scholarly journals Membrane Stabilization and Detoxification of Acetaminophen-Mediated Oxidative Onslaughts in the Kidneys of Wistar Rats by Standardized Fraction ofZea maysL. (Poaceae),Stigma maydis

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
S. Sabiu ◽  
F. H. O’Neill ◽  
A. O. T. Ashafa
Keyword(s):  
Vitamin C ◽  
Defense Mechanisms ◽  
Wistar Rats ◽  
Renal Damage ◽  
Antioxidant Defense ◽  
Ethyl Acetate Fraction ◽  
Membrane Stabilization ◽  
Sodium Potassium ◽  
Kidney Functions ◽  
Oxidized Products

This study evaluated membrane stabilization and detoxification potential of ethyl acetate fraction ofZea maysL.,Stigma maydisin acetaminophen-induced oxidative onslaughts in the kidneys of Wistar rats. Nephrotoxic rats were orally pre- and posttreated with the fraction and vitamin C for 14 days. Kidney function, antioxidative and histological analyses were thereafter evaluated. The acetaminophen-mediated significant elevations in the serum concentrations of creatinine, urea, uric acid, sodium, potassium, and tissue levels of oxidized glutathione, protein-oxidized products, lipid peroxidized products, and fragmented DNA were dose-dependently assuaged in the fraction-treated animals. The fraction also markedly improved creatinine clearance rate, glutathione, and calcium concentrations as well as activities of superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase in the nephrotoxic rats. These improvements may be attributed to the antioxidative and membrane stabilization activities of the fraction. The observed effects compared favorably with that of vitamin C and are informative of the fraction’s ability to prevent progression of renal pathological conditions and preserve kidney functions as evidently supported by the histological analysis. Although the effects were prominently exhibited in the fraction-pretreated groups, the overall data from the present findings suggest that the fraction could prevent or extenuate acetaminophen-mediated oxidative renal damage via fortification of antioxidant defense mechanisms.

scholarly journals EVALUATION OF THE TOXICITY OF THE ETHANOLIC EXTRACTS OF THE LEAVES OF HEXALOBUS MONOPETALUS ON THE KIDNEYS AND THE LIVER OF WISTAR RATS

2020 ◽  
Vol 5 (11) ◽  
pp. 1-12
Author(s):  
Abderaman Souham ◽  
Justin Behanzin ◽  
Ahokpe Melanie ◽  
Alphonse Sezan
Keyword(s):  
Acute Toxicity ◽  
Wistar Rats ◽  
Renal Damage ◽  
Ethanolic Extract ◽  
Histopathological Study ◽  
Feeding Trial ◽  
Ethanolic Extracts ◽  
Liver And Kidney ◽  
The One ◽  
Kidney Functions

The overall objective of our study is to evaluate the toxicity of ethanolic extracts of Hexalobus monopetalus leaves on the liver and kidney functions of rats in its therapeutic use. Thus, an ethanolic extract of the leaves was made, then a phytochemical screening of this extract. On the one hand, acute toxicity was measured in a 14-day feeding trial in Wistar rats, and on the other hand, a histopathological study of the organs removed was performed. The phytochemical screens of the ethanolic extracts obtained showed the presence of several phytochemical groups with therapeutic activity. Acute toxicity was noted at 3000 and 5000mg / kg PC doses of rats. Histopathological study revealed hepatic pycnosis at a dose of 5000 mg / kg PC in rats. Finally, no renal damage was observed

Structural and functional renal alterations in five-sixth nephrectomized rats on unrestricted diet

1986 ◽  
Vol 44 ◽  
pp. 342-343
Author(s):  
I. Stachura ◽  
M. Pardo ◽  
J. Costello ◽  
D.M. Landwehr
Keyword(s):  
Wistar Rats ◽  
Renal Damage ◽  
Standard Diet ◽  
Experimental Conditions ◽  
Phosphate Intake ◽  
Dietary Restrictions ◽  
Severe Reduction ◽  
Male Wistar Rats ◽  
Unrestricted Diet ◽  
Progressive Renal Insufficiency

Under experimental conditions severe reduction of renal mass results in the hyperfiltration of the remaining nephrons leading to a progressive renal insufficiency. Similar changes are observed in patients with various renal disorders associated with a loss of the functioning nephrons. The progression of renal damage is accelerated by high protein and phosphate intake, and may be modified by the dietary restrictions.We studied 50 five-sixth nephrectarrized male Wistar rats on a standard diet (Rodent Laboratory Chow 5001 Ralston Purina Co., Richmond, Indiana; containing 23.4% protein) over a 20 week period.

