scholarly journals Long-Term Antibacterial Film Nanocomposite Incorporated with Patchouli Essential Oil Prepared by Supercritical CO2 Cyclic Impregnation for Wound Dressing

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 5005
Author(s):  
Jingfu Jia ◽  
Shulei Duan ◽  
Xue Zhou ◽  
Lifang Sun ◽  
Chengyuan Qin ◽  
...  
Keyword(s):  
Essential Oil ◽  
Supercritical Co2 ◽  
Wound Dressing ◽  
Mesoporous Silica Nanoparticles ◽  
Skin Wound ◽  
Mouse Fibroblast ◽  
Elongation At Break ◽  
Promising Strategy ◽  
Dressing Materials

Biocompatible skin wound dressing materials with long-term therapeutic windows and anti-infection properties have attracted great attention all over the world. The cooperation between essential oil and non-toxic or bio-based polymers was a promising strategy. However, the inherent volatility and chemical instability of most ingredients in essential oils make the sustained pharmacological activity of essential oil-based biomaterials a challenge. In this study, a kind of film nanocomposite loaded with patchouli essential oil (PEO-FNC) was fabricated. PEO-loaded mesoporous silica nanoparticles (PEO-MSNs) with drug load higher than 40 wt% were firstly prepared using supercritical CO2 cyclic impregnation (SCCI), and then combined with the film matrix consisting of polyvinyl alcohol and chitosan. The morphology of PEO-MSNs and PEO-FNC was observed by transmission and scanning electron microscope. The mechanical properties, including hygroscopicity, tensile strength and elongation at break (%), were tested. The release behavior of PEO from the film nanocomposite showed that PEO could keep releasing for more than five days. PEO-FNC exhibited good long-term (>48 h) antibacterial effect on Staphylococcus aureus and non-toxicity on mouse fibroblast (L929 cells), making it a promising wound dressing material.

scholarly journals A handy skin wound dressing prepared by alginate and cationic nanofibrillated cellulose derived from solid residues of herbs

BioResources ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. 5926-5946
Author(s):  
Ting Jiang ◽  
Xiaoyan Feng ◽  
Rui Xu ◽  
Sheng Dong ◽  
Meiyan Wu ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Cost Effective ◽  
Nanofibrillated Cellulose ◽  
Antibacterial Activities ◽  
Skin Wound ◽  
Natural Medicine ◽  
Nanofibrous Structure ◽  
New Strategy ◽  
Physical Interactions ◽  
Dressing Materials

Large amounts of solid residues are generated after extraction of active ingredients from herbs for the production of natural medicine, but the residues have not been well utilized. In this work, cationic nanofibrillated cellulose (CCNF) was prepared from the solid residues of Astragali Radix by etherification and homogenization. The CCNF was mixed with sodium alginate (SA) to create a hydrogel dressing by physical interactions between CCNF and SA without any addition of cross-linker. The CCNF-SA dressing exhibited moderate viscosity, good moisture-maintaining property, great antibacterial activities, good cytocompatibility, and clear acceleration of wound healing on rats. Furthermore, this CCNF-SA dressing with nanofibrous structure had moderate air permeability. Therefore, the CCNF-SA hydrogel could be used potentially as a skin wound dressing. Development of cost-effective and bioactive wound dressing materials is of crucial importance to reduce the burden on patients and healthcare systems. Also, this work provides a new strategy for valorization of the solid residues of herbs.

scholarly journals Experimental Investigation of the Properties of Electrospun Nanofibers for Potential Medical Application

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Anhui Wang ◽  
Chao Xu ◽  
Chuanwei Zhang ◽  
Yunna Gan ◽  
Bin Wang
Keyword(s):  
Wound Dressing ◽  
Transmission Rate ◽  
Electrospun Nanofibers ◽  
Medical Application ◽  
Superior Performance ◽  
Fluid Uptake ◽  
Ag Particles ◽  
Dressing Materials ◽  
Potential Use

