The Combined Extract ofZingiber officinaleandZea mays(Purple Color) Improves Neuropathy, Oxidative Stress, and Axon Density in Streptozotocin Induced Diabetic Rats

Based on the protective effect of the combined extract of purple waxy corn and ginger (PWCG) on oxidative stress related disorders in diabetic condition, we aimed to determine the effect of PWCG on the functional, biochemical, and structural change of the lesion nerve in streptozotocin- (STZ-) diabetic rats. PWCG at doses of 100, 200, and 300 mg·kg−1BW were orally given to STZ-diabetic rats which were subjected to chronic constriction (CCI) at right sciatic nerve for 21 days. The blood sugar was assessed before and at the end of study whereas the sciatic function index (SFI), paw withdrawal threshold intensity (PWTI), and paw withdrawal latency (PWL) were assessed every 3 days until the end of study. At the end of study, the determination of nerve conduction velocity (NCV), axon density, oxidative stress status, and aldose reductase (AR) activity of the lesion nerve were performed. It was found that PWCG improved SFI, PWTI, PWL, and NCV together with the improved oxidative stress status and the axon density in the lesion nerve. No changes of AR activity or blood sugar level were observed. Therefore, PWCG might improve the functional and structural changes in STZ-diabetic rats plus CCI via the improved oxidative stress status.

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Beneficial Effect of Aqueous Garlic Extract on Inflammation and Oxidative Stress Status in the Kidneys of Type 1 Diabetic Rats

Indian Journal of Clinical Biochemistry ◽

10.1007/s12291-016-0621-6 ◽

2016 ◽

Vol 32 (3) ◽

pp. 329-336 ◽

Cited By ~ 12

Author(s):

Abolfazl Nasiri ◽

Nasrin Ziamajidi ◽

Roghayeh Abbasalipourkabir ◽

Mohammad Taghi Goodarzi ◽

Massoud Saidijam ◽

...

Keyword(s):

Oxidative Stress ◽

Beneficial Effect ◽

Diabetic Rats ◽

Garlic Extract ◽

Oxidative Stress Status ◽

And Oxidative Stress

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Assessment of thiol/disulfide balance as an oxidative stress marker in children with β-thalassemia major

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.35.1.307 ◽

2019 ◽

Vol 35 (1) ◽

Cited By ~ 1

Author(s):

Ahmet Guzelcicek ◽

Gokhan Cakirca ◽

Ozcan Erel ◽

Abdullah Solmaz

Keyword(s):

Oxidative Stress ◽

Ferritin Level ◽

Thalassemia Major ◽

Oxidative Stress Marker ◽

Creative Commons ◽

Pediatric Hematology ◽

Stress Marker ◽

Oxidative Stress Status ◽

Blood Specimens

Objective: We aimed to investigate the oxidative stress status in children with β-thalassemia major (β-TM) by measuring native thiol (SH), disulfide (SS) and total thiol (SH + SS) plasma levels. Methods: This study was carried out from November 2017 to March 2018 at the Pediatric Hematology Clinic of the Harran University Medical Faculty Hospital. Blood specimens were collected from 100 participants, including 50 β-TM patients and 50 controls, and SH, SS and SH+SS levels were detected through a newly developed method. Results: SH, SS, SH+SS levels and SS/SH ratio were markedly higher in β-TM patients than in controls. In β-TM group, SH and SH+SS levels were positively correlated with age, albumin and total bilirubin. Serum ferritin level was positively correlated with SH, SH+SS, aspartate transaminase and alanine transaminase. Conclusions: We found that the SS/SH ratio was high in patients with β-TM, which shows increased oxidative stress. This ratio may be considered as a tool for the determination of oxidative status in such patients due to easily calculate, suitable for routine use and economical. How to cite this:Guzelcicek A, Cakirca G, Erel O, Abdullah Solmaz4. Assessment of thiol/disulfide balance as an oxidative stress marker in children with β-thalassemia major. Pak J Med Sci. 2019;35(1):---------. doi: https://doi.org/10.12669/pjms.35.1.307 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Electrospun Nanofibers Loaded with Quercetin Promote the Recovery of Focal Entrapment Neuropathy in a Rat Model of Streptozotocin-Induced Diabetes

BioMed Research International ◽

10.1155/2017/2017493 ◽

2017 ◽

Vol 2017 ◽

pp. 1-12 ◽

Cited By ~ 10

Author(s):

Chonlathip Thipkaew ◽

Jintanaporn Wattanathorn ◽

Supaporn Muchimapura

Keyword(s):

Oxidative Stress ◽

Functional Recovery ◽

Electrospun Nanofibers ◽

Diabetic Rats ◽

Nerve Lesion ◽

Electrospinning Technique ◽

Oxidative Stress Status ◽

Male Wistar Rats ◽

Streptozotocin Induced Diabetes ◽

The Right

In this study, quercetin-loaded zein-based nanofibers were developed using electrospinning technique. The therapeutic effect of these quercetin-loaded nanofibers on neuropathy in streptozotocin- (STZ-) induced diabetes in rats was assessed. Diabetic condition was induced in male Wistar rats by STZ, after which a crush injury of the right sciatic nerve was performed to induce mononeuropathy. Functional recovery was assessed using walking track analysis, measurements of foot withdrawal reflex, nerve conduction velocity, and morphological analysis. The oxidative stress status and the ratio of phosphorylated extracellular recognition kinase (pERK)/extracellular recognition kinase (ERK) expression in the nerve lesion were also assessed in order to elucidate the potential mechanisms involved. Results showed that quercetin-loaded zein-based nanofibers slightly enhanced functional recovery from neuropathy in STZ-diabetic rats. The potential mechanism might partially involve improvements in oxidative stress status and the ratio of pERK/ERK expression in the nerve lesion.

