Environmental risk factors and their footprints in vivo – A proposal for the classification of oxidative stress biomarkers

Objective. Neonates have a high risk of oxidative stress during anesthetic procedures. The predictive role of oxidative stress biomarkers on the occurrence of brain injury in the perioperative period has not been reported before. Methods. A prospective cohort study of patients requiring major surgery in the neonatal period was conducted. Biomarker levels of nonprotein-bound iron (NPBI) in plasma and F2-isoprostane in plasma and urine before and after surgical intervention were determined. Brain injury was assessed using postoperative MRI. Results. In total, 61 neonates were included, median gestational age at 39 weeks (range 31–42) and weight at 3000 grams (1400–4400). Mild to moderate brain lesions were found in 66%. Logistic regression analysis showed a significant difference between plasma NPBI in patients with nonparenchymal injury versus no brain injury: 1.34 umol/L was identified as correlation threshold for nonparenchymal injury (sensitivity 67%, specificity 91%). In the multivariable analysis, correcting for GA, no other significant relation was found with the oxidative stress biomarkers and risk factors. Conclusion. Oxidative stress seems to occur during anaesthesia in this cohort of neonates. Plasma nonprotein-bound iron showed to be associated with nonparenchymal injury after surgery, with values of 1.34 umol/L or higher. Risk factors should be elucidated in a more homogeneous patient group.

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Effect of daily consumption of cranberry beverage on insulin sensitivity and modification of cardiovascular risk factors in adults with obesity: a pilot, randomised, placebo-controlled study

British Journal Of Nutrition ◽

10.1017/s0007114520001336 ◽

2020 ◽

Vol 124 (6) ◽

pp. 577-585 ◽

Cited By ~ 1

Author(s):

Daniel S. Hsia ◽

Derek J. Zhang ◽

Robbie S. Beyl ◽

Frank L. Greenway ◽

Christina Khoo

Keyword(s):

Oxidative Stress ◽

Risk Factors ◽

Cardiovascular Risk ◽

Insulin Sensitivity ◽

Glucose Tolerance ◽

Cardiovascular Risk Factors ◽

Controlled Study ◽

Oxidative Stress Biomarkers ◽

Beverage Consumption ◽

Stress Biomarkers

AbstractCranberries are high in polyphenols, and epidemiological studies have shown that a high-polyphenol diet may reduce risk factors for diabetes and CVD. The present study aimed to determine if short-term cranberry beverage consumption would improve insulin sensitivity and other cardiovascular risk factors. Thirty-five individuals with obesity and with elevated fasting glucose or impaired glucose tolerance participated in a randomised, double-blind, placebo-controlled, parallel-designed pilot trial. Participants consumed 450 ml of low-energy cranberry beverage or placebo daily for 8 weeks. Changes in insulin sensitivity and cardiovascular risk factors including vascular reactivity, blood pressure, RMR, glucose tolerance, lipid profiles and oxidative stress biomarkers were evaluated. Change in insulin sensitivity via hyperinsulinaemic–euglycaemic clamp was not different between the two groups. Levels of 8-isoprostane (biomarker of lipid peroxidation) decreased in the cranberry group but increased in the placebo group (–2·18 v. +20·81 pg/ml; P = 0·02). When stratified by baseline C-reactive protein (CRP) levels, participants with high CRP levels (>4 mg/l) benefited more from cranberry consumption. In this group, significant differences in the mean change from baseline between the cranberry (n 10) and the placebo groups (n 7) in levels of TAG (–13·75 v. +10·32 %; P = 0·04), nitrate (+3·26 v. −6·28 µmol/l; P = 0·02) and 8-isoprostane (+0·32 v. +30·8 pg/ml; P = 0·05) were observed. These findings indicate that 8 weeks of daily cranberry beverage consumption may not impact insulin sensitivity but may be helpful in lowering TAG and changing certain oxidative stress biomarkers in individuals with obesity and a proinflammatory state.

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The use of oxidative stress biomarkers in live animals (in vivo) to predict meat quality deterioration postmortem (in vitro) caused by changes in muscle biochemical components

Journal of Animal Science ◽

10.2527/jas2016.0887 ◽

2017 ◽

Vol 95 (7) ◽

pp. 3012

Author(s):

E. N. Ponnampalam ◽

D. L. Hopkins ◽

K. Giri ◽

J. L. Jacobs ◽

T. Plozza ◽

...

