the pelvis in uterus and ovary cancers) radiotherapy is sometimes considered unsuitable because of considerations concerning the integral dose to be reached, the acute or late reactions expected, difficulties in the choice of the irradiation technique and the execution itself of the therapy. Actually the irradiation of the pelvis in obese patients is clinically possible: it has been performed without complications by the author up to integral doses of 6 × 107 grads in 50 days. The most important problem is the correct choice of treatment technique: when Co 60 gamma rays are employed, obese patients must be irradiated by means of moving beam techniques. The author brings into evidence that obese women, bearing uterus carcinomas, can be irradiated by means of biaxial pendular techniques, employing the same parameters (field at axis, arc width, position of the axis) as in normal subjects. In effect the pelvis in obese subjects is in the center of the corporal section, as in thin subjects. The shape of isodoses in pendular axial irradiations, for Co 60, does not dipend from the dimensions of the body irradiated. The properties of high voltage moving beam radiotherapy turn to the advantage of obese patients. Technical difficulties, which are not negligible, may always be overcome with proper devise.

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Cardiac Changes in Overweight and Obese Patients

Romanian Journal of Internal Medicine ◽

10.1515/rjim-2016-0022 ◽

2016 ◽

Vol 54 (3) ◽

pp. 161-172 ◽

Cited By ~ 1

Author(s):

Teodora Gabriela Alexescu ◽

Angela Cozma ◽

Adela Sitar-Tăut ◽

V. Negrean ◽

M.I. Handru ◽

...

Keyword(s):

Body Mass Index ◽

Left Ventricle ◽

Diastolic Dysfunction ◽

Body Mass ◽

Body Surface ◽

Interventricular Septum ◽

Normal Weight ◽

The Body ◽

Obese Patients ◽

Left Ventricle Mass

Abstract Background. Obesity and overweight are two pathologies that are more and more frequent in the XXIst century diagnosis and are causing high morbidity and mortality rates in the general population, especially through cardiovascular complications.Aims. Identification and early diagnosis of cardiac changes in overweight and obese patients. Material and method. We carried out a sectional, analytical and observational study on 111 subjects: 27 normal weight subjects and 84 overweight and obese patients, which were submitted to a clinical exam, biochemical exams and 2D ultrasound.Results. The presence of diastolic dysfunction is twice more frequent in overweight patients in comparison to normal weight ones (30% vs 15%) and 5 times more frequent in obese patients than normal weight ones (75% vs 15%). The size increase of the interventricular septum is correlated with the body mass index, there being statistically significant differences between normal weight vs overweight vs obese patients, as well as between overweight and obese ones. Within the whole group and within the groups, both the left ventricle mass (g) as well as the left ventricle mass to body surface ratio (g/m²) are statistically significantly higher in patients with present diastolic dysfunction (E/A < 1). This indicates a relation between the presence of diastolic dysfunction, increased left ventricle mass and body mass index (p < 0.05).Conclusions. Overweight and obese patients, unlike normal weight ones, present early cardiac changes, such as: a decrease of left ventricle ejection fraction, diastolic dysfunction, thickening of the interventricular septum, increase of the left ventricle mass both per se as well as in ratio to body surface.

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Measuring changes in serum, hair and urinary levels of cobalt, copper, manganese, and iron in obesity and hypertention using the ICP-MS technique

ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» ◽

10.25557/0031-2991.2020.02.89-95 ◽

2020 ◽

pp. 89-95

Author(s):

А.А. Тиньков ◽

О.П. Айсувакова ◽

М.Г. Скальная ◽

М.Ю. Карганов ◽

S. J.-S. Chang ◽

...

Keyword(s):

