scholarly journals Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Dian-dian Zhao ◽  
Pei-lin Jiao ◽  
Jing-jia Yu ◽  
Xiao-jing Wang ◽  
Lin Zhao ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Chinese Men ◽  
Endogenous Antioxidant ◽  
The Relationship

Accumulating evidence suggests that oxidative stress is associated with osteoporosis. Serum uric acid (UA) is a strong endogenous antioxidant. Therefore, we investigated the relationship between the serum UA and BMD in Chinese men with T2DM. In this cross-sectional study of 621 men with T2DM, BMDs at lumbar spine (L2–4), femoral neck (FN), and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). Serum levels of UA, calcium (Ca), 25-OH vitamin D3 (vitD3), parathyroid hormone (PTH), and creatinine (Cr) were also tested. Data analyses revealed that serum UA levels were positively associated with BMD at all sites (p<0.05) in men with T2DM after adjusting for multiple confounders. The serum UA levels were positively correlated with body weight (r=0.322), body mass index (BMI) (r=0.331), Ca (r=0.179), and Cr (r=0.239) (p<0.001) and were also positively associated with the concentrations of PTH (r=0.10,p<0.05). When compared with those in the lowest tertile of UA levels, men with T2DM in the highest tertile had a lower prevalence of osteoporosis or osteopenia (adjusted odds ratio 0.54, 95% confidence interval [CI] 0.31–0.95). These data suggest that higher serum levels of UA are associated with higher BMDs and lower risks of osteoporosis in Chinese men with T2DM.

scholarly journals Serum uric acid levels in type 2 diabetes mellitus among South Indian Urban Population: A cross sectional study

2020 ◽  
Vol 9 (6) ◽  
pp. 20-24
Author(s):  
Harish Rangareddy ◽  
Venkateshappa C
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Waist Hip Ratio

Background and aim: Hyperuricemia is common in individuals with obesity, metabolic syndrome and type 2 diabetes mellitus. This has been attributed to the hyperinsulinemia due to insulin resistance in T2DM and it’s effect on the renal excretion of uric acid. There have been recent studies depicting that hyperuricemia may independently predict the development of diabetes. However, there are conflicting studies of hypouricemia in T2DM as well which may be due to increased glomerular filtration rate with increased renal clearance of uric acid. In order to add further evidence to the existing database of knowledge about uric acid metabolism in T2DM this study was carried out. Material and Methods: This cross sectional study and the subjects were selected according to inclusion and exclusion criteria. Data recorded included serum uric acid, HbA1c, fasting and post prandial plasma glucose, serum creatinine, fasting lipid profile and waist hip ratio. Results: The mean value of serum uric acid was 5.11±1.2 mg/dL in diabetics and 4.59±1.12 mg/dL in non-diabetics, though within the normal reference range was statistically significant (p=0.029). However, the association of hyperuricemia (serum uric acid >7mg/dL) as a risk factor for diabetes mellitus was not significant (p=1.000). Waist circumference in cases was 94.8 ± 10 cm and in controls it was 86.6 ± 11.6 cm (p<0.001). Waist-hip ratio in diabetics was 1.0 ± 0.11 and in non-diabetics 0.9 ± 0.08 (p<0.001). HbA1c, FBS, PPBS, serum creatinine, waist circumference, waist-hip ratio were significantly increased and HDLc was decreased significantly in diabetes mellitus. Conclusion: Increased serum uric acid, decreased HDLc and increased waist-hip ratio are observed in type 2 diabetes mellitus. Steps should be taken to monitor serum uric acid, lipid profile and anthropometric measurements of diabetics and non-diabetics. Keywords: Uric acid, type 2 Diabetes mellitus

Relationship Between Serum Uric Acid Levels and Non-alcoholic Fatty Liver Disease in the Non-Obese Chinese Population: A Secondary Analysis Based on A Cross-Sectional Study

2021 ◽  
Author(s):  
Shengqiang Gao ◽  
Kuvaneshan Ramen ◽  
Shian Yu ◽  
Jiansheng Luo
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Chinese Population ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Relationship Of ◽  
The Relationship ◽  
Alcoholic Fatty Liver Disease

Abstract Background: Non-alcoholic fatty liver disease (NAFLD) is linked to some metabolic disorders. Herein, we explored the relationship of levels of serum uric acid （SUA）with NAFLD in a population of non-obese Chinese. Methods: This was a cross-sectional study that involved 183,903 Chinese men and women with an average age of 40.98 years who underwent physical examinations at a health screening center at Wenzhou People’s Hospital. We defined NAFLD by ultrasound detection of steatosis. We employed univariate analysis along with multivariate Cox proportional hazards analyses to investigate the relationship of SUA level with NAFLD. Moreover, we employed the receiver operating characteristic curve to establish the SUA cutoffs of estimating NAFLD. Results: Overall, 25,501 participants (13.9%) had NAFLD. The NAFLD ORs were 1.47 (95% CI 1.35 to 1.59), 2.01 (95% CI 1.85 to 2.18) and 2.77 (95% CI 2.55 to 3.02) compared with Q1.AUC values for SUA ratios was 0.728. The optimal SUA level cut-off value for identification of NAFLD was 287.5, with a specificity and a sensitivity of 60.7% and 73.9%, respectively.Conclusion: High Serum uric acid levels shows positive correlation with NAFLD. SUA constitutes a cheap, simple, non-invasive, as well as a beneficial biomarker that could be utilized to forecast NAFLD in the non-obese Chinese population.

scholarly journals No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaoli Li ◽  
Lianju Li ◽  
Lixian Yang ◽  
Jiaxun Yang ◽  
Hua Lu
Keyword(s):  
Bone Mineral Density ◽  
Uric Acid ◽  
Lumbar Spine ◽  
Serum Uric Acid ◽  
Bone Mineral ◽  
Cross Sectional Study ◽  
Adult Males ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional

AbstractAvailable evidence linking serum uric acid (SUA) and bone mineral density (BMD) remains controversial, and data on this association are limited among adult men in the general population. Thus, the aim of this study was to evaluate the association of SUA with lumbar spine BMD in US adult males. A cross-sectional study was conducted based on the National Health and Nutrition Examination Survey (NHANES, 1999–2006) database. Multivariate linear regression analyses were employed to assess the association of SUA with lumbar spine BMD, considering complex survey design and sampling weights. Through rigorous eligibility criteria, a total of 6704 individuals were yielded for final data analysis (average age, 40.5 years; 70.6% white). After fully adjusting potential confounders, no associations were detected between SUA and lumbar spine BMD [β (95% confidence interval, CI), − 0.003 (− 0.007, 0.002)]. Additionally, similar results were observed in all stratification analyses, and no interactions were found based on all priori specifications. In brief, our findings did not provide an inspiring clue for the hypothesis that SUA may be beneficial to lumbar spine BMD. Future more prospective studies are needed to further explore the causal relationship of SUA with lumbar spine BMD.

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