DYNAMICS OF BARLEY FLAVONOID AND PRODUCTIVITY UNDER UF-A RADIATION

1970 ◽  
pp. 14-18
Author(s):  
L. I. Goncharova ◽  
P. N. Tsygvintsev ◽  
О. А. Guseva
Keyword(s):  
Grain Yield ◽  
Defense Mechanisms ◽  
Antioxidant Defense ◽  
Malonic Dialdehyde ◽  
Growth Period ◽  
Negative Effects ◽  
Uv Spectrum ◽  
Quantum Energy ◽  
Dry Soil ◽  
Universal Mechanism

The effect of increased UV-A radiation during the ontogeny of barley plants of the Vladimir variety in the vegetation experiment was studied. Changes in the content of malonic dialdehyde, flavonoids and grain yield were revealed. UV-A radiation as compared to UV-B radiation, has lower quantum energy and can have both positive and negative effects on plant regulatory and photosynthetic processes. One of the most damaging effects of increased levels of UV-A radiation is oxidative stress, which causes lipid peroxidation of biological membranes. The existence of a plant cell in such conditions is possible only thanks to a system of antioxidant defense mechanisms. The accumulation of phenolic compounds under the action of UV radiation is a universal mechanism of protection against photodamage, which was formed in the early stages of the evolution of photoautotrophic organisms. Flavonoids are localized in the epidermis of plant tissues and act as an internal filter. The content of flavonoids is determined by the genotype and due to ontogenetic patterns. Plants were grown in a greenhouse, in vessels containing 4.5 kg of air-dry soil. The repetition is threefold (3 vessels in each variant). Sowing density - 13 plants in each vessel. As a source of UV-A radiation used lamps Black Light BLUE company Philips. Plants were irradiated for 5 hours a day from 10 to 15 hours at 13, 25, 34, 43 and 52 stages of organogenesis. The magnitude of the daily biologically effective dose of UV-A radiation was 60.7 kJ / m2. The solar part of the UV spectrum in the vegetation experiment was absent in the greenhouse. The nature of changes in the content of flavonoids under the action of UV-A irradiation during the growing season of plants with the dynamics of the oxidative process has been established. The first maximum was observed during the vegetative growth period, the second - at the earing stage. The data obtained indicate that flavonoids have ontogenetic conditionality and perform photoprotective functions. The increase in their content under the action of UV-A radiation is accompanied by an increase in resistance to photodamage, which is confirmed by the formation of grain yield.

The Impact of Plant Bioactive Compounds on Aging and Fertility of Diverse Organisms: A Review

2020 ◽  
Vol 20 (13) ◽  
pp. 1287-1299
Author(s):  
Muhammad Akram Mohd Noordin ◽  
Mahanem Mat Noor ◽  
Wan Mohd Aizat
Keyword(s):  
Clinical Trial ◽  
Bioactive Compounds ◽  
Defense Mechanisms ◽  
Healthy Aging ◽  
Antioxidant Defense ◽  
Senior Citizens ◽  
Aging Population ◽  
Human Clinical Trial ◽  
Fertility Reduction ◽  
The Impact

It is expected that in 2050, there will be more than 20% of senior citizens aged over 60 years worldwide. Such alarming statistics require immediate attention to improve the health of the aging population. Since aging is closely related to the loss of antioxidant defense mechanisms, this situation eventually leads to numerous health problems, including fertility reduction. Furthermore, plant extracts have been used in traditional medicine as potent antioxidant sources. Although many experiments had reported the impact of various bioactive compounds on aging or fertility, there is a lack of review papers that combine both subjects. In this review, we have collected and discussed various bioactive compounds from 26 different plant species known to affect both longevity and fertility. These compounds, including phenolics and terpenes, are mostly involved in the antioxidant defense mechanisms of diverse organisms such as rats, mites, fruit flies, roundworms, and even roosters. A human clinical trial should be considered in the future to measure the effects of these bioactive compounds on human health and longevity. Ultimately, these plant-derived compounds could be developed into health supplements or potential medical drugs to ensure a healthy aging population.

