scholarly journals Pilot Study of Blood Perfusion Changes at PC4 and Its Surrounding Points Induced by Acupuncture and Moxibustion

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Shuyong Jia ◽  
Qizhen Wang ◽  
Hongyan Li ◽  
Xiaojing Song ◽  
Shuyong Wang ◽  
...  
Keyword(s):  
Blood Flow ◽  
Clinical Practice ◽  
Pilot Study ◽  
Blood Perfusion ◽  
Frequency Interval ◽  
Wavelet Method ◽  
Acupuncture And Moxibustion ◽  
Flow Perfusion ◽  
Significant Difference ◽  
Improve Blood Flow

Acupuncture and moxibustion are widely used in clinical practice; however, the differences between their mechanisms are unclear. In the present study, the response of blood perfusion resulting from acupuncture or moxibustion at Ximen (PC4) and its surrounding points was explored. Using the wavelet method, the differences in the frequency interval of blood flux were observed. Furthermore, the correlations between these points were analyzed. The results suggested that moxibustion could significantly improve blood flow perfusion at PC4 compared to acupuncture; however, there was no significant difference around PC4. The response of blood flux at PC4 to different stimulations was related to the frequency V (0.4–1.6 Hz) component. However, a difference in response at other points was not observed. Correlation analysis showed that both acupuncture and moxibustion could cause a decline in the correlation of blood flux signals at these recorded points, but there was no significant difference between these techniques. The results suggested that, at least in the forearm, the acupuncture or moxibustion only influenced the level of blood perfusion locally.

scholarly journals Intra-Arterial Labetalol and Nitroglycerin in Preventing Radial Artery Spasm Following Transradial Angiography: A New Approach

2020 ◽  
Vol 26 (2) ◽  
pp. 142-149
Author(s):  
Gohar Eslami ◽  
Samad Golshani ◽  
Mahmood Moosazadeh ◽  
Faezeh Shadfar
Keyword(s):  
Blood Flow ◽  
Clinical Practice ◽  
Pain Intensity ◽  
Radial Artery ◽  
P Value ◽  
Analog Scale ◽  
New Approach ◽  
Vasomotor System ◽  
End Of Treatment ◽  
Significant Difference

Background: Radial artery spasm (RAS) resulted from decreasing blood flow and activation of vasomotor system leads to a decrease in artery diameter, perfusion and patency, and increase the risk of procedure failure. In this study, we investigated the effects of intra-arterial administration of nitroglycerin and labetalol on radial artery diameter, RAS, and pain intensity in patients undergoing diagnostic radial angiography. Methods: Sixty-four patients randomly enrolled into one of the nitroglycerin (150 μg) or labetalol (500 μg) groups. The radial artery size, and the incidence of RAS were measured before, immediately after puncture, and at the end of treatment. Pain intensity was evaluated using a visual-analog-scale (VAS) at the end of the procedure. Hemodynamic status before, and during the procedure was also recorded. Results: Labetalol causes a significantly larger increase in radial diameter than nitroglycerin immediately after intra-arterial injection (2.24±0.58 mm vs. 1.65±0.39 mm, P-value<0.001). The rate of RAS immediately after vasodilator administration in the labetalol group was 3.1% vs. 12.5% in the nitroglycerin group (P-value=0.355), but the overall incidence (immediately after administration+ at the end of procedure) did not show a statistically significant difference (53.125% vs 31.25% respectively, P-value=0.076). The VAS score did not show a significant difference between two groups (1.15±0.44 in nitroglycerin vs. 1.50±0.91, P-value=0.063). Conclusion: Labetalol increases radial artery diameter more than nitroglycerin. However, the efficacy of labetalol in terms of RAS incidence, and patients’ pain was similar to nitroglycerin. Therefore, intra-arterial labetalol could be considered as one of the therapeutic options in clinical practice in order to reduce RAS and procedure failure.

scholarly journals Acupuncture and Lifestyle Myopia in Primary School Children—Results from a Transcontinental Pilot Study Performed in Comparison to Moxibustion