Data Acquisition ◽

Inductively Coupled Plasma ◽

Elevated Serum ◽

Serum Levels ◽

Normal Weight ◽

Single Element ◽

Obese Patients ◽

Urinary Levels ◽

Obese Subjects ◽

Clinical Records

Введение. Нарушения металлолигандного гомеостаза патогенетически связаны с развитием ожирения. Несмотря на то, что обмен железа при ожирении изучен достаточно детальноно, данные касающиеся обмена других металлов недостаточны. Цель исследования -- изучение содержания кобальта, железа, меди и марганца в сыворотке крови, моче и волосах пациентов с ожирением в зависимости от наличия у них артериальной гипертонии. Методика. Обследованы 395 лиц обоего пола: 196 с ожирением и 199 с нормальной массой тела. На основании данных амбулаторных карт среди обследуемых пациентов с ожирением артериальная гипертония была диагностирована у 43%, атеросклероз у 9% и нарушение толерантности к глюкозе и/или сахарный диабет 2 типа -- 11%. Анализ содержания кобальта (Co), железа (Fe), меди (Cu) и марганца (Mn) в волосах, сыворотке крови и моче проводили с использованием масс-спектрометра с индуктивно-связанной плазмой NexION 300D (PerkinElmer Inc., США) оснащенном ESI SC-2 DX4 autosampler (Elemental Scientific Inc., США). Калибровка ICP-DRC-MS системы проводилась с использованием растворов металлов, приготовленных на основе Universal Data Acquisition Standards Kit (PerkinElmer Inc., США). Внутренняя стандартизация проводилась с использованием растворов иттрия и родия 10 мг/л Pure Single-Element Standard (PerkinElmer Inc., США). Контроль качества проводился с использованием референтных образцов волос (GBW09101, SINR, Китай), сыворотки и мочи (ClinChek Plasma/Urine Control, Recipe, Германия). Результаты. Установлено, что в сыворотке крови пациентов с ожирением концентрация Co и Fe снижалась статистически значимо на 32% и 12% соответственно. Уровень Cu и Mn превышал соответствующие контрольные значения на 12% и 4%. Содержание Co, Cu и Mn в волосах обследуемых пациентов с ожирением было ниже контроля на 16%, 8% и 20%, соответственно. Отмечалось статистически значимое увеличение содержания железа в волосах на 55% по сравнению с контролем. Концентрация Co и Fe в моче пациентов с ожирением была соответственно ниже на 34% и выше на 25% относительно контрольных значений. При этом у пациентов с ожирением и гипертонией обнаруживалось статистически значимое повышение концентрации меди в сыворотке крови (на 9%), кобальта в моче (на 69%), а также содержания марганца в волосах (на 69%) по сравнению с соответствующими показателями у пациентов с ожирением без гипертонии. Заключение. Можно предположить, что дисбаланс металлов в организме вносит вклад в формирование ожирение-ассоциированных патологий, в том числе в развитие артериальной гипертензии. Background. Disorders of the metal-ligand homeostasis are pathogenetically associated with obesity. Although impaired iron metabolism in obesity is relatively well studied information about other essential metals is insufficient. Objective. The objective of the study was to assess serum, urine, and hair levels of cobalt, iron, copper, and manganese in obese subjects in relation to the presence of hypertension. Methods. 396 adults with obesity (n = 196) and normal weight (n = 199) were examined. Based on clinical records of the patients with obesity, 43% of them had arterial hypertension, 9% had atherosclerosis, and 11% had impaired glucose tolerance and/or type 2 diabetes mellitus. Measurements of hair, serum, and urinary levels of cobalt (Co), iron (Fe), copper (Cu) and manganese (Mn) were performed using a NexIOD 300D inductively-coupled plasma mass-spectrometer (PerkinElmer Inc., USA) equipped with an ESI SC-2 DX4 autosampler (Elemental Scientific Inc., USA). The ICP-DRC-MS system was calibrated with metal solutions prepared with a Universal Data Acquisition Standards Kit (PerkinElmer Inc., USA). Pure Single-Element Standard yttrium and rhodium solutions (10 mg/l) (PerkinElmer Inc., USA) were used as internal standards. Reference samples of hair (GBW09101, SINR, China), serum, and urine (ClinChek Plasma/Urine Control, Recipe, Germany) were used for quality control. Results. Serum levels of Co and Fe were statistically significantly 32% and 12%, respectively, lower in obese patients than in normal-weight controls. Serum concentrations of Cu and Mn in obese patients exceeded the control values by 12% and 4%, respectively. Hair contents of Co, Cu, and Mn in obese subjects were 16%, 8%, and 20%, respectively, lower as compared to the respective control values. Hair Fe in obesity was 55% elevated compared to normal-weight values. Urinary Co and Fe in obese subjects were 34% lower and 25% higher, respectively, than in healthy controls. At the same time, patients with obesity and hypertension had elevated serum Cu, urinary Co, and hair Mn compared to obese normotensive subjects. Conclusion. The impaired metal homeostasis may contribute to the development of obesity-associated disorders including hypertension.

