scholarly journals Development of Polymer and Surfactant Based Naringenin Nanosuspension for Improvement of Stability, Antioxidant, and Antitumour Activity

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Shadab Md ◽  
Nabil A. Alhakamy ◽  
Sohail Akhter ◽  
Zuhier A. Y. Awan ◽  
Hibah M. Aldawsari ◽  
...  
Keyword(s):  
Particle Size ◽  
Antitumor Activity ◽  
Sodium Dodecyl Sulfate ◽  
Drug Release ◽  
Size Distribution ◽  
Hydroxypropyl Methylcellulose ◽  
Sodium Dodecyl ◽  
Average Particle ◽  
Dodecyl Sulfate

Nanosuspensions are widely reported to enhance the solubility of poorly soluble drugs. In addition to enhancement in solubility, improvement of stability and therapeutic efficacy would be an added advantage. In the present study, premilling and subsequent high-pressure homogenization were carried out to produce naringenin nanosuspension. Hydroxypropyl methylcellulose and sodium dodecyl sulfate were evaluated for their performance as stabilizers under various homogenization cycles. The prepared nanosuspensions were studied for average particle size and size distribution, zeta potential, solubility, drug release, antioxidant activity, and in vitro antitumor activity. It was observed that both hydroxypropyl methylcellulose-stabilized nanosuspension and sodium dodecyl sulfate-stabilized nanosuspension produced an enhancement in physical stability, antioxidant potential, and in vitro cytotoxicity compared with naringenin. Furthermore, hydroxypropyl methylcellulose-stabilized nanosuspension was found to be better than sodium dodecyl sulfate-stabilized nanosuspension in terms of particle size and size distribution, storage stability, and drug release. This study showed that nanosuspension formulations could be a potential strategy for improving dissolution and antitumor activity of naringenin.

Determination of Particle Size in Latex

1953 ◽  
Vol 26 (2) ◽  
pp. 481-486 ◽  
Author(s):  
E. G. Cockbain
Keyword(s):  
Particle Size ◽  
Sodium Dodecyl Sulfate ◽  
Natural Rubber ◽  
Sodium Dodecyl ◽  
Average Particle ◽  
Particle Sizes ◽  
Sulfate Concentration ◽  
Titration Method ◽  
Dodecyl Sulfate

Abstract The soap titration method of determining average particle sizes in synthetic latexes has been modified so as to make it applicable to natural rubber latexes. The method consists essentially in determining the distribution of an added detergent (sodium dodecyl sulfate) between the rubber and aqueous phases at a pH of approximately 6.0, the total dodecyl sulfate concentration being just sufficient for the formation of micelles in the aqueous phase. The average particle sizes of nine ammoniated latexes have been measured, including centrifuged and electrodecanted concentrates, two clonal field latexes and a sample of latex skim.

scholarly journals Formulation and Evaluation of Mucoadhesive Acarbose Microspheres

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Manish Kumar Sharma
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Guar Gum ◽  
Hydroxypropyl Methylcellulose ◽  
Average Particle Size ◽  
Prolonged Release ◽  
Average Particle ◽  
In Vitro Drug Release ◽  
In Vitro Adhesion

The purpose of the present investigation was the formulation and characterization of mucoadhesive sustained release microsphere of antidibetic drug Acarbose that would adhere in mucosa and release continuously to provide long term effect. There was various formulations of Acarbose were prepared by solvent evaporation technique using hydroxypropyl methylcellulose (HPMC), Sodium Alginate, Carbopol, Xanthan gum, Guar gum as a polymer. The prepared mucoadhesive microspheres were evaluated for particle size, surface morphology, drug entrapment efficiency, Drug content, buoyancy percentage and In-vitro drug release, In-vitro adhesion test and stability studies. The particle was found to be discrete and spherical with the average particle size in the range of 105.5 to 413.5μm. As the concentration of polymers increases it affects the various evaluation parameters like particle size, in-vitro drug release and In-vitro adhesion. The floating microspheres of optimized formulation exhibited the prolonged release of 85.8% in continuous manner up to 12 hrs. It is concluded that the optimized formulation of Acarbose mucoadhesive microspheres can be selected for sustained drug delivery system for improved bioavailability.

scholarly journals Chitosan/Sodium Dodecyl Sulfate Complexes for Microencapsulation of Vitamin E and Its Release Profile—Understanding the Effect of Anionic Surfactant

2021 ◽  
Vol 15 (1) ◽  
pp. 54
Author(s):  
Jelena Milinković Budinčić ◽  
Lidija Petrović ◽  
Ljiljana Đekić ◽  
Milijana Aleksić ◽  
Jadranka Fraj ◽  
...  
Keyword(s):  
Vitamin E ◽  
Sodium Dodecyl Sulfate ◽  
Anionic Surfactant ◽  
Sodium Dodecyl ◽  
Pharmaceutical Products ◽  
Release Mechanism ◽  
Bioactive Substances ◽  
Water Emulsion ◽  
Dodecyl Sulfate

Microencapsulation of bioactive substances is a common strategy for their protection and release rate control. The use of chitosan (Ch) is particularly promising due to its abundance, biocompatibility, and interaction with anionic surfactants to form complexes of different characteristics with relevance for use in microcapsule wall design. In this study, Ch/sodium dodecyl sulfate (SDS) microcapsules, without and with cross-linking agent (formaldehyde (FA) or glutaraldehyde (GA)), were obtained by the spray drying of vitamin E loaded oil-in-water emulsion. All of the microcapsules had good stability during the drying process. Depending on the composition, their product yield, moisture content, and encapsulation efficiency varied between 11–34%, 1.14–1.62%, and 94–126%, respectively. SEM and FTIR analysis results indicate that SDS as well as cross-linkers significantly affected the microcapsule wall properties. The profiles of in vitro vitamin E release from the investigated microcapsules fit with the Korsmeyer-Peppas model (r2 > 0.9). The chemical structure of the anionic surfactant was found to have a significant effect on the vitamin E release mechanism. Ch/SDS coacervates may build a microcapsule wall without toxic crosslinkers. This enabled the combined diffusion/swelling based release mechanism of the encapsulated lipophilic substance, which can be considered favorable for utilization in food and pharmaceutical products.

