scholarly journals GH Responsiveness to Combined GH-Releasing Hormone and Arginine Administration in Obese Patients with Fibromyalgia Syndrome

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Antonello E. Rigamonti ◽  
Graziano Grugni ◽  
Marco Arreghini ◽  
Paolo Capodaglio ◽  
Alessandra De Col ◽  
...  
Keyword(s):  
Area Under The Curve ◽  
Tender Point ◽  
Fat Free Mass ◽  
Obese Women ◽  
Arginine Test ◽  
High Prevalence ◽  
Stimulation Tests ◽  
Severely Obese ◽  
Prevalence Of Obesity ◽  
Ghrh Plus Arginine Test

Reportedly, fibromyalgia (FM) is frequently associated with reduced IGF-1 levels and GH hyporesponsiveness to different GH stimulation tests. Since there is a high prevalence of obesity in FM, and obesity itself is characterized by hyposomatotropism, the aim of this study was to assess IGF-1 levels and GH responsiveness in sixteen severely obese women suffering from FM, who, subdivided into two subgroups on the basis of their age-dependent IGF-1 values (> or <−2 SDS), underwent the combined GHRH plus arginine test. Four out of 16 obese women with FM (25%) had low IGF-1 SDS values, 2 cases of this subgroup (12.5%) failing also to normally respond to the test. Among patients with normal GH responses, 4 showed a delayed GH peak. The subgroup with low IGF-1 SDS values had higher BMI than that with normal IGF-1 SDS. GH peak and area under the curve were not correlated with CRP, ESR, or tender point score, while significant correlations were found with fat-free mass and fat mass. In conclusion, this study shows the existence of a high prevalence of GH-IGF-1 dysfunction in patients with both FM and obesity, presumably as a consequence of the obese rather than fibromyalgic condition.

Postprandial hormone response after endurance or resistance exercise in obese women

2017 ◽  
Vol 13 (4) ◽  
pp. 227-235
Author(s):  
P.M. Davitt ◽  
G.C. Henderson ◽  
A.J. Walker ◽  
S.M. Arent
Keyword(s):  
Area Under The Curve ◽  
Exercise Bout ◽  
Fat Free Mass ◽  
Hormonal Changes ◽  
Obese Women ◽  
Post Exercise ◽  
Postprandial Period ◽  
Single Bout ◽  
Main Effect ◽  
Total Body

Physiological changes with endurance exercise (EE) and resistance training (RT) are likely influenced by the metabolic and hormonal response to each exercise bout, but may be blunted in obese individuals. To compare acute effects of EE, RT, and a control upon hormonal changes in obese women, sedentary, obese women (n=12) participated in a randomised crossover-design study on 3 occasions. EE consisted of treadmill walking (65% VO2max for 1 h). A total-body RT workout consisted of 3 sets of 10 repetitions, 90 s rest for 8 exercises at 90-100% of 10RM. Blood samples were taken 30 min before exercise (0 min), 30 min post-exercise (120 min), and again at 200, 280, and 520 min to assess changes in growth hormone (GH), cortisol, and insulin throughout the postprandial period. A 20 kcal/kg fat-free mass (FFM) meal was given after post-exercise blood sample. There was a main effect of condition for GH ΔAUC (change in area under the curve), with both RT and EE significantly different from the control (RT = 463.0±138.2; EE = 243.2±131.6; Control = -90.4±157.6 ng/ml * 400 min, P<0.02, Control vs EE, effect size (ES) = 2.3; Control vs RT, ES=3.7; EE vs RT, ES=1.6). There were no condition effects for cortisol or insulin ΔAUC. There were no significant time-by-condition interactions for any variables. In obese women, circulating GH concentration is enhanced in the postprandial state following a single bout of either EE or RT, with the GH response being more robust than cortisol or insulin. As circulating GH has shown to be reduced in obesity, the present observations could be considered beneficial, particularly alongside the absence of enhanced cortisol level after exercise.

scholarly journals Genetic causes of severe childhood obesity: a remarkably high prevalence (≥49%) in an inbred population of Pakistan

