scholarly journals Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Hasan Hawamdeh ◽  
Basim Al-Zoubi ◽  
Yasameen Al Sharqi ◽  
Ayman Qasrawi ◽  
Yousef Abdelaziz ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Positive Association ◽  
High Sensitivity ◽  
Histopathological Changes ◽  
Significant Positive Association ◽  
Histological Changes ◽  
Gluten Enteropathy ◽  
High Positive Predictive Value ◽  
Relationship Of

Celiac disease is usually diagnosed by demonstrating gluten enteropathy in small bowel biopsy. Celiac specific antibodies are used as an initial screening test. The goal of this study is to test the relationship of the anti-tTG titer and severity of histological changes in Jordanian children with celiac disease. Method. The medical records of 81 children who had elevated anti-tTG titer and had duodenal biopsies available were retrospectively reviewed. Result. Assessing the association of anti-tTG titer with duodenal histopathological changes, 94% of those with high anti-tTG titer (≥180 U/mL) had histological evidence of celiac disease. There was statistically significant positive association between high anti-tTG titer and Marsh grading as 82% of patients with Marsh III had high anti-tTG titer (Chi2 18.5; P value 0.00; Odds Ratio 8.5). The fraction of patients with Marsh III who were correctly identified as positive by anti-tTG titer ≥ 180 U/mL was high (sensitivity = 81.6). Moreover, the fraction of patients with anti-tTG titer ≥ 180 U/mL who had Marsh III was also high (positive predictive value = 78.4). Conclusion. Anti-tTG titer ≥ 180 U/mL had significant positive association with Marsh III histopathological changes of celiac disease.

Exploring the relationship of human–nature interaction and mindfulness: a cross-sectional study

2021 ◽  
Author(s):  
Pooja Sahni ◽  
Jyoti Kumar
Keyword(s):  
Mental Health Problems ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
Nature Relatedness ◽  
Relationship Of ◽  
The Relationship ◽  
Nature Experience

History is replete with examples where humans have sought refuge in nature for psychological restoration. In this cross-sectional study we explore the relationship of nature experience and mindfulness. Nature experience is assessed through “nature in the neighbourhood”, “frequency of visit” to nature-rich spaces, as well as one's inherent connection with nature described as “nature relatedness”. The study sample consisted of 334 Indian adults. The findings from this study show that frequency of visit to nature-rich spaces has a significant positive association with mindfulness. The hierarchical regression analysis suggests an interaction effect of “nature relatedness” in the association of the presence of nature rich spaces in the neighbourhood, frequency of visit as well as mindfulness. Interestingly, when childhood experiences were explored they had a significant association with “nature relatedness” and mindfulness. The evidence from this research suggests that nature experience may find its application as one of the mindfulness techniques prescribed for self-management of mental health problems.

scholarly journals THE PREVALENCE OF CELIAC DISEASE AMONG PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER

2015 ◽  
Vol 52 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Sedat IŞIKAY ◽  
Nurgül IŞIKAY ◽  
Halil KOCAMAZ
Keyword(s):  
Celiac Disease ◽  
Familial Mediterranean Fever ◽  
Tissue Transglutaminase ◽  
Control Group ◽  
Marsh Type ◽  
Significant Difference ◽  
Healthy Control ◽  
Mediterranean Fever ◽  
Relationship Of ◽  
The Relationship

Background Familial Mediterranean Fever and celiac disease are both related to auto-inflammation and/or auto-immunity and they share some common clinical features such as abdominal pain, diarrhea, bloating and flatulence. Objectives We aimed to determine the association of these two diseases, if present. Methods Totally 112 patients diagnosed with Familial Mediterranean Fever and 32 cases as healthy control were included in the study. All participants were examined for the evidence of celiac disease, with serum tissue transglutaminase IgA levels (tTG IgA). Results Totally 144 cases, 112 with Familial Mediterranean Fever and 32 healthy control cases were included in the study. tTG IgA positivity was determined in three cases with Familial Mediterranean Fever and in one case in control group. In that aspect there was no significant difference regarding the tTG IgA positivity between groups (P=0.81). Duodenum biopsy was performed to the tTG IgA positive cases and revealed Marsh Type 3b in two Familial Mediterranean Fever cases and Marsh Type 3c in the other one while the biopsy results were of the only tTG IgA positive case in control group was Marsh Type 3b. In HLA evaluation of the celiac cases; HLA DQ2 was present in two celiac cases of the Familial Mediterranean Fever group and in the only celiac case of the control group while HLA DQ8 was present in one celiac case of the Familial Mediterranean Fever group. Conclusions We did not determine an association of Familial Mediterranean Fever with celiac disease. Larger studies with subgroup analysis are warranted to determine the relationship of these two diseases.

