scholarly journals Predictors of Treatment Outcome for Retreatment Pulmonary Tuberculosis Cases among Tribal People of an Eastern India District: A Prospective Cohort Study

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Rajib Saha
Keyword(s):  
Cohort Study ◽  
Treatment Outcome ◽  
Pulmonary Tuberculosis ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Unfavorable Outcome ◽  
Study Cohort ◽  
Eastern India ◽  
Initiation Phase ◽  
Antituberculosis Treatment

Objective. The study was conducted to assess the treatment outcome of different category retreatment cases with the aim of finding out the important predictors of unfavorable outcomes.Methodology. This hospital based prospective cohort study was conducted in three tuberculosis units (TUs) of west Midnapore (a district of Eastern India), covering mostly the tribal populated areas. Patients who were registered for Category II antituberculosis treatment between 1st quarter of 2013 (Jan to Mar) and 4th quarter of 2013 (Oct to Dec) were considered as our study cohort and they were followed up till December 2014. The study was started with 177 patients but ultimately ended with 165 patients.Results. Unfavorable outcome was observed among 24.8% patients. Among them mostly 51.2% were defaulter, 22% were failure case, and 26.8% died during treatment. Patients, who were minority by religion, were found 4 times more vulnerable for unfavorable outcome. Unfavorable outcome was found 7 times more common among retreatment TB cases who remain sputum positive after completion of initiation phase of Category II treatment.Conclusion. Programmatic approach should be specified to address the minority by religion population and to reduce the load of sputum positive cases after completion of initiation phase treatment by tracking them.

scholarly journals Nexus Between Tuberculosis and Diabetic Mellitus, A Prospective Cohort Study.

2020 ◽  
Author(s):  
Berhanu Elfu Feleke ◽  
Teferi Elfu Feleke ◽  
Melkamu Beyene Kassahun ◽  
Wondemu Gebrekirose Adane ◽  
Abere Genetu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Treatment Outcome ◽  
Glycemic Control ◽  
Clinical Response ◽  
Treatment Outcomes ◽  
Median Time ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Hba1c Level ◽  
Tb Treatment

Abstract Background: This work aimed to describe the clinical presentation of TB in patient with DM, to determine the effects of DM on TB treatment outcomes, to identify the effects of TB on glycemic control, and to describe the lipid profile of TB and DM patients. Methods: This prospective cohort study design was conducted. The data were collected from September 2018 to June 2020 using patient interviews, examining the patients, chart review, and collecting blood samples. Binary logistic regression was used to identify the determinants of TB treatment outcomes in the context of DM. Kaplan Meier survival curve was used to see the effects of DM on TB clinical response. Linear regression was used to identify the determinants of the HbA1c level during TB infection. Results: A total of 1092 study participants were included giving for the response rate at 93.81 %. Good TB treatment outcome was observed in 72.5 % of the patients [95 % CI: 69 % - 76 %]. The odds of good TB treatment outcomes were at 75 % lower in the presence of DM (AOR 0.25 [95 % CI: 0.08 – 0.73]). The median time of clinical response in TB and DM patients was 45 days interquartile range (IQR) of 8 days; the median time of clinical response in DM free TB patients was 9 days [IQR 2 days]. TB increased the HbA1c level of DM patients by 1.22 % (B 1.22 [95% CI: 1.11 – 1.34]). In six months period, 60 % of TB and DM patients had got 3 episodes of acute complications. Conclusion: DM significantly decreases the favorable treatment outcome of DOTS. TB predisposed DM patients for bad glycemic control and increased episodes of acute DM complications.

