scholarly journals Effectiveness of Long Term Supervised and Assisted Physiotherapy in Postsurgery Oral Submucous Fibrosis Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
S. Kale ◽  
N. Srivastava ◽  
V. Bagga ◽  
A. Shetty
Keyword(s):  
Treatment Options ◽  
Oral Submucous Fibrosis ◽  
Scar Contracture ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
Conservative And Surgical Treatment ◽  
Subsequent Relapse

Oral submucous fibrosis is one of the leading potentially malignant disorders prevailing in India. A number of conservative and surgical treatment options have been suggested for this potentially malignant disorder (Arakeri and Brennan, 2013). While the role of physiotherapy has been highlighted in the conservative management, its importance in postsurgical cases to avoid scar contracture and subsequent relapse has not been given due importance in the literature. The following is a case report of a male patient surgically treated for OSMF (oral submucous fibrosis) and meticulously followed up for recalls and physiotherapy. The constant supervision and motivation for physiotherapy along with the constant assistance helped achieve satisfying results.

scholarly journals Screening of Oral Potentially Malignant Disorders Using Exfoliative Cytology: A Diagnostic Modality

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Arpita Kabiraj ◽  
Tanya Khaitan ◽  
Debarati Bhowmick ◽  
Uday Ginjupally ◽  
Aritri Bir ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Submucous Fibrosis ◽  
Class Ii ◽  
Class I ◽  
Exfoliative Cytology ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
Oral Lichen

Objective. Oral exfoliative cytology (OEC) has been implemented in the diagnosis of pathologic lesions for ages. The present study was undertaken to evaluate the cytomorphological features of some of the commonest potentially malignant disorders (leukoplakia, lichen planus, and oral submucous fibrosis) through a simple procedure and illustrate its importance in mass screening.Materials and Method. A total of 160 subjects with 25–50 years of age were included in the study. Among them, 40 were clinically diagnosed with oral leukoplakia, 40 were diagnosed with oral lichen planus, 40 were diagnosed with oral submucous fibrosis, and 40 were in the control group. The prepared smears were subjected to Papanicolaou stain and analyzed microscopically for the evaluation of the cytomorphological features.Results and Discussion. When analyzed microscopically, 36 (90%) out of the 40 oral leukoplakic lesions showed Class II cytological features whereas 4 (10%) revealed Class I features. Among 40 patients with oral lichen planus, 26 (65%) showed Class II features while the remaining 14 (35%) revealed Class I features. In 40 subjects with oral submucous fibrosis, 32 (80%) showed Class II features while the other 8 (20%) showed Class I features. All the 40 control subjects showed Class I features. Thus, OEC can be widely advocated as an addition to clinical conclusion and an adjunct to biopsy.

scholarly journals Premalignant lesions of the oral cavity: current perspectives

2021 ◽  
Vol 9 (6) ◽  
pp. 1816
Author(s):  
Santosh Kumar Swain
Keyword(s):  
Oral Cavity ◽  
Treatment Options ◽  
Oral Submucous Fibrosis ◽  
Current Treatment ◽  
Premalignant Lesions ◽  
Transformation Rate ◽  
Etiological Factors ◽  
Life Saving ◽  
Potentially Malignant ◽  
Submucous Fibrosis

Premalignant lesions of the oral cavity are also called as potentially malignant disorders. The common premalignant lesions of the oral cavity include leukoplakia, oral submucous fibrosis (OSMF) and oral erythroplakia. These lesions have a very high malignant transformation rate. The exact etiological factors for development of the premalignant lesions of the oral cavity are not fully understood till date. Use of tobacco, alcohol drinking, chewing betel quid containing areca nut and solar rays are important etiological factors for resulting the premalignant lesions of the oral cavity. Early diagnosis is an important step for preventing the malignant transformations of these lesions and can be also life-saving. There are several treatment options including conservative to surgical for eliminating the premalignant lesions of the oral cavity. The aim of this study was to discuss the details of epidemiology, etiopathology, clinical presentations, diagnosis and current treatment of the premalignant lesions of the oral cavity.  