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The association between body mass index and the oral Firmicutes and Bacteroidetes profiles of healthy individuals

Malaysian Family Physician ◽

10.51866/oa1129 ◽

2021 ◽

Vol 16 (3) ◽

pp. 36-43

Author(s):

Roshna Mohamed Qadir ◽

Mahde Saleh Assafi

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Bacterial Species ◽

Oral Bacteria ◽

Normal Weight ◽

The Body ◽

Oral Microbiome ◽

Bacterial Phyla ◽

Obese Subjects ◽

Health Objective

Introduction: Microbiome status is considered an important factor that contributes to obesity. Investigations have shown that the oral microbiome comprises a vast array of bacterial species that can influence human health. Objective: To determine the association between the presence of the bacterial phyla Firmicutes and Bacteroidetes and the body mass index (BMI) status of normal, overweight and obese subjects in Duhok, Iraq. Additionally, to investigate the composition of oral Firmicutes and Bacteroidetes profiles for individuals with different BMI statuses. Methods: A total of 155 saliva samples were collected from participants in Duhok, Iraq. Bacterial genomic DNA was then extracted from the collected saliva. The presence of Firmicutes and Bacteroidetes phyla was detected via polymerase chain reaction. Results: Firmicutes and Bacteroidetes were detected in 63.2 and 37.4% of the population, respectively. Differences in the carriage rates of oral Firmicutes in overweight (78%) and obese individuals (83%) were statistically significant when compared to normal weight individuals (36%) (P<0.0001). The percentage rates of Bacteroidetes in obese individuals (26.4%) was statistically significant when compared to normal weight individuals (50.8%) (P=0.0078). The Firmicutes/Bacteroidetes ratios (obese=3.1, overweight=2.5 and normal weight=0.7) were higher with increasing BMI. Conclusion: This study provides evidence of the Firmicutes/Bacteroidetes ratio growing with increasing BMI. High rates of Firmicutes could serve a role in the development of obesity. Further studies are required to clarify the exact relationship between oral bacteria and obesity, which could lead to a promising therapeutic method for improving the physical health of humans.

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Abstract 6256: Absence of Leptin Resistance in Platelets from Obese Individuals Suggests a Mechanism for Increased Thrombosis Risk in Obesity

Circulation ◽

10.1161/circ.118.suppl_18.s_1168-a ◽

2008 ◽

Vol 118 (suppl_18) ◽

Author(s):

Claudia Dellas ◽

Katrin Schaefer ◽

Ilonka Rohm ◽

Mareike Lankeit ◽

Gerd Hasenfuss ◽

...

Keyword(s):

Platelet Aggregation ◽

Normal Weight ◽

The Body ◽

Leptin Resistance ◽

Morbidly Obese ◽

Thrombosis Risk ◽

Obese Subjects ◽

Plasma Leptin ◽

And Control ◽

Induced Aggregation

Clinical studies have demonstrated that elevated leptin levels, such as frequently found in obesity, are an independent cardiovascular risk factor. We and others have shown that leptin promotes platelet aggregation and thrombosis. However, little is known about the existence of platelet resistance to leptin, particularly in the setting of obesity and central leptin resistance. In the present study, we examined the effects of leptin on platelet aggregation in morbidly obese subjects (n=40; BMI 41.6±1.1 kg/m2; leptin 49.7±3.4 ng/mL) in comparison to normal-weight controls (n=36; BMI 23.3±0.4; leptin 6.5±0.7). The aggregatory response to ADP was significantly increased in platelets from obese donors compared to controls as shown by a left-shift in the ADP dose curves. Thus, percent platelet aggregation at 2, 3, 4, and 5 μM ADP was 18.7±4.8 in the obese vs. 4.7±2.0 in controls (P=0.01), 37.2±6.6 vs. 17.1±4.4 (P=0.01), 60.8±6.0 vs. 37.8±6.5 (P=0.01), and 80.2±6.5 vs. 44.5±8.8 (P=0.002), respectively. Plasma leptin levels, but not the body-mass-index, were significantly higher in subjects with stronger (above the median) platelet aggregation in response to ADP compared to those with weaker (below the median) aggregation (35.9±5.1 vs. 22.4±4.1 ng/mL; P=0.04). In further experiments, exogenous leptin stimulation promoted ADP-induced platelet aggregation by 25% on average, and there was no difference in the responsiveness to leptin between platelets from obese and those from lean donors (controls; P=0.99). Using Western blot analysis we found that leptin induced phosphorylation of the signaling molecules JAK2 and STAT3 to a similar extent in platelets from both groups. Expression of potential mediators of leptin resistance (SOCS3 and PTP1B) also did not differ in platelets from obese and control subjects. Taken together, our data indicate that platelets from obese donors show increased aggregatory response to ADP, which might partly result from the increased circulating leptin levels. Platelets from obese individuals were not resistant to the enhancing effects of leptin on ADP-induced aggregation. Our results thus support the existence of a direct link between obesity, hyperleptinemia and thrombosis.