scholarly journals Vegetables, Potatoes and Their Products as Sources of Energy and Nutrients to the Average Diet in Poland

2021 ◽  
Vol 18 (6) ◽  
pp. 3217
Author(s):  
Hanna Górska-Warsewicz ◽  
Krystyna Rejman ◽  
Joanna Kaczorowska ◽  
Wacław Laskowski
Keyword(s):  
Cluster Analysis ◽  
Vitamin A ◽  
Vitamin C ◽  
Vitamin B6 ◽  
Dietary Energy ◽  
Sodium Potassium ◽  
Vegetable Products ◽  
Kohonen Neural Networks ◽  
Calcium Phosphorus ◽  
Total Fat

The aim of our study was to analyse vegetables, potatoes and their products as sources of energy and nutrients in the average diet in Poland. Representative data of the 2016 Household Budget Survey from 36,886 households were used. This is the largest study sample in Poland, so we generalized the conclusions to the whole population using the statement ‘average diet’. We analysed three main product groups: vegetables, vegetable products, and potatoes and potatoes products, dividing them into 14 subgroups (e.g., tomatoes, cabbage, carrots, other vegetables, and mushrooms). The percentages of energy, protein, carbohydrates, total fat, nine vitamins (thiamine, riboflavin, niacin, vitamin B6, folate, vitamin C, vitamin A, vitamin D, and vitamin E), seven minerals (calcium, phosphorus, sodium, potassium, iron, magnesium and zinc), and fibre from the analysed food subgroups are presented. Additionally, the influence of household characteristics on the supply of energy and nutrients from each subgroup of vegetables, potatoes, and their products was evaluated using cluster analysis. In the analysis, R programme and Kohonen neural networks were applied. Our study showed that vegetables, potatoes, and their products provide 7.3% of daily dietary energy supply. Vegetables contribute more than 20% of the supply of six nutrients: vitamin C (51.8%), potassium (32.5%), folate (31.0%), vitamin A (30.6%), vitamin B6 (27.8%), and magnesium (20.2%), as well as fibre (31.8%). Cluster analysis distinguished three clusters that differed in nutritional supply from vegetables, potatoes, and their products. Educational level, income measured by quintile groups, village size, socio-economic characteristics, urbanization degree, and land use were the most important factors determining differences between clusters.

scholarly journals Redox Regulation in Diazotrophic Bacteria in Interaction with Plants

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 880
Author(s):  
Karine Mandon ◽  
Fanny Nazaret ◽  
Davoud Farajzadeh ◽  
Geneviève Alloing ◽  
Pierre Frendo
Keyword(s):  
Defense Mechanisms ◽  
Host Plants ◽  
Redox Regulation ◽  
Antioxidant Defense ◽  
Plant Growth Promoting Bacteria ◽  
Oxygen Species ◽  
Diazotrophic Bacteria ◽  
Number Of Microorganisms ◽  
Plant Growth Promoting ◽  
Growth Promoting

Plants interact with a large number of microorganisms that greatly influence their growth and health. Among the beneficial microorganisms, rhizosphere bacteria known as Plant Growth Promoting Bacteria increase plant fitness by producing compounds such as phytohormones or by carrying out symbioses that enhance nutrient acquisition. Nitrogen-fixing bacteria, either as endophytes or as endosymbionts, specifically improve the growth and development of plants by supplying them with nitrogen, a key macro-element. Survival and proliferation of these bacteria require their adaptation to the rhizosphere and host plant, which are particular ecological environments. This adaptation highly depends on bacteria response to the Reactive Oxygen Species (ROS), associated to abiotic stresses or produced by host plants, which determine the outcome of the plant-bacteria interaction. This paper reviews the different antioxidant defense mechanisms identified in diazotrophic bacteria, focusing on their involvement in coping with the changing conditions encountered during interaction with plant partners.

Sign in / Sign up

Export Citation Format

Share Document