scholarly journals The Correlation between Serum Uric Acid and Renal Function in Elderly Chinese Diabetes with Normoalbuminuria

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Qiaojing Qin ◽  
Yingjun Qian ◽  
Guanghua Zhu ◽  
Weifeng Fan ◽  
Jianying Niu ◽  
...  
Keyword(s):  
Renal Function ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Pearson Correlation ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Urine Ph ◽  
Elderly Chinese

Objective. The elder diabetic patients increases rapidly in China and often accompany with hyperuricemia. Recently evidences show that renal function has been impaired in part of diabetic patients with normoalbuminuria. Therefore, we investigated the relationship between serum uric acid (SUA) and renal function in Chinese elder diabetes with normoalbuminuria. Methods. The physical examination data from 1052 cases of diabetic residents with normoalbuminuria aged 70 years and over in the Jiangchuan community of Minhang District, Shanghai, from October 2011 to September 2014 was analyzed retrospectively. Each received height, body weight, waist circumference (WC), waist-to-hip ratio (WHR), blood pressure (BP), and collected samples of fasting blood and morning urine to detect blood routine, blood glucose, glycosylated hemoglobin (HbA1c), blood lipids, serum creatinine, urinary albumin, urine creatinine, and urine PH value. Correlation between SUA and renal function, an index of which is estimated using estimated glomerular filtration rate (eGFR), was analyzed. Results. The prevalence of hyperuricemia was 21.10%. Levels of WC and triglyceride (TG) increased and the levels of HbA1c, high density lipoprotein-cholesterol (HDL-C), eGFR, and urine PH decreased while the levels of SUA increased. Moreover, negative correlation of eGFR with age, WC, leukocyte, and SUA (Pearson r=0.415) was observed via Pearson correlation analysis. It indicates the strong association between SUA and eGFR. Furthermore, eGFR independently associated with SUA, age, leukocyte, hemoglobin (Hb), and fasting blood glucose (FBG) was confirmed by multiple linear stepwise regression analysis. Conclusion. SUA may play an important role in the decrease of eGFR in elderly Chinese diabetic patients with normoalbuminuria.

scholarly journals Lack of Associations between Elevated Serum Uric Acid and Components of Metabolic Syndrome Such as Hypertension, Dyslipidemia, and T2DM in Overweight and Obese Chinese Adults

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Li Li ◽  
Qifa Song ◽  
Xi Yang
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Muscle Mass ◽  
Alanine Aminotransferase ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Elevated Serum ◽  
Chinese Adults

The overweight and obese population experiences a higher occurrence of both hyperuricemia and metabolic syndrome. The present study was to explore the relationship between serum uric acid and metabolic syndrome-related risk factors among 409 obese Chinese adults (254 women and 155 men) with >24 kg/m2 BMI. Based on sex-specific reference ranges, 233 (57%) patients showed elevated serum uric acid. A total of 15 attributes were selected to assess the associations between elevated serum uric acid and components of metabolic syndrome, including serum uric acid, total cholesterol, HDL-C, LDL-C, triglyceride, systolic blood pressure, fasting blood glucose, glycosylated hemoglobin, HOMA-IR, alanine aminotransferase, creatinine, urine microalbumin, muscle mass amount, BMI, and age. Among the participants stratified into three groups of grade I, grade II, and grade III obesity, as well as among the participants stratified into male and female groups, univariate correlation analysis identified a negative association (P<0.01) for age, positive associations (P<0.01) for BMI, muscle mass, alanine aminotransferase, and creatinine. The stepwise multivariate logistic regression proved similar associations for age, BMI, creatinine, and alanine aminotransferase. No significant associations were testified between serum uric acid levels and cholesterol, HDL-C, LDL-C, triglyceride, fasting blood glucose, glycosylated hemoglobin, HOMA-IR, and urine microalbumin. Factor analysis illustrated that 15 attributes could be grouped into two common factors and five individual factors. A common underlying factor was identified among uric acid, muscle mass, creatinine, alanine aminotransferase, and BMI. The results indicate that serum uric acid has no apparent association with metabolic syndromes that are commonly characterized by hypertension, dyslipidemia, and T2DM.

