scholarly journals Obesity Increases Prevalence of Colonic Adenomas at Screening Colonoscopy: A Canadian Community-Based Study

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Theodore F. Shapero ◽  
Grant I. Chen ◽  
Tim Devlin ◽  
Alison Gibbs ◽  
Iain C. Murray ◽  
...  
Keyword(s):  
Colorectal Neoplasia ◽  
Binary Logistic Regression ◽  
Screening Colonoscopy ◽  
Multinomial Regression ◽  
Community Based ◽  
Canadian Population ◽  
Colonic Neoplasia ◽  
Older Subjects ◽  
Advanced Adenomas ◽  
Tobacco Usage

Background and Aims. Obesity is a risk factor for colorectal neoplasia. We examined the influence of obesity and metabolic syndrome (MetS) on prevalence of neoplasia at screening colonoscopy. Methods. We evaluated 2020 subjects undergoing first screening colonoscopy. Body mass index (BMI) was calculated at enrolment. Hyperlipidemia (HL), hypertension (HT), and diabetes mellitus (DM) were identified. Details of colonoscopy, polypectomy, and histology were recorded. Odds for adenomas (A) and advanced adenomas (ADV) in overweight (BMI 25.1–30) and obese (BMI > 30) subjects were assessed by multinomial regression, adjusted for covariates. Analyses included relationships between HL, HT, DM, age, tobacco usage, and neoplasia. Discriminatory power of HT, HL, DM, and BMI for neoplasia was assessed by binary logistic regression. Odds were calculated for neoplasia in each colonic segment related to BMI. Results. A and ADV were commoner in overweight and obese males, obese females, older subjects, and smokers. HL, HT, and DM were associated with increased odds for neoplasia, significantly for A with hypertension. BMI alone predicted neoplasia as well as HT, HL, DM, or combinations thereof. All segments of the colon were affected. Multiple polyps were particularly prevalent in the obese. Conclusions. Obesity and MetS are risk factors for colonic neoplasia in a Canadian population.

scholarly journals The Prevalence and Characteristics of Colorectal Neoplasia in Acromegaly

2000 ◽  
Vol 85 (9) ◽  
pp. 3417-3424 ◽  
Author(s):  
Andrew G. Renehan ◽  
Pudhupalayan Bhaskar ◽  
John E. Painter ◽  
Sarah T. O’Dwyer ◽  
Najib Haboubi ◽  
...  
Keyword(s):  
General Population ◽  
Regression Models ◽  
Serum Insulin ◽  
Colorectal Neoplasia ◽  
Screening Colonoscopy ◽  
Prevalence Rates ◽  
Linear Regression Models ◽  
Colonic Neoplasia ◽  
Duration Of Disease ◽  
Age Range

Abstract An increased prevalence of colorectal neoplasia has been reported in acromegalic patients, and recommendations have been made for early colonoscopic screening and regular surveillance. This assumption, however, is frequently drawn from studies using selected control populations. To clarify colonoscopic management in these patients, we undertook a 2-center prospective screening colonoscopy study in 122 acromegalics (age range, 25–82 yr). In the absence of ideal age-matched controls, we calculated prevalence rates of occult adenocarcinomas and adenomas in the general population using cumulative data in the published literature from 8 autopsy studies (model 1, n = 3559) and 4 screening colonoscopy studies (model 2, n = 810), applying linear regression models. Of the 115 patients with complete examinations, adenocarcinomas were discovered in 3 (2.6%), and at least 1 adenoma was found in 11, giving an overall prevalence of neoplasia of 12% (14 of 115). Prevalence rates for age bands 30–40, 40–49, 50–59, 60–69, and 70+ yr were 0%, 8%, 12%, 20%, and 21%, respectively. Compared with the 2 control models, the prevalence of occult colorectal cancer was not significantly increased (acromegalics vs. models 1 and 2, 2.6% vs. 2.3% and 0.9%), nor was there an increase in the prevalence of adenomas in any age band. Pathological characteristics showed some differences, in that adenomas in acromegalics tended to be right sided (68% vs. 57% and 56%), larger (for ≥10 mm, 27% vs. 13% and 9%), and of advanced histology (for tubulovillous, 27% vs. 4% and 22%). No associations were found between the presence of colonic neoplasia and the duration of disease, total GH exposure, cure status, and serum insulin-like growth factor I. This study has failed to demonstrate an increased prevalence of neoplasia in acromegalic patients compared with the expected prevalence in the general population and questions the need for an aggressive colonoscopic screening policy.

scholarly journals Atrial Fibrillation: A New Indicator for Advanced Colorectal Neoplasia in Screening Colonoscopy

