scholarly journals Decrease in Anti-HBs Antibodies over Time in Medical Students and Healthcare Workers after Hepatitis B Vaccination

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
H. V. Sahana ◽  
N. Sarala ◽  
S. R. Prasad

Background. Hepatitis B is one of the most important occupational hazards among healthcare workers (HCWs). This study aimed to measure the anti-HBs titres among the medical students and HCWs vaccinated against hepatitis B virus and to determine the association between anti-HBs levels and time since vaccination. Materials and Methods. In this cross-sectional study, medical students and healthcare workers who had received all three doses of hepatitis B vaccination and completed at least six months after vaccination since the last dose were included. 3 ml blood was collected from subjects (n=340) and anti-HBs titre was estimated using ELISA. Results. A total of 340/400 subjects were aged between 18 and 60 years; 204 were females and 136 males. The median and interquartile range for time since vaccination were 5 and 5 years, respectively. Duration since vaccination was ≤5 years in 223 (65.5%), 6–10 years in 84 (24.7%), and >10 years in 33 (9.70%); among them, antibody titres were >10 mIU/ml in 94.1%, 79.7%, and 72.7% subjects, respectively. There was significant decline in antibody titres as duration of postvaccination increased. Conclusion. The proportion of subjects who were unprotected after 5 and 10 years after vaccination were 20% and 27%, respectively. The need for a booster dose can be made mandatory at least for healthcare professionals.

2021 ◽  
pp. 84-85
Author(s):  
Aditya Rana ◽  
Anuradha Sood

Background: Hepatitis B(HBV) is a blood borne virus and it is one of the most important occupational hazards among healthcare workers (HCWs) & Medical students. This study aimed to measure the anti-HBs titres and to assess the seroprevalence of Hepatitis B in HCW and medical students. It was a prospective,descriptive and cross sectional hospital base Material and method: d study. Medical students and healthcare workers who had received all three doses of hepatitis B vaccination were included in the study. A total of 200 subjects , aged between 18 and Result: 62 years were taken. 182 were vaccinated and 18 were unvaccinated. 85 were males and 115 females. Seroprevalence of Hepatitis B was nil. Antibody titres were >100mIU/ml in 51.6% , 10-100mIU/ml in 16.4% & <10 mIU/ml in 31.8% respectively.Negative correlation of decreasing antibiotic titer and age was seen. HCW and medical students are at hi Conclusion: gher risk due to their continuous exposure to blood products. Vaccination should be compulsory to the HCW and medical workers in the institution as Hepatitis B is a preventable disease. Monitoring of antibody titers should be done from time to time to see waning off antibody titers after vaccination


2017 ◽  
Vol 24 (08) ◽  
pp. 1167-1169
Author(s):  
Nahdia Ashraf ◽  
Muhammad Usman Hussain ◽  
Iqra Qamar ◽  
Muhammad Ashraf

Introduction: The doctors and paramedical staff are at high risk of developingHepatitis B, infection. Hepatitis B vaccine is mandatory for medical students prior to admissionin medical colleges. After completion of vaccination determination of anti HBS is not in practice.All over the world some people remain non responders and don’t develop adequate antibodytitre essential for protection against hepatitis B virus. This study is therefore designed to estimatethe anti HBs titre among the medical students, who have completed three doses of hepatitisB vaccine. Objectives: To determine the serum anti HBs antibodies among the outgoing finalyear MBBS students who have received complete 03 doses of hepatitis B vaccine. StudyDesign: Descriptive cross sectional study. Place and Duration: This study was conductedfrom November 2010 to December 2015 at Biochemistry department Punjab Medical College incollaboration with Nawaz Medicare Hospital Faisalabad. Material and Methods: Two hundredand fifty nine female medical (MBBS) students from outgoing classes during the period ofNovember 2010 to December 2015 were enrolled in this study. All subjects were at the ageof 22-24 years at the time of sampling. Each received 03 doses of injection Engerix B, 10mcg/0.5ml each in a schedule of 0, 01, 06 months since the last 05 years. The blood sampleswere allowed to clot and serum was separated. The anti HBs and HBsAg were determined by3rd generation ELISA method. Results: A total 259 female medical students from outgoing finalyear MBBS classes were enrolled in this study. Among these subjects 48 (18.5%) had serumanti HBs levels < 10 IU/L, 77 subjects (29.7%) have levels 10-20 IU/L, 116 subjects (44.8 %)have serum levels 21-100 IU/L, while 18 subjects (10%) have > 100 IU/L serum anti HBs levels.Conclusion: The incidence of non responders and poor responders is higher among thevaccinees in this study as compared to foreign studies after five years of Hepatitis B vaccination.


