scholarly journals Phytochemicals as Potential Anticancer Drugs: Time to Ponder Nature’s Bounty

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Mohammad Arif Ashraf
Keyword(s):  
Drug Delivery ◽  
Herbal Medicine ◽  
Medicinal Plants ◽  
Anticancer Drugs ◽  
Target Genes ◽  
Potential Drug ◽  
Traditional Herbal Medicine ◽  
Information Gap ◽  
Pharmaceutical Industries ◽  
Synthetic Drug

Medicinal plants have been used from the beginning of human civilization, which is mostly evident from the ancient script and traditional herbal medicine recipe. Despite the historically enriched demonstration about the use of plant as therapeutics, the pharmaceutical industries lack interest on phytochemical research compared with synthetic drug. Mostly, the absence of information about plant-based medicinal therapeutics is responsible to draw the attention of researchers to think about natural products as potential drug for detrimental diseases, such as cancer. This review will cover about clinically successful plant-based anticancer drugs and underappreciated, but potential, drugs to bridge the information gap between plant biologists and clinical researchers. Additionally, unprecedented advancement of synthetic chemistry, omics study to pin point the target genes/proteins, and efficient drug delivery system have made it easier for researchers to develop a phytochemical as an efficient anticancer drug.

scholarly journals Ethnopharmacological Survey of Herbal Remedies Used for the Treatment of Cancer in the Greater Casablanca-Morocco

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Mohammed Bourhia ◽  
Abdelaaty Abdelaziz Shahat ◽  
Omer Mohammed Almarfadi ◽  
Fahd Ali Naser ◽  
Wael Mostafa Abdelmageed ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Cancer Treatment ◽  
Traditional Medicine ◽  
Local Population ◽  
Traditional Healers ◽  
Herbal Remedies ◽  
Traditional Herbal Medicine ◽  
Ethnobotanical Survey ◽  
Scientific Validity

Medicinal plants played an important role in traditional medicine for the treatment of diseases since antiquities. The aim of the study is to carry out an ethnobotanical survey on medicinal plants used traditionally in cancer treatment in the region of Greater Casablanca-Morocco, and to enhance the traditional herbal medicine knowledge. 110 traditional healers in the study area were interviewed face to face to response a survey questionnaire including the names of plants used in cancer treatment, used parts, methods of preparation, and route of administration. Indices of Fidelity Level (FL), Use Value (UV), and Relative Frequency of Citation (RFC) were calculated to identify the most effective plants used for cancer treatment. Eight species were specified including Aristolochia baetica, Aristolochia paucinervis, Bryonia dioica, Aquilaria malaccensis, Marrubium vulgare, Lavandula maroccana, Ephedra alata, and Euphorbia resinifera belonging to 7 families. Aristolochiaceae, Aquilariaceae, and Cucurbitaceae were the most useful families in cancer treatment with high significant indices of UV, FL, and RFC with values of 1, 100%, and 1, respectively. Roots and leaves were the most commonly used plant parts. Decoction and powder mixed with honey were the frequently used method for remedies preparation. The present study showed that the people living in Morocco’s economic capital are still highly dependent on traditional herbal medicine for the treatment of cancer. Therefore, it seems that herbal medicine still plays a crucial role in the primary healthcare system for the local population. During this survey, it was reported that even some plant families are highly toxic for humans like Aristolochiaceae that are frequently used in cancer treatment in the study area. As many people still rely on natural traditional medicine considering (it is safe with no side effects), so combined effort between all social categories including scientists and traditional healers should be established for involving the scientific validity of the used plants in the treatment of diseases.

scholarly journals Nature as a Treasure Trove for Anti-COVID-19: Luteolin and Naringenin from Indonesian Traditional Herbal Medicine Reveal Potential SARS-CoV-2 Mpro Inhibitors Insight from in Silico Studies

2020 ◽  
Author(s):  
Wahyu Prasetyo ◽  
Triana Kusumaningsih ◽  
Maulidan Firdaus
Keyword(s):  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Medicinal Plants ◽  
Small Molecule ◽  
In Silico ◽  
Dft Studies ◽  
Traditional Herbal Medicine ◽  
In Silico Studies ◽  
Bioactive Phytochemicals

<div>Since the worldwide is currently facing the COVID-19 pandemic, there are no drugs or vaccines have been approved</div><div>for the treatment of SARS-CoV-2 infection. Therefore, there is an urgent need for in-depth research on emerging</div><div>human infectious coronaviruses. As part of our endeavour in combating this COVID-19 pandemic, in this paper, we</div><div>report on the discovery of an active antiviral small-molecule from Indonesian traditional herbal medicine used in Jamu</div><div>to inhibit 3CLpro of SARS-CoV-2 using in-silico approaches. As one of the mega biodiversity countries, Indonesia has</div><div>more than 1,180 species that can be prospected for medicine plants. Jamu, the Indonesian traditional herbal medicine,</div><div>is supposed to have similar potentials as those of traditional Chinese medicine (TCM). However, due to the lack of</div><div>scientific proof, Jamu is not recognised in the Guideline of COVID-19 Patients, particularly in Indonesia. Thus, in</div><div>this study, we performed virtual docking screening along with pharmacokinetic and DFT studies of selected 49</div><div>bioactive phytochemicals from several medicinal plants used in Jamu against the 3CLpro enzyme of SARS-CoV-2.</div><div>From the result, it was noted that from a set of 49 phytochemicals of medicinal plants used in Jamu, 2 phytochemicals,</div><div>i.e., Luteolin and Naringenin were identified as potential druggable inhibitors candidates of 3CLpro of SARS CoV-2.</div>