Relationship between uric acid and creatinine in pre-diabetic and diabetic patients: Vidarbha region of Maharashtra

2020 ◽  
Vol 11 (3) ◽  
pp. 3412-3417
Author(s):  
Ranjit S. Ambad ◽  
Rakesh Kumar Jha ◽  
Lata Kanyal Butola ◽  
Nandkishor Bankar ◽  
Brij Raj Singh ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Type Ii Diabetes ◽  
Fasting Blood Glucose ◽  
General Medicine ◽  
Control Group ◽  
Diabetic Patients ◽  
Type Ii ◽  
Develop Type ◽  
Low Levels

Prediabetes is a glucose homeostasis condition characterized by decreased absorption to glucose or reduced fasting glucose. Both of these are reversible stages of intermediate hyperglycaemia providing an increased type II DM risk. Pre-diabetes can therefore be viewed as a significant reversible stage which could lead to type II DM, and early detection of prediabetes may contribute to type II DM prevention. Prediabetes patients are at high risk for potential type II diabetes, and 70 percent of them appear to develop Type II diabetes within 10 years. The present study includes total 200 subjects that include 100 Prediabetic patients, 50 T2DM patients and 50 healthy individual. Blood samples were collected from the subjects were obtained for FBS, PPBS, Uric acid and Creatinine estimation, from OPD and General Medicine Wards. Present study showed low levels of Serum Uric Acid in prediabetic and T2DM patients were decreased as compared to control group, while the level of creatinine in prediabetic and diabetic were elevated as compared to control group, were not statically significant. Serum Uric Acid was high in control group and low in prediabetic and diabetic patients. Serum creatinine was declined in control group and increased in prediabetic and diabetic patients with increasing Fasting blood glucose level.

The Insulin Regimen That Works

2018 ◽  
Vol 11 (2) ◽  
pp. 165-168
Author(s):  
Svitlana Crawley ◽  
Susan Chaney
Keyword(s):  
Blood Glucose ◽  
Insulin Therapy ◽  
Nurse Practitioners ◽  
Basal Insulin ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Insulin Regimen ◽  
Acting Insulin ◽  
Antihyperglycemic Therapy

Background: Type 2 diabetes mellitus requires monitoring patients’ glycemic control. Treatment must be escalated if glucose levels remain above the recommended goal in patients who are adherent to their current treatment. If glycosylated hemoglobin (HbA1c) levels remain unmet with maximum doses as recommended by the American Diabetes Association (ADA) after adding basal insulin, but fasting blood glucose is at goal, one to three injections daily of rapid-acting insulin are typically added to the treatment plan to be injected prior to meals while continuing all other antihyperglycemic medications. Objective: To describe an effective method of intensifying insulin therapy based on patients’ needs and abilities to self-manage their medications. Methods: We retrospectively reviewed the case of a patient who was referred to the Endocrinology Specialty Clinic for diabetes management. Results: Diabetes control was improved after intensifying insulin therapy by adding once-daily rapid-acting insulin injections. Conclusions: Intensifying insulin therapy by adding one dose of rapid-acting insulin prior to meals can improve HbA1c to < 7% in patients on maximum doses of basal insulin whose fasting blood glucose is at goal but whose HbA1c is above goal. Implications for Nursing: Nurse practitioners must use current care guidelines supported by evidence-based literature to improve patients’ outcomes. This case study supports ADA recommendations on early intensification of antihyperglycemic therapy in diabetic patients to decrease the risk of complications by achieving and maintaining HbA1c goals early.

scholarly journals Status of serum uric acid in diabetic and non-diabetic subjects.

2020 ◽  
Vol 27 (11) ◽  
pp. 2458-2462
Author(s):  
Naveed Ahsan ◽  
Fasiha Fatima ◽  
Sarwat Jahan ◽  
Shahid Zafar ◽  
Jai Kershan
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Medical Center ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Relative Deficiency