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Effect of Body Mass Index on Overall Survival of Patients with Allogeneic Hematopoietic Stem Cell Transplantation

Blood ◽

10.1182/blood.v126.23.5510.5510 ◽

2015 ◽

Vol 126 (23) ◽

pp. 5510-5510 ◽

Cited By ~ 1

Author(s):

Shengli Xue ◽

Jing Yang ◽

Xiang Zhang ◽

Yueping Shen ◽

Wu Depei

Keyword(s):

Body Mass Index ◽

Overall Survival ◽

Stem Cell ◽

Hematopoietic Stem Cell Transplantation ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Normal Weight ◽

Obese Patients ◽

Hematopoietic Stem

Abstract AIM: The present study was performed to investigate the association between body mass index (BMI) before transplantation and the overall survival (OS) of patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS: Data from 310 adults who were diagnosed with acute leukemia and underwent allo-HSCT between March 2001 and December 2011 were analyzed. Demographic and clinical data were collected from medical records. In accordance with the suggested BMI categories for Asian population, patients with BMIs of ≥23 and ≥25 kg/m2 were identified as overweight and obese, respectively. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, which were adjusted for possible confounding factors. RESULTS: The median follow-up time among the patients was 19.7 months (interquartile range = 8.1 to 37.7). A total of 93 (34.8%) patients died within the follow-up period. After adjusted for the potential confounders, normal-weight, overweight, and obese patients showed significantly lower HRs than underweight patients, with a significant trend of OS improvement upon increasing BMI (P = 0.019). Overweight and obese patients survived longer, with a significantly decreased HR by approximately 40% (HR = 0.60;95% CI: 0.38 to 0.95) compared with underweight and normal-weight patients. CONCLUSIONS: An increased OS was seen in allo-HSCT patients with BMI≥23 compared to those with lower BMI. Further studies are required to obtain better understanding of the effects of BMI or body composition on the survival of allo-HSCT patients. Disclosures No relevant conflicts of interest to declare.

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Ureteroenteric strictures: a single center experience comparing Bricker versus Wallace ureteroileal anastomosis in patients after urinary diversion for bladder cancer

BMC Urology ◽

10.1186/s12894-019-0529-6 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Frank Christoph ◽

Franziska Herrmann ◽

Peter Werthemann ◽

Thomas Janik ◽

Martin Schostak ◽

...

Keyword(s):

Bladder Cancer ◽

Ileal Conduit ◽

Anastomotic Stricture ◽

The Body ◽

Stricture Formation ◽

Obese Patients ◽

Single Institution ◽

Single Center Experience ◽

Stricture Rate

Abstract Background To evaluate the outcome and complication rate in a single institution experience using the two most commonly used techniques of ureteroenteric anastomosis, the Bricker and Wallace anastomosis. Methods A total of 137 patients underwent ileal conduit for bladder cancer. Ureters were anastomosed by two experienced surgeons, one performing a Bricker and the other, a Wallace anastomosis. Stricture was identified during clinical follow-up. Results Seventy-five patients underwent a Bricker anastomotic, and 65 received a Wallace anastomosis. The average age was 70 in both groups, males were predominant (66% Bricker, 70% Wallace). Follow up period was 36.5 months in Bricker group and 17 months in Wallace group. In both groups, the body mass index (BMI) was similar (26.1 kg/m2 Bricker and 26.4 kg/m2 Wallace). We observed that the stricture rate after performing the Bricker anastomosis technique was 25.3% (19/75) as compared to 7.7% (5/65) after Wallace anastomosis technique, which was statistically significant (p = 0.001). In the Bricker group, patients with strictures had higher BMI (28.3 vs. 25.7 kg/m2, p = 0.05). On average it took 8.5 months in the Bricker group and three months in the Wallace group (p = 0.6) to develop stricture. Conclusions The stricture rate was significantly higher when Bricker technique was applied. Although the BMI was not different in both groups, patients with a higher BMI were more likely to develop stricture. We believe that the approach of the separate and refluxing technique of Bricker anastomosis especially in obese patients poses a higher risk for anastomotic stricture formation.

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