scholarly journals Recent Progress on Nanostructures for Drug Delivery Applications

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Haijiao Lu ◽  
Jingkang Wang ◽  
Ting Wang ◽  
Jian Zhong ◽  
Ying Bao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Nucleic Acids ◽  
Small Molecules ◽  
Self Assembly ◽  
Building Materials ◽  
Driving Forces ◽  
Rapid Development ◽  
Poorly Soluble Drugs ◽  
Normal Tissues ◽  
Poorly Soluble

With the rapid development of nanotechnology, the convergence of nanostructures and drug delivery has become a research hotspot in recent years. Due to their unique and superior properties, various nanostructures, especially those fabricated from self-assembly, are able to significantly increase the solubility of poorly soluble drugs, reduce cytotoxicity toward normal tissues, and improve therapeutic efficacy. Nanostructures have been successfully applied in the delivery of diverse drugs, such as small molecules, peptides, proteins, and nucleic acids. In this paper, the driving forces for the self-assembly of nanostructures are introduced. The strategies of drug delivery by nanostructures are briefly discussed. Furthermore, the emphasis is put on a variety of nanostructures fabricated from various building materials, mainly liposomes, polymers, ceramics, metal, peptides, nucleic acids, and even drugs themselves.

Self-microemulsion Technology for Water-insoluble Drug Delivery

2019 ◽  
Vol 15 (6) ◽  
pp. 576-588 ◽  
Author(s):  
Beibei Yan ◽  
Yu Gu ◽  
Juan Zhao ◽  
Yangyang Liu ◽  
Lulu Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
New Chemical Entities ◽  
Poorly Soluble ◽  
Water Insoluble Drug ◽  
Semi Solid ◽  
Solidification Technology

: According to the drug discovery, approximately 40% of the new chemical entities show poor bioavailability due to their low aqueous solubility. In order to increase the solubility of the drugs, self-micro emulsifying drug delivery systems (SMEDDS) are considered as an ideal technology for enhancing the permeability of poorly soluble drugs in GI membranes. The SMEDDS are also generally used to enhance the oral bioavailability of the hydrophobic drugs. At present, most of the self-microemulsion drugs are liquid dosage forms, which could cause some disadvantages, such as the low bioavailability of the traditional liquid SMEDDS. Therefore, solid self-micro emulsifying drug delivery systems (S-SMEDDS) have emerged widely in recent years, which were prepared by solidifying a semi-solid or liquid self-emulsifying (SE) ingredient into a powder in order to improve stability, treatment and patient compliance. The article gives a comprehensive introduction of the study of SMEDDS which could effectively tackle the problem of the water-insoluble drug, especially the development of solidification technology of SMEDDS. Finally, the present challenges and the prospects in this field were also discussed.

scholarly journals Nanosuspension Technology: Recent Patents on Drug Delivery and their Characterizations

2019 ◽  
Vol 13 (2) ◽  
pp. 91-104 ◽  
Author(s):  
Surya Goel ◽  
Monika Sachdeva ◽  
Vijay Agarwal
Keyword(s):  
Drug Delivery ◽  
Crucial Role ◽  
Specific Drug ◽  
Poorly Soluble Drugs ◽  
Site Specific ◽  
The Past ◽  
Dosing Frequency ◽  
The Future ◽  
Poorly Soluble

Background: Nanosuspension has arisen as a remunerative, lucrative as well as a potent approach to improve the solubility and bioavailability of poorly aqueous soluble drug entities. Several challenges are still present in this approach which need more research. The prime aim of this review is to identify such challenges that can be rectified in the future. Methods: Through this review, we enlighten the recent patents and advancement in nanosuspension technology that utilize the different drug moieties, instruments and characterization parameters. Results: Nanosuspension has been found to possess great potential to rectify the several issues related to poor bioavailability, site-specific drug delivery, dosing frequency, etc. In the past decade, nanosuspension approach has been complementarily utilized to solve the developed grievances, arisen from poorly soluble drugs. But this field still needs more attention to new discoveries. Conclusion: Nanosuspension contributes a crucial role in administering the different drug entities through a variety of routes involving oral, transdermal, ocular, parenteral, pulmonary, etc. with solving the different issues. This review also confirms the significance of nanosuspension in safety, efficacy, and communal as well as the economic expense associated with healthcare.

