scholarly journals Predictive Role of F2-Isoprostanes as Biomarkers for Brain Damage after Neonatal Surgery

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
L. J. Stolwijk ◽  
P. M. A. Lemmers ◽  
M. Y. A. van Herwaarden ◽  
D. C. van der Zee ◽  
F. van Bel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Brain Injury ◽  
Multivariable Analysis ◽  
Major Surgery ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Significant Difference ◽  
Predictive Role

Objective. Neonates have a high risk of oxidative stress during anesthetic procedures. The predictive role of oxidative stress biomarkers on the occurrence of brain injury in the perioperative period has not been reported before. Methods. A prospective cohort study of patients requiring major surgery in the neonatal period was conducted. Biomarker levels of nonprotein-bound iron (NPBI) in plasma and F2-isoprostane in plasma and urine before and after surgical intervention were determined. Brain injury was assessed using postoperative MRI. Results. In total, 61 neonates were included, median gestational age at 39 weeks (range 31–42) and weight at 3000 grams (1400–4400). Mild to moderate brain lesions were found in 66%. Logistic regression analysis showed a significant difference between plasma NPBI in patients with nonparenchymal injury versus no brain injury: 1.34 umol/L was identified as correlation threshold for nonparenchymal injury (sensitivity 67%, specificity 91%). In the multivariable analysis, correcting for GA, no other significant relation was found with the oxidative stress biomarkers and risk factors. Conclusion. Oxidative stress seems to occur during anaesthesia in this cohort of neonates. Plasma nonprotein-bound iron showed to be associated with nonparenchymal injury after surgery, with values of 1.34 umol/L or higher. Risk factors should be elucidated in a more homogeneous patient group.

scholarly journals Assessment of Plasma Oxidative Stress Biomarkers and Metabolic Parameters of Dairy Heifers: Relationship with Success at First Service

2021 ◽  
Vol 78 (2) ◽  
pp. 11
Author(s):  
Sofiane BOUDJELLABA ◽  
Habiba SAADI ◽  
Mohamed ZAOUANI ◽  
Lynda AINOUZ ◽  
Amira Fatma HANI ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dairy Herds ◽  
Glutathione S Transferase ◽  
Oxidative Stress Biomarkers ◽  
Dairy Heifers ◽  
Stress Biomarkers ◽  
Significant Difference ◽  
The Difference ◽  
The Relationship

First insemination success is considered as good indicator of heifer fertility to ensure renewal of dairy herds. The objective of this study was to determine the relationship between first insemination success and biomarkers of oxidative stress (OS). A total of 25 heifers were divided into two groups according to their success at first insemination: group FS+ (heifers that were pregnant at first service, n = 14) and group FS- (heifers that were not pregnant at first service, n = 11). The serum of these two groups were analyzed for malondialdehyde (MDA), glutathione S-transferase (GST), reduced glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), myeloperoxidase (MPO), nitric Oxide (NO) and superoxide dismutase (SOD) as oxidative stress biomarkers and biochemical parameters. Heifers in the group FS+ showed no significant difference in all OS parameters compared to heifers in the group FS-. The OS parameters showed almost similar values in both groups except for GST and CAT where the difference was at the limit of significance. The plasma concentration of OS biomarkers assessed in our study were not related to first service success in heifers. Further studies are needed to clarify the role of oxidative status in the reproductive performance of heifers.