Keyword(s):

Oxidative Stress ◽

Meat Quality ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Quality Deterioration ◽

Biochemical Components

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The effect of cold atmospheric plasma on diabetes-induced enzyme glycation, oxidative stress, and inflammation; in vitro and in vivo

Scientific Reports ◽

10.1038/s41598-019-56459-y ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 3

Author(s):

Alireza Rezaeinezhad ◽

Pegah Eslami ◽

Hossein Mirmiranpour ◽

Hamid Ghomi

Keyword(s):

Oxidative Stress ◽

Antioxidant Activity ◽

Enzyme Activity ◽

Fluorescence Analysis ◽

Atmospheric Plasma ◽

Oxidative Stress Biomarkers ◽

Cold Atmospheric Plasma ◽

Stress Biomarkers

AbstractCold atmospheric plasma (CAP) is known as the versatile tool in different biological, and medical applications. In this study, we investigated the effect of cold plasma on diabetes via in vitro and in vivo assessments. We performed the in vitro assay to evaluate the impact of CAP on glycated glutathione peroxidase (GPx) through enzyme activity measurement as a function index and far- and near-UV circular dichroism (CD) and fluorescence analysis as structure indices. The result of in vitro assessment showed that the exposure of glycated GPx to plasma causes a considerable increase in enzyme activity up to 30%. Also, the evaluation of far- and near-UV CD and fluorescence analysis indicated a modification in the protein structure. According to obtained result from in vitro assessment, in vivo assay evaluated the effect of CAP on diabetic mice through analyzing of blood glucose level (BGL), advanced glycation end products (AGEs), antioxidant activity, oxidative stress biomarkers such as malondialdehyde (MDA), advanced oxidation protein products (AOPP), and oxidized low-density lipoprotein (oxLDL), and inflammation factors including tumor necrosis factor (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6). The result of in vivo experiment also showed a 20% increase in antioxidant activity. Also, the reduction in AGEs, oxidative stress biomarkers, and inflammatory cytokines concentrations was observed. The result of this study revealed that CAP could be useful in diabetes treatment and can be utilized as a complementary method for diabetes therapy.

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Traffic-related environmental risk factors and their impact on oxidative stress and cardiovascular health

Oxidative Stress ◽

10.1016/b978-0-12-818606-0.00025-0 ◽

2020 ◽

pp. 489-510

Author(s):

Andreas Daiber ◽

Jos Lelieveld ◽

Sebastian Steven ◽

Matthias Oelze ◽

Swenja Kröller-Schön ◽

...

Keyword(s):

Oxidative Stress ◽

Risk Factors ◽

Environmental Risk ◽

Cardiovascular Health ◽

Environmental Risk Factors

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Oxidative stress biomarkers in four Bloom syndrome (BS) patients and in their parents suggest in vivo redox abnormalities in BS phenotype

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2007.06.003 ◽

2007 ◽

Vol 40 (15) ◽

pp. 1100-1103 ◽

Cited By ~ 9

Author(s):

Adriana Zatterale ◽

Frank J. Kelly ◽

Paolo Degan ◽

Marco d'Ischia ◽

Federico V. Pallardó ◽

...

Keyword(s):

Oxidative Stress ◽

Bloom Syndrome ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers

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Studies on Early Allergic Sensitization in the Lithuanian Birth Cohort

The Scientific World JOURNAL ◽

10.1100/2012/909524 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 7

Author(s):

Ruta Dubakiene ◽

Odilija Rudzeviciene ◽

Indre Butiene ◽

Indre Sezaite ◽

Malvina Petronyte ◽

...

Keyword(s):

Risk Factors ◽

Food Allergy ◽

Birth Cohort ◽

Environmental Risk ◽

Allergic Sensitization ◽

Environmental Risk Factors ◽

Food Allergens ◽

The Impact

Cohort studies are of great importance in defining the mechanism responsible for the development of allergy-associated diseases, such as atopic dermatitis, allergic asthma, and allergic rhinoconjunctivitis. Although these disorders share genetic and environmental risk factors, it is still under debate whether they are linked or develop sequentially along an atopic pathway. The current study was aimed to determine the pattern of allergy sensitization in the Lithuanian birth cohort “Alergemol” (n= 1558) established as a part of the multicenter European birth cohort “EuroPrevall”. Early sensitization to food allergens in the “Alergemol” birth cohort was analysed. The analysis revealed 1.3% and 2.8% of symptomatic-sensitized subjects at 6 and 12 months of age, respectively. The sensitization pattern in response to different allergens in the group of infants with food allergy symptoms was studied using allergological methodsin vivoandin vitro. The impact of maternal and environmental risk factors on the early development of food allergy in at 6 and 12 months of age was evaluated. Our data showed that maternal diet, diseases, the use of antibiotics, and tobacco smoke during pregnancy had no significant impact on the early sensitization to food allergens. However, infants of atopic mothers were significantly more often sensitized to egg as compared to the infants of nonatopic mothers.

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