Psychometric validation of the Breast Cancer Treatment Outcome Scale (BCTOS-12): a prospective cohort study

2019 ◽  
Vol 300 (6) ◽  
pp. 1679-1686
Author(s):  
Manuel Feißt ◽  
Jörg Heil ◽  
Ilona Stolpner ◽  
Alexandra von Au ◽  
Christoph Domschke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Treatment Outcome ◽  
Cancer Treatment ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Breast Cancer Treatment ◽  
Psychometric Validation

scholarly journals Treatment Outcome of Tubercular Uveitis in a High TB and HIV Setting: A Prospective Cohort Study

2021 ◽  
Vol Volume 15 ◽  
pp. 4839-4846
Author(s):  
Hassan Dawood Alli ◽  
Naseer Ally ◽  
Ismail Mayet ◽  
Lavania Joseph ◽  
Shaheed Omar ◽  
...  
Keyword(s):  
Cohort Study ◽  
Treatment Outcome ◽  
Prospective Cohort Study ◽  
Prospective Cohort

scholarly journals Paracelsus 10,000: A Prospective Cohort Study Based On The Population of Salzburg, Austria. Rationale, Objectives And Study Design

2021 ◽  
Author(s):  
Vanessa Natalie Frey ◽  
Patrick Langthaler ◽  
Emanuel Raphaelis ◽  
Susanne Ring-Dimitriou ◽  
Ludmilla Kedenko ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Epidemiological Data ◽  
Population Based ◽  
Cerebrovascular Diseases ◽  
Communicable Diseases ◽  
Study Cohort ◽  
Non Communicable Diseases ◽  
Insight Into

Abstract Paracelsus 10,000 is a prospective cohort study with the objective to investigate the health status of the population in and around the city of Salzburg. The focus lies on common non-communicable diseases, mainly cardiovascular and cerebrovascular diseases, and their risk factors in a population-based cohort aged between 40 and 70 years. Between the years 2013 and 2020, 10,062 randomly selected participants (w: 5,187, m: 4,875) were investigated, of whom 2,620 underwent an intensified examination. The program consists not only of medical examinations, but was extended to inventories on mental disorders, lifestyle including nutrition and physical activity. From all study participants biological samples were stored in a biobank at -80°C enabling future investigations of biomarkers and utilization of the whole spectrum of multi-omics. The first follow-up phase of the study has started in late 2020 and will allow us to investigate the development of common non-communicable diseases occurring over time in the cohort of the Paracelsus 10,000 study. This gives the study a unique position within the framework of Austrian epidemiological research with the potential to gain new insight into the role of interaction between genetic predisposition and lifestyle factors for disease development in the Salzburg population. Obtaining high-quality epidemiological data is also of particular relevance for the development of evidence-based prevention strategies. This report describes rationale, objectives and design of the study and provides insight into the main characteristics of the study cohort.

Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study

2017 ◽  
Vol 52 (3) ◽  
pp. 192-198 ◽  
Author(s):  
Thomas Roland Terrell ◽  
Ruth Abramson ◽  
Jeffery T Barth ◽  
Ellen Bennett ◽  
Robert C Cantu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Genetic Polymorphisms ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
College Athletes ◽  
Positive Association ◽  
American Football ◽  
Study Cohort ◽  
Significant Positive Association ◽  
Adjusted Logistic Regression

Background/aimTo evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser53Pro, MAPT/tau Hist47Tyr, IL-6572 G/C and IL-6RAsp358Ala with the risk of concussion in college athletes.MethodsA 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion.ResultsThe study cohort consisted of 1056 athletes of mean±SD age 19.7±1.5 years, 89.3% male, 59.4% Caucasian, 35.0% African-American, 5.6% other race. The athletes participated in American football, soccer, basketball, softball, men’s wrestling and club rugby. A total of 133 (12.1% prevalence) concussions occurred during an average surveillance of 3 years per athlete. We observed a significant positive association between IL-6R CC (p=0.001) and a negative association between APOE4 (p=0.03) and the risk of concussion. Unadjusted and adjusted logistic regression analysis showed a significant association between IL-6R CC and concussion (OR 3.48; 95% CI 1.58 to 7.65; p=0.002) and between the APOE4 allele and concussion (OR 0.61; 95% CI 0.38 to 0.96; p=0.04), which persisted after adjustment for confounders.ConclusionsIL-6R CC was associated with a three times greater concussion risk and APOE4 with a 40% lower risk.

Sign in / Sign up

Export Citation Format

Share Document