scholarly journals Research Achievements of Oral Submucous Fibrosis: Progress and Prospect

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Hui Xu ◽  
Feng-yuan Lyu ◽  
Jiang-yuan Song ◽  
Yu-ming Xu ◽  
Er-hui Jiang ◽  
...  
Keyword(s):  
Oral Submucous Fibrosis ◽  
Treatment Strategies ◽  
Areca Nut ◽  
Health It ◽  
Comprehensive Review ◽  
Potentially Malignant Disorders ◽  
Regional Problem ◽  
Potentially Malignant ◽  
New Ideas ◽  
Submucous Fibrosis

Oral submucous fibrosis (OSMF) is a kind of chronic, insidious disease, and it is categorized into potentially malignant disorders (PMD), which poses a global and regional problem to public health. It is considered to be a multifactorial disease, such as due to areca nut chewing, trace element disorders, and genetic susceptibility. However, there is still no unanimous conclusion on its pathogenesis, diagnosis, and treatment strategies. Hence, this article provides a comprehensive review and prospect of OSMF research, providing scholars and clinicians with a better perspective and new ideas for the research and treatment of OSMF.

scholarly journals Coetaneous Presentation of Oral Leukoplakia and Oral Submucous Fibrosis with High Grade Dysplasia and Its Management with Lasers: A Case Report

2021 ◽  
Vol 6 (08) ◽  
pp. 464-469
Author(s):  
Preethi R ◽  
Malarkodi T ◽  
Arvind Krishnamurthy ◽  
Aravind Warrier S
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Oral Leukoplakia ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Oral Potentially Malignant Disorders ◽  
Oral Epithelial Dysplasia ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Submucous Fibrosis

Oral potentially malignant disorders (OPMD) are diverse lesions associated with an increased likelihood for malignant transformation to oral cancer. The most frequently encountered OPMD in clinical practice are Oral Leukoplakia and oral submucous fibrosis (OSMF). The use of tobacco is consistently linked with leukoplakia and areca/betel nut with OSMF. Histopathological features of oral epithelial dysplasia, its varying grades are of immense clinical significance to evaluate its ability for malignant transformation. We report a case of homogenous leukoplakia and OSMF, two oral potentially malignant disorders occurring at the same site with high-grade dysplasia and its management using lasers.

scholarly journals Assessment of Nicotine Dependence Using Fagerstrom Test among Patients with Leukoplakia and Oral Submucous Fibrosis

2020 ◽  
pp. 97-106
Author(s):  
N. Prashaanthi ◽  
Sreedevi Dharman
Keyword(s):  
Nicotine Dependence ◽  
Oral Submucous Fibrosis ◽  
Tobacco Consumption ◽  
Chi Square ◽  
High Dependency ◽  
Potentially Malignant Disorders ◽  
Dental Hospital ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
Oral Malignancy

Tobacco consumption has an influence on the oral mucosa and causes oral malignancy in the due time. On assessing nicotine dependence, appropriate counselling can be given to prevent further progression of the habit. Aim of this study was to assess the nicotine dependence levels among patients with potentially malignant disorders such as leukoplakia and Oral Submucous Fibrosis (OSMF) using fagerstrom test. This study included 140 patients from October 2019 to January 2020 in a dental hospital. Variables such as age, gender, tobacco form and lesion were assessed. Descriptive and chi square statistics were performed. Out of 140 patients, higher prevalence with tobacco usage were among 41-50 years (40%), 94.29% were males and 5.71% were females, 16.43% had low dependency, 52.86% had medium dependency and 30.71% had high dependency. Association between   age; nicotine dependency in patients with and without lesion p=0.000(p<0.05), statistically significant. Association between gender and patients with and without lesions p=0.151(p>0.05), statistically not significant. Within the limitations of the present study, males had higher prevalence of tobacco use among 41-50 years. Patients with potentially malignant disorders and smokers without lesion had medium dependence while smokeless tobacco users without lesion had a high dependence.

scholarly journals Molecular Pathogenesis of Oral Submucous Fibrosis: A Critical Appraisal

