scholarly journals Application of Cornelian Cherry Iridoid-Polyphenolic Fraction and Loganic Acid to Reduce Intraocular Pressure

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Dorota Szumny ◽  
Tomasz Sozański ◽  
Alicja Z. Kucharska ◽  
Wojciech Dziewiszek ◽  
Narcyz Piórecki ◽  
...  
Keyword(s):  
Animal Model ◽  
Intraocular Pressure ◽  
Chemical Compounds ◽  
Hypotensive Effect ◽  
The Other ◽  
Cornelian Cherry ◽  
Cornus Mas ◽  
Strongly Connected ◽  
Main Components ◽  
New Zealand Rabbits

One of the most common diseases of old age in modern societies is glaucoma. It is strongly connected with increased intraocular pressure (IOP) and could permanently damage vision in the affected eye. As there are only a limited number of chemical compounds that can decrease IOP as well as blood flow in eye vessels, the up-to-date investigation of new molecules is important. The chemical composition of the dried Cornelian cherry (Cornus masL.) polar,iridoid-polyphenol-rich fraction was investigated. Loganic acid (50%) and pelargonidin-3-galactoside (7%) were found as the main components. Among the other constituents, iridoid compound cornuside and the anthocyans cyanidin 3-O-galactoside, cyanidin 3-O-robinobioside, and pelargonidin 3-O-robinobioside were quantified in the fraction. In an animal model (New Zealand rabbits), the influence of loganic acid and the polyphenolic fraction isolated from Cornelian cherry fruit was investigated. We found a strong IOP-hypotensive effect for a 0.7% solution of loganic acid, which could be compared with the widely ophthalmologically used timolol. About a 25% decrease in IOP was observed within the first 3 hours of use.

scholarly journals Effect of topically applied nimodipine on the intraocular pressure on ocular normotensive and betamethasone-induced hypertensive eyes in rabbits

2019 ◽  
Vol 10 (4) ◽  
pp. 2727-2732
Author(s):  
Waleed K. Abdulsahib ◽  
Osama Q. Fadhil ◽  
Hussam H.Tizkam
Keyword(s):  
Intraocular Pressure ◽  
Vision Loss ◽  
Hypotensive Effect ◽  
Negative Control ◽  
The Other ◽  
Diurnal Fluctuation ◽  
Control Group ◽  
Subconjunctival Injection ◽  
Other Hand ◽  
Ophthalmic Solutions

Glaucoma is a leading cause of irreversible blindness worldwide. Lowering intraocular pressure (IOP) is the only strategy documented to delay the appearance and retard the progression of vision loss. The present investigation was conducted to evaluate the effect of topical nimodipine (0.5%) drop on IOP of both normotensive and induced -hypertensive eyes in rabbits. Thirty six rabbits were included in the present study .Two groups (each group contains 6 rabbits) were used to evaluate the effect of nimodipine, one as a normotensive group and the other for induction of hypertensive.  Nimodipine ophthalmic solutions were instilled twice daily for 7 days in both normotensive and induced -hypertensive eyes (that induced by weakly subconjunctival injection of 0.7 ml of betamethasone suspension for 4 weeks). On the other hand another two groups were used to evaluate the effect of (twice daily instillation for 7 days) of Timolol and distilled water (DW).  IOP measured by Schiotz tonometer daily at about the same time (9.0 am) to avoid IOP diurnal fluctuation. The main findings of the present study were the followings: Nimodipine (0.5%) was very effective in lowering IOP in both normotensive and ocular hypertensive rabbits. Mean IOP decreased after one day of nimodipine instillation by (1.5 ± 0.43 mmHg) in normotensive eyes and by (4.5± 1.45 mmHg) in hypertensive eyes. A significant results (P ≤ 0.05) were obtained when compared the results of nimodipine with DW (as a negative control group), on the other hand no significant differences were obtained when compared with that of Timolol (as a positive group). The results obtained in this study provide experimental evidences for the effectiveness of nimodipine (0.5%) ophthalmic solutions in the reduction of IOP. In addition to above nimodipine in   applied doses were found to have tolerable ocular hypotensive effect.   

scholarly journals Vegetative propagation of cornelian cherry (Cornus mas L.) selections

2020 ◽  
Vol 12 (4) ◽  
pp. 836-841
Author(s):  
Felicia CORNESCU ◽  
Gheorghe ACHIM ◽  
Sina COSMULESCU
Keyword(s):  
Vegetative Propagation ◽  
Average Length ◽  
The Other ◽  
Cornelian Cherry ◽  
Planting Material ◽  
Cornus Mas ◽  
Growth Increase ◽  
Fruit Setting ◽  
The Future

