scholarly journals Comparison of Corneal Biomechanical Properties among Axial Myopic, Nonaxial Myopic, and Nonmyopic Eyes

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Aratchaporn Tubtimthong ◽  
Sunee Chansangpetch ◽  
Nitee Ratprasatporn ◽  
Anita Manassakorn ◽  
Visanee Tantisevi ◽  
...  

Purpose. To compare corneal deformation characteristics using ultra-high-speed Scheimpflug camera (Corvis ST) in patients with nonmyopic (NM), mild-to-moderate nonaxial myopic (MM), and high axial myopic (HM) eyes. Methods. In this cross-sectional study, normal subjects aged >40 years with no history of ocular laser/surgery were classified according to axial length (AL) and spherical equivalence (SE) into three groups: (1) NM (SE > −0.50 D and AL < 26 mm), (2) MM (SE −6.00 D to −0.50 D and AL < 26 mm), and (3) HM (SE ≤ −6.00 D and AL ≥ 26 mm). Seven parameters including corneal deformation amplitude (CDA), inward/outward corneal applanation length, inward/outward corneal velocity (ICV and OCV), peak distance, and radius were measured. Pearson correlation and linear mixed-effects model were done. Results. A total of 180 eyes were recruited. 98 eyes were NM, 30 eyes were MM, and 52 eyes were HM. There were significant correlations of OCV to the degree of refractive error (r = 0.203, p<0.001) and AL (r = −0.242, p<0.001). After adjusting for age, sex, intraocular pressure, and corneal thickness, there was significantly higher CDA (β = 0.07, p<0.001), faster OCV (β = −0.08, p<0.001), and smaller radius (β = −0.39, p=0.01) in the HM group compared to the NM group. Conclusion. The higher CDA, faster OCV, and smaller radius found in the HM may suggest that these eyes have reduced ocular stiffness and may be less stable and more prone to stress.

2020 ◽  
Vol 13 (12) ◽  
pp. 1922-1927
Author(s):  
Sara Garcia Caride ◽  
Federico Sáenz Francés ◽  
Julián García Feijoo

AIM: To study of corneal biomechanical properties and intraocular pressure (IOP) measured with Corvis Scheimpflug Technology (ST) in patients with childhood glaucoma (CG). METHODS: Cross-sectional study in which 89 eyes were included 56 of them with CG. Only one eye per patient was included. The following variables were obtained from the clinical history and the ophthalmological examination: age, sex, IOP, number of surgeries, and the cup/disc ratio (CDR). The following parameters were recorded using Corvis ST: corrected by biomechanics IOP (bIOP), not corrected IOP (nctIOP), central corneal thickness (CCT), maximum concavity [radius, peak distance (PD) and deformation amplitude], applanation 1 and 2 (length and velocity). The mean age was 23±14.55 and 33±19.5 years old for the control group and CG group, respectively. Totally 36 were males and 53 were females. In the CG group, 7 patients were controlled only with medical treatment. Sixteen had at least one previous goniotomy, 19 had at least one trabeculectomy, and 11 had an Ahmed implant. RESULTS: A significant and positive intraclass correlation coefficient was found between Goldman IOP and the IOP measured by Corvis in both groups. No differences were found between the IOP measured with Corvis and Goldman using a student t-test. Regarding biomechanical parameters, there were differences in the applanation length 2 (A-L2), in the applanation velocity 2 (A-V2) and in the PD. By sex, only the applanation length 1 (A-L1) was found to be different in control group. A positive and significant Pearson correlation was found between CDR and the A-L1. CONCLUSION: Corneal biomechanical properties have shown differences between CG and healthy subjects and also between men and women.


Author(s):  
Mohammad-Reza Sedaghat ◽  
Hamed Momeni-Moghaddam ◽  
Abbas Azimi ◽  
Zohreh Fakhimi ◽  
Mohammed Ziaei ◽  
...  