Polymer based nanofibers using ethylene-co-vinyl alcohol (EVOH) were fabricated by electrospinning technology. The nanofibers were studied for potential use as dressing materials for skin wounds treatment. Properties closely related to the clinical requirements for wound dressing were investigated, including the fluid uptake ability (FUA), the water vapour transmission rate (WVTR), the bacteria control ability of nanofibers encapsulated with different antibacterial drugs, and Ag of various concentrations. Nanofibre degradation under different environmental conditions was also studied for the prospect of long term usage. The finding confirms the potential of EVOH nanofibers for wound dressing application, including the superior performance compared to cotton gauze and the strong germ killing capacity when Ag particles are present in the nanofibers.

scholarly journals Enhanced wound repair ability of arginine-chitosan nanocomposite membrane through the antimicrobial peptides-loaded polydopamine-modified graphene oxide

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Chuan Fu ◽  
Zhiping Qi ◽  
Chengliang Zhao ◽  
Weijian Kong ◽  
Hongru Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Graphene Oxide ◽  
Antimicrobial Peptides ◽  
Wound Dressing ◽  
Skin Wound ◽  
Nanocomposite Membrane ◽  
Modified Graphene Oxide ◽  
Repair Ability ◽  
Modified Graphene ◽  
Dressing Materials

AbstractSkin wound healing is a complicated and lengthy process, which is influenced by multiple factors and need a suitable cellular micro-environment. For skin wound, wound dressings remain a cornerstone of dermatologic therapy at present. The dressing material can create an effective protective environment for the wound, and the interactions between the dressing and the wound has a great impact on the wound healing efficiency. An ideal wound dressing materials should have good biocompatibility, moisturizing property, antibacterial property and mechanical strength, and can effectively prevent wound infection and promote wound healing. In this study, in order to design wound dressing materials endowed with excellent antibacterial and tissue repair properties, we attempted to load antimicrobial peptides onto dopmine-modified graphene oxide (PDA@GO) using lysozyme (ly) as a model drug. Then, functionalized GO was used to the surface modification of arginine-modified chitosan (CS-Arg) membrane. To evaluate the potential of the prepared nanocomposite membrane in wound dressing application, the surface morphology, hydrophilic, mechanical properties, antimicrobial activity, and cytocompatibility of the resulting nanocomposite membrane were analyzed. The results revealed that prepared nanocomposite membrane exhibited excellent hydrophilic, mechanical strength and antimicrobial activity, which can effectively promote cell growth and adhesion. In particular, using PDA@GO as drug carrier can effectively maintain the activity of antimicrobial peptides, and can maximize the antibacterial properties of the nanocomposite membrane. Finally, we used rat full-thickness wound models to observe wound healing, and the surface interactions between the prepared nanocomposite membrane and the wound. The results indicated that nanocomposite membrane can obviously accelerated wound closure, and the wounds showed reduced inflammation, improved angiogenesis and accelerated re-epithelialization. Therefore, incorporation of antimicrobial peptides-functionalize graphene oxide (ly-PDA@GO) into CS-Arg membrane was a viable strategy for fabricating excellent wound dressing. Together, this study not only prepared a wound dressing with excellent tissue repair ability, but also provided a novel idea for the development of graphene oxide-based antibacterial dressing.

scholarly journals Enhanced wound repair ability of arginine-chitosan nanocomposite membrane through the antimicrobial peptides-loaded dopmine-modified graphene oxide

2021 ◽  
Author(s):  
Chuan Fu ◽  
Zhiping Qi ◽  
Chengliang Zhao ◽  
Wenlai Kong ◽  
Hongru Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Graphene Oxide ◽  
Antimicrobial Peptides ◽  
Wound Dressing ◽  
Skin Wound ◽  
Nanocomposite Membrane ◽  
Modified Graphene Oxide ◽  
Repair Ability ◽  
Modified Graphene ◽  
Dressing Materials

