scholarly journals Effect of Caffeine on Some Selected Biochemical Parameters Using Rat Model

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Agomuo Emmanuel ◽  
Duru Majesty ◽  
Amadi Benjamin ◽  
Amadi Peter ◽  
Ugwokaegbe Princess
Keyword(s):  
Rat Model ◽  
Biochemical Parameters ◽  
Good Work ◽  
Standard Methods ◽  
Methods Of Analysis ◽  
Haematological Indices

Effect of caffeine on some selected biochemical parameters using rat model was investigated. Standard methods of analysis were used for the study. A total of sixty (60) rats divided equally into five groups of which one group served as the control, and the rest as test groups were used. The test rats were placed on different concentrations of caffeine for twenty-eight (28) days. Results obtained for the selected biochemical parameters revealed that AST and ALT levels of the liver increased significantly (p<0.05) in test rats against the control. Creatinine and electrolyte ions of the kidney increased significantly (p<0.05) in test groups when compared to the control. Haematological indices such as WBC, monocytes, lymphocytes, MCV, MCHC, and MCV levels were significantly altered (p<0.05) in test rats against those of the control. It therefore becomes imperative for those that consume caffeine with believe that it does more good work than harm to take note of these findings. This study has revealed the effect of caffeine on some selected biochemical parameters using rat model.

scholarly journals Assessment of Toxicity and Therapeutic Effects of Goose Bone in a Rat Model

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Md. Yousuf Ali ◽  
Alamgir Kabir ◽  
Shahad Saif Khandker ◽  
Tareq Hossan ◽  
Md. Salman Shakil ◽  
...  
Keyword(s):  
Rat Model ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Atherogenic Index ◽  
Control Group ◽  
Histopathological Study ◽  
Therapeutic Effects ◽  
Related Disorder ◽  
Serum Biochemical ◽  
Hematological And Biochemical Parameters

Goose bone is traditionally used in the treatment of many ailments including in bone fracture. The aim of the present study was to evaluate the subacute toxicity of goose bone in a rat model by investigating some hematological and biochemical parameters in rats. Subsequently, a histopathological study was performed to confirm the presence of pathological lesions in the rat’s vital organs including the liver, kidney, heart, brain, pancreas, lung, spleen, and stomach. Adult Wistar rats were divided into four groups (n = 8) and were orally administrated with three doses (30, 60, and 120 mg/kg) of goose bone once daily for 21 days as compared to control animals (received only drinking water). Goose bone did not cause any significant changes on body weight, relative organ weight, and percentage water content at any of the administered doses. There were also no significant alterations in hematological parameters seen. All three doses administered significantly reduced the triglyceride levels as well as the atherogenic index of plasma (AIP). Animals treated with 120 mg/kg doses had significantly reduced alkaline phosphatase (ALP) activity as compared to the control group. There was no significant alteration on other serum biochemical parameters seen. Additionally, histopathological findings confirmed that there was no inflammatory, necrotic, or other toxicological feature seen for all three doses. It is concluded that goose bone is nontoxic and is safe for consumption besides having the potential to be investigated for the treatment of high triglycerides or liver-related disorder.

scholarly journals Effects of sulfur dioxide, ozone, and ambient air pollution on bone metabolism related biochemical parameters in a rat model

2020 ◽  
Vol 35 (4) ◽  
pp. e2020023
Author(s):  
Sorayya Kheirouri ◽  
Mohammad Alizadeh ◽  
Razieh Musapour Sultan Abad ◽  
Sona Barkabi-Zanjani ◽  
Mehran Mesgari-Abbasi
Keyword(s):  
Air Pollution ◽  
Sulfur Dioxide ◽  
Bone Metabolism ◽  
Rat Model ◽  
Biochemical Parameters ◽  
Ambient Air ◽  
Ambient Air Pollution

scholarly journals Abnormal biochemical parameters among term neonates with perinatal asphyxia and their non-asphyxiated controls in Osogbo

2021 ◽  
Vol 9 (3) ◽  
pp. 308-319
Author(s):  
O.V. Kayode ◽  
O.J. Adebami ◽  
O.A. Oyedeji ◽  
S.O. Oninla ◽  
S.B.A. Oseni ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Case Control Study ◽  
Perinatal Asphyxia ◽  
Serum Levels ◽  
Case Control ◽  
Serum Electrolytes ◽  
Term Neonates ◽  
Standard Methods ◽  
Control Study ◽  
Prospective Case Control Study

Objective: This study aimed to determine the prevalence of abnormal biochemical parameters among neonates with perinatal asphyxia in comparison to their non-asphyxiated controls.Methodology: This is a prospective case - control study involving 54 asphyxiated term neonates and 54 non-asphyxiated term babies at LAUTECH teaching hospital, Osogbo. Serum levels of Sodium, Bicarbonate, Chloride, Calcium and Potassium were determined daily for 72 hours in both groups using standard methods. The results were compared.Results: The overall prevalence of abnormal biochemical parameters namely hyponatraemia, hypocalcaemia, metabolic acidosis, hypochloraemia and hypokalaemia among the asphyxiated versus non-asphyxiated babies in the first 72 hours of life were 30.9% vs 19.8% (p < 0.020); 28.4% vs 4.9% (p < 0.000); 30.9% vs 3.1% (p < 0.0001); 27.2% vs 25.9% (p < 0.200) and 24.7% vs 3.1% (p < 0.070) respectively.Conclusion: Babies with hypoxic ischaemic encephalopathy stage III significantly showed the worst biochemical parameters; early estimation of serum electrolytes in neonates with perinatal asphyxia may be appropriate for timely intervention.  

scholarly journals Salivary biomarkers and proteomics: future diagnostic and clinical utilities

2021 ◽  
Vol 19 (3) ◽  
pp. 171-174
Author(s):  
A. V. Mitronin ◽  
O. A. Khvorostenko ◽  
D. A. Ostanina ◽  
Yu. A. Mitronin
Keyword(s):  
Biochemical Parameters ◽  
Oral Fluid ◽  
Biological Fluids ◽  
Inorganic Compounds ◽  
Non Invasive ◽  
Fluid Analysis ◽  
Methods Of Analysis ◽  
Wide Range ◽  
Biological Environment ◽  
Physiological And Biochemical

The search for new, fast and non-invasive methods of diagnosing diseases of both the oral cavity and general diseases of various etiologies and their introduction into practical health care is still a priority in the field of medicine. Among the known methods of analysis of biological fluids, a special place is occupied by the study of saliva. Oral fluid analysis has a high potential in screening for various diseases, since it contains a wide range of organic and inorganic compounds. A significant number of works have been devoted to the study of the quantitative and qualitative composition of the oral fluid, as well as to the study of saliva biomarkers, however, the study of the saliva proteome is at the stage of data accumulation. The lack of standardization in the collection of samples and methods of analysis, as well as poorly studied physiological and biochemical parameters of the oral fluid, hinders the introduction of advances in the study of the saliva proteome into diagnostic practice. The solution of these problems will allow the oral fluid to be used as a biological environment for both detecting diseases and predicting their course.

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