Diabetes Mellitus is a chronic metabolic disorder which occurs due to absolute or relative deficiency of insulin hormone and the diabetic patients are more prone to develop stroke, heart attack, kidney failure, blindness, coronary artery disease, neuropathy and gangrene. Increased uric acid levels in serum are one of the metabolic abnormalities associated with diabetes mellitus type 2. Objectives: The purpose of the research is to assess the status of serum uric acid in non-diabetic and diabetic subjects. Study Design: Cross Sectional Comparative study. Setting: Department of Medicine Jinnah Postgraduate Medical Center, Karachi. Period: Feb 2018 till September 2018. Material & Methods: A total of 80 subjects of both sexes were taken and divided into two groups. Fasting glucose levels, serum uric acid were performed by enzymatic method. Results: This study showed significantly raised levels of serum uric acid and Fasting blood glucose (FBS) in diabetic type 2 subjects when compared to non-diabetic subjects(p<0.01). Conclusion: The results of the present study suggests that compared to non‐diabetic subject’s diabetic subjects have significantly higher level of uric acid.

scholarly journals ASSOCIATION OF SERUM SIALIC ACID AND SERUM URIC ACID LEVELS WITH FASTING BLOOD GLUCOSE LEVELS IN TYPE-2 DIABETES MELLITUS PATIENTS

2020 ◽  
pp. 83-86
Author(s):  
YENDREMBAM PASCAL SINGH ◽  
VED PAL SINGH PUNIA ◽  
GLADYS RAI ◽  
MANOJ KUMAR NANDKEOLIAR
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Blood Glucose ◽  
Sialic Acid ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
Serum Sialic Acid

Objectives: The objective of the study was to estimate the serum sialic acid and serum uric acid levels in patients with type-2 diabetes mellitus and non-diabetic individuals and determining the association of serum sialic acid and serum uric acid levels with fasting blood glucose levels in patients with type-2 diabetes mellitus and also in non-diabetic individuals. Methods: The study was a cross-sectional analysis where 70 individuals in the age group of 30–70 years participated during 6 months period. This included two groups, one for type-2 diabetes patients as cases and other non-diabetics as controls. In each group, 35 individuals participated. There were 15 males and 20 females in type-2 diabetic group and 16 males and 19 females in non-diabetic group. Fasting blood glucose, serum sialic acid, and serum uric acid were estimated in both the groups. Results: In this study, the serum sialic acid levels of type-2 diabetes mellitus were shown to be increased (76.60 ± 7.89) when compared to non-diabetics (39.66 ± 9.55) with a statistically significant, p < 0.001. The serum uric acid concentrations were also found to be slightly elevated in type-2 diabetes mellitus (4.48 ± 0.79) when compared to non-diabetics (4.28 ± 0.89) with a statistically non-significant, p = 0.323. Conclusion: Based on this study, it is concluded that serum sialic acid and serum uric acid levels have been found to be positively associated with type- 2 diabetes mellitus in both men and women, indicating the risk of developing microvascular complications in those patients. Therefore, estimating the sialic acid and uric acid levels can aid in the early diagnosis and prevention of microvascular complications caused by type-2 diabetes mellitus.

scholarly journals Polyherbal antidiabetic drug: An approach to cure diabetes

2020 ◽  
Vol 11 (2) ◽  
pp. 2679-2683
Author(s):  
Ranjit Sidram Ambad ◽  
Gaikwad S B ◽  
Anshula G ◽  
Nandkishor Bankar
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Complete Recovery ◽  
Health Concern ◽  
Diabetic Patients ◽  
Medical College ◽  
The World ◽  
Animal House

In recent years, diabetes has become a major health concern. India is referred to as the diabetes capital of the world. There are plenty of chemical agents available to monitor and treat diabetic patients, but up to this date, no complete recovery from diabetes has been recorded. Many herbal plants with hypoglycemic properties are known from around the world as an alternative to these synthetic agents; which is a natural remedy to keep the blood sugar under control by consuming vegetables & herbs in our diet. Such medicinal plants & their herbal preparation with proven antidiabetic and related beneficial effects were used in the treatment of diabetes in rats. The effect of polyherbal drug Anti-hyperglycemic activity is studied in rats against alloxaninduced diabetes. This polyherbal drug consists of 16 antidiabetic plants. Disorders in diabetes-induced glucose metabolism have been shown to be regulated. The present study was conducted in the Dept. of Pharmacology and Dept. of Biochemistry at Central Animal House Facility of the SBH Govt Medical College, Dhule, in collaboration with Datta Meghe Medical College, (Datta Meghe Institute of Medical Sciences Sawangi, Meghe) Nagpur, Maharashtra, India. After the treatment, fasting blood glucose, plasma insulin and glycosylated hemoglobin (HbA1c) were determined in normal and experimental rats. Polyherbal mixture was seen to be an effective and safe method for management of diabetes which reduces blood sugar levels & shows positive effect in altering blood glucose levels. The herbal formulation could be lowering the insulin resistance, thereby normalizing the uptake of glucose by cells.