2019 ◽  
Vol 8 (7) ◽  
pp. 1083 ◽  
Author(s):  
Peter C. Kahr ◽  
Sabrina Hammerl ◽  
Ursula Huber-Schönauer ◽  
Christian M Schmied ◽  
Laurent M. Haegeli ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Colorectal Neoplasia ◽  
Surrogate Marker ◽  
Screening Colonoscopy ◽  
Increased Risk ◽  
Colon Cancer Prevention ◽  
Artery Disease ◽  
And Gender ◽  
Advanced Adenomas ◽  
Shared Risk

Background: Colorectal cancer (CRC) is a common and potentially preventable malignancy. Evidence has emerged that coronary artery disease patients are at increased risk for developing CRC by shared risk factors. Here we investigated an association between CRC and atrial fibrillation (AF), a surrogate marker of cardiovascular risk, in the setting of routine screening colonoscopy. Methods: We investigated 1949 asymptomatic participants (median age 61 [54–67] years, 49% females) undergoing screening colonoscopy within the SAKKOPI registry (Salzburg Colon Cancer Prevention Initiative). Forty-six participants with AF (2.4%) were identified, and colonoscopy findings were compared to non-AF participants. Propensity Score Matching (PSM) was used to create 1:1 and 3:1 age- and gender-matched couples. Results: Abnormal findings on screening colonoscopy (any form of adenoma or carcinoma) were more common in AF participants with an odds ratios (OR) of 2.4 [1.3–4.3] in the unmatched analysis, and 2.6 [1.1–6.3] and 2.0 [1.1–4.0] in the 1:1 and 3:1 matched groups, respectively. Correspondingly, the odds of finding advanced adenomas or carcinomas was elevated about three-fold across the different matched and unmatched analyses (OR 3.3 [1.1–10.8] for 3:1 matched participants). At the same time, the prevalence and number of colonic lesions were significantly higher in AF participants (63.0% vs. 33.4% for 3:1 matched participants, p < 0.001). Non-CRC related findings on colonoscopy, like diverticulosis, were non-different between groups. Conclusion: Participants with AF had a higher burden of advanced premalignant adenomas and CRC in routine colonoscopy screening. Our data suggest that practitioners should monitor the CRC screening status, especially in AF patients.

scholarly journals Factors Associated with COVID-19 Vaccine Hesitancy

Vaccines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 300
Author(s):  
Patricia Soares ◽  
João Victor Rocha ◽  
Marta Moniz ◽  
Ana Gama ◽  
Pedro Almeida Laires ◽  
...  
Keyword(s):  
Health Status ◽  
Vaccine Hesitancy ◽  
Multinomial Regression ◽  
Community Based ◽  
Safety And Efficacy ◽  
Perceived Safety ◽  
Factors Associated ◽  
Health Authorities ◽  
Flu Vaccine ◽  
Release Of Information

It is critical to develop tailored strategies to increase acceptability of the COVID-19 vaccine and decrease hesitancy. Hence, this study aims to assess and identify factors associated with COVID-19 vaccine hesitancy in Portugal. We used data from a community-based survey, “COVID-19 Barometer: Social Opinion”, which includes data regarding intention to take COVID-19 vaccines, health status, and risk perception in Portugal from September 2020 to January 2021. We used multinomial regression to identify factors associated with intention to delay or refuse to take COVID-19 vaccines. COVID-19 vaccine hesitancy in Portugal was high: 56% would wait and 9% refuse. Several factors were associated with both refusal and delay: being younger, loss of income during the pandemic, no intention of taking the flu vaccine, low confidence in the COVID-19 vaccine and the health service response during the pandemic, worse perception of government measures, perception of the information provided as inconsistent and contradictory, and answering the questionnaire before the release of information regarding the safety and efficacy of COVID-19 vaccines. It is crucial to build confidence in the COVID-19 vaccine as its perceived safety and efficacy were strongly associated with intention to take the vaccine. Governments and health authorities should improve communication and increase trust.

Tu1444 Prevalence of Advanced Adenomas in Diminutive and Small Polyps in a Large Austrian Screening Colonoscopy Cohort

2014 ◽  
Vol 79 (5) ◽  
pp. AB541-AB542
Author(s):  
Elisabeth Waldmann ◽  
Petra Salzl ◽  
Cord Langner ◽  
Martha Britto-Arias ◽  
Angelika Geroldinger ◽  
...  
Keyword(s):  
Screening Colonoscopy ◽  
Advanced Adenomas

Colorectal Neoplasia Screening with CT Colonography in Average-Risk Asymptomatic Subjects: Community-based Study

Radiology ◽  
2004 ◽  
Vol 230 (2) ◽  
pp. 459-464 ◽  
Author(s):  
John T. Edwards ◽  
Richard M. Mendelson ◽  
Lin Fritschi ◽  
Noellene M. Foster ◽  
Christopher Wood ◽  
...  
Keyword(s):  
Ct Colonography ◽  
Colorectal Neoplasia ◽  
Average Risk ◽  
Community Based ◽  
Asymptomatic Subjects

scholarly journals Knowledge and attitude of the communities towards COVID-19 and associated factors among Gondar City residents, northwest Ethiopia: A community based cross-sectional study