Medicines ◽  
2018 ◽  
Vol 5 (3) ◽  
pp. 95 ◽  
Author(s):  
Xiaojuan Shang ◽  
Luquan Chen ◽  
Gerhard Litscher ◽  
Yanxia Sun ◽  
Chuxiong Pan ◽  
...  
Keyword(s):  
Pilot Study ◽  
Group Analysis ◽  
Young Patients ◽  
Computer Work ◽  
Primary School Children ◽  
Public Health Issue ◽  
Complementary Methods ◽  
Acupuncture And Moxibustion ◽  
Significant Difference ◽  
Before And After

Background: Lifestyle risks for myopia are well known and the disease has become a major global public health issue worldwide. There is a relation between reading, writing, and computer work and the development of myopia. Methods: Within this prospective pilot study in 44 patients aged between 6 and 12 years with myopia we compared possible treatment effects of acupuncture or moxibustion. The diopters of the right and left eye were evaluated before and after the two treatment methods. Results: Myopia was improved in 14 eyes of 13 patients (15.9%) within both complementary methods. Using acupuncture an improvement was observed in seven eyes from six patients out of 22 patients and a similar result (improvement in seven eyes from seven patients out of 22 patients) was noticed in the moxibustion group. The extent of improvement was better in the acupuncture group (p = 0.008 s., comparison before and after treatment); however, group analysis between acupuncture and moxibustion revealed no significant difference. Conclusions: Possible therapeutic aspects with the help of evidence-based complementary methods like acupuncture or moxibustion have not yet been investigated adequately in myopic patients. Our study showed that both acupuncture and moxibustion can improve myopia of young patients. Acupuncture seems to be more effective than moxibustion in treating myopia, however group analysis did not prove this trend. Therefore, further Big data studies are necessary to confirm or refute the preliminary results.

scholarly journals Construction and evaluation of medication reconciliation instruments for pediatric patients

2019 ◽  
Vol 9 (4) ◽  
Author(s):  
Diana Domingues Da Camara Graça ◽  
Walter Viera Mendes Junior ◽  
Saint Clair Dos Santos Gomes Junior
Keyword(s):  
Clinical Practice ◽  
Pilot Study ◽  
Medication Reconciliation ◽  
Pediatric Patients ◽  
Information Source ◽  
Pearson Correlation ◽  
Relevant Information ◽  
Medication History ◽  
Significant Difference ◽  
Drug History

Objective: To construct and evaluate medication reconciliation instruments for hospital admission moments and the internal transfers of pediatric patients to the context of Brazilian hospitals. Methods: Prospective descriptive study was performed from April 2014 to March 2015 in a pediatric public hospital. Four instruments were designed based on international literature to record the primary medication history, participant data and medication reconciliation. The instruments were analyzed by experts in Delphi technique. A pilot study assessed the need for adjustments and the clinical practice application compared to the primary drug history with the best possible drug history. A pilot study evaluated the necessity for adjustments and applicability in clinical practice compared to the primary medication history with the best possible medication history. The Pearson correlation and the Wilcoxon-Mann-Whitney test were used for statistical analysis. Results: Experts suggested improvements in “Clear language and correct terminology”. The pilot study indicated the need for instrument adjustments. Clinical practice identified a significant difference (P <0.05) in the comparison of the pharmaceutical researcher registry with the other professional registry for almost all variables analyzed, except for the information source and the intervention record. Conclusion: The medication reconciliation forms were valid for pediatric patients in the institution studied and their allocation in a visible and accessible place of the medical records of similar institutions would allow the availability of relevant information about the drugs in use by pediatric patients to all those involved in their care, contributing to a safer care.

2 Hz Electro-Acupuncture at Yinlingquan (SP9) and Ququan (LR8) Acupoints Induces Changes in Blood Flow in the Liver and Spleen

2012 ◽  
Vol 40 (01) ◽  
pp. 75-84 ◽  
Author(s):  
Wen-Cheng Chou ◽  
Hsu-Jan Liu ◽  
Yi-Wen Lin ◽  
Chin-Yi Cheng ◽  
Tsai-Chung Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
The Body ◽  
Arterial Blood ◽  
Flow Perfusion ◽  
Significant Difference ◽  
Specific Organ ◽  
The Mean ◽  
The Right ◽  
Measurement Period

According to the principles of traditional Chinese medicine, channels and collaterals within the body provide pathways through which qi and blood travel, and each channel or collateral is linked with a specific organ. The Yinlingquan (spleen 9, SP9) and Ququan (liver 8, LR8) acupoints represent the sea points of the spleen and liver meridians, respectively, from which qi and blood flow into their specific visceral organs. The purpose of this study was to investigate the changes in blood flow/perfusion in the liver and spleen resulting from the application of 2 Hz electro-acupuncture (EA) to the Yinlingquan (SP9) or Ququan (LR8) acupoints. A total of 18 Spragrue-Dawley rats were randomly divided into three groups of six rats each as follows: sham group receiving sham EA; Yinlingquan (SP9) group receiving 2 Hz EA, applied at bilateral Yinlingquan (SP9) acupoints; and Ququan (LR8) groups receiving 2 Hz EA, applied at bilateral Ququan (LR8) acupoints. The mean blood flow/perfusion of the spleen and liver was recorded using a laser Doppler blood flow monitor prior to EA (representing the baseline), during EA, and post-EA. Each measurement period lasted ten minutes. Nitric oxide levels were also measured from the right femoral arterial blood, following the conclusion of each series of blood flow/perfusion recordings. The results indicate that the sham EA did not increase the mean blood flow/perfusion in the liver or spleen; 2 Hz EA at bilateral Yinlingquan (SP9) acupoints increased the mean blood flow/perfusion in the spleen, but not in the liver. In contrast, 2 Hz EA at bilateral Ququan (LR8) acupoints increased the mean blood flow/perfusion in the liver, but not in the spleen. Nitric oxide levels showed no significant difference between any of the groups at any stage of the measurements. According to the results, we conclude that EA at the Yinlingquan (SP9) and Ququan (LR8) acupoints can increase the blood flow in the spleen and liver, respectively.

scholarly journals The Recovery Benefit on Skin Blood Flow Using Vibrating Foam Rollers for Postexercise Muscle Fatigue in Runners

2020 ◽  
Vol 17 (23) ◽  
pp. 9118
Author(s):  
Yi-Horng Lai ◽  
Ai-Yi Wang ◽  
Chia-Chi Yang ◽  
Lan-Yuen Guo
Keyword(s):  
Blood Flow ◽  
Muscle Fatigue ◽  
Skin Blood Flow ◽  
Gastrocnemius Muscle ◽  
Blood Perfusion ◽  
Endothelial Activation ◽  
Flow Oscillation ◽  
Flow Perfusion ◽  
Before And After ◽  
Blood Flow Oscillation

Purpose: To determine the effect of vibrating rollers on skin blood flow after running for recovery from muscle fatigue. Method: 23 healthy runners, aged between 20 to 45 years, participated in a crossover trial. Muscle fatigue was induced by running, and recovery using a vibrating roller was determined before and after the intervention. Each subject was measured at three time points (prerun, postrun, and postroller) to compare skin blood flow perfusion and blood flow oscillation at the midpoint of the dominant gastrocnemius muscle. The results show that blood perfusion is greater when a vibrating roller is used than a foam roller, but there is no statistical difference. The analysis of blood flow oscillation shows that vibrating rollers induce 30% greater endothelial activation than a foam roller. Vibrating rollers significantly stimulate the characteristic frequency for myogenic activation (p < 0.05); however, the effect size is conservative.

scholarly journals Changes of Blood Flux at BL21 and Points along BL Meridian Resulted from Acupuncture or Moxibustion: Case Cross Design Study

