Influence of Synbiotics on Selected Oxidative Stress Parameters

The aim of the present study was to assess synbiotic (Lactobacillus casei+ inulin) influence on oxidative stress parameters such as concentrations of malondialdehyde (MDA), hydrogen peroxide (H2O2), glutathione, and free sulfhydryl groups content. Experiments were carried out on healthy volunteers (n=32). The subjects were divided into women group (n=16) and men group (n=16) and randomly assigned to synbiotic and control groups. Blood samples were collected before synbiotic supplementation and after 7 wks, at the end of the study. The administration of synbiotic resulted in a significant decrease in MDA (p<0.01), H2O2(p<0.01), and GSSG concentrations (p<0.05) as compared with the control groups and significant increase in the concentrations of GSHt (p<0.001), GSH (p<0.01), and -SH group content (p<0.05) versus control. Synbiotics containingL. caseiplus inulin may have positive influence on selected oxidative stress markers.

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Effect of Probiotic, Prebiotic, and Synbiotic Supplementation on Cardiometabolic and Oxidative Stress Parameters in Patients with Chronic Kidney Disease: a Systematic Review and Meta-analysis

Clinical Therapeutics ◽

10.1016/j.clinthera.2020.12.021 ◽

2021 ◽

Author(s):

Mahsa Bakhtiary ◽

Mojgan Morvaridzadeh ◽

Shahram Agah ◽

Mehran Rahimlou ◽

Edward Christopher ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Meta Analysis ◽

Oxidative Stress Parameters ◽

Synbiotic Supplementation ◽

And Oxidative Stress ◽

Stress Parameters

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Presentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: an observational pilot study

F1000Research ◽

10.12688/f1000research.55166.1 ◽

2021 ◽

Vol 10 ◽

pp. 719

Author(s):

Marija Petrushevska ◽

Dragica Zendelovska ◽

Emilija Atanasovska ◽

Aleksandar Eftimov ◽

Katerina Spasovska

Keyword(s):

Oxidative Stress ◽

Care Setting ◽

High Sensitivity ◽

Photometric System ◽

Oxidative Stress Parameters ◽

Stress Markers ◽

Tnf Α ◽

Array Technology ◽

Ifn Γ ◽

Stress Parameters

Introduction: COVID-19 can be worsened by hyper-production of cytokines accompanied by increased level of oxidative stress. The aim of this study was to investigate the correlation between a set of cytokines and the markers of the oxidative stress. Methods: The levels of cytokines IL-2, IL-4, IL-6, IL8, IL-10, VEGF, IFN-γ, TNF-α, IL-1α, MCP-1 and EGF were determined by using High Sensitivity Evidence Investigator™ Biochip Array technology. The oxidative stress parameters (d-ROM, PAT, OS index) were measured in serum on FRAS5 analytical photometric system. Results: IL-6, IL-8, IL-10, VEGF, MCP-1 and EGF were significantly higher (p<0.05) in the patients with severe COVID-19 with increased levels of IL-2, IFN-g, TNF-a and IL-1α. The d-ROM, OS index, and PAT were significantly higher (p<0.05) in severe COVID-19 patients. IL-6 demonstrated the strongest correlation with all of the markers of the oxidative stress, d-ROM (r=0.9725, p=0.0001), PAT (r=0.5000, p=0.0001) and OS index (r=0.9593, p=0.012). Similar behavior was evidenced between IFN-g and d-ROM (r=0.4006, p=0.0001), PAT (r=0.6030, p=0.0001) and OS index (r=0.4298, p=0.012). Conclusion: The oxidative stress markers show good correlation with the tested cytokines which can be measured at the beginning of the disease in a primary care setting to predict the course of COVID-19.

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ANALYSIS OF OXIDATIVE STRESS MARKERS IN CROSSBRED COWS WITH SUBCLINICAL MASTITIS AND CONCURRENT METABOLIC AND INFECTIOUS DISEASES

International Journal on Environmental Sciences ◽

10.53390/ijes.v12i1.5 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Mohammed Khaleel Ulla ◽

A.M. Kotresh ◽

Anantha Krishna L.R ◽

Shambulingappa B.E ◽

Rudresh. B.H ◽

...

Keyword(s):

Oxidative Stress ◽

Infectious Diseases ◽

Subclinical Mastitis ◽

Clinical Mastitis ◽

Crossbred Cows ◽

Oxidative Stress Parameters ◽

Stress Markers ◽

History Of ◽

Loss Of Appetite ◽

Stress Parameters

The aim of this study was to evaluate the oxidative status in crossbred cows with subclinical mastitis and concurrent metabolic and infectious diseases. The crossbred cows were groped asGp-C (n=6) as controls,Gp-M (n=6) with clinical mastitis ,Gp-TS consists cows affected withstenosis of teat,Gp-RA with ruminal acidosis,Gp-ND with diarrhea along with dehydration and loss of appetite, Gp-RTIwith coughing, fever, decreased appetite, varying degrees of dyspnea, GpRB with a history of failure to conceive after at least two successive inseminations. oxidative stress parameters likecatalase, SOD, GPx, GSH and malondialdehyde were estimated spectrophotometrically. The antioxidant enzymes like catalase, super oxide dismutase (SOD), Glutathione Peroxidase (GPx) levels were significantly declined and the non enzymatic parameters reduced glutathione (GSH) and malondialdehyde (MDA) are significantly elevated in affected animals than in healthy animals. The results of the oxidative stress parameters indicate imbalance of antioxidant profile and oxidative stress in the animals with various disorders and previous illness along with subclinical mastitis.

