scholarly journals Synthesis and Antimicrobial Activity of N-(6-Carboxyl Cyclohex-3-ene Carbonyl) Chitosan with Different Degrees of Substitution

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Mohamed E. I. Badawy ◽  
Entsar I. Rabea
Keyword(s):  
Antimicrobial Activity ◽  
Mycelial Growth ◽  
Antimicrobial Agents ◽  
Water Solubility ◽  
Crop Protection ◽  
Erwinia Carotovora ◽  
Botryodiplodia Theobromae ◽  
Remarkable Improvement ◽  
Rhodococcus Fascians ◽  
Synthetic Pesticides

Five products of N-(6-carboxyl cyclohex-3-ene carbonyl) chitosan as antimicrobial agents were prepared by reaction of chitosan with tetrahydrophthalic anhydride (THPA) at different degrees of substitution (DS). The antimicrobial activity was evaluated against four plant bacteria and eight fungi. The results proved that the inhibitory property and water solubility of the synthesized chitosan derivatives, with increase of the DS, exhibited a remarkable improvement over chitosan. The product with a DS of 0.40 was the most active one with MIC of 510, 735, 240, and 385 mg/L against Erwinia carotovora, Ralstonia solanacearum, Rhodococcus fascians, and Rhizobium radiobacter, respectively, and also in mycelial growth inhibition against Alternaria alternata (EC50 = 683 mg/L), Botrytis cinerea (EC50 = 774 mg/L), Botryodiplodia theobromae (EC50 = 501 mg/L), Fusarium oxysporum (EC50 = 500 mg/L), F. solani (EC50 = 260 mg/L), Penicillium digitatum (EC50 = 417 mg/L), Phytophthora infestans (EC50 = 298 mg/L), and Sclerotinia sclerotiorum (EC50 = 763 mg/L). These compounds based on a biodegradable and biocompatible chitosan could be used as potentially antimicrobial agents in crop protection instead of hazardous synthetic pesticides.

scholarly journals A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Soheil Zorofchian Moghadamtousi ◽  
Habsah Abdul Kadir ◽  
Pouya Hassandarvish ◽  
Hassan Tajik ◽  
Sazaly Abubakar ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Water Solubility ◽  
Curcuma Longa ◽  
Antimicrobial Activities ◽  
Inhibitory Effect ◽  
Polyphenolic Compound ◽  
Future Studies ◽  
Chemical Derivatives ◽  
Antimicrobial Studies

Curcuma longaL. (Zingiberaceae family) and its polyphenolic compound curcumin have been subjected to a variety of antimicrobial investigations due to extensive traditional uses and low side effects. Antimicrobial activities for curcumin and rhizome extract ofC. longaagainst different bacteria, viruses, fungi, and parasites have been reported. The promising results for antimicrobial activity of curcumin made it a good candidate to enhance the inhibitory effect of existing antimicrobial agents through synergism. Indeed, different investigations have been done to increase the antimicrobial activity of curcumin, including synthesis of different chemical derivatives to increase its water solubility as well ass cell up take of curcumin. This review aims to summarize previous antimicrobial studies of curcumin towards its application in the future studies as a natural antimicrobial agent.

scholarly journals A Biopolymer Chitosan and Its Derivatives as Promising Antimicrobial Agents against Plant Pathogens and Their Applications in Crop Protection

2011 ◽  
Vol 2011 ◽  
pp. 1-29 ◽  
Author(s):  
Mohamed E. I. Badawy ◽  
Entsar I. Rabea
Keyword(s):  
Antimicrobial Activity ◽  
Plant Pathogens ◽  
Antimicrobial Agents ◽  
Crop Protection ◽  
Chemical Modifications ◽  
Research Papers ◽  
Physiochemical Properties ◽  
Functional Derivatives ◽  
Derivatives Of ◽  
Chitosan Molecule