2017 ◽  
Vol 56 (3) ◽  
pp. 179-184 ◽  
Author(s):  
Vuk Marusic ◽  
Ljiljana Markovic-Denic ◽  
Olivera Djuric ◽  
Dragana Protic ◽  
Emilija Dubljanin-Raspopovic

AbstractIntroductionMedical students are mainly exposed to needle stick and sharp object injuries in the course of their clinical activities during studying. They are at high risk due to their undeveloped skills, restricted clinical experience, lack of knowledge and risk perception. The objectives of this study were to determine the prevalence of needle stick injuries of the fourth and final year medical students, and to estimate their knowledge about blood-borne pathogens disease transmission and standard precautions.MethodsThis cross-sectional study was conducted at the Faculty of Medicine, in February 2014. The students were invited to self-administer a questionnaire of 26 closed questions prepared for this study.ResultsThe questionnaire was filled in and returned by 637 students. The prevalence of needle sticks and sharp object injuries was 29.5%. Needle stick injuries were the most common type of accidents, more frequent among the fourth compared to the sixth year students (p=0.002). The majority of accidents occurred in patient rooms (53%) and the emergency department (15%). 54% of participants reported an accident to the responsible person. Students without accidents had a significantly better perception of risk (3.79 vs. 3.35; p<0.05). Out of the total participating students, only 16.6% (106/637) received all three doses of Hepatitis B vaccination, while 16.2% were partially vaccinated.ConclusionsThere is a need for additional theoretical and practical education of our students on blood exposure via accidents, raising the awareness of the necessity of hepatitis B vaccination, and introducing the unique/comprehensive procedure for accident reporting for students and healthcare workers in the entire country.


2017 ◽  
Vol 29 (1) ◽  
pp. 29 ◽  
Author(s):  
Froid Chipetah ◽  
Aaron Chirambo ◽  
Ednas Billiat ◽  
Isaac Thom Shawa

2014 ◽  
Vol 1 (1) ◽  
pp. 3-7
Author(s):  
Kamrun Nahar Sweety ◽  
Shamim Akther Mimi

Background: The awareness regarding Hepatitis B vaccination is necessary in the general population of Bangladesh.Objective: This study was carried out to determine the level of knowledge and the vaccination coverage of hepatitis B virus in rural population.Methodology: This cross sectional study was conducted at Bangladesh Institute of Administration and Management (BIAM), Dhaka, Bangladesh from February 2011 to April 2011. Sirajdikhan upazila of Munshiganj District was taken as a study place. All the villagers with an age group of 15 to 55 years were taken as study population. Result: A total number of 30 respondents were recruited of which male (60.0%) is predominant than female (40.0%). The mean age with SD was 23±7.256 years (range 15-53 years). Majority has told about the knowledge regarding the sequel of hepatitis B virus infection (33.3%). Almost all respondents (96.7%) are unknown about the treatment of HBV infection. Majority (76.7%) are unknown regarding taking HBV vaccination. Nobody has given positive answer in response to take vaccine. Conclusion: In conclusion information and knowledge regarding HBV infection and vaccination is very poor in the rural area of Bangladesh.DOI: http://dx.doi.org/10.3329/jcamr.v1i1.19558J Curr Adv Med Res 2014;1(1):3-7


2021 ◽  
Vol 8 (9) ◽  
pp. 242-246
Author(s):  
Aditya Rana ◽  
Subhash Chand Jaryal ◽  
Anuradha Sood