Purpose: To investigate corneal biomechanical response parameters in varying degrees of myopia and their correlation with corneal geometrical parameters and axial length.Methods: In this prospective cross-sectional study, 172 eyes of 172 subjects, the severity degree of myopia was categorized into mild, moderate, severe, and extreme myopia. Cycloplegic refraction, corneal tomography using Pentacam HR, corneal biomechanical assessment using Corvis ST and Ocular Response Analyser (ORA), and ocular biometry using IOLMaster 700 were performed for all subjects. A general linear model was used to compare biomechanical parameters in various degrees of myopia, while central corneal thickness (CCT) and biomechanically corrected intraocular pressure (bIOP) were considered as covariates. Multiple linear regression was used to investigate the relationship between corneal biomechanical parameters with spherical equivalent (SE), axial length (AXL), bIOP, mean keratometry (Mean KR), and CCT.Results: Corneal biomechanical parameters assessed by Corvis ST that showed significant differences among the groups were second applanation length (AL2, p = 0.035), highest concavity radius (HCR, p &lt; 0.001), deformation amplitude (DA, p &lt; 0.001), peak distance (PD, p = 0.022), integrated inverse radius (IR, p &lt; 0.001) and DA ratio (DAR, p = 0.004), while there were no significant differences in the means of pressure-derived parameters of ORA between groups. Multiple regression analysis showed all parameters of Corvis ST have significant relationships with level of myopia (SE, AXL, Mean KR), except AL1 and AL2. Significant biomechanical parameters showed progressive reduction in corneal stiffness with increasing myopia (either with greater negative SE or greater AXL), independent of IOP and CCT. Also, corneal hysteresis (CH) or ability to dissipate energy from the ORA decreased with increasing level of myopia.Conclusions: Dynamic corneal response assessed by Corvis ST shows evidence of biomechanical changes consistent with decreasing stiffness with increasing levels of myopia in multiple parameters. The strongest correlations were with highest concavity parameters where the sclera influence is maximal.


2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
João N. Beato ◽  
João Esteves-Leandro ◽  
David Reis ◽  
Manuel Falcão ◽  
Vítor Rosas ◽  
...  

Purpose. To analyze and compare corneal structural and biomechanical properties, characterized by corneal hysteresis (CH) and resistance factor (CRF), between patients with and without type 2 diabetes mellitus (DM), and determine the main ocular variables that influence them. Methods. Sixty diabetic and 48 age- and sex-matched non-DM patients were enrolled in this cross-sectional study. The DM group was analyzed according to DM duration (<or ≥ 10 years), HbA1c levels (<or ≥ 7%), and presence of retinopathy. CH and CRF were evaluated using the Ocular Response Analyzer® (ORA). Central corneal thickness (CCT) was determined by Scheimpflug tomography (Pentacam® HR). Intraocular pressure was obtained with ORA (IOPcc) and Goldmann applanation tonometry (IOP-GAT). Univariate and multivariate linear regression analyses were performed to evaluate the relationship between demographical, clinical, and ocular variables with the biomechanical properties. Results. There were no statistically significant differences in the CH and the CRF between DM and non-DM groups (p=0.637 and p=0.439, respectively). Also, there was no statistical difference between groups for the CCT, IOPcc, or IOP-GAT. Multivariate linear regression analysis showed that CH was positively associated with CCT (p<0.001) and negatively associated with IOPcc (p<0.001), while CRF was positively associated with CCT (p<0.001) and IOPcc (p=0.014). Conclusion. The CCT and IOPcc were found to be the main parameters that affect corneal biomechanical properties both in diabetics and controls. In this study, there was no significant effect of DM type 2 on corneal biomechanics.


2021 ◽  
pp. 157-159
Author(s):  
Pravin Uttam Jadhav ◽  
Santosh Banshelkikar ◽  
Binoti A. Sheth

INTRODUCTION: Knowledge of normal value of carrying angle is important while managing injuries around elbow. However there is paucity of literature documenting carrying angle in Indian children. Inuence of various factors like age, sex, height, weight on carrying angle is still debated. With this study we tried to bridge this gap in knowledge. MATERIALS AND METHODS: We conducted cross sectional study of 1893 children in the age group of 3 to 15 years. Student having history of previous fractures, orthopaedic deformities, neurological conditions were excluded. To assess the effect of the age, the patients were separated into ve cohorts: 3 to 5, 5 to 7, 7 to 9, 9 to 11, 11 to 13 and 13 to 15. The carrying angle of elbow was measured using universal standard extendable goniometer. To avoid interobserver variability, all measurements were recorded by a single orthopaedic surgeon with 5 years postgraduate experience. RESULT: Carrying angle was more in females 9.67 (SD 3.16) compared to males 8.33 (SD 2.63). . We observed increasing value of carrying angle with age. Pearson correlation coefcient showed carrying angle had positive correlation with age (r= 0.5, P< 0.001), height(r= 0.5, P< 0.001). However BMI Z score, which is weight adjusted for age and sex did not show any correlation with carrying angle and no signicant difference was noted between carrying angle on right and left side. DISCUSSION: Finding of our study differed with available literature in respect to lower value of carrying angle in both males and females. We did not found changes in carrying angle on left or right side in contrast to previous studies showing larger carrying angle in dominant side. Further studies with larger sample size are required in this aspect.


