scholarly journals Effect of Saffron Extract and Crocin in Serum Metabolites of Induced Obesity Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Fatin Najwa Ramli ◽  
Azliana Abu Bakar Sajak ◽  
Faridah Abas ◽  
Zulfitri Azuan Mat Daud ◽  
Azrina Azlan
Keyword(s):  
High Fat Diet ◽  
Crocus Sativus ◽  
Proton Nuclear Magnetic Resonance ◽  
High Fat ◽  
H Nmr ◽  
Metabolite Profiles ◽  
Obese Rats ◽  
Saffron Extract ◽  
Primary Compound ◽  
Different Doses

The effect of saffron extract (Crocus sativus L.) and its primary compound crocin was studied on an induced obesity rat model. Our study is aimed at investigating and comparing the metabolite changes in obese and obese treated with saffron extract and crocin and at improving the understanding of the therapeutic effect of saffron extract and crocin. Two different doses of saffron extracts and crocin (40 and 80 mg/kg) were incorporated in a high-fat diet (HFD) and were given for eight weeks to the obese rats. The changes in metabolite profiles of the serum were determined using proton nuclear magnetic resonance (1H-NMR). Pattern recognition by multivariate data analysis (MVDA) showed that saffron extract and crocin at 80 mg/kg was the best dosage compared to 40 mg/kg. It also showed that both treatments work in different pathways, especially concerning glucose, lipid, and creatinine metabolism. In conclusion, although the pure compound, crocin, is superior to the saffron crude extract, this finding suggested that the saffron extract can be considered as an alternative aside from crocin in treating obesity.

scholarly journals Protective effects of saffron extract and crocin supplementation on fatty liver tissue of high-fat diet-induced obese rats

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Maryam Mashmoul ◽  
Azrina Azlan ◽  
Norhafizah Mohtarrudin ◽  
Barakatun Nisak Mohd Yusof ◽  
Huzwah Khaza’ai ◽  
...  
Keyword(s):  
Fatty Liver ◽  
High Fat Diet ◽  
Liver Tissue ◽  
Protective Effects ◽  
High Fat ◽  
Obese Rats ◽  
Saffron Extract

Antiobesity activity of fermentedAngelicae gigantisby high fat diet-induced obese rats

2011 ◽  
pp. 1-11 ◽  
Author(s):  
Jae-Young Cha ◽  
Jae-Jun Jeong ◽  
Chang-Su Park ◽  
Hee-Young Ahn ◽  
Hyung-In Moon ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Obese Rats

Anti-obesity and anti-inflammatory effects of high hydrostatic pressure extracts of ginseng in high-fat diet induced obese rats

2014 ◽  
Vol 10 ◽  
pp. 169-177 ◽  
Author(s):  
Sunyoon Jung ◽  
Mak-Soon Lee ◽  
Yoonjin Shin ◽  
Chong-Tai Kim ◽  
In-Hwan Kim ◽  
...  
Keyword(s):  
Hydrostatic Pressure ◽  
High Hydrostatic Pressure ◽  
High Fat Diet ◽  
High Fat ◽  
Obese Rats ◽  
Anti Inflammatory

scholarly journals POTENTIAL OF DUNALIELLA SALINA MICROALGAE TO AMELIORATE HIGH-FAT DIET‑INDUCED OBESITY IN ANIMALS’ RODENT

2018 ◽  
Vol 11 (3) ◽  
pp. 312 ◽  
Author(s):  
Farouk K El-baz ◽  
Hanan F Aly
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Dunaliella Salina ◽  
Body Weight Gain ◽  
Ethanolic Extract ◽  
High Fat ◽  
Related Complication ◽  
Standard Drug ◽  
Reduced Body ◽  
Obese Rats

 Objective: This study was carried out to investigate the potential of Dunaliella salina microalgae to ameliorate obesity induced by high-fat diet (HFD) in male Wistar rats.Methods: Fifty rats weighing 150–160 g were fed HFD for 12 weeks. The rats were randomly divided into five groups of ten rats each. Obese rats were orally administered D. salina ethanolic extract (150 mg/Kg body weight), and orlistat as standard drug (12 mg/Kg body weight), for 6 weeks.Results: Treatment of obese rats with both D. salina and orlistat had a significant effect in reducing body and liver weights as well as visceral fat, inhibiting pancreatic lipase activity, decreased lipid profile, and increased fecal fat and ameliorating liver function enzymes activity, insulin, blood glucose, and leptin levels. Besides, food intake was insignificantly increased as a result of D. salina and orlistat treatments compared with normal control rats.Conclusion: It could be concluded that D. salina rich in β-carotene significantly reduced body weight gain and ameliorated several metabolic pathways implicated in obesity and its related complication. Hence, further intensive study must be carried out to formulate D. Salina extracts to apply as a promising natural anti-obesity nutraceutical drug.

The ameliorative effect of the Pyracantha fortuneana (Maxim.) H. L. Li extract on intestinal barrier dysfunction through modulating glycolipid digestion and gut microbiota in high fat diet-fed rats

2019 ◽  
Vol 10 (10) ◽  
pp. 6517-6532 ◽  
Author(s):  
Hang Xu ◽  
Chunfang Zhao ◽  
Yutian Li ◽  
Ruiyu Liu ◽  
Mingzhang Ao ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Intestinal Barrier ◽  
High Fat ◽  
Barrier Dysfunction ◽  
Fruit Extract ◽  
Intestinal Barrier Dysfunction ◽  
Beneficial Effects ◽  
Obese Rats ◽  
Ameliorative Effect

Pyracantha fortuneana fruit extract (PFE) exhibits beneficial effects on IBF in association with the modulation of glycolipid digestion and gut microbiota in HFD-fed obese rats.

Hepatoprotective effect of coffee pulp aqueous extract combined with simvastatin against hepatic steatosis in high-fat diet-induced obese rats

2019 ◽  
Vol 54 ◽  
pp. 568-577 ◽  
Author(s):  
Atcharaporn Ontawong ◽  
Oranit Boonphang ◽  
Tipthida Pasachan ◽  
Acharaporn Duangjai ◽  
Anchalee Pongchaidecha ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Aqueous Extract ◽  
High Fat Diet ◽  
Hepatoprotective Effect ◽  
High Fat ◽  
Coffee Pulp ◽  
Obese Rats
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