In VivoPrecipitation of Poorly Soluble Drugs from Lipid-Based Drug Delivery Systems

2016 ◽  
Vol 13 (10) ◽  
pp. 3417-3426 ◽  
Author(s):  
P. J. Sassene ◽  
M. H. Michaelsen ◽  
M. D. Mosgaard ◽  
M. K. Jensen ◽  
E. Van Den Broek ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

scholarly journals Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 134 ◽  
Author(s):  
Maria Gigliobianco ◽  
Cristina Casadidio ◽  
Roberta Censi ◽  
Piera Di Martino
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Colloidal Particles ◽  
Poorly Soluble Drugs ◽  
Drug Bioavailability ◽  
Free System ◽  
Surface Active Agents ◽  
Carrier Free ◽  
Poorly Soluble ◽  
Surface Active

Many approaches have been developed over time to overcome the bioavailability limitations of poorly soluble drugs. With the advances in nanotechnology in recent decades, science and industry have been approaching this issue through the formulation of drugs as nanocrystals, which consist of “pure drugs and a minimum of surface active agents required for stabilization”. They are defined as “carrier-free submicron colloidal drug delivery systems with a mean particle size in the nanometer range, typically between 10–800 nm”. The primary importance of these nanoparticles was the reduction of particle size to nanoscale dimensions, with an increase in the particle surface area in contact with the dissolution medium, and thus in bioavailability. This approach has been proven successful, as demonstrated by the number of such drug products on the market. Nonetheless, despite the definition that indicates nanocrystals as a “carrier-free” system, surface active agents are necessary to prevent colloidal particles aggregation and thus improve stability. In addition, in more recent years, nanocrystal properties and technologies have attracted the interest of researchers as a means to obtain colloidal particles with modified biological properties, and thus their interest is now also addressed to modify the drug delivery and targeting. The present work provides an overview of the achievements in improving the bioavailability of poorly soluble drugs according to their administration route, describes the methods developed to overcome physicochemical and stability-related problems, and in particular reviews different stabilizers and surface agents that are able to modify the drug delivery and targeting.

Development and Characterization of a Self-Nanoemulsifying Drug Delivery System Comprised of Rice Bran Oil for Poorly Soluble Drugs

2019 ◽  
Vol 20 (2) ◽  
Author(s):  
Georgios K. Eleftheriadis ◽  
Panagiota Mantelou ◽  
Christina Karavasili ◽  
Paschalina Chatzopoulou ◽  
Dimitrios Katsantonis ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

scholarly journals Bioinspired Extracellular Vesicles: Lessons Learned From Nature for Biomedicine and Bioengineering

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2172 ◽  
Author(s):  
Assaf Zinger ◽  
Ava Brozovich ◽  
Anna Pasto ◽  
Manuela Sushnitha ◽  
Jonathan O. Martinez ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Nucleic Acids ◽  
Structure Function ◽  
Small Molecules ◽  
Extracellular Vesicles ◽  
Clinical Applications ◽  
Lessons Learned ◽  
Efficient Communication ◽  
Exchange Information ◽  
Cell Carriers

Efficient communication is essential in all layers of the biological chain. Cells exchange information using a variety of signaling moieties, such as small molecules, proteins, and nucleic acids. Cells carefully package these messages into lipid complexes, collectively named extracellular vesicles (EVs). In this work, we discuss the nature of these cell carriers, categorize them by their origin, explore their role in the homeostasis of healthy tissues, and examine how they regulate the pathophysiology of several diseases. This review will also address the limitations of using EVs for clinical applications and discuss novel methods to engineer nanoparticles to mimic the structure, function, and features of EVs. Using lessons learned from nature and understanding how cells use EVs to communicate across distant sites, we can develop a better understanding of how to tailor the fundamental features of drug delivery carriers to encapsulate various cargos and target specific sites for biomedicine and bioengineering.

scholarly journals VP6-SUMO Self-Assembly as Nanocarriers for Gastrointestinal Delivery

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
V. Palmieri ◽  
F. Bugli ◽  
M. Papi ◽  
G. Ciasca ◽  
G. Maulucci ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Oral Delivery ◽  
Drug Stability ◽  
Intestinal Cells ◽  
Chimeric Construct ◽  
Poorly Soluble ◽  
Epithelial Barriers ◽  
Natural Target ◽  
Poor Absorption

High proteolytic degradation and poor absorption through epithelial barriers are major challenges to successful oral delivery of therapeutics. Nanoparticle platforms can enhance drug stability and extend the residence time in gastrointestinal (GI) tract. However, drug delivery systems are often inactivated in acidic environment of stomach or suffer poor absorption from intestinal cells due to the mucus layer. To overcome these issues we developed a drug delivery system constituted by a protein construct made by a Rotavirus capsid protein (VP6) and the small ubiquitin-like modifier SUMO. This chimeric construct allows specificity towards intestinal cells, the Rotavirus natural target, combined by an enhanced stability given by the eukaryotic protein transporter SUMO. Furthermore SUMO can act as a molecular switch that facilitates import/export of its ligand to the nucleus, the hypersensitive subcellular site target of many cell killing therapies. In this paper we show that SUMO-VP6 constructs self-assembly into stable nanocarriers. SUMO-VP6 nanocarriers display ideal features for drug delivery: a small size and high monodispersity, a high stability in different pH conditions and a high uptake in the nuclear and cytoplasmic compartment of intestinal cells. These features make SUMO-VP6 nanocarriers a promising novel system for oral delivery of poorly soluble drugs.

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