2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Tamer M. Attia ◽  
Ahmad M. Hamdan

Abstract Background Olfaction is a complex process involving different neurological mechanisms with a correlation between the chemical structure and quality of odors regarding pleasantness. This study aimed to compare the detection of pleasant and unpleasant odors in different grades of hyposmia. A descriptive cross-sectional study was conducted preceded by a preliminary pilot study, including 20 normal subjects without a history of hyposmia. The pilot study was carried out using the University of Pennsylvania Smell Identification Test (UPSIT) with the assessment of pleasantness of odors using a visual analog scale (VAS). Fifty patients diagnosed with organic hyposmia/anosmia were included in the main study and assessed for the degree of hyposmia/anosmia using UPSIT. The number of detected odors out of the five odors with highest VAS for pleasantness and five odors with lowest VAS for pleasantness, as detected by the pilot study, for every patient was assessed and compared. Results There was a significant difference between the detection of pleasant and unpleasant odors in mild, moderate, and severe hyposmia (p value = 0.02, 0.005, and 0.03 respectively) with a highly significant difference in the whole study group ( p < 0.00001) with more loss of ability to detect unpleasant odors compared with pleasant odors. Conclusion The current study showed significantly less ability to detect unpleasant odors compared with pleasant odors in different grades of hyposmia. This finding suggests that the pattern of degeneration of the olfactory sense organ is not uniform with the topographic nature of the olfactory membrane.


Neurology ◽  
2021 ◽  
Vol 98 (1 Supplement 1) ◽  
pp. S7.1-S7
Author(s):  
Dipali P. Nemade ◽  
Norman Cottrill ◽  
Mary Payne

ObjectiveWe aim to identify the potential risk factors associated with increased susceptibility for persistent post-concussive headaches.BackgroundConcussions are common, but complex, traumatic brain injuries seen in pediatric athletes of all ages & skill levels & occur in a wide variety of athletic settings. These mild traumatic brain injuries often have neurologic sequelae, including headaches. Although athletes are advised to rest, duration of post-concussive symptoms is often unpredictable.Design/MethodsWe conducted a cross sectional study on patients with head injury aged 5–18 years presented to pediatric concussion clinic (N = 603) from September 2013 to Dec 2018. We excluded patients with skull fractures and intracranial hemorrhage. The data was compiled & analyzed using frequency, Pearson correlation test, chi square & ANOVA test using IBM SPSS- 26.ResultsPatient cohort consisted of 364 males & 239 females. The age range for males was 5–18 years (Mean age ± SD: 13.45 ± 2.86) & for females was 6–18 years (Mean age ± SD: 13.97 ± 2.84). There was statically significant association between various age groups & presence of headache at 3 & 6 months (p < 0.05). Out of all ages, age group 5–8 years had highest risk of persistent headache while the age group 14–18 years reported headaches at 3 months but then resolution of symptoms by one year (p < 0.05). Females were more likely than males (of all ages) to have persistent headaches despite treatment (p = 0.00). There was also a statistically significant difference between loss of consciousness, prior history of headaches & prior history of concussions towards the development of persistent headaches (p < 0.05). Furthermore, football, soccer and basketball had significantly more headaches compared to other sports related injuries (p = 0.001).ConclusionsThere was a statistically higher risk of developing persistent headaches for females and those with a history of prior headache, prior concussion, younger age, and those playing football, soccer or basketball.