Moderate physical activity reduces 10-year diabetes incidence: the mediating role of oxidative stress biomarkers

2017 ◽  
Vol 63 (2) ◽  
pp. 297-305 ◽  
Author(s):  
Efi Koloverou ◽  
◽  
Konstantinos Tambalis ◽  
Demosthenes B. Panagiotakos ◽  
Ekavi Georgousopoulou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Moderate Physical Activity ◽  
Diabetes Incidence ◽  
Oxidative Stress Biomarkers ◽  
Mediating Role ◽  
Stress Biomarkers

scholarly journals Modulation ofN-methyl-d-aspartate receptors in isolated rat heart

2017 ◽  
Vol 95 (11) ◽  
pp. 1327-1334 ◽  
Author(s):  
Ivan Srejovic ◽  
Vladimir Zivkovic ◽  
Tamara Nikolic ◽  
Nevena Jeremic ◽  
Isidora Stojic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Albino Rats ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Combined Application ◽  
Wistar Albino Rats ◽  
Isolated Rat

Considering the limited data on the role of NMDA-Rs in the cardiovascular system, the aim of the present study was to examine the effects of NMDA and DL-Hcy TLHC, alone and in combination with glycine, memantine, and ifenprodil, in the isolated rat heart. The hearts of Wistar albino rats were retrogradely perfused according to the Langendorff technique at a constant perfusion pressure. The experimental protocol for all experimental groups included the stabilization period, application of estimated substance for 5 min, followed by a washout period of 10 min. Using a sensor placed in the left ventricle, we registered the following parameters of myocardial function: dp/dtmax, dp/dtmin, SLVP, DVLP, HR; CF was measured using flowmetry). We estimated the following oxidative stress biomarkers in the coronary venous effluent using spectrophotometry: TBARS, NO2−, O2−, and H2O2. NMDA alone did not induce any change in any of the observed parameters, while DL-Hcy TLHC alone, as well as a combined application of NMDA and DL-Hcy TLHC with glycine, induced a reduction of most cardiodynamic parameters. Memantine and ifenprodil induced a reduction of cardiodynamic parameters and CF, as well as some oxidative stress biomarkers.

Effect of daily consumption of cranberry beverage on insulin sensitivity and modification of cardiovascular risk factors in adults with obesity: a pilot, randomised, placebo-controlled study

2020 ◽  
Vol 124 (6) ◽  
pp. 577-585 ◽  
Author(s):  
Daniel S. Hsia ◽  
Derek J. Zhang ◽  
Robbie S. Beyl ◽  
Frank L. Greenway ◽  
Christina Khoo
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Cardiovascular Risk Factors ◽  
Controlled Study ◽  
Oxidative Stress Biomarkers ◽  
Beverage Consumption ◽  
Stress Biomarkers

AbstractCranberries are high in polyphenols, and epidemiological studies have shown that a high-polyphenol diet may reduce risk factors for diabetes and CVD. The present study aimed to determine if short-term cranberry beverage consumption would improve insulin sensitivity and other cardiovascular risk factors. Thirty-five individuals with obesity and with elevated fasting glucose or impaired glucose tolerance participated in a randomised, double-blind, placebo-controlled, parallel-designed pilot trial. Participants consumed 450 ml of low-energy cranberry beverage or placebo daily for 8 weeks. Changes in insulin sensitivity and cardiovascular risk factors including vascular reactivity, blood pressure, RMR, glucose tolerance, lipid profiles and oxidative stress biomarkers were evaluated. Change in insulin sensitivity via hyperinsulinaemic–euglycaemic clamp was not different between the two groups. Levels of 8-isoprostane (biomarker of lipid peroxidation) decreased in the cranberry group but increased in the placebo group (–2·18 v. +20·81 pg/ml; P = 0·02). When stratified by baseline C-reactive protein (CRP) levels, participants with high CRP levels (>4 mg/l) benefited more from cranberry consumption. In this group, significant differences in the mean change from baseline between the cranberry (n 10) and the placebo groups (n 7) in levels of TAG (–13·75 v. +10·32 %; P = 0·04), nitrate (+3·26 v. −6·28 µmol/l; P = 0·02) and 8-isoprostane (+0·32 v. +30·8 pg/ml; P = 0·05) were observed. These findings indicate that 8 weeks of daily cranberry beverage consumption may not impact insulin sensitivity but may be helpful in lowering TAG and changing certain oxidative stress biomarkers in individuals with obesity and a proinflammatory state.

Sign in / Sign up

Export Citation Format

Share Document