Recently, much attention has been paid to chitosan as a potential polysaccharide resource. Although several efforts have been reported to prepare functional derivatives of chitosan by chemical modifications, few attained their antimicrobial activity against plant pathogens. The present paper aims to present an overview of the antimicrobial effects, mechanisms, and applications of a biopolymer chitosan and its derivatives in crop protection. In addition, this paper takes a closer look at the physiochemical properties and chemical modifications of chitosan molecule. The recent growth in this field and the latest research papers published will be introduced and discussed.

scholarly journals Chemically modified chitosans as antimicrobial agents against some plant pathogenic bacteria and fungi

2010 ◽  
Vol 46 (No. 4) ◽  
pp. 149-158 ◽  
Author(s):  
E.I. Rabea ◽  
W. Steurbaut
Keyword(s):  
High Activity ◽  
Spore Germination ◽  
Mycelial Growth ◽  
Pathogenic Bacteria ◽  
Antimicrobial Agents ◽  
Erwinia Carotovora ◽  
Fungal Spore ◽  
Plant Pathogenic Bacteria ◽  
Chemically Modified

The antimicrobial activity of eight chemically modified chitosans against plant pathogenic bacteria of crown gall disease Agrobacterium tumefaciens and soft mould disease Erwinia carotovora and fungi of early blight disease Alternaria alternata, root rot disease Fusarium oxysporum, and damping off disease Pythium debaryanum was investigated. The minimum inhibitory concentration (MIC) of these compounds against the tested bacteria showed that N-(o,o-dichlorobenzyl)chitosan exhibited a high activity against A. tumefaciens and E. carotovora (MIC = 500 and 480 mg/l, respectively). In addition, the antifungal behaviour was investigated in vitro on mycelial growth and spore germination. N-(p-fluorobenzyl)chitosan was the most active against the mycelial growth of A. alternata with an EC<sub>50</sub> of 703.4 mg/l, while the N-(o-chloro,o-fluorobenzyl)chitosan exhibited a high activity against F. oxysporum and P. debaryanum (EC<sub>50</sub> = 641.2 and 155.7 mg/l, respectively). Against the fungal spore germination, all modified chitosans showed a higher inhibition of spore germination than unmodified chitosan. The compound of N-(o,o-di fluorobenzyl)chitosan exhibited a high inhibition percentage against A. alternata. However, N-(o-chlorobenzyl)chitosan and N-(p-chlorobenzyl)chitosan were significantly highly active against the spore germination of F. oxysporum.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF 3-FORMYL INDOLE BASED SCHIFF BASES

2018 ◽  
Vol 7 (6) ◽  
Author(s):  
Singh Gurvinder ◽  
Singh Prabhsimran ◽  
Dhawan R. K.
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Analysis ◽  
Schiff Bases ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Fungal Strain ◽  
Bacterial Strains ◽  
Standard Drug ◽  
Gram Negative ◽  
E Coli

In order to develop new antimicrobial agents, a series of 3-formyl indole based Schiff bases were synthesized by reacting 3-formyl indole(indole-3-carboxaldehyde) with substituted aniline taking ethanol as solvent. The reaction was carried in the presence of small amount of p-toluene sulphonic acid as catalyst.All the synthesized compounds were characterized by IR, 1H-NMR spectral analysis. All the synthesized compounds were evaluated for antimicrobial activity against two gram positive bacterial strains (B. subtilisand S. aureus) and two gram negative bacterial strains (P. aeruginosaand E. coli) and one fungal strain (C. albicans). All the synthesized compounds were found to have moderate to good antimicrobial activity. The  standard drug amoxicillin, fluconazole were used for antimicrobial activity. Among the synthesized compounds, the maximum antimicrobial activity was shown by compounds GS04, GS07, GS08 and GS10.

