scholarly journals Influence of a 10-Day Mimic of Our Ancient Lifestyle on Anthropometrics and Parameters of Metabolism and Inflammation: The “Study of Origin”

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Leo Pruimboom ◽  
Begoña Ruiz-Núñez ◽  
Charles L. Raison ◽  
Frits A. J. Muskiet
Keyword(s):  
Healthy Subjects ◽  
Immune Status ◽  
Stress Factors ◽  
Low Grade ◽  
Mild Stress ◽  
Short Term ◽  
Clinical Chemical ◽  
Metabolic Indices ◽  
Low Grade Inflammation ◽  
Apparently Healthy

Chronic low-grade inflammation and insulin resistance are intimately related entities that are common to most, if not all, chronic diseases of affluence. We hypothesized that a short-term intervention based on “ancient stress factors” may improve anthropometrics and clinical chemical indices. We executed a pilot study of whether a 10-day mimic of a hunter-gatherer lifestyle favorably affects anthropometrics and clinical chemical indices. Fifty-five apparently healthy subjects, in 5 groups, engaged in a 10-day trip through the Pyrenees. They walked 14 km/day on average, carrying an 8-kilo backpack. Raw food was provided and self-prepared and water was obtained from waterholes. They slept outside in sleeping bags and were exposed to temperatures ranging from 12 to 42°C. Anthropometric data and fasting blood samples were collected at baseline and the study end. We found important significant changes in most outcomes favoring better metabolic functioning and improved anthropometrics. Coping with “ancient mild stress factors,” including physical exercise, thirst, hunger, and climate, may influence immune status and improve anthropometrics and metabolic indices in healthy subjects and possibly patients suffering from metabolic and immunological disorders.

scholarly journals Lifestyle-related determinants of inflammation in adolescence

2007 ◽  
Vol 98 (S1) ◽  
pp. S116-S120 ◽  
Author(s):  
Julia Wärnberg ◽  
Esther Nova ◽  
Javier Romeo ◽  
Luís A. Moreno ◽  
Michael Sjöström ◽  
...  
Keyword(s):  
Physical Activity ◽  
Inflammatory Markers ◽  
Large Scale ◽  
Dietary Habits ◽  
Epidemiological Studies ◽  
Low Grade ◽  
Inflammatory Processes ◽  
Young Subjects ◽  
Low Grade Inflammation ◽  
Apparently Healthy

Inflammatory processes are involved in the pathogenesis of the most common chronic non-communicable diseases and may also play an important initiating role in their development. Only recently have inflammatory markers been included in epidemiological studies focusing on nutritional status, body composition and physical activity. We are just starting to understand how different lifestyles can determine basal levels of inflammatory biomarkers in early ages. This review aims to summarise what is known about the relationships between lifestyle-related determinants (focusing on overweight, physical activity and dietary habits) and inflammatory markers in apparently healthy young populations. Obesity is the most widely studied determinant. Several large-scale studies have now demonstrated that healthy young subjects with more body fat or higher BMI have moderately higher concentrations of inflammatory markers than their leaner peers, supporting the idea that obesity should be considered as a state of chronic low-grade inflammation. Less data is available to allow us to elucidate how physical activity/fitness or dietary patterns may have a direct effect on inflammation in apparently healthy, disease-free young populations.

Association of Fear of Terror With Low-Grade Inflammation Among Apparently Healthy Employed Adults

2004 ◽  
Vol 66 (4) ◽  
pp. 484-491 ◽  
Author(s):  
Samuel Melamed ◽  
Arie Shirom ◽  
Sharon Toker ◽  
Shlomo Berliner ◽  
Itzhak Shapira
Keyword(s):  
Low Grade ◽  
Low Grade Inflammation ◽  
Apparently Healthy

scholarly journals A Simple Biomarker to Exclude the Presence of Low Grade Inflammation in Apparently Healthy Individuals

2002 ◽  
Vol 9 (5) ◽  
pp. 281-286 ◽  
Author(s):  
S. Berliner ◽  
D. Zeltser ◽  
I. Shapira ◽  
E. B. Assayag ◽  
T. Mardi ◽  
...  
Keyword(s):  
Low Grade ◽  
Healthy Individuals ◽  
Low Grade Inflammation ◽  
Apparently Healthy

scholarly journals Exercise-induced AMPK and pyruvate dehydrogenase regulation is maintained during short-term low-grade inflammation

2014 ◽  
Vol 467 (2) ◽  
pp. 341-350 ◽  
Author(s):  
Rasmus Sjørup Biensø ◽  
Jesper Olesen ◽  
Line van Hauen ◽  
Simon Meinertz ◽  
Jens Frey Halling ◽  
...  
Keyword(s):  
Pyruvate Dehydrogenase ◽  
Low Grade ◽  
Short Term ◽  
Exercise Induced ◽  
Low Grade Inflammation

scholarly journals TLR4-NF-κB Signal Involved in Depressive-Like Behaviors and Cytokine Expression of Frontal Cortex and Hippocampus in Stressed C57BL/6 and ob/ob Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Yihe Wang ◽  
Jingjing Xu ◽  
Yuan Liu ◽  
Ziyang Li ◽  
Xiaohong Li
Keyword(s):  
Frontal Cortex ◽  
Normal Weight ◽  
Behavioral Disorder ◽  
Low Grade ◽  
Mild Stress ◽  
Obese Mice ◽  
Serum Corticosterone ◽  
Low Grade Inflammation ◽  
Necrosis Factor

Studies found that elevated levels of cytokines such as interleukin- (IL-) 1β, IL-6, and tumor necrosis factor-α (TNF-α) are closely associated with the pathogenesis of depression. Obesity providing a low-grade inflammation state was proposed to be implicated in susceptibility to depression in obesity. However, the alterations of cytokines and the TLR4-NF-κB signal in the brain of normal-weight and obese mice under stress have not been fully elucidated. This study used chronic unpredictable mild stress (CUMS) to induce a depressive-like behavior in an animal model and examine depressive-like behaviors, memory changes, and serum corticosterone levels, as well as the expressions of cytokines and NF-κB in the frontal cortex and hippocampus. We aimed to observe the role of neuroinflammation in susceptibility to depression in obesity under CUMS. In addition, we investigated the protective effect of inhibiting the TLR4-NF-κB signal. Our results demonstrated that CUMS induced depressive-like behavior and spatial memory damage, higher level of serum corticosterone, and overexpression of cytokines and NF-κB in the frontal cortex and hippocampus in both C57BL/6 and ob/ob mice. ob/ob mice displayed serious behavioral disorder and higher levels of IL-1β, IL-6, TNF-α, and NF-κB. Our results concluded that a hyperactive TLR4-NF-κB signal and higher level of cytokines are involved in susceptibility to depression in stressed obese mice.

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