Cornelian cherry (Cornus mas L) is one of the most valuable fruit shrubs of the Cornaceae family, and therefore the vegetative propagation of the valuable selections is necessary because the material obtained must be used for the future. 4 genotypes were studied (2 perspective selections: H1 and H3 and two cultivars used as a control: ‘De Bucovăț’ (B) and ‘De Orhei’ (O) and propagated by grafting (the grafting method used was improved copulation. Biometric observations were focused on diameter below the point of graft (mm), diameter at the graft point (mm), diameter above the graft point (mm), height of graft (cm), number of anticipated, average length of the anticipated (cm), the sum of the anticipated length (cm), the growth increase (cm). Based on the results obtained, it can be concluded that the grafting method, enhanced copulation, within vegetative propagation, can be successfully used in the production of cornelian cherry planting material next to the other known methods; the growth of the anticipated shoots on plant could cause the appearance of flowering buds and implicitly earliness in fruit-setting.

scholarly journals Ingredients, Functionality, and Safety of the Japanese Traditional Sweet Drink Amazake

2021 ◽  
Vol 7 (6) ◽  
pp. 469
Author(s):  
Atsushi Kurahashi
Keyword(s):  
Clinical Trials ◽  
Blood Glucose ◽  
Bowel Movement ◽  
Skin Barrier ◽  
Fermented Food ◽  
The Other ◽  
Added Sugar ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Main Components

The sweet drink amazake is a fermented food made from Aspergillus oryzae and related koji molds in Japan. There are two types of drinks called amazake, one made from koji (koji amazake) and the other made from sake lees, a by-product of sake (sakekasu amazake). The sweetness of koji amazake is from glucose, derived from starch broken down by A. oryzae amylase. The other, sakekasu amazake, depends on added sugar. The main components are glucose and sucrose, but they also contain more than 300 other ingredients. Koji amazake contains oligosaccharides and ergothioneine, and sakekasu amazake has a resistant protein and α-ethyl glucoside, which are characteristic ingredients of each amazake. However, there are also common ingredients such as glycosylceramide. Functionality is known to include anti-fatigue, bowel movement, skin barrier, and other effects on human health. In particular, the bowel movement-improving effects have been well studied for both amazakes. These functions result from ingesting approximately 100 mL per day, but human clinical trials have clarified that this amount has no effect on blood glucose levels and weight gain. In the future, the identification of substances associated with each function is required.

Fruit Characteristics of Different Varieties of Cornelian Cherry (Cornus mas L.) Cultivated in the Czech Republic

2021 ◽  
Author(s):  
Zuzana Jurečková ◽  
Pavel Diviš ◽  
Jitka Cetkovská ◽  
Milena Vespalcová ◽  
Jaromír Pořízka ◽  
...  
Keyword(s):  
Czech Republic ◽  
Fruit Characteristics ◽  
The Czech Republic ◽  
Cornelian Cherry ◽  
Cornus Mas

scholarly journals Characterization of calcium oxide in root perforation sealer materials

2012 ◽  
Vol 23 (5) ◽  
pp. 539-546 ◽  
Author(s):  
Carlos Estrela ◽  
Manoel Damião Sousa-Neto ◽  
Orlando Aguirre Guedes ◽  
Ana Helena Gonçalves Alencar ◽  
Marco Antonio Hungaro Duarte ◽  
...  
Keyword(s):  
Calcium Oxide ◽  
Mineral Trioxide Aggregate ◽  
Chemical Compounds ◽  
Internal Diameter ◽  
X Ray ◽  
Final Sample ◽  
Materials Used ◽  
Main Components ◽  
White Mineral

Root perforation represents an undesirable complication that may lead to an unfavorable prognosis. The aims of this study were to characterize and to compare the presence of calcium oxide (CaO) on the chemical composition of materials used for root perforation therapy: gray and white mineral trioxide aggregate (MTA) and Portland cement (PC), gray MTA+5%CaO and gray MTA+10%CaO. The last two materials were analyzed to evaluate the increase of CaO in the final sample. CaO alone was used as a standard. Eighteen polyethylene tubes with an internal diameter of 3 mm and 3 mm in length were prepared, filled and then transferred to a chamber with 95% relative humidity and a temperature of 37ºC. The chemical compounds (particularly CaO) and the main components were analyzed by energy-dispersive X-ray microanalysis (EDX). EDX revealed the following concentrations of CaO: gray MTA: 59.28%, white MTA: 63.09%; PC: 72.51%; gray MTA+5%CaO: 63.48% and gray MTA+10%CaO: 67.55%. The tested materials presented different concentrations of CaO. Even with an increase of 5 and 10% CaO in gray MTA, the CaO levels found in the MTA samples were lower than those found in PC.