Menstrual characteristics, bleeding and other non-pelvic-pain symptoms in women presenting with severe endometriotic disease

2020 ◽  
Vol 12 (2) ◽  
pp. 77-85
Author(s):  
Robert Markham ◽  
Georgina M Luscombe ◽  
Frank Manconi ◽  
Ian S Fraser
Keyword(s):  
Pelvic Pain ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
Resistance To Infection ◽  
Pain Symptoms ◽  
Relationship Of ◽  
The Relationship ◽  
Detailed Nature

Introduction: The purpose of this study was to investigate the detailed nature of menstrual characteristics, bleeding and other symptoms in women with and without endometriosis. Pelvic pain symptoms in this cohort have been reported elsewhere. Method: This is a self-administered cross-sectional study and was conducted using a structural questionnaire. A total of 737 women completed the study: women with endometriosis (n = 529) and with no current gynaecological complaint, ‘control’ (n = 208). Results: Some of the key findings in this study included significant differences between the control and endometriosis subjects in terms of bleeding symptoms, increased length and heaviness of menses, rectal and bladder bleeding, infertility and obstetric complications which were all more common in the endometriosis group. Other symptoms found to have a highly significant positive association with endometriosis included abdominal bloating, low resistance to infection, fatigue, increased urinary frequency, diarrhoea and constipation (p < 0.000). Data were cross-tabulated to examine the association of a number of symptoms to each other. The relationship of symptoms to a range of psychosocial factors was investigated to determine how the effects of endometriosis impacted on the life of subjects. Most women reported that endometriosis sometimes or often interfered with daily aspects of their life. Conclusion: The range of non-pain symptoms in women with endometriosis was generally much more diverse and extensive than recognised by most clinicians.

scholarly journals Frequency of Celiac Disease in Children Presented with Liver Disease at a Tertiary Care Center

2017 ◽  
Vol 40 (3) ◽  
pp. 144-148
Author(s):  
Faika Hussain ◽  
ASM Bazlul Karim ◽  
Md Rukunuzzaman ◽  
Syeda Afria Anwar ◽  
Kaniz Sultana ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Liver Disease ◽  
Tissue Transglutaminase ◽  
Care Center ◽  
Tertiary Care ◽  
Chronic Inflammatory Disease ◽  
Multisystem Disease ◽  
Cross Sectional ◽  
Histological Changes ◽  
Positive Group

Background: Celiac disease is (CD) a genetically determined chronic inflammatory disease induced by an environmental precipitant. It is a multisystem disease and can develop at any point of time during life in genetically susceptible individuals upon ingestion of wheat gluten and related cereal proteins. The onset of symptoms in the atypical form generally occurs between 4-15 years of age. Diagnosis of CD with extraintestinal manifestations is frequently missed as it presents without diarrhoea.Objective: To observe the frequency of celiac disease in children with liver disease.Methods: This cross sectional study was conducted at BSMMU from January 2014 to June 2015. A total of 59 children (age 18 months to16 years) with clinical and biochemical features of liver disease were initially enrolled for the study. Their clinical history, examination findings and investigation reports were recorded in a data collection sheet and informed consent was obtained from parents. Routine investigations, liver function tests, tissue transglutaminase tTG (IgA), total IgA. were done. After exclusion of other causes of liver disease endoscopy of upper gastrointestinal tract (GIT) was done on patients who were tTG (titer of >50 iu/mL) positive. Patients who were tTG negative but found IgA deficient (1 patient) was also selected for upper GI endoscopy and biopsy fragments were taken from second part of duodenum (D2) sent for histopathology.Results: Mean age of studied children was 8.33 ± 3.64 years. Out of 59 children with liver disease, 32.2% were tTG positive of whom female were 8 (13.6%) and male 11 (18.6%). Mean age at diagnosis of all patients with tTG positive group was 8.24 ± 2.78 (range 4-12) years. Among 19 sero-positive patients, short stature was found in 57.9% children. Mean Hb level in tTG positive group was 8.83 ± 2.64 gm/dl and in tTG negative group (10.27 ± 1.74 gm/dl). Sixteen (84.2%) out of 19 tTG positive patients had raised S. ALT. Out of 19 tTG positive children, endoscopy was done in 15 cases (endoscopy could not be done in 4 patients due to persistently raised PT) along with 1 patient who was IgA deficient. Endoscopic changes were mosaic and scalloping of D2 mucosa in 1 and 2 cases respectively. Histological changes compatible with CD were found in 5 (31.3%) patients. Marsh 3a category was found in 2 (12.5%) cases and 3b in 3 (18.8%) cases.Conclusion: In the present study, 32.2% liver disease cases were found tTG positive. Histological changes compatible with CD were found in about one-third cases. Screening for celiac disease may be included in the diagnostic tests for evaluation of liver disease in children.Bangladesh J Child Health 2016; VOL 40 (3) :144-148