Particle Size Distribution of ZrO2:Pr3+ – Influences of pH, High Power Ultrasound, Surfactant and Dopant Quantity

2007 ◽  
Vol 128 ◽  
pp. 97-100 ◽  
Author(s):  
Stephanie Möller ◽  
Janusz D. Fidelus ◽  
Witold Łojkowski
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
High Power ◽  
Average Particle Size ◽  
Sodium Dodecyl ◽  
Average Particle ◽  
Power Ultrasound ◽  
High Power Ultrasound ◽  
Influence Of Ph

The aim of the work was to examine the influence of pH, high power ultrasound, surfactant and dopant quantity on the particle size distribution of ZrO2:Pr3+, with praseodymium content varying between 0.05 and 10 %. The nanopowders were obtained via a hydrothermal microwave driven process. To establish if the dopant was located on the surface of the zirconia nanoparticles, the particle size distribution, as a function of pH, was measured to obtain an estimate of the isoelectric point of the samples. All results indicated that the dopant was concentrated on the surface: the measurements of the particle size distribution show that the pH corresponding to maximum average particle size changes towards higher values when the Pr content increases. Measurements of the particle size distribution dependency on the application of high power ultrasound and the addition of the sodium dodecyl sulphate surfactant show that, under certain conditions, there is a better stabilisation of the nanopowders in a dispersion and undesirable agglomeration is hindered.

scholarly journals Comparative In Vitro Sensitivities of Human Immune Cell Lines, Vaginal and Cervical Epithelial Cell Lines, and Primary Cells to Candidate Microbicides Nonoxynol 9, C31G, and Sodium Dodecyl Sulfate

2002 ◽  
Vol 46 (7) ◽  
pp. 2292-2298 ◽  
Author(s):  
Fred C. Krebs ◽  
Shendra R. Miller ◽  
Bradley J. Catalone ◽  
Raina Fichorova ◽  
Deborah Anderson ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Sodium Dodecyl Sulfate ◽  
Cell Viability ◽  
Cell Lines ◽  
Sodium Dodecyl ◽  
Primary Cells ◽  
Cytokine Activation ◽  
Dodecyl Sulfate ◽  
Human Immune

ABSTRACT In experiments to assess the in vitro impact of the candidate microbicides nonoxynol 9 (N-9), C31G, and sodium dodecyl sulfate (SDS) on human immune and epithelial cell viability, cell lines and primary cell populations of lymphocytic and monocytic origin were generally shown to be equally sensitive to exposures ranging from 10 min to 48 h. However, U-937 cells were more sensitive to N-9 and C31G after 48 h than were primary monocyte-derived macrophages. Cytokine activation of monocytes and lymphocytes had no effect on cell viability following exposure to these microbicidal compounds. Primary and passaged vaginal epithelial cultures and cell lines differed in sensitivity to N-9 and C31G but not SDS. These studies provide a foundation for in vitro experiments in which cell lines of human immune and epithelial origin can be used as suitable surrogates for primary cells to further investigate the effects of microbicides on cell metabolism, membrane composition, and integrity and the effects of cell type, proliferation, and differentiation on microbicide sensitivity.

scholarly journals Development and Evaluation of Floating Microspheres of Sumatriptan Succinate using Ethyl Cellulose and Mucilage Extracted from Vigna Mungo

2021 ◽  
pp. 24-36
Author(s):  
Nilesh S. Kulkarni ◽  
Mukta A. Kulkarni ◽  
Rahul H. Khiste ◽  
Mohini C. Upadhye ◽  
Shashikant N. Dhole
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Ethyl Cellulose ◽  
Polymer Concentration ◽  
Average Particle Size ◽  
Entrapment Efficiency ◽  
Vigna Mungo ◽  
Average Particle ◽  
Sumatriptan Succinate

Aim: The present investigation is to formulate and evaluate gastroretentive floating microspheres for sumatriptan succinate. Gastric retention is widely used approach to retain dosage form in stomach and to enhance absorption of drugs. Methods: The gastroretentive floating microspheres was prepared by two different techniques as solvent evaporation and W/O/W multiple emulsion technique. Ethyl cellulose, HPMC K4M polymer and mucilage extracted from Vigna Mungo in various proportions were used for formulation of microspheres. Combination of ethyl acetate and acetone in different proportion was used as organic phase and the microspheres were characterized for particle size, shape, morphology, percentage yield, entrapment efficiency, drug loading, In-Vitro Floating/Buoyancy study, In-vitro Floating/Buoyancy study and release kinetics. Results: The average particle size of all batches was found in the range 100 to 210 μm and the entrapment efficiency of all formulations was found in the range of 17.46 % to 59.28 %.Total floating time for Sumatriptan succinate floating microspheres was observed more than 12 h. The In-Vitro drug release study was performed for all formulations showed drug release in controlled manner. Conclusion: The particle size was increased with increased polymer concentration and it showed that polymer concentration has an impact on the entrapment efficiency. Ethyl cellulose microspheres showed more entrapment and sustained delivery of sumatriptan Succinate than microspheres prepared by combination of Ethyl cellulose: HPMC K4M and Ethyl cellulose: Vigna mungo mucilage.

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