scholarly journals Intraocular Pressure-Lowering Potential of Subthreshold Selective Laser Trabeculoplasty in Patients with Primary Open-Angle Glaucoma

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Hong Yang Zhang ◽  
Yong Jie Qin ◽  
Yang Fan Yang ◽  
Jian Gang Xu ◽  
Min Bin Yu
Keyword(s):  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Initial Energy ◽  
The Other ◽  
Open Angle ◽  
Selective Laser Trabeculoplasty ◽  
Laser Trabeculoplasty ◽  
Pressure Lowering ◽  
Laser Flare

Purpose.To compare the efficacy of subthreshold and conventional selective laser trabeculoplasty (SLT) in lowering intraocular pressure (IOP) in the patients with primary open-angle glaucoma (POAG).Methods.Fifty-two eyes from fifty-two POAG patients were randomized into two groups, one group treated with subthreshold SLT using two-thirds of the conventional energy and the other one treated with the conventional energy. IOP was measured with the Goldmann tonometer and the anterior chamber inflammation was determined using laser flare meter.Results.The initial energy dosage used in subthreshold SLT group was significantly lower than the amount of the energy used in conventional SLT group (0.4±0.1 mJ versus0.6±0.1 mJ,P=0.030). The total energy dosage was also significantly lower in subthreshold SLT group compared to the other group (37.6±3.3 mJ versus51.8±5.7 mJ,P=0.036). However, the level of inflammation in aqueous humor, amount of reduction in IOP, and the success rate in controlling IOP was the same in both groups.Conclusion.The efficacy of subthreshold SLT group in reducing IOP in POAG patients is comparable to the efficacy of conventional SLT group.

Determination of Bioactive Components of 60°С Volatiles from Cinnamomum camphora Branches by TD-GC/MS

2011 ◽  
Vol 230-232 ◽  
pp. 852-856
Author(s):  
Qing Li ◽  
Dang Quan Zhang ◽  
Qi Mei Liu ◽  
Kuan Peng
Keyword(s):  
Chemical Compounds ◽  
Chemical Components ◽  
Cinnamomum Camphora ◽  
Bioactive Components ◽  
Industrial Materials ◽  
Analytical Result ◽  
Main Components

The chemical components of helium volatiles from the fresh branches of Cinnamomum camphora were studied by TD-GC/MS. The analytical result by 60°С-based TD-GC/MS showed that 55 peaks were obtained from the helium volatiles from the fresh branches of Cinnamomum camphora and 53 chemical compounds were identified. The results showed that the main components were as: Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R)- (15.4328%), 1,3-Benzodioxole, 5-(2-propenyl)- (14.881%), Tricyclo[2.2.1.0(2,6)]heptane, 1,7-dimethyl-7-(4-methyl-3-pentenyl)-, (-)- (12.694%), p-menth-1-en-8-ol (9.832%), Bicyclo[2.2.1]heptane, 2-methyl-3-methylene-2-(4-methyl-3- pentenyl)-, (1S-exo)- (6.143%), 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl- (5.365%), Bicyclo[3.1.1] hept-2-ene, 2,6-dimethyl-6-(4-methyl-3-pentenyl)- (4.527%), Naphthalene, 1,2,3,5,6,8a- hexahydro-4,7-dimethyl-1-(1-methylethyl)-, (1S-cis)- (4.129%), 3-Cyclohexen-1-ol, 4-methyl-1- (1-methylethyl)- (2.965%), Borneol (2.627%), Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, acetate, (1S-endo)- (2.586%), Copaene (2.534%), 1,6,10-Dodecatriene, 7,11-dimethyl-3-methylene-, (Z)- (1.612%), (-)-Isosativene (1.121%), etc. The analytical result suggested that the helium volatiles from the fresh branches of Cinnamomum camphora could be used as industrial materials of biomedicines and spicery.