Family Communication, Prosocial Behavior and Emotional/Behavioral Problems in a Sample of Pakistani Adolescents

2021 ◽  
pp. 106648072110239
Author(s):  
Sadia Saleem ◽  
Sayyeda T. Zahra ◽  
Sara Subhan ◽  
Zahid Mahmood
Keyword(s):  
Prosocial Behavior ◽  
Family Communication ◽  
Behavioral Problems ◽  
Child Behavior Checklist ◽  
Sampling Strategy ◽  
Positive Association ◽  
Significant Positive Association ◽  
Multistage Sampling ◽  
Relationship Of ◽  
The Relationship

The current study aimed to determine the predictive relationship of family communication, prosocial behavior, and emotional/behavioral problems in adolescents. A sample of 273 adolescents (girls = 148; boys = 125), aged 11–18 years ( M = 14.41, SD = 1.53) were recruited through multistage sampling strategy. Family Communication Scale, Prosocial Scale, and Youth version of Child Behavior Checklist were used to measure family communication, prosocial behavior, and emotional/behavioral problems, respectively. Results indicated a significant positive association of family communication and prosocial behavior ( p < .001), and a significant negative association of family communication ( p < .001) and prosocial behavior ( p < .001) with emotional/behavioral problems. Moreover, mediation analysis revealed that prosocial behavior partially mediated the relationship between family communication and emotional/behavioral problems ( p < .002). Results are discussed in terms of the manifestation of adolescents' problems in traditional and collectivistic cultures.

scholarly journals Celiac Disease Prevalence Among Children with Dermatologic Pathology: Cross Sectional Study with Clinical Case Series

2021 ◽  
Vol 20 (5) ◽  
pp. 402-406
Author(s):  
Leonid A. Opryatin ◽  
Tatiana E. Borovik ◽  
Elena A. Roslavtseva ◽  
Nikolay N. Murashkin
Keyword(s):  
Celiac Disease ◽  
Positive Result ◽  
Tissue Transglutaminase ◽  
Rapid Test ◽  
Gluten Free Diet ◽  
Hla Typing ◽  
Gluten Free ◽  
Dermatology Department ◽  
Gluten Enteropathy ◽  
Rapid Tests

Background. Celiac disease (gluten enteropathy) is relatively rare disease. However, such patients have higher risk of skin pathology than general the population, and their therapy efficacy is limited by the use of gluten-free diet. Therefore, screening of dermatologic patients on celiac disease may be relevant. Objective. Our aim was to study the prevalence of celiac disease among children with skin pathology. Methods. The study included children hospitalized in dermatology department. Screening for celiac disease included detection in blood serum of antibodies (IgA, IgG, IgM) to tissue transglutaminase via rapid tests. In case of positive result of rapid test, we have repeated the estimation of antibodies (IgA, IgG) to tissue transglutaminase via immunochemiluminescent method with ImmunoCAP technology or via enzyme immunoassay. In case of positive serological test, we have performed HLA typing to determine haplotypes of DQ2 and DQ8, as well as esophagogastroduodenojejunoscopy (EGDJS) with biopsy of the duodenal and jejunal mucosa for further histological verification of the diagnosis. Results. We examined 1,000 children with various dermatologic pathologies. Rapid tests showed positive result in 21 patients (2.1%; 95% C11.3-3.2%). The presence of antibodies to tissue transglutaminase was confirmed via additional serological examination in all cases. HLA-haplotypes DQ2/8 were revealed in all patients with positive rapid test results. Typical form of gluten enteropathy was confirmed in 18/21 patients (86%) according to a histological study, thus, estimated prevalence of celiac disease is 1.8% (95% C11.1-2.8%). Conclusion. The prevalence of celiac disease remains underestimated among children with skin diseases. More studies are needed on the diagnostic features of rapid tests on tissue transglutaminase, as well as the benefits of screening for celiac disease to achieve patient-relevant clinical outcomes of skin pathology with wider gluten-free diet.