2020 ◽  
Author(s):  
Ada Admin ◽  
Sadia Saeed ◽  
Muhammad Arslan ◽  
Jaida Manzoor ◽  
Sadia M. Din ◽  
...  
Keyword(s):  
Simultaneous Detection ◽  
Point Mutations ◽  
Copy Number Variations ◽  
Coding Regions ◽  
New Genes ◽  
Whole Exome ◽  
High Prevalence ◽  
Severely Obese ◽  
Prevalence Of Obesity ◽  
Obese Subjects

Monogenic forms of obesity have been identified in ≤10% of severely obese European patients. However, the overall spectrum of deleterious variants (point mutations and structural variants) responsible for childhood severe obesity remains elusive. In this study, we genetically screened 225 severely obese children from consanguineous Pakistani families through a combination of techniques including an in-house developed augmented whole-exome sequencing (CoDE-seq) enabling simultaneous detection of whole exome copy number variations (CNVs) and of point mutations in coding regions. We identified 110 probands (49%) carrying 55 different pathogenic point mutations and CNVs in 13 genes/loci responsible for non-syndromic and syndromic monofactorial obesity. CoDE-seq also identified 28 rare or novel CNVs associated with intellectual disability in 22 additional obese subjects (10%). Additionally, we highlight variants in candidate genes for obesity warranting further investigation. Altogether, 59% of the studied cohort are likely to have a discrete genetic cause with 13% of these due to CNVs demonstrating a remarkably higher prevalence of monofactorial obesity than hitherto reported and a plausible over lapping of obesity and intellectual disabilities in several cases. Finally, inbred populations with high prevalence of obesity, provide a unique genetically enriched material in quest of new genes/variants influencing energy balance.

Obesity, Type II diabetes and the β2 adrenoceptor gene Gln27Glu polymorphism in the Tongan population

2003 ◽  
Vol 104 (3) ◽  
pp. 211-215 ◽  
Author(s):  
Natalia L. DUARTE ◽  
Stephen COLAGIURI ◽  
Taniela PALU ◽  
Xing L. WANG ◽  
David E.L. WILCKEN
Keyword(s):  
Glucose Metabolism ◽  
Type Ii Diabetes ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Fat Free Mass ◽  
Type Ii ◽  
Genotype Frequencies ◽  
Gln27glu Polymorphism ◽  
High Prevalence ◽  
Prevalence Of Obesity

As there is a high prevalence of obesity in Tonga, we aimed to determine the distribution of the β2 adrenoceptor gene Gln27Glu polymorphism and to assess its relevance to obesity and to Type II diabetes, known to be prevalent in that population. A random sample of 1022 individuals from Tonga were genotyped for the Gln27Glu polymorphism in the β2 adrenoceptor gene. To assess the prevalence of obesity we measured body-mass index (BMI), fat-free mass, percentage fat and waist-to-hip ratio (WHR). To assess glucose metabolism we measured HbA1c, fasting blood glucose, fasting serum insulin, and 1- and 2-h glucose; we also measured serum lipid and creatinine levels. We found that 84% of the Tongan men and 93% of the women were overweight or obese (BMI⩾25kg/m2) and 15.1% had Type II diabetes. Genotype frequencies among the 1022 Tongans were: Gln/Gln 90.3% and Gln/Glu 9.6%; we found one Glu/Glu homozygote. The mean BMI (±S.D.) for men was not significantly different for those who were homozygous (30.2±5.4kg/m2) or heterozygous (30.1±5.5kg/m2) for the Gln allele; this was also true for women (33.7±6.2kg/m2 for homozygous and 34.0±5.6kg/m2 for heterozygous). The Glu allele was not associated with other measures of obesity or abnormal glucose metabolism in this generally overweight population. There is a unique frequency of the Gln/Glu β2 adrenoceptor polymorphism among Tongans. We found no association of the polymorphism with obesity measures or Type II diabetes-related variables in the Tongan population among whom we documented a high prevalence of obesity and Type II diabetes and a low frequency of the Glu allele.