Mycelial Growth and Antimicrobial Activity of Pleurotus Species (Agaricomycetes)

2018 ◽  
Vol 20 (2) ◽  
pp. 191-200 ◽  
Author(s):  
Teresa A. Castillo ◽  
Renata A. Lemos ◽  
José Raimundo G. Pereira ◽  
José Maria A. Alves ◽  
Maria Francisca S. Teixeira
Keyword(s):  
Antimicrobial Activity ◽  
Mycelial Growth ◽  
Pleurotus Species

Assessment of Antimicrobial Activity and total Polyphenol Content of Rosa multiflora and Rosa wichuraiana

2019 ◽  
Vol 10 (04) ◽  
pp. 646-650
Author(s):  
Hyeusoo Kim ◽  
Kyeong Won Yun
Keyword(s):  
Antimicrobial Activity ◽  
Ethyl Acetate ◽  
Antimicrobial Agents ◽  
Ethyl Acetate Fraction ◽  
Rosa Multiflora ◽  
Polyphenol Content ◽  
Total Polyphenol ◽  
Water Fraction ◽  
Total Polyphenol Content ◽  
Rosa Species

The fruit of Rosa multiflora has been used as traditional herbal medicine in Asian countries. The present investigation was undertaken to study the antimicrobial activity and total polyphenol content of hexane, ether, ethyl acetate, water fraction of methanol extract of fruit and flower from Rosa multiflora and Rosa wichuraiana. Antimicrobial activity of the mentioned fractions against 3 gram-positive and 4 gram-negative bacteria using disk diffussion method. The measurement of minimal inhibition concentration (MIC) showed that the ethyl acetate fraction of the two Rosa species is the most effective against the tested bacteria. The total polyphenol content of ethyl acetate fraction of the two Rosa species is higher than the other fractions. The results indicate the antimicrobial activity was related with the total polyphenol content and the fruit and flower of the two Rosa species can be considered as a natural source of antimicrobial agents.

The Chemistry Of Antibiofilm Phytocompounds.

2020 ◽  
Vol 20 ◽  
Author(s):  
Dibyajit Lahiri ◽  
Moupriya Nag ◽  
Sayantani Garai ◽  
Rina Rani Ray
Keyword(s):  
Antimicrobial Activity ◽  
Antibiotic Resistance ◽  
Antibiotic Therapy ◽  
Antimicrobial Agents ◽  
Chemical Nature ◽  
Rapid Development ◽  
Wide Spread ◽  
Chronic Infections ◽  
Therapeutic Uses

: Phytocompounds are long known for their therapeutic uses due to their competence as antimicrobial agents. The antimicrobial activity of these bioactive compounds manifests their ability as an antibiofilm agent and is thereby proved to be competent to treat the wide spread of biofilm-associated chronic infections. Rapid development of antibiotic resistance in bacteria has made the treatment of these infections almost impossible by conventional antibiotic therapy, which forced in the switch over to the use of phytocompounds. The present overview deals with the classification of the huge array of phytocompounds according to their chemical nature, detection of their target pathogen, and elucidation of their mode of action.

Copper-catalyzed Convenient Synthesis and SAR Studies of Substituted-1,2,3-triazole as Antimicrobial Agents

2018 ◽  
Vol 16 (1) ◽  
pp. 3-10
Author(s):  
Aniket P. Sarkate ◽  
Kshipra S. Karnik ◽  
Pravin S. Wakte ◽  
Ajinkya P. Sarkate ◽  
Ashwini V. Izankar ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Triazole Derivatives ◽  
Sar Studies ◽  
Convenient Synthesis ◽  
Antibacterial And Antifungal

Background:A novel copper-catalyzed synthesis of substituted-1,2,3-triazole derivatives has been developed and performed by Huisgen 1,3-dipolar cycloaddition reaction of azides with alkynes. The reaction is one-pot multicomponent.Objective:We state the advancement and execution of a methodology allowing for the synthesis of some new substituted 1,2,3-triazole analogues with antimicrobial activity.Methods:A series of triazole derivatives was synthesized by Huisgen 1,3-dipolar cycloaddition reaction of azides with alkynes. The structures of the synthesized compounds were elucidated and confirmed by 1H NMR, IR, MS and elemental analysis. All the synthesized compounds were tested for their antimicrobial activity against a series of strains of Bacillus subtilis, Staphylococcus aureus and Escherichia coli for antibacterial activity and against the strains of Candida albicans, Aspergillus flavus and Aspergillus nigar for antifungal activity, respectively.Results and Conclusion:From the antimicrobial data, it was observed that all the newly synthesized compounds showed good to moderate level of antibacterial and antifungal activity.