Abstract Skin wound healing is a complicated and lengthy process, which is influenced by multiple factors and need a suitable cellular micro-environment. For skin wound, wound dressings remain a cornerstone of dermatologic therapy at present. The dressing material can create an effective protective environment for the wound, and the interactions between the dressing and the wound has a great impact on the wound healing efficiency. An ideal wound dressing materials should have good biocompatibility, moisturizing property, antibacterial property and mechanical strength, and can effectively prevent wound infection and promote wound healing. In this study, in order to design wound dressing materials endowed with excellent antibacterial and tissue repair properties, we attempted to load antimicrobial peptides onto dopmine-modified graphene oxide (PDA@GO) using lysozyme (ly) as a model drug. Then, functionalized GO was used to the surface modification of arginine-modified chitosan (CS-Arg) membrane. To evaluate the potential of the prepared nanocomposite membrane in wound dressing application, the surface morphology, hydrophilic, mechanical properties, antimicrobial activity, and cytocompatibility of the resulting nanocomposite membrane were analyzed. The results revealed that prepared nanocomposite membrane exhibited excellent hydrophilic, mechanical strength and antimicrobial activity, which can effectively promote cell growth and adhesion. In particular, using PDA@GO as drug carrier can effectively maintain the activity of antimicrobial peptides, and can maximize the antibacterial properties of the nanocomposite membrane. Finally, we used rat full-thickness wound models to observe wound healing, and the surface interactions between the prepared nanocomposite membrane and the wound. The results indicates that nanocomposite membrane can obviouly accelerated wound closure, and the wounds showed reduced inflammation, improved angiogenesis and accelerated re-epithelialization. Therefore, incorporation of antimicrobial peptides -functionalize graphene oxide (ly-PDA@GO) into CS-Arg membrane was a viable strategy for fabricating excellent wound dressing. Together, this study not only prepared a wound dressing with excellent tissue repair ability, but also provided a novel idea for the development of graphene oxide-based antibacterial dressing.

scholarly journals Zein/MCM-41 Nanocomposite Film Incorporated with Cinnamon Essential Oil Loaded by Modified Supercritical CO2 Impregnation for Long-Term Antibacterial Packaging

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 169
Author(s):  
Xiaojing Liu ◽  
Jingfu Jia ◽  
Shulei Duan ◽  
Xue Zhou ◽  
Anya Xiang ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Supercritical Co2 ◽  
Phosphate Buffer Solution ◽  
Continuous Illumination ◽  
Buffer Solution ◽  
Supercritical Impregnation ◽  
Cinnamon Essential Oil ◽  
Mcm 41

Antimicrobial medicine and food packages based on bio-based film containing essential oils have attracted great attention worldwide. However, the controlled release of essential oils from these film nanocomposites is still a big challenge. In this study, a long-term antibacterial film nanocomposite composed of zein film and cinnamon essential oil (CEO) loaded MCM-41 silica nanoparticles was prepared. The CEO was loaded into MCM-41 particles via modified supercritical impregnation efficiently with a high drug load (>40 wt%). The morphologies of the prepared nanoparticles and film nanocomposite were characterized by a scanning electron microscope. The release behaviors of CEO under different temperatures, high humidity, continuous illumination and in phosphate buffer solution (PBS) solution were investigated. The results showed that the film nanocomposite had an outstanding release-control effect. The addition of MCM-41 nanoparticles also improved the mechanical properties of zein films. The antibacterial effect of CEO was significantly prolonged by the film nanocomposite; indicating the CEO film nanocomposite fabricated via modified supercritical CO2 impregnation was a potential long-term antibacterial medicine or food package material.

scholarly journals ANTIMICROBIAL PROPERTIES OF RABBIT COLLAGEN GLUE-CHITOSAN BIOMATERIAL LOADED WITH CYMBOPOGON FLEXUOSUS ESSENTIAL OIL