Snacking, Emotional and Behavioural Problems among Overweight and Obese Adolescents in MyBFF@school Program

2019 ◽  
Author(s):  
Zahari Ishak ◽  
Suet Fin Low ◽  
Wan Abdul Hakim Wan Ibrahim ◽  
Abqariyah Yahya ◽  
Fuziah Md. Zain ◽  
...  
Keyword(s):  
Positive Association ◽  
Self Report ◽  
Behavioural Problems ◽  
Emotional And Behavioural Problems ◽  
Significant Positive Association ◽  
Obese Adolescents ◽  
History Of ◽  
Relationship Of ◽  
The Relationship ◽  
Knowledge Attitude And Practice

This study aimed to investigate the relationship of snacking with emotional and behavioural problems among 620 overweight and obese adolescents with a mean age(SD) of 14.6(13) years old. Snacking frequencies in the past week were assessed using a pre-tested nutrition knowledge, attitude and practice (KAP) questionnaire while the emotional and behavioural problems were measured using the Youth Self-Report questionnaire. The study found a significant positive association between snacking and all symptoms of emotional and behavioural problems. There were also differences in the association based on gender, school location and ethnicity. The findings suggested that there are significant positive associations between snacking and emotional and behavioural problems among overweight and obese adolescents. History of snacking may be used to identify overweight and obese adolescents with these problems and various initiatives may be implemented to overcome them.

scholarly journals PYOGENIC LIVER ABSCESS: DIAGNOSTIC AND THERAPEUTIC MANAGEMENT

2016 ◽  
Vol 29 (3) ◽  
pp. 194-197 ◽  
Author(s):  
Otto Mauro dos SANTOS-ROSA ◽  
Henrique Simonsen LUNARDELLI ◽  
Marcelo Augusto Fontenelle RIBEIRO-JUNIOR
Keyword(s):  
Liver Abscess ◽  
Percutaneous Drainage ◽  
Clinical Manifestations ◽  
Biliary Tract Disease ◽  
Positive Association ◽  
High Sensitivity ◽  
Pyogenic Liver Abscess ◽  
Treatment Method ◽  
Significant Positive Association ◽  
Epidemiological Characteristics

ABSTRACT Background: The pyogenic liver abscess has an incidence of 1.1/1,000 habitants. Mortality can reach 100%. The use of less invasive procedures diminish morbidity and hospital stay. Aim: Identify risk factors in patients who underwent percutaneous drainage guided by ultrasound as treatment. Method: Were analyzed 10 patients submitted to the method. Epidemiological characteristics, laboratory markers and imaging exams (ultrasound and CT) were evaluated. Results: The majority of the patients were men with mean age of 50 years old. Liver disease, alcoholism and biliary tract disease were the most common prodromes. Abdominal pain (90%), fever (70%) and jaundice (40%) were the most common clinical manifestations. Mortality of 20% was observed in this series. Hypoalbuminemia and days of hospitalization had a statistically significant positive association with death. Conclusion: The pyogenic liver abscess has subacute evolution which makes the diagnosis difficult. Image exams have high sensitivity in diagnosis, particularly computed tomography. Percutaneous drainage associated with antibiotic therapy is safe and effective therapeutic resource.

scholarly journals Shame as a Predictor of the Guilt of Sexual Offenders in the Correctional Institutions

2021 ◽  
Vol 9 (2) ◽  
pp. 379
Author(s):  
Imaduddin Hamzah
Keyword(s):  
Sexual Offenders ◽  
Positive Association ◽  
Correctional Institutions ◽  
Significant Positive Association ◽  
Sexual Crimes ◽  
Normal Populations ◽  
Shame Proneness ◽  
Shame And Guilt ◽  
Relationship Of ◽  
The Relationship

Studies of shame and guilt have focused more on normal populations and cultural and religious contexts. The study of this topic for a group of subjects who commit crimes is still limited, especially sexual crimes as actions that are considered socially embarrassing. This study focused on examining the relationship of shame with guilt on inmates of sexual crimes (N = 143) who are carrying out sentences in correctional institutions. Shame and guilt are measured using the Guilt and Shame Proneness (GASP) Scale developed by Cohen et al. This study found a significant positive association so that shame can be a predictor of guilt. This study has implications for the importance of correctional institutions providing treatment to increase shame for prisoners of sexual crimes, thereby preventing the re-offense of their crimes.

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