Synthesis of Novel 3(N,N-dialkylamino)alkyl/phenyl Substituted Thieno [2,3-d]pyrimidinones as H1-Anti-Histaminic and Antimicrobial Agents

2019 ◽  
Vol 15 (1) ◽  
pp. 63-70
Author(s):  
Shiv Dev Singh ◽  
Arvind Kumar ◽  
Firoz Babar ◽  
Neetu Sachan ◽  
Arun Kumar Sharma
Keyword(s):  
Antimicrobial Activity ◽  
Potassium Hydroxide ◽  
Antimicrobial Agents ◽  
Pyrimidine Ring ◽  
Antimicrobial Activities ◽  
Screening Methods ◽  
Chlorpheniramine Maleate ◽  
In Vivo Screening

Background: Thienopyrimidines are the bioisoster of quinazoline and unlike quinazoline exist in three isomeric forms corresponding to the three possible types annulation of thiophene to the pyrimidine ring viz thieno[2,3-d] pyrimidine, thieno[3,2-d] pyrimidine and thieno[3,4-d]pyrimidine. Heterocyclic containing the thienopyrimidinone moiety exhibits various pronounced activities such as anti-hypertensive, analgesic and anti-inflammatory, antiviral, platelet aggregation inhibitory, antiprotozoal bronchodilatory, phosphodiesterase inhibitory, antihistaminic, antipsychotic and antimicrobial activity. Objective: Synthesis of novel 3(N,N-dialkylamino)alkyl/phenyl substituted thieno[2,3-d]pyrimidinones as H1-anti-histaminic and antimicrobial agents. Methods: A series of 3-[(N,N-dialkylamino)alkyl/phenyl]-2-(1H)thioxo-5,6,7,8-tetrahydrobenzo(b) thieno(2,3-d)pyrimidine-4(3H)-ones[4a-d], their oxo analogous [5a-d] and 3-[(N,N-dialkylamino)alkyl]- 2-chlorophenyl-5,6,7,8-tetrahydrobenzo(b)thieno(2,3-d)pyrimidine- 4 (3H)-ones[6a-d]derivative were synthesized from 2-amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carboxylic acid by nucleophilic substitution of different N,N-dialkyl alkylene/phenylene diamines on activated 3-acylchloride moiety followed by cyclocondensation with carbon disulfide and ethanolic potassium hydroxide to get [4a-d] and in second reaction by condensation with 4-chlorobenzoyl chloride to get [6a-d] by single pot novel innovative route. The oxo analogous [5a-d] were prepared by treating derivatives [4a-d] with potassium permagnate in ethanolic KOH. The synthesized compound were evaluated for H1-antihistaminic and antimicrobial activities. Results: All synthesized compounds exhibited significant H1-antihistaminic activity by in vitro and in vivo screening methods and data were verified analytically and statistically. The compound 4a, 4b, 5a and 5b showed significant H1-antihistaminiic activity than the reference standard chlorpheniramine maleate. The compound 6d, 6c, 5c and 4c exhibited significant antimicrobial activity.

Integrated Pest Management — How to do It?

1996 ◽  
Vol 25 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Reuben Ausher
Keyword(s):  
Pest Management ◽  
Chemical Control ◽  
Ornamental Plants ◽  
Crop Protection ◽  
Environmental Concerns ◽  
Modern Agriculture ◽  
The World ◽  
Synthetic Pesticides ◽  
Control Failures ◽  
Intensive Control

Protection of crop and ornamental plants from noxious organisms — insects, nematodes, mites, pathogens and weeds — is indispensable to modern agriculture. Despite intensive control efforts, about 50% of the world's crops are lost to these organisms, at an estimated annual cost of about 400 billion dollars. Ever since the advent of synthetic pesticides in the 1940s, modern crop protection has been largely based on chemical control. Pesticide expenditures are about 20% of total farming input costs, although this figure varies substantially according to crop and region. Mounting environmental concerns and pest control failures have made It increasingly clear that the use of toxic pesticides In agriculture should be drastically reduced all over the world.

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