2021 ◽  
Vol 2021 ◽  
pp. 385-390
Author(s):  
M. Râpă ◽  
M.D. Berechet ◽  
C. Gaidău ◽  
R.R. Constantinescu ◽  
A. Moșuțiu
Keyword(s):  
Wound Healing ◽  
Essential Oil ◽  
Wound Dressing ◽  
Antimicrobial Agents ◽  
Antimicrobial Properties ◽  
Natural Polymers ◽  
Cymbopogon Flexuosus ◽  
Dressing Materials ◽  
Lemongrass Essential Oil ◽  
Wound Dressing Materials

One approach to develop innovative antimicrobial wound dressing materials is to use natural polymers loaded with antimicrobial agents. The valorisation of animal proteins as biomaterials with antimicrobial properties is a new concern for development of wound healing. Plant esssential oils (EO) also indicate a potential approach for new wound dressing materials able to replace the synthetic antymicrobial agents. In this paper, plant-polymeric film was prepared by casting film-forming emulsion based on lemongrass (Cymbopogon flexuosus) essential oil/Tween 80 dispersed into rabbit collagen glue hydrolysate– chitosan biomaterial. The effect of biomaterial film composition on Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 10536 standard bacteria, and Candida albicans ATCC 10231 pathogenic fungus was studied according to European Pharmacopoeia 10/2020 as compared with biomaterial film without essential oil. The in vitro antibacterial tests against three bacterial strains showed that the rabbit collagen glue hydrolysate–chitosan biomaterial inhibited all the three microorganisms. The rabbit collagen hydrolysate glue-chitosan film loaded with lemongrass essential oil exhibits antimicrobial activity towards tested microorganisms but lower as compared with control. The explanation could be due to the short time of investigation, or maybe some active compounds constituents of EO, which favour the cellular proliferation. Preparation of rabbit collagen glue hydrolysate-chitosan biomaterial loaded with lemongrass essential oil is an environmentally friendly solution, which may contribute to the development of wound healing materials as an alternative to topical antimicrobial agents.

Investigation of Dialdehyde Corn Starch as Crosslinking Agent in Collagen-Based Wound Dressing Materials

2016 ◽  
Author(s):  
Cigdem Kilicarislan Ozkan ◽  
Hasan Ozgunay ◽  
Stefania Marin ◽  
Madalina Georgiana Albu Kaya
Keyword(s):  
Wound Dressing ◽  
Corn Starch ◽  
Crosslinking Agent ◽  
Dressing Materials ◽  
Wound Dressing Materials

Chinese Medicine Protein and Peptide in Gene and Cell Therapy

2019 ◽  
Vol 20 (3) ◽  
pp. 251-264 ◽  
Author(s):  
Yinlu Feng ◽  
Zifei Yin ◽  
Daniel Zhang ◽  
Arun Srivastava ◽  
Chen Ling
Keyword(s):  
Chinese Medicine ◽  
Cell Therapy ◽  
Future Research ◽  
The Past ◽  
Promising Strategy ◽  
Wide Range ◽  
New Directions ◽  
Gene And Cell Therapy ◽  
Proteins And Peptides

The success of gene and cell therapy in clinic during the past two decades as well as our expanding ability to manipulate these biomaterials are leading to new therapeutic options for a wide range of inherited and acquired diseases. Combining conventional therapies with this emerging field is a promising strategy to treat those previously-thought untreatable diseases. Traditional Chinese medicine (TCM) has evolved for thousands of years in China and still plays an important role in human health. As part of the active ingredients of TCM, proteins and peptides have attracted long-term enthusiasm of researchers. More recently, they have been utilized in gene and cell therapy, resulting in promising novel strategies to treat both cancer and non-cancer diseases. This manuscript presents a critical review on this field, accompanied with perspectives on the challenges and new directions for future research in this emerging frontier.

scholarly journals Breathable, stretchable and adhesive nanofibrous hydrogels as wound dressing materials

2021 ◽  
Author(s):  
Xueting Liu ◽  
Yumin Liu ◽  
Jingtao Du ◽  
Xiaoran Li ◽  
Jianyong Yu ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Dressing Materials ◽  
Wound Dressing Materials
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