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Effects of Spiruline (Spirulina platensis) Supplementation on Oxidative Stress Markers, Biochemical Characteristics, and Hematological Parameters in Rabbit (Oryctolagus cuniculus) Does

Asian Journal of Agriculture and Rural Development ◽

10.18488/journal.ajard.2021.112.163.170 ◽

2021 ◽

Vol 11 (2) ◽

pp. 163-170

Author(s):

Chongsi Margaret Mary Momo ◽

Mahamat Tahir Markhous Adam ◽

Tchoffo Herve ◽

Vemo Bertin Narcisse ◽

Ngoula Ferdinand ◽

...

Keyword(s):

Oxidative Stress ◽

Hematological Parameters ◽

Control Group ◽

Oxidative Stress Markers ◽

Feed Supplementation ◽

Biochemical Characteristics ◽

Oxidative Stress Parameters ◽

Stress Markers ◽

Sexually Mature ◽

Stress Parameters

The present study was carried out in order to evaluate the effects of feed supplementation with spiruline powder on the oxidative stress markers, biochemical characteristics, and hematological parameters in rabbit doe. Twenty-one nulliparous and sexually mature does (7–8 months old) were distributed into three groups of seven does each, comparable in terms of body weight. After a week of feeding with experimental feed, does of each group were mated. During the trial, does of group 1 (control group) were fed ad libitum with a feed free from spiruline (control feed), while those of groups 2 and 3 received the control feed supplemented with spiruline powder at 0.6 and 1.2%, respectively. Immediately after parturition, blood was collected for analyses of hematological, biochemical, and oxidative stress parameters. Studied parameters included serum concentrations of total proteins, cholesterol, aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), creatinine, and urea; malondialdehyde, reduced glutathione, catalase, and superoxide dismutase; and hematological parameters. The total protein concentration, number of white and red blood cells, platelets, hemoglobin, hematocrit, and mean corpuscular volume were significantly (P<0.05) higher in does treated compared to control. Oxidative stress parameters were comparable (P>0.05) among treatments. Hence, these results show that feed supplementation with spirulina powder can improve rabbit doe health, notably at 1.2%, since optimal results were obtained at this percentage.

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Presentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: a case-control pilot study

F1000Research ◽

10.12688/f1000research.55166.2 ◽

2021 ◽

Vol 10 ◽

pp. 719

Author(s):

Marija Petrushevska ◽

Dragica Zendelovska ◽

Emilija Atanasovska ◽

Aleksandar Eftimov ◽

Katerina Spasovska

Keyword(s):

Oxidative Stress ◽

Care Setting ◽

High Sensitivity ◽

Photometric System ◽

Oxidative Stress Parameters ◽

Stress Markers ◽

Tnf Α ◽

Array Technology ◽

Ifn Γ ◽

Stress Parameters

Introduction: COVID-19 can be worsened by hyper-production of cytokines accompanied by increased level of oxidative stress. The aim of this study was to investigate the correlation between a set of cytokines and the markers of the oxidative stress. Methods: The levels of cytokines IL-2, IL-4, IL-6, IL8, IL-10, VEGF, IFN-γ, TNF-α, IL-1α, MCP-1 and EGF were determined by using High Sensitivity Evidence Investigator™ Biochip Array technology. The oxidative stress parameters (d-ROM, PAT, OS index) were measured in serum on FRAS5 analytical photometric system. Results: IL-6, IL-8, IL-10, VEGF, MCP-1 and EGF were significantly higher (p<0.05) in the patients with severe COVID-19 with increased levels of IL-2, IFN-y, TNF-α and IL-1α. The d-ROM, OS index, and PAT were significantly higher (p<0.05) in severe COVID-19 patients. IL-6 demonstrated the strongest correlation with all of the markers of the oxidative stress, d-ROM (r=0.9725, p=0.0001), PAT (r=0.5000, p=0.0001) and OS index (r=0.9593, p=0.012). Similar behavior was evidenced between IFN-y and d-ROM (r=0.4006, p=0.0001), PAT (r=0.6030, p=0.0001) and OS index (r=0.4298, p=0.012). Conclusion: The oxidative stress markers show good correlation with the tested cytokines which can be measured at the beginning of the disease in a primary care setting to predict the course of COVID-19.

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