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Effect of Curculigo pilosa supplemented diet on blood sugar, lipid metabolism, hepatic oxidative stress and carbohydrate metabolism enzymes in streptozotocin-induced diabetic rats

Journal of Diabetes & Metabolic Disorders ◽

10.1007/s40200-020-00618-w ◽

2020 ◽

Author(s):

Kayode Olayele Karigidi ◽

Emmanuel Sina Akintimehin ◽

Damilola Alex Omoboyowa ◽

Foluso Olutope Adetuyi ◽

Charles Ojo Olaiya

Keyword(s):

Oxidative Stress ◽

Lipid Metabolism ◽

Carbohydrate Metabolism ◽

Blood Sugar ◽

Diabetic Rats ◽

Hepatic Oxidative Stress ◽

Metabolism Enzymes

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Comment on “The Combined Extract ofZingiber officinaleandZea mays(Purple Color) Improves Neuropathy, Oxidative Stress, and Axon Density in Streptozotocin Induced Diabetic Rats”

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/593734 ◽

2015 ◽

Vol 2015 ◽

pp. 1-2

Author(s):

Rômulo Dias Novaes ◽

Reggiani Vilela Gonçalves

Keyword(s):

Oxidative Stress ◽

Diabetic Rats ◽

Axon Density ◽

Purple Color

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Neuroprotective and Memory-Enhancing Effect of the Combined Extract of Purple Waxy Corn Cob and Pandan in Ovariectomized Rats

Oxidative Medicine and Cellular Longevity ◽

10.1155/2017/5187102 ◽

2017 ◽

Vol 2017 ◽

pp. 1-12 ◽

Cited By ~ 11

Author(s):

Woranan Kirisattayakul ◽

Jintanaporn Wattanathorn ◽

Sittichai Iamsaard ◽

Jinatta Jittiwat ◽

Bhalang Suriharn ◽

...

Keyword(s):

Oxidative Stress ◽

Object Recognition ◽

Hormone Replacement ◽

Ovariectomized Rats ◽

Acetylcholinesterase Inhibition ◽

Corn Cob ◽

Neuron Density ◽

Oxidative Stress Status ◽

Waxy Corn ◽

Memory Enhancing

The neuroprotectant and memory enhancer supplement for menopause is required due to the side effects of hormone replacement therapy. Since purple waxy corn cob and pandan leaves exert antioxidant and acetylcholinesterase inhibition (AChEI) effects, we hypothesized that the combined extract of both plants (PCP) might provide synergistic effect leading to the improved brain damage and memory impairment in experimental menopause. To test this hypothesis, female Wistar rats were ovariectomized bilaterally and orally given various doses of the functional drink at doses of 20, 40, and 80 mg/kg for 28 days. The animals were assessed nonspatial memory using object recognition test every 7 days throughout the study period. At the end of study, they were assessed with oxidative stress status, AChEI, neuron density, and ERK1/2 signal in the prefrontal cortex (PFC). Interestingly, all doses of PCP increased object recognition memory and neuron density but decreased oxidative stress status in PFC. Low dose of PCP also decreased AChE activity while medium dose of PCP increased phosphorylation of ERK1/2 in PFC. Therefore, the improved oxidative stress status and cholinergic function together with signal transduction via ERK in PFC might be responsible for the neuroprotective and memory-enhancing effects of PCP.

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Anticataractogenesis and Antiretinopathy Effects of the Novel Protective Agent Containing the Combined Extract of Mango and Vietnamese Coriander in STZ-Diabetic Rats

Oxidative Medicine and Cellular Longevity ◽

10.1155/2017/5290161 ◽

2017 ◽

Vol 2017 ◽

pp. 1-13 ◽

Cited By ~ 3

Author(s):

Jintanaporn Wattanathorn ◽

Paphaphat Thiraphatthanavong ◽

Wipawee Thukham-mee ◽

Supaporn Muchimapura ◽

Panakaporn Wannanond ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetic Retinopathy ◽

Aldose Reductase ◽

Diabetic Rats ◽

Potential Candidate ◽

Protective Agent ◽

The Novel ◽

Diabetic Cataract ◽

Oxidative Stress Status ◽

Mango Seed

The novel protectant against diabetic cataract and diabetic retinopathy is currently required due to the increased prevalence and therapeutic limitation. Based on the advantage of polyphenol on diabetic eye complications, we hypothesized that the combined extract of mango seed Vietnamese coriander (MPO), a polyphenol-rich substance, should possess anticataractogenesis and antiretinopathy in streptozotocin- (STZ-) diabetic rats. MPO at doses of 2, 10, and 50 mg/kg·BW were orally given to STZ-diabetic rats for 10 weeks. Lens opacity was evaluated every week throughout a study period whereas the evaluation of cataract severity and histological changes of both rat lens epithelium and retina together with the biochemical assays of oxidative stress status, aldose reductase, p38MAPK, ERK1/2, and VEGF were performed at the end of experiment. Our data showed that MPO improved cataract and retinopathy in STZ-diabetic rats. The improved oxidative stress status and the decreased p38MAPK, ERK1/2, and VEGF were also observed. Therefore, anticataractogenesis and antiretinopathy of MPO might occur partly via the decreased oxidative stress status and the suppression of aldose reductase, p38MAPK, ERK1/2, and VEGF. This study points out that MPO is the potential candidate protectant against diabetic cataract and diabetic retinopathy. However, the exploration for possible active ingredient (S) still requires further researches.

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