The Effect of Vitamin C Alone or in Combination with Vitamin E on Fasting Blood Glucose , Glycosylated Hemoglobin and Lipid Profile inType 2 Diabetic Patients ( Gaza Strip ) = تأثير فيتامين C بمفرده أو مع فيتامين E على مستوى السكر في حالة الصيام ، مخزون السكر في الجسم و دهون الدم علي مرضى السكري من النوع الثاني في قطاع غزة

2016 ◽  
Vol 9 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Amin T. Hamed ◽  
Sherin M. Al Zinati ◽  
Ashraf Al Swirky
Keyword(s):  
Blood Glucose ◽  
Vitamin E ◽  
Vitamin C ◽  
Lipid Profile ◽  
Gaza Strip ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Diabetic Patients

scholarly journals Profile of Blood Glucose and Insulin after Vitamin C and Vitamin E Supplementation on Active Teenagers

2018 ◽  
Vol 7 (4.26) ◽  
pp. 136
Author(s):  
Irfiansyah Irwadi ◽  
Hayuris Kinandita ◽  
Jamaluddin Mahmud ◽  
Lilik Herawati
Keyword(s):  
Blood Glucose ◽  
Vitamin E ◽  
Vitamin C ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Combination Group ◽  
Control Group ◽  
High Dose ◽  
Moderate Dose ◽  
Significant Difference

Aim: Antioxidants, such as vitamin C and vitamin E, is widely used as supplements. The aim of this study is to analyze the profile of blood glucose, serum insulin, and  HOMA in active teenagers after vitamin C and vitamin E supplementation.Methods: Subjects (14-16 y.o) consisted of 12 boys and 5 girls, divided into 3 groups: control (4 boys, 2 girls), ‘moderate dose’ of vitamin C and vitamin E combination group (5 boys, 1 girls), and ‘high dose’ of vitamin C and vitamin E combination group (3 boys, 2 girls). The treatment was given for 5 days. Vitamin C and vitamin E for ‘moderate dose’ was 500mg;  200IU, and for ‘high dose’ was 1000mg; 400IU. Fasting Blood Glucose (FGB) and 1 hour BG (1hr_BG), fasting serum insulin (FSI) and 1 hour SI (1hr_SI) was collected after treatment. We also calculated the HOMA-IR and HOMA-β.Result: There was no significant difference on FBG, 1hr_BG, FSI, 1hr_SI, HOMA-IR, and HOMA-β (p≥ 0.05). However, mean FBG and 1hr_BG tended to be higher on the treatment groups. The control group had the lowest HOMA-IR and the highest HOMA-β.Conclusions: We suggest that the supplementation of vitamin C and vitamin E in active teenagers is not essential on glucose homeostasis.  

The Insulin Regimen That Works

2018 ◽  
Vol 11 (2) ◽  
pp. 165-168
Author(s):  
Svitlana Crawley ◽  
Susan Chaney
Keyword(s):  
Blood Glucose ◽  
Insulin Therapy ◽  
Nurse Practitioners ◽  
Basal Insulin ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Insulin Regimen ◽  
Acting Insulin ◽  
Antihyperglycemic Therapy

Background: Type 2 diabetes mellitus requires monitoring patients’ glycemic control. Treatment must be escalated if glucose levels remain above the recommended goal in patients who are adherent to their current treatment. If glycosylated hemoglobin (HbA1c) levels remain unmet with maximum doses as recommended by the American Diabetes Association (ADA) after adding basal insulin, but fasting blood glucose is at goal, one to three injections daily of rapid-acting insulin are typically added to the treatment plan to be injected prior to meals while continuing all other antihyperglycemic medications. Objective: To describe an effective method of intensifying insulin therapy based on patients’ needs and abilities to self-manage their medications. Methods: We retrospectively reviewed the case of a patient who was referred to the Endocrinology Specialty Clinic for diabetes management. Results: Diabetes control was improved after intensifying insulin therapy by adding once-daily rapid-acting insulin injections. Conclusions: Intensifying insulin therapy by adding one dose of rapid-acting insulin prior to meals can improve HbA1c to < 7% in patients on maximum doses of basal insulin whose fasting blood glucose is at goal but whose HbA1c is above goal. Implications for Nursing: Nurse practitioners must use current care guidelines supported by evidence-based literature to improve patients’ outcomes. This case study supports ADA recommendations on early intensification of antihyperglycemic therapy in diabetic patients to decrease the risk of complications by achieving and maintaining HbA1c goals early.

scholarly journals Polyherbal antidiabetic drug: An approach to cure diabetes

2020 ◽  
Vol 11 (2) ◽  
pp. 2679-2683
Author(s):  
Ranjit Sidram Ambad ◽  
Gaikwad S B ◽  
Anshula G ◽  
Nandkishor Bankar
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Complete Recovery ◽  
Health Concern ◽  
Diabetic Patients ◽  
Medical College ◽  
The World ◽  
Animal House