DOSAGE AND ADMINISTRATION LENGTH OF CENTELLA ASIATICA (L.) URBAN DECREASE THE LEVEL OF SOD AND MDA AND IMPROVE BRAIN HISTOLOGICAL CONDITION OF RATS

2016 ◽  
Vol 78 (5) ◽  
Author(s):  
Bayyinatul Muchtaromah ◽  
Mujahidin Ahmad ◽  
Suyono Suyono ◽  
Romaidi Romaidi ◽  
Samsul Bahri ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Nervous System ◽  
Herbal Medicine ◽  
Medicinal Plants ◽  
Medicinal Plant ◽  
Centella Asiatica ◽  
Dosage Forms ◽  
Diabetic Rat ◽  
Traditional Herbal Medicine ◽  
Degenerative Disorders

Medicinal plants have been used for treating many kinds of illness due to their safety, cheap and easy to be accessed by all level of society. This study was aimed to determine the effect of the dosage forms (fresh, boiled and ethanol extracted) and the duration (24 and 42 days) of medicinal plant Centella asiatica to the levels of superoxide dismutase (SOD), malondialdehyde (MDA) and the histopathology of diabetic rat brain. The results showed that administration of various dosage forms of C. asiatica were able to increase the number of pyramid cells and neuroglia in the cerebrum significantly (P <0.01) but had no significant effect (P>0.01) at the administration length and the interaction between both treatments. This finding resulted in the new traditional herbal medicine that can be used for treating degenerative disorders on nervous system.

scholarly journals Current Updates On Global Phytoceuticals and Novel Phyto Drug Delivery System In Herbal Medicine

2021 ◽  
Author(s):  
Selvakumari Sreenathkumar
Keyword(s):  
Drug Delivery ◽  
Herbal Medicine ◽  
Drug Delivery System ◽  
Delivery System ◽  
Complex Structure ◽  
Natural Origin ◽  
Pharmaceutical Industries ◽  
Novel Drug Delivery System ◽  
Nano Emulsion ◽  
Novel Drug

The acceptance of the herbal drugs globally is increased in the modern era, is due to its potent active molecules and also its usage as excipients from natural origin in the pharmaceutical industries is remarkable. Due to complex structure, poor solubility, instability and lacuna in the standardization protocol, there is always a hindrance in the usage of herbal medicine at par with modern drugs. The formulation of phytomedicine in the area of Novel drug delivery system should be focused in basic research and also in the clinical trials, to overcome the solubility and bioavailability challenges in the phytoceuticals. This chapter gives the in-depth perception of phytomolecules, formulated in the domain of novel drug delivery system, especially in nano dosage forms in specific to nano-emulsion, methods of formulation, challenges in formulating nano-emulsion including characterization techniques, colon specific drug carriers and the usage of excipients from natural origin in formulation of modern drugs in the pharmaceutical industries globally.

scholarly journals Nature as a Treasure Trove for Anti-COVID-19: Luteolin and Naringenin from Indonesian Traditional Herbal Medicine Reveal Potential SARS-CoV-2 Mpro Inhibitors Insight from in Silico Studies

2020 ◽  
Author(s):  
Wahyu Prasetyo ◽  
Triana Kusumaningsih ◽  
Maulidan Firdaus
Keyword(s):  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Medicinal Plants ◽  
Small Molecule ◽  
In Silico ◽  
Dft Studies ◽  
Traditional Herbal Medicine ◽  
In Silico Studies ◽  
Bioactive Phytochemicals

<div>Since the worldwide is currently facing the COVID-19 pandemic, there are no drugs or vaccines have been approved</div><div>for the treatment of SARS-CoV-2 infection. Therefore, there is an urgent need for in-depth research on emerging</div><div>human infectious coronaviruses. As part of our endeavour in combating this COVID-19 pandemic, in this paper, we</div><div>report on the discovery of an active antiviral small-molecule from Indonesian traditional herbal medicine used in Jamu</div><div>to inhibit 3CLpro of SARS-CoV-2 using in-silico approaches. As one of the mega biodiversity countries, Indonesia has</div><div>more than 1,180 species that can be prospected for medicine plants. Jamu, the Indonesian traditional herbal medicine,</div><div>is supposed to have similar potentials as those of traditional Chinese medicine (TCM). However, due to the lack of</div><div>scientific proof, Jamu is not recognised in the Guideline of COVID-19 Patients, particularly in Indonesia. Thus, in</div><div>this study, we performed virtual docking screening along with pharmacokinetic and DFT studies of selected 49</div><div>bioactive phytochemicals from several medicinal plants used in Jamu against the 3CLpro enzyme of SARS-CoV-2.</div><div>From the result, it was noted that from a set of 49 phytochemicals of medicinal plants used in Jamu, 2 phytochemicals,</div><div>i.e., Luteolin and Naringenin were identified as potential druggable inhibitors candidates of 3CLpro of SARS CoV-2.</div>

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