Stumbling on the rehabilitation gold? Foucault vs. Foucault in San Quentin and beyond

Ethnography ◽  
2017 ◽  
Vol 18 (4) ◽  
pp. 471-492 ◽  
Author(s):  
Bowen Paulle
Keyword(s):  
Emotional Intelligence ◽  
Rehabilitation Program ◽  
Prison System ◽  
The Other ◽  
Trauma Treatment ◽  
Treatment Model ◽  
Authentic Self ◽  
State Prison ◽  
Main Components ◽  
Central Claim

This article examines GRIP, a rehabilitation program currently spreading through California’s state prison system. While most ‘violent offenders’ come to GRIP hoping to increase chances of parole, this yearlong program with four main components – stopping violence, mindfulness, emotional intelligence, understanding victim impact – is meant to create conditions in which inmates can ‘do the work’ leading to genuine transformation. A central claim is that due in part to the trauma-treatment model GRIP follows, inmates end up ‘stumbling on the gold’ and going through changes (involving recovery of an ‘authentic self ’ rooted in childhood) that helps enable skillful responses even to ‘moments of imminent danger’. Understandably, researchers of such programs may seek theoretical inspiration from the ‘dominant’ version of Foucault. Yet this paper sets out to change the conversation about prisons and rehabilitation in part by demonstrating the utility of the ‘other’ Foucault’s pragmatic recovery of body-based self-disciplining practices and regimes.

Pigmentary Glaucoma After Cataract Surgery with Single-Piece Hydrophobic Intraocular Lens Implanted into the Ciliary Sulcus: Case Report

2021 ◽  
Vol 5 (1) ◽  
Keyword(s):  
Intraocular Pressure ◽  
Intraocular Lens ◽  
Corneal Endothelium ◽  
Surgical Intervention ◽  
Posterior Segment ◽  
The Other ◽  
Pigmentary Glaucoma ◽  
Single Piece ◽  
History Of ◽  
Capsular Bag

A 59 years old man presented with a history of phacoemulsification with an hydrophobic intraocular lens implant in his left eye 4 years ago. The biomicroscopy revealed pigments in the corneal endothelium (Krukenberg’s spindle), peripheral transillumination of the iris and intraocular pressure of 52 mmHg in the left eye. Gonioscopy revealed hyperpigmentation of the posterior trabeculate. Posterior segment examination and visual field revealed a cup/disc 0.9 with significant field damage in strategy 10-2. Biomicroscopic ultrasonography showed asymmetric implantation of the IOL loops in the left eye (one loop in the ciliary sulcus and the other in the capsular bag). He underwent antiglaucomatous treatment with adequate control of intraocular pressure, with no need for surgical intervention.

Factors affecting changes in the intraocular pressure after phacoemulsification surgery

2020 ◽  
Vol 1 (3) ◽  
pp. 166-172
Author(s):  
Rita Dhamankar ◽  
◽  
Suhas S Haldipurkar ◽  
Tanvi Haldipurkar ◽  
Vijay Shetty ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Anterior Chamber ◽  
Axial Length ◽  
Anterior Chamber Depth ◽  
The Other ◽  
Factors Affecting ◽  
Factors Associated ◽  
Post Surgery ◽  
Unit Increase ◽  
The Mean

AIM: To assess the changes in anterior chamber parameters and examine the factors associated with changes in the intraocular pressure (IOP) in individuals who have undergone phacoemulsification surgery. METHODS: It is a longitudinal analysis of secondary clinical data collected from 105 non-glaucomatous eyes (82 patients) undergoing a cataract surgery. We studied the association between anterior chamber parameters, grade of cataract, demographics, and changes in the IOP over a period of three weeks. We also evaluated the association between the pressure-depth (PD) ratio and changes in the IOP during this time. RESULTS: The mean age (SD) of the 82 patients was 60.1±7.8y. The mean±standard deviation (SD) IOP was 15.06±3.36 mm Hg pre-operatively; it increased to 15.75±4.21 mm Hg on day one (P=0.20). In the multifactorial models, the mean IOP was -1.715 (95%CI: -2.795, -0.636) mm Hg on day 21±5 compared with the pre-operative values. The anterior chamber depth (ACD), axial length, age, sex, and grade of cataract were not significantly associated with changes in the IOP. Each unit increase in the PD ratio was associated with an increase in the mean IOP by 1.289 mm Hg (95%CI: 0.906, 1.671). After adjusting for pre-operative PD ratio, none of the other variables (ACD, axial length, temporal angle) were significantly associated with changes in mean IOP. CONCLUSION: The PD ratio was the single most important factor associated with the changes in post-operative IOP over three weeks post-surgery.

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