2019 ◽  
Vol 12 (04) ◽  
pp. 2027-2036 ◽  
Author(s):  
Arpita Rai ◽  
Musarrat Siddiqui ◽  
Shama Parveen ◽  
Saba Parveen ◽  
Abdur Rasheed ◽  
...  
Keyword(s):  
Critical Appraisal ◽  
Epithelial Mesenchymal Transition ◽  
Oral Submucous Fibrosis ◽  
Molecular Pathogenesis ◽  
Areca Nut ◽  
Mesenchymal Transition ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
Malignant Condition

Oral submucous fibrosis (OSMF) is a chronic, potentially malignant condition of the oral mucosa and the habitual chewing of areca nut is believed to be the most potent etiological factor. The role of reactive oxygen species (ROS), epithelial-mesenchymal transition (EMT) and various cytokines and growth factors has been established in recent studies. The components of areca nut particularly, arecoline, flavonoids and copper have been found to affect fibroblasts, endothelial and epithelial cells through various biological pathways which are either down-regulated or up-regulated during different stages of the disease. However, the underlying molecular pathogenesis of OSMF is still partially understood.

Considering a Potential Role of Linalool as a Mood Stabilizer for Bipolar Disorder

2020 ◽  
Vol 26 (40) ◽  
pp. 5128-5133
Author(s):  
Kate Levenberg ◽  
Wade Edris ◽  
Martha Levine ◽  
Daniel R. George
Keyword(s):  
Bipolar Disorder ◽  
Treatment Options ◽  
Mood Stabilizer ◽  
Well Being ◽  
Epidemiologic Studies ◽  
Treatment Regimens ◽  
Bipolar Spectrum Disorders ◽  
Short And Long Term

Epidemiologic studies suggest that the lifetime prevalence of bipolar spectrum disorders ranges from 2.8 to 6.5 percent of the population. To decrease morbidity and mortality associated with disease progression, pharmacologic intervention is indicated for the majority of these patients. While a number of effective treatment regimens exist, many conventional medications have significant side effect profiles that adversely impact patients’ short and long-term well-being. It is thus important to continue advancing and improving therapeutic options available to patients. This paper reviews the limitations of current treatments and examines the chemical compound Linalool, an alcohol found in many plant species, that may serve as an effective mood stabilizer. While relatively little is known about Linalool and bipolar disorder, the compound has been shown to have antiepileptic, anti-inflammatory, anxiolytic, anti-depressive, and neurotrophic effects, with mechanisms that are comparable to current bipolar disorder treatment options.

Thrombopoietin Receptor Agonists in Children with Immune Thrombocytopenia: A New Therapeutic Era

2020 ◽  
Vol 20 ◽  
Author(s):  
Giuseppe Lassandro ◽  
Valentina Palladino ◽  
Giovanni Carlo Del Vecchioa ◽  
Viviana Valeria Palmieri ◽  
Paola Carmela Corallo ◽  
...  
Keyword(s):  
Immune Thrombocytopenia ◽  
Treatment Options ◽  
Thrombopoietin Receptor Agonists ◽  
Receptor Agonists ◽  
Thrombopoietin Receptor ◽  
Related Quality ◽  
Health Related

Background and Objective: Immune thrombocytopenia (ITP) is a common bleeding disorder in childhood. The management of ITP in children is controversial, requiring personalized assessment of patients and therapeutic choices. Thrombopoietin receptor agonists (TPO-RAs), eltrombopag and romiplostim, have been shown to be safety and effective for the treatment of pediatric ITP. The aim of our research is defining the role of thrombopoietin receptor agonists in the management of pediatric ITP. Method: This review focuses on the use of TPO-RAs in pediatric ITP, in randomized trials and in clinical routine, highlighting their key role in management of the disease. Results: Eltrombopag and romiplostim appear effective treatment options for children with ITP. Several clinical studies have assessed that the use of TPO-RAs increases platelet count, decreases bleeding symptoms and improves health-related quality of life. Moreover, TPO-RAs are well tolerated with minor side effects. Conclusion: Although TPO-RAs long term efficacy and safety still require further investigations, their use is gradually expanding in clinical practice of children with ITP.

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