scholarly journals Genetic causes of severe childhood obesity: a remarkably high prevalence (≥49%) in an inbred population of Pakistan

2020 ◽  
Author(s):  
Ada Admin ◽  
Sadia Saeed ◽  
Muhammad Arslan ◽  
Jaida Manzoor ◽  
Sadia M. Din ◽  
...  
Keyword(s):  
Simultaneous Detection ◽  
Point Mutations ◽  
Copy Number Variations ◽  
Coding Regions ◽  
New Genes ◽  
Whole Exome ◽  
High Prevalence ◽  
Severely Obese ◽  
Prevalence Of Obesity ◽  
Obese Subjects

Monogenic forms of obesity have been identified in ≤10% of severely obese European patients. However, the overall spectrum of deleterious variants (point mutations and structural variants) responsible for childhood severe obesity remains elusive. In this study, we genetically screened 225 severely obese children from consanguineous Pakistani families through a combination of techniques including an in-house developed augmented whole-exome sequencing (CoDE-seq) enabling simultaneous detection of whole exome copy number variations (CNVs) and of point mutations in coding regions. We identified 110 probands (49%) carrying 55 different pathogenic point mutations and CNVs in 13 genes/loci responsible for non-syndromic and syndromic monofactorial obesity. CoDE-seq also identified 28 rare or novel CNVs associated with intellectual disability in 22 additional obese subjects (10%). Additionally, we highlight variants in candidate genes for obesity warranting further investigation. Altogether, 59% of the studied cohort are likely to have a discrete genetic cause with 13% of these due to CNVs demonstrating a remarkably higher prevalence of monofactorial obesity than hitherto reported and a plausible over lapping of obesity and intellectual disabilities in several cases. Finally, inbred populations with high prevalence of obesity, provide a unique genetically enriched material in quest of new genes/variants influencing energy balance.

High prevalence of multimorbidity in overweight and obese women with Polycystic Ovary Syndrome (PCOS)

2017 ◽  
Author(s):  
Hamidreza Mani ◽  
Yogini Chudasama ◽  
Danielle Bodicoat ◽  
Miles Levy ◽  
Laura Gray ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Obese Women ◽  
Ovary Syndrome ◽  
High Prevalence

Impact of obesity on female sexual dysfunction: A remiss

2020 ◽  
Vol 16 ◽  
Author(s):  
Asma Farooq Shah ◽  
Isha Chawla ◽  
Kirti Goel ◽  
Rakesh Gollen ◽  
Randhir Singh
Keyword(s):  
Sexual Dysfunction ◽  
Female Sexual Dysfunction ◽  
Kidney Diseases ◽  
Public Health Problem ◽  
Point Of View ◽  
Sexual Disorders ◽  
Sexual Dysfunctions ◽  
Obese Women ◽  
Prevalence Of Obesity ◽  
The Impact

: The prevalence of obesity around the globe is increasing at such an alarming rate that WHO consultation on obesity designated obesity as a major unattended public health problem worldwide. Obesity is associated with a greater risk of excessive fat related metabolic and endocrinal diseases associated with different set of illness and disabilities, including type 2 diabetes, cardiovascular diseases, kidney diseases, sleep apnea, arthritis, lung diseases and sexual disorders. Obesity is found to be associated with male and female sexual dysfunctions and several studies have indicated a positive correlation between obesity and sexual dysfunction among both males and females. The relationship between male obesity and sexual dysfunction has been widely discussed, whereas a very little emphasis is laid on relationship between obesity and female sexual dysfunctions. Sexual dysfunctions are common and affects 20-50% of obese women. Particularly, female sexual dysfunction is a multi-factorial problem, including organic and psychological aspects involved into it. These disorders not only affect physical health of women but to a greater extent mental health is also affected. Considering this point of view, present review is emphasized on the impact of obesity on female sexual dysfunctions.

scholarly journals Evaluation of Nutritional Risk and Prevalence of Obesity in Patients with Covid-19 in A Reference Hospital in Salvador, Bahia, Brazil: A Cross-Sectional Study