Background: Hepatitis B(HBV) is one of the most important occupational hazards among the medical student and healthcare workers(HCW's) due to risk of exposure to infected bodily fluids and blood. This study aimed to assess status of HBV vaccination and factors affecting anti-HBs titres levels for HBV in HCW and medical students. Material and Method: It was a prospective, descriptive and cross sectional study done at the Department of Microbiology, DRPGMC Kangra at Tanda(H.P). Randomly 215 HCW’s and medical students were taken in the study who fulfilled the inclusion criteria. Results: Total of 215 subjects were included in the study. Males were 89 and females were 126. 182 subjects were vaccinated and 33 were unvaccinated for hepatitis B. Out of 182 vaccinated 137 were completely vaccinated. Significant correlation was seen with decrease in antibody titers with gender, duration of vaccination and smoking. Conclusion: Vaccination should be mandatory for every HCW and medical student entering the health institutions. The factors affecting the antibody titers must be evaluated and antibody titers must be reviewed from time to time. The need for a booster dose can be made mandatory at least for healthcare professionals. Keywords: Hepatitis B virus, Vaccination, Antibody titers, HCW.


2018 ◽  
Vol 8 (3) ◽  
pp. 138-141
Author(s):  
Mustafa Sajid ◽  
Muhammad Jamil ◽  
Mohsin Javaid ◽  
Maryam Sultan

Background: Hepatitis B is included in top ten diseases of the world which has serious threats to life1. Hepatitis B is a serious threat to healthcare workers because healthcare workers have direct contact with patients who have hepatitis B. Methods: This questionnaire-based descriptive cross-sectional survey was conducted at the Multan Medical and Dental College, Multan. In Dental department two hundred and ten students responded. In medical section 467 students responded. Results: Two hundred and ninety nine were males and three hundred and seventy eight were female students. A total of four hundred and thirty students got vaccinated and two hundred and forty seven failed to get vaccination. Most of the students failed to get vaccination due to busy schedule. Conclusion: Medical and dental institutes should take responsibility to educate their health care workers regarding precautions and vaccination against hepatitis B virus. Students must be educated about the threats regarding hepatitis B virus.


Rev Rene ◽  
2021 ◽  
Vol 22 ◽  
pp. e60690
Author(s):  
Vanessa Moura Carvalho de Oliveira ◽  
Marli Teresinha Gimeniz Galvão ◽  
Rômulo Veloso Nunes ◽  
Matheus Sousa Marques Carvalho ◽  
Cecília Natielly da Silva Gomes ◽  
...  

Objective: to estimate the adherence to hepatitis B vaccine in homeless people. Methods: a cross-sectional study with 90 homeless people, with the collection of 5 ml of blood for the detection of antibody against the surface antigen of the hepatitis B virus. Results: of the total, 89 (98.9%) were vaccinated with the first dose; of these, 45 (50.7%) had antibodies against hepatitis B virus surface antigen lower than 10 IU/L; 25 (53.3%) received the second dose of hepatitis B vaccine, and nine (45.8%) participants received the third dose of vaccine. Individuals who were related to both genders were more likely to adhere to the full hepatitis B vaccine schedule. Conclusion: the low adherence to hepatitis B vaccination and the small number of participants with antibodies that confer immunity against this infection were evidenced.


Author(s):  
Arun Jacob ◽  
Teena Mary Joy ◽  
Sreelakshmi Mohandas ◽  
Harsha Lais ◽  
Nimitha Paul

Background: Hepatitis B virus is transmitted by body fluids, such as blood and serum. Sexual transmission, vertical transmission, and unsafe injections, including intravenous drug use, are the most common routes of infection for Hepatitis B infection. Medical students have a very important role in preventing the disease by improving the disease knowledge among themselves and the patients they will eventually treat.Methods: A cross sectional study was conducted to assess the KAP among medical students of the first three academic years regarding hepatitis B virus infection. The sample size was 222 students. Data were collected from 230 students using a semi structured questionnaire and analyzed using SPSS v20.Results: Among 230 medical students, 79.1% students had good knowledge about hepatitis B whereas 84.3% of the respondents had the right attitude towards hepatitis B. The practice component was low with only 44.8% of the respondents having correct practice regarding hepatitis B infection.Conclusions: Although the knowledge and attitude regarding hepatitis B infection is high, the practice levels are low indicating the need to encourage proper practices among the medical students.


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