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0248821
Author(s):  
Asefa Adimasu Taddese ◽  
Zelalem Nigussie Azene ◽  
Mehari Woldemariam Merid ◽  
Atalay Goshu Muluneh ◽  
Demiss Mulatu Geberu ◽  
...  
Keyword(s):  
Family Size ◽  
Educational Level ◽  
Associated Factors ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Knowledge And Attitude ◽  
Significant Factors

Background COVID-19 is the novel coronavirus responsible for the ongoing global outbreak of acute respiratory disease and viral pneumonia. In order to tackle the devastating condition of the virus, countries need to attack the virus with aggressive and targeted tactics. Thus, to strengthen the COVID-19 mitigation measures and to give rapid response, there is an urgent need to understand the public’s knowledge and attitude about of the pandemic at this critical moment. Objective This study was aimed to assess the knowledge and attitude of communities about COVID-19 and associated factors among Gondar City residents. Methods A community based cross-sectional study was done among 623 respondents in Gondar city from April 20-27/2020. Data were collected using a structured questionnaire adapted from different literatures. The data were entered using Epi data version 3.1 and then exported into STATA version 14 for analysis. Bi-variable and multivariable binary logistic regression were performed. Adjusted odds ratio with 95% CI was used to declare statistically significant variables on the basis of p value less than 0.05 in the multivariable binary logistic regression model. Results The overall knowledge and attitude of the community towards COVID19 was 51.85% [95% CI (47.91%-55.78%)] and 53.13% [95% CI (49.20, 57.06%)], respectively. In this study, being married [AOR = 0.60 at 95% CI: (0.42, 0.86)], educational level; primary [AOR = 3.14 at 95% CI: (1.78,5.54)], secondary [AOR = 2.81 at 95% CI: (1.70,4.63)], college and above [AOR = 4.49 at 95% CI: 7.92, 13.98)], and family size [AOR = 1.80, at 95% CI: (1.05, 3.08)] were emerged as statistically significant factors impacting the knowledge of the community about COVID-19. Besides, educational level; primary [AOR = 1.76 at 95% CI: (1.03, 3.01)], secondary [AOR = 1.69 at 95% CI: (1.07, 2.68)], and college & above [AOR = 2.38 at 95% CI: (1.50, 3.79)], and family size; four to six members [AOR = 1.84 at 95% CI (1.27, 2.67)], above seven members [AOR = 1.79 at 95% CI (1.08, 2.96)] were factors identified as significantly attribute for positive attitude of the communities towards COVID-19. Conclusion More than half of the respondents had better knowledge and attitude regarding COVID-19. Higher educational level and larger family size were significant factors predominantly affecting the knowledge and attitude of the communities towards COVID-19.

Neighborhood Disorder, Social Ties, and Preventive Healthcare Utilization among Urban-Dwelling Older Adults

2020 ◽  
Vol 32 (10) ◽  
pp. 1387-1398
Author(s):  
Kenzie Latham-Mintus ◽  
Ashley Vowels ◽  
Swapnali Chavan
Keyword(s):  
Older Adults ◽  
Dental Care ◽  
Social Ties ◽  
Binary Logistic Regression ◽  
Healthcare Services ◽  
Screening Colonoscopy ◽  
Neighborhood Disorder ◽  
Preventive Healthcare ◽  
Using Data ◽  
Restricted Use

Objectives: This research examines whether perceived neighborhood disorder influences the use of preventive healthcare services (i.e. influenza vaccine, pneumonia vaccine, cholesterol screening, colonoscopy, and dental care) by older adults and whether social ties buffer the potential adverse effects of perceived neighborhood disorder. Methods: Using data from the 2012 wave of the Health and Retirement Study, binary logistic regression was used to generate odds ratio estimates of preventive healthcare use in the past 2 years. Results: We find that greater levels of neighborhood disorder were associated with fewer dental care visits net of social and health factors. Regular participation in four or more social activities was associated with decreased odds of restricted use and increased odds of receiving a pneumonia vaccine and colonoscopy. Discussion: This research provides evidence that perceived neighborhood disorder may act as a barrier for specific preventive healthcare services and highlights the need for targeted intervention.

Tu1213 Risk Factors for Advanced Adenomas in Veterans Undergoing Screening Colonoscopy

2012 ◽  
Vol 142 (5) ◽  
pp. S-775-S-776 ◽  
Author(s):  
Rexy A. Thomas ◽  
Deepthi S. Rao ◽  
Olurinde A. Oni ◽  
Ajay Bansal ◽  
Prateek Sharma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Screening Colonoscopy ◽  
Advanced Adenomas
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