2021 ◽  
Vol 14 (01) ◽  
pp. 011-015
Author(s):  
Rodrigo Fernandes Weyll Pimentel ◽  
Gilson Cruz de Moraes ◽  
Shalla Gomes Cavalcanti Barcelos ◽  
Pedro Carlos Muniz de Figueiredo ◽  
Magno Conceição Das Merces
Keyword(s):  
Cross Sectional Study ◽  
Nutritional Risk ◽  
Sectional Study ◽  
Cross Sectional ◽  
High Prevalence ◽  
Reference Hospital ◽  
Prevalence Of Obesity ◽  
Nrs 2002 ◽  
Study Type ◽  
Nutritional Risk Screening

Abstract Introduction The Coronavirus has spread to almost every country in the world, causing the coronavirus disease (COVID-19). The coronavirus stands out among the other infections especially by it's high contagious power and important effects on the respiratory system. The COVID-19 has differents ways of presentation and these are influenced by the patient's previous nutricional status, correlated with the patient's lifestyle and comorbities. Objective this survey seeks to analyze the nutritional status and the prevalence of obesity in patients hospitalized with SARS-CoV-2. Methods: this is a descriptive, prospective and cross-sectional study type, which 41 patients affected by COVID-19 were interviewed. Patient's weight and height were used to assess the BMI, and nutritional risk assessment was performed using the Nutritional Risk Screening tool (NRS 2002). For the analysis, Absolute (AF) and Relative Frequency (RF), the mean and the standard deviation were calculated. Results It was observerd that 78% of the participants had a high nutritional risk, while only 22% had a low nutritional risk. Besides that, 34% showed overweight and 41.4% showed obesity. Conclusion the existence of a high prevalence of increased nutritional risk was evidenced, in addition to the high frequency of overweight in patients affected by SARS-CoV-2.

scholarly journals Effect of weight and body composition changes on waist measurement of severely obese women receiving carbohydrate-restricted diet

2014 ◽  
Vol 27 (1) ◽  
pp. 05-13 ◽  
Author(s):  
Andresa Toledo Triffoni-Melo ◽  
Rita de Cássia Lusia dos Santos ◽  
Rosa Wanda Diez-Garcia
Keyword(s):  
Body Composition ◽  
Waist Circumference ◽  
Intervention Group ◽  
Control Group ◽  
Obese Women ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
Conventional Diet ◽  
Severely Obese ◽  
Composition Changes

OBJECTIVE: To evaluate the effect of weight and body composition changes on waist measurement of severely obese women receiving a low-carbohydrate diet for a short-term. METHODS: Nineteen severely obese women divided into an intervention and a control group received a low-carbohydrate diet and a conventional diet, respectively, both with 1,200kcal, for seven days. Anthropometric measurements such as weight, body mass index, arm circumference, waist circumference (at the navel), two proposed measurements of waist circumference (waist circumference 1, 10cm above the navel; and waist circumference 2, 20cm above the navel), hip circumference; and body composition (lean mass and fat mass) were performed at baseline and end of the study. RESULTS: There was significant reduction of all variables in the intervention group (p<0.01), but the control group had no change in waist circumference (p=0.06) and hip circumference (p=0.36). Patients of the intervention group presented greater weight loss (4.4kg, p<0.01) and reduction of body mass index, waist circumference, waist circumference 1, waist circumference 2 (p<0.01), and fat mass (p=0.04) than the control group. CONCLUSION: The weight loss and body composition changes were greater in the low-carbohydrate group than in the conventional-diet group, and they had a greater impact on waist measurements. The proposed measurements (waist circumference 1 and waist circumference 2) were sensitive to weight reduction in both groups.

High prevalence of obesity in a Spanish working population

2013 ◽  
Vol 60 (4) ◽  
pp. 173-178
Author(s):  
Alberto Goday-Arnó ◽  
Eva Calvo-Bonacho ◽  
Miguel-Ángel Sánchez-Chaparro ◽  
José-Antonio Gelpi ◽  
Juan-Carlos Sainz ◽  
...  
Keyword(s):  
Working Population ◽  
High Prevalence ◽  
Prevalence Of Obesity
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