scholarly journals Frequency of the anti-glutamic acid decarboxylase immunological marker in patients with diabetes duration longer than three years in southern Brazil

2011 ◽  
Vol 129 (3) ◽  
pp. 130-133 ◽  
Author(s):  
Marina Carolina Moreira ◽  
Gustavo Müller Lara ◽  
Rafael Linden ◽  
Luciane Rosa Feksa ◽  
Rejane Giacomelli Tavares ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Acid Decarboxylase ◽  
Diabetic Patients ◽  
Southern Brazil ◽  
The Mean

CONTEXT AND OBJECTIVE: The anti-GAD (glutamic acid decarboxylase) antibody is considered to be an important marker for type 1 diabetes mellitus (DM1), with frequency that varies depending on the population studied and the duration of the disease. Therefore, the aim of this study was to determine the frequency of this autoantibody in a group of patients in southern Brazil with DM1 that had been diagnosed more than three years previously. DESIGN AND SETTING: Analytical cross-sectional study with a control group conducted at the Biomedicine Laboratory of Universidade Feevale. METHODS: This study was conducted between June 2007 and December 2008, and 109 individuals were enrolled during this period. Fifty-eight were DM1 patients and 51 were individuals free from DM1 and without any history of diabetes, who constituted the control group. RESULTS: In the DM1 group, the mean age was 27 ± 1.7 years and 50% were men. The mean fasting blood glucose in the DM1 group was 208 ± 15 mg/dl and mean HbA1c (glycosylated hemoglobin) was 8.7 ± 0.25%. In the control group, the mean fasting blood glucose and HbA1c were 82 mg/dl and 5.0% respectively. Thirty-seven individuals with DM1 (63.8%) were positive for anti-GAD, and this proportion was significantly larger than in the control group. CONCLUSIONS: These results show the high prevalence of anti-GAD in the population of diabetic patients in southern Brazil, thus indicating that the antibody was still present a long time after the disease had been diagnosed.

scholarly journals ASSOCIATION OF SERUM URIC ACID AND LIPID PROFILE IN TYPE 2 DIABETIC PATIENTS WITH AND WITHOUT DIABETIC RETINOPATHY

2017 ◽  
Vol 10 (6) ◽  
pp. 112
Author(s):  
Ramesh Venkatachalam ◽  
Rathna Kumar ◽  
Ramachandran Kaliaperumal ◽  
Anitha Devaraj ◽  
Anebaracy V ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Uric Acid ◽  
Lipid Profile ◽  
Serum Uric Acid ◽  
Microvascular Complications ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Large Sample Size ◽  
Early Management

Objectives: Diabetic retinopathy (DR) is one of the microvascular complications in type 2 diabetes (T2D).  Elevated serum uric acid (SUA) has been shown to play a significant role in diabetic neuropathy and nephropathy but there is little information on retinopathy. Therefore, the present study was aimed to investigate the SUA and lipid profile in T2D patients with and without DR and the association between SUA and severity of DR.Methods: The study was conducted in the ophthalmology OPD at Sri Lakshmi Narayana Institute of Medical Sciences. The presence of T2D was confirmed by investigating fasting blood glucose level (normal limit < 110 mg/dl) in all the individuals. DR was examined by detailed dilated fundoscopic examination. Based on the fundus examination, patients were divided in to diabetes with signs of DR and those without signs of DR. Age and sex matched healthy were taken as controls. Fasting blood sugar, SUA and lipid profile were investigated for these groups. Results: The study found elevated SUA and abnormal lipid profile in DR group when compared to non-DR and control groups. We also found the significant association between SUA and severity of DR particularly in males.Conclusion: We found a significant association between SUA and severity of DR in T2D patients. Further studies with large sample size are needed to establish the role of elevated SUA and the mechanism involved in the pathogenesis of retinopathy in diabetic patients. Regular measurements of SUA level could be advised to the diabetic patients for the early management.

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