2020 ◽  
Author(s):  
Weifen Gong ◽  
Fan Yang ◽  
Shibin Lin ◽  
Geng Wang

Abstract PurposeTo compare the biometric characteristics between concomitant exotropia (XT) and orthotropia (OT) with OA2000.MethodThis cross-sectional study collected 4–18 years old children. All subjects underwent a comprehensive ophthalmic examination and prism alternate cover test for ocular alignment measurement. Included subjects had no any eye surgery, structural ocular anomalies, amblyopia of either eyes, ptosis, cataract and nystagmus. OA-2000 was used for the measurement of ocular biological parameters. Spherical equivalent (SE, spherical power + (cylindrical power)/2), keratometry, central corneal thickness (CCT), white to white distance (WTW), pupil diameter (PD), anterior chamber depth (ACD), lens thickness (LT), axial lengths (AL) and intereye differences in SE, keratometry, CCT, WTW, PD, ACD, LT and AL were analyzed by independent sample t-tests. Pearson correlation was used for correlations assessment. Partial correlation was used to control for intereye differences in SE.ResultsA total of 156 subjects (79 XT and 77 OT) were collected. Intereye differences in spherical equivalent (SE) (t 2.369, P 0.019), AL (t 3.423, P 0.001), ACD (t 3.782, P < 0.001), LT (t 3.136, P 0.002) and PD (t 3.229, P 0.002) were significantly larger in XT patients than OT patients. The correlation coefficient of XT with SE asymmetry was 0.187 (P 0.020), 0.265 with AL asymmetry (P 0.001), 0.289 with ACD asymmetry (P < 0.001), 0.251 with PD asymmetry (P 0.002) and 0.243 with LT asymmetry (P 0.002). Strong correlation (r 0.875) was found between anisometropia and AL asymmetry. After controlling the effect of anisometropia, the correlation coefficients slightly reduced between XT patients and intereye differences in AL (reduced to 0.213), ACD (reduced to 0.266), PD (reduced to 0.230) and LT (reduced to 0.230). Strong correlation (r 0.855) was found between intereye differences in ACD and LT.ConclusionCompared with OT subjects, intereye differences in SE, AL, ACD, LT and PD were significantly larger in XT patients and had positive correlation with XT and may be associated with the pathogenesis of XT.


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Min Chen ◽  
Lina Zhang ◽  
Jia Xu ◽  
Xinyi Chen ◽  
Yuxiang Gu ◽  
...  

Abstract Background Measurement of intraocular pressure (IOP) is essential for glaucoma patients. Many factors such as central corneal thickness (CCT) can affect the accuracy of IOP measurement. The purpose of this study was to evaluate the agreement of IOP measured by non-contact tonometer (NCT), iCare pro rebound tonometer (iCare), and Goldmann applanation tonometer (GAT) in different IOP group. Methods This was a Hospital-based cross-sectional study. Two hundred subjects were enrolled in this study. All subjects underwent IOP measurement using an NCT–iCare–GAT sequence. Bland-Altman, Pearson correlation and intraclass correlation analysis were performed using SPSS 17.0 software. The influence of CCT on each IOP measurement methods was evaluated by linear regression analysis. Results The mean difference (Δ) of NCT–GAT did not differ from (Δ) iCare–GAT in IOP < 10 and 10–21 mmHg group. However, (Δ) NCT–GAT was significantly higher than (Δ) iCare–GAT in IOP 22–30 and > 30 mmHg group (P < 0.05). Bland–Altman analysis showed significant agreement between the three devices (P < 0.01). IOP measurements of the three methods were significantly correlated with CCT (P < 0.01). Conclusions ICare pro shows a higher agreement with GAT over a wide range of IOP compared with NCT. The consistency between the three tonometers was similar in a low and normal IOP range. However, NCT shows a greater overestimate of IOP in moderate and higher IOP group. The variability of IOP measurement affected by CCT is NCT > iCare pro > GAT.


2018 ◽  
Vol 10 (3) ◽  
pp. 64
Author(s):  
Karol Marian Karnowski ◽  
Ewa Mączyńska ◽  
Maciej Nowakowski ◽  
Bartłomiej Kałużny ◽  
Ireneusz Grulkowski ◽  
...  

The deformation amplitudes measured with air-puff OCT are sensitive to both (intraocular pressure) IOP and biomechanical properties of the cornea. Analysis of the amplitudes of corneal deformation is challenging due to interrelation of IOP and corneal biomechanics. In this study, we used natural diurnal IOP fluctuations to investigate corneal deformations in a number of subjects whose eyes were measured multiple times during a day. The results of analysis, based on corneal hysteresis, revealed a corneal hysteresis parameter, which remains constant during a day for each individual eye. We hypothesize that above-mentioned metric might correlate with biomechanical properties of the cornea without influence of IOP. Full Text: PDF ReferencesMeek KM, Tuft SJ, Huang Y, Gill PS, Hayes S, Newton RH, Bron AJ, "Changes in Collagen Orientation and Distribution in Keratoconus Corneas", Invest Ophthalmol Vis Sci, 2005. 46(6): p. 1948-56. CrossRef Zimmermann DR, Fisher RW, Winterhalter KH, Witmer R, Vaughan L, "Comparative studies of collagens in normal and keratoconus corneas", Exp Eye Res, 1988. 46(3): p. 431-42. CrossRef Andreassen TT, Simonsen AH, and Oxlund H, "Biomechanical properties of keratoconus and normal corneas", Experimental Eye Research, 1980. 31(4): p. 435-441. CrossRef Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M, "Reduction of Intraocular Pressure and Glaucoma Progression", Arch Ophthalmol, 2002. 120(10): p. 1268-79. CrossRef Chauhan BC and Drance SM, "The influence of intraocular pressure on visual field damage in patients with normal-tension and high-tension glaucoma", Investigative Ophthalmology & Visual Science, 1990. 31(11): p. 2367-2372. DirectLink Gelaw Y, "The impact of central corneal thickness on intraocular pressure among Ethiopian glaucoma patients: a cross-sectional study", BMC Ophthalmology, 2012. 12(1): p. 58. CrossRef Doughty MJ and Zaman ML, "Human Corneal Thickness and Its Impact on Intraocular Pressure Measures: A Review and Meta-analysis Approach", Surv Ophthalmol, 2000. 44(5): p. 367-408. CrossRef Liu J, and Roberts CJ, "Influence of corneal biomechanical properties on intraocular pressure measurement: Quantitative analysis", J Cataract Refract Surg, 2005. 31(1): p. 146-55. CrossRef Ehlers N, Hansen FK, and Aasved H, "Biometric Correlations of Corneal Thickness", Acta Ophthalmol (Copenh), 1975. 53(4): p. 652-9. CrossRef Harada Y, Hirose N, Tawara A, "The Influence of Central Corneal Thickness and Corneal Curvature Radius on The Intraocular Pressure as Measured By Different Tonometers: Noncontact and Goldmann Applanation Tonometers", J Glaucoma, 2008. 17(8): p. 619-25. CrossRef Alonso-Caneiro D, Karnowski K, Kaluzny BJ, Kowalczyk A, Wojtkowski M, "Assessment of corneal dynamics with high-speed swept source Optical Coherence Tomography combined with an air puff system", Optics Express, 2011. 19(15): p. 14188-14199. CrossRef Dorronsoro C, Pascual D, Perez-Merino P, Kling S and Marcos S, "Dynamic OCT measurement of corneal deformation by an air puff in normal and cross-linked corneas", Biomedical Optics Express, 2012. 3(3): p. 473-487. CrossRef Karnowski K, Kaluzny BJ, Szkulmowski M, Gora M, Wojtkowski M, "Corneal topography with high-speed swept source OCT in clinical examination", Biomedical Optics Express, 2011. 2(9): p. 2709-2720. CrossRef A. N. S. Institute, "American National Standard for Safe use of Lasers," (American National Standards Institute, Orlando, FL, 2000) DirectLink David R, Zangwill L, Briscoe D, Dagan M, Yagev R, Yassur Y, "Diurnal intraocular pressure variations: an analysis of 690 diurnal curves", Br J Ophthamlom, 1992, 76(5): p. 280-282 CrossRef Maczynska E, Karnowski K, Szulzycki K, Malinowska M, Dolezyczek H, Cichanski A, Wojtkowski M, Kaluzny BJ, Grulkowski I, Journal of Biophotonics (to be published).


Author(s):  
Seyed Saeed Mazloomy Mahmoodabad ◽  
Saeedeh Sadeghi ◽  
Mohammad Saeed Jadgal ◽  
Nooshin Yooshany ◽  
Rabee Agh Atabay ◽  
...  

Introduction:  Drug abuse is one of the important challenges in the field of mental health and adolescence health promotion. Due to the social and medical costs of drug abuse and its consequences among the youth, it is necessary to deal with this issue effectively. Therefore, in this theoretical study, the predictability of the Theory of Planned Behavior on drug abuse related behaviors was explained among adolescents. Methods: This cross-sectional study was conducted in Chabahar City in 2015 among 300 male adolescents, recruited randomly. All data were collected using a researcher-made questionnaire with confirmed reliability and validity. The data were analyzed by independent t- test and pearson correlation.  Results: we found that 77% of the participants had no history of parental drug abuse. Furthermore, 72% of participants reported a history of using industrial drugs in their friends. The Chi-square test showed that adolescent's smoking had a significant relationship with father's education, family size, history of using industrial drugs in parents , history of using industrial drugs in friends, and the participants' business o (P˃0.000). However, the level of maternal education (P = 682) and living with parents (P = 729) had no significant relationship with the adolescents' smoking rate. Conclusions: since knowledge and attitude had the highest correlation and predictability with industrial drug abuse among the adolescents, theory of planned behavior can be used properly and effectively to plan and implement  prevention programs among the adolescents.


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