In recent years, diabetes has become a major health concern. India is referred to as the diabetes capital of the world. There are plenty of chemical agents available to monitor and treat diabetic patients, but up to this date, no complete recovery from diabetes has been recorded. Many herbal plants with hypoglycemic properties are known from around the world as an alternative to these synthetic agents; which is a natural remedy to keep the blood sugar under control by consuming vegetables & herbs in our diet. Such medicinal plants & their herbal preparation with proven antidiabetic and related beneficial effects were used in the treatment of diabetes in rats. The effect of polyherbal drug Anti-hyperglycemic activity is studied in rats against alloxaninduced diabetes. This polyherbal drug consists of 16 antidiabetic plants. Disorders in diabetes-induced glucose metabolism have been shown to be regulated. The present study was conducted in the Dept. of Pharmacology and Dept. of Biochemistry at Central Animal House Facility of the SBH Govt Medical College, Dhule, in collaboration with Datta Meghe Medical College, (Datta Meghe Institute of Medical Sciences Sawangi, Meghe) Nagpur, Maharashtra, India. After the treatment, fasting blood glucose, plasma insulin and glycosylated hemoglobin (HbA1c) were determined in normal and experimental rats. Polyherbal mixture was seen to be an effective and safe method for management of diabetes which reduces blood sugar levels & shows positive effect in altering blood glucose levels. The herbal formulation could be lowering the insulin resistance, thereby normalizing the uptake of glucose by cells.

scholarly journals Frequency of the anti-glutamic acid decarboxylase immunological marker in patients with diabetes duration longer than three years in southern Brazil

2011 ◽  
Vol 129 (3) ◽  
pp. 130-133 ◽  
Author(s):  
Marina Carolina Moreira ◽  
Gustavo Müller Lara ◽  
Rafael Linden ◽  
Luciane Rosa Feksa ◽  
Rejane Giacomelli Tavares ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Acid Decarboxylase ◽  
Diabetic Patients ◽  
Southern Brazil ◽  
The Mean

CONTEXT AND OBJECTIVE: The anti-GAD (glutamic acid decarboxylase) antibody is considered to be an important marker for type 1 diabetes mellitus (DM1), with frequency that varies depending on the population studied and the duration of the disease. Therefore, the aim of this study was to determine the frequency of this autoantibody in a group of patients in southern Brazil with DM1 that had been diagnosed more than three years previously. DESIGN AND SETTING: Analytical cross-sectional study with a control group conducted at the Biomedicine Laboratory of Universidade Feevale. METHODS: This study was conducted between June 2007 and December 2008, and 109 individuals were enrolled during this period. Fifty-eight were DM1 patients and 51 were individuals free from DM1 and without any history of diabetes, who constituted the control group. RESULTS: In the DM1 group, the mean age was 27 ± 1.7 years and 50% were men. The mean fasting blood glucose in the DM1 group was 208 ± 15 mg/dl and mean HbA1c (glycosylated hemoglobin) was 8.7 ± 0.25%. In the control group, the mean fasting blood glucose and HbA1c were 82 mg/dl and 5.0% respectively. Thirty-seven individuals with DM1 (63.8%) were positive for anti-GAD, and this proportion was significantly larger than in the control group. CONCLUSIONS: These results show the high prevalence of anti-GAD in the population of diabetic patients in southern Brazil, thus indicating that the antibody was still present a long time after the disease had been diagnosed.

scholarly journals The Correlation between Serum Uric Acid and Renal Function in Elderly Chinese Diabetes with Normoalbuminuria

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Qiaojing Qin ◽  
Yingjun Qian ◽  
Guanghua Zhu ◽  
Weifeng Fan ◽  
Jianying Niu ◽  
...  
Keyword(s):  
Renal Function ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Pearson Correlation ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Urine Ph ◽  
Elderly Chinese

Objective. The elder diabetic patients increases rapidly in China and often accompany with hyperuricemia. Recently evidences show that renal function has been impaired in part of diabetic patients with normoalbuminuria. Therefore, we investigated the relationship between serum uric acid (SUA) and renal function in Chinese elder diabetes with normoalbuminuria. Methods. The physical examination data from 1052 cases of diabetic residents with normoalbuminuria aged 70 years and over in the Jiangchuan community of Minhang District, Shanghai, from October 2011 to September 2014 was analyzed retrospectively. Each received height, body weight, waist circumference (WC), waist-to-hip ratio (WHR), blood pressure (BP), and collected samples of fasting blood and morning urine to detect blood routine, blood glucose, glycosylated hemoglobin (HbA1c), blood lipids, serum creatinine, urinary albumin, urine creatinine, and urine PH value. Correlation between SUA and renal function, an index of which is estimated using estimated glomerular filtration rate (eGFR), was analyzed. Results. The prevalence of hyperuricemia was 21.10%. Levels of WC and triglyceride (TG) increased and the levels of HbA1c, high density lipoprotein-cholesterol (HDL-C), eGFR, and urine PH decreased while the levels of SUA increased. Moreover, negative correlation of eGFR with age, WC, leukocyte, and SUA (Pearson r=0.415) was observed via Pearson correlation analysis. It indicates the strong association between SUA and eGFR. Furthermore, eGFR independently associated with SUA, age, leukocyte, hemoglobin (Hb), and fasting blood glucose (FBG) was confirmed by multiple linear stepwise regression analysis. Conclusion. SUA may play an important role in the decrease of eGFR in elderly Chinese diabetic patients with normoalbuminuria.

Relation of Vitamins in Diabetes Melliatus

2018 ◽  
Vol 3 (04) ◽  
Author(s):  
Dr. Vaibhav D. Lotake ◽  
Dr. Supriya Barsode
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Blood Glucose ◽  
Vitamin C ◽  
Vitamin B12 ◽  
Glycosylated Hemoglobin ◽  
Active Form ◽  
Diabetic Patients ◽  
Plasma Vitamin ◽  
Long Term Treatment

Introduction Diabetes is a chronic metabolic disorder which is linked to energy metabolism, particularly carbohydrate and fat.  Obesity and physical inactivity are shown to be the major risk factors for type 2 diabetes (T2DM). Oxidative stress may also contribute to increase in blood glucose levels, thus contribute to the pathogenesis of T2DM by increasing insulin resistance or impairing insulin secretion.[1] The consequences and complications of diabetes are due to imbalance between free radical formation and their control by natural antioxidants.[2] Thus nutrients having antioxidant function are important in disease development and control also non oxidant vitamins have also shown relationship with diabetes.[3] Long-term treatment of diabetic patients with metformin may cause a higher risk of developing vitamin B-12 deficiency.[4] Vitamin A plays important role as antioxidant, thus helping to maintain the organism’s homeostasis when subjected to various forms of stress.[5] Vitamin B6 consists of a group of three compounds: Pyridoxal, pyridoxine and pyridoxamine, and their corresponding phosphorylase forms and the active form of this vitamin is pyridoxal-5’-phospate (PLP).  In new diabetic patients lower PLP concentrations were found as compared to non-diabetic persons.[6] Niacin or B3, Nicotinic acid is a component of NAD and NADH, which are essential for ATP production and energy efficiency at the cellular level and has been found to increase HDL-cholesterol, decreases TG and LDL cholesterol.[7] As T2DM is an oxidative stress disease; vitamin B12 and folic acid deficiencies in diabetic subjects have been found associated to oxidative stress so it is conceivable that vitamin B12 deficiency should be considered a risk factor for diabetic complications.[8] Plasma vitamin C concentrations have been inversely correlated to glycosylated hemoglobin and fasting and postprandial blood, Vitamin C has also been shown to reduce anxiety levels.[9] and supplementation for 3 months of vitamins C and E decreases hypertension, blood glucose while increasing superoxide dismutase and glutathione levels.[10] Vitamin D may play an important role in modifying the risk of diabetes.[11] The role of vitamin D in the function of pancreatic cells can be mediated by the union of 1,25-dihydroxyvitamin D to its receptors in the beta cell.[12]

scholarly journals Relationship of Glycated Haemoglobin with Lipid Profile among Patients with Type 2 Diabetes Mellitus

2017 ◽  
Vol 7 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Tasrina Shamnaz Samdani ◽  
Palash Mitra ◽  
Muhammad Abdur Rahim
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Significant Positive Correlation ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Positive Correlation

Background: Glycated hemoglobin (HbA1c) is widely used as an index of mean glycaemia, a measure of risk for the development of diabetic complications and a measure of the quality of diabetes care. Patients with type 2 diabetes have an increased prevalence of dyslipidemia. Treatment of dyslipidaemia improves cardiovascular outcomes. The aim of this study was to determine the impact of glycemic control on lipid profile.Methods: This cross-sectional study was conducted among 300 type 2 diabetic patients admitted in BIRDEM General Hospital from November 2013 to April 2015. Fasting blood samples were collected and different lipid fractions along with fasting blood glucose and HbA1c were estimated. Pearson’s correlation test was applied to evaluate the correlation between HbA1c and components of lipid profile.Results: The mean value of total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDLC), fasting blood glucose (FBG) and HbA1c were higher and high density lipoprotein-cholesterol (HDL-C) was lower in females when compared with these values for males. HbA1c had significant positive correlation with LDL-C (p=0.045) and negative correlation with HDL-C (p=0.024). Serum lipid profile and glycaemic controls were significantly (p=0.000) better in older age group (age ? 50 years).Conclusions: Significant positive correlation of HbA1c with lipid profiles specially LDL-C suggested that HbA1c can also be used as predictor of dyslipidemia in addition to glycemic control.Birdem Med J 2017; 7(1): 43-47

scholarly journals Medication Adherence to Oral Hypoglycemic Agents Among Type II Diabetic Patients and Their Clinical Outcomes with Special Reference to Fasting Blood Glucose and Glycosylated Hemoglobin Levels

2015 ◽  
Vol 11 (3) ◽  
pp. 226-232 ◽  
Author(s):  
SS Shrestha ◽  
R Shakya ◽  
BM Karmacharya ◽  
P Thapa
Keyword(s):  
Blood Glucose ◽  
Glycemic Control ◽  
Special Reference ◽  
Clinical Outcomes ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Age Group ◽  
Oral Hypoglycemic Agents

Background Oral hypoglycemic agents (OHAs) are the major treatment for people with type 2 diabetes mellitus (DM2). However, non-adherence to OHAs remains as one of the main reasons for poor glycemic control. Objectives To assess the adherence pattern to OHAs and clinical outcomes with special reference to fasting blood glucose (FBG) level and glycosylated hemoglobin (HbA1c) levels. Methods Informed consent was obtained from patients fulfilling the criteria and from the patient party in case of incapacitated patients. Information was obtained by interviewing them and filled in the appropriate questionnaire. All the medical information of the patients was obtained from the medical case records and laboratory reports. Results OHAs had been discontinued by 25% of patients. Overall 38% had ever discontinued and/ or often missed OHAs. Intentional discontinuation of OHAs attributed for 72% of the patients, followed by forgetfulness (42.9%), carelessness (30.6%), and hypoglycemia, (24%). There were 50.50% patients who had uncontrolled FBG (>130 mg/dl) level and 39% had uncontrolled HbA1c (≥ 7%) level. Taking reference age group 51-60 years, control of FBG level was found to be statistically associated with the decreasing age group (p = 0.006, OR = 4.8) as well as increasing age group (p = 0.008, OR = 4.034). There was significant association between controlled HbA1c level and patients’ knowledge about the precautions to be taken while using OHAs (p = 0.044, OR = 4). However, there was no significant association between glycemic control and OHAs adherence. Conclusion Majority of the patients who had missed OHAs attributed it to forgetfulness. Hypoglycemia may also be one of the contributing factors for poor adherence to OHAs. However no association was found between adherence and various other factors like age groups, treatment complexity, health literacy and social or family support. DOI: http://dx.doi.org/10.3126/kumj.v11i3.12508 Kathmandu Univ Med J 2013; 43(3):226-232

scholarly journals The Potential Anti-Obesity, Anti-Diabetic and Anti-Oxidant Effects of Vitamin a in Streptozotocin-Induced Diabetic Mice

2021 ◽  
pp. 50-64
Author(s):  
Yosra Alhindi ◽  
Anwar Bafaraj ◽  
Abeer Barasain ◽  
Massarah Hadidi ◽  
Norah Bajandooh ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Vitamin A ◽  
Lipid Profile ◽  
Fat Mass ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Diabetic Mice ◽  
Water Control

Background: Evidence suggests that there is a link between diabetes mellitus and Vitamin A. Moreover, it has been reported that diabetes induces oxidative stress. Lately, a wide attention has been developed to the protective biochemical function of natural antioxidants contained vitamins, which can reduce the oxidative damage caused by free radical species. Objective: To investigate the anti-obesity, anti-diabetic and anti-oxidative effects of vitamin A in streptozotocin (STZ)-induced diabetic mice. Methods: Male mice were randomly divided into three groups: Control- nondiabetic, received a normal diet and water; Control-diabetic, received STZ 45mg/kg once intraperitoneally; and Treated-diabetic, received both STZ as before plus Vitamin A (4-IU/day) orally daily for 16 weeks. Food intake, body weight, fat mass, fasting blood glucose, serum insulin, and lipid profile were estimated. Also, superoxide dismutase (SOD), glutathione peroxidase (GPO), catalase (CAT), and malonaldehyde (MDA) were measured. Results: Treated diabetic mice with Vitamin A showed a significant improvement in their body weight, fat mass, lipid profile as well as SOD, GPO and CAT compared to Control-diabetic mice. However, Vitamin A caused no significant change on fasting blood glucose and insulin levels. Furthermore, plasma level of MDA was significantly elevated in diabetic mice compared to normal mice. Diabetic mice treated with vitamin A had a significantly reduced level of MDA, suggesting that vitamin A might have a vital role in the protection of tissues from damage by free radicals. Conclusion: Supplementation with vitamin A may be a useful treatment strategy for diabetic patients to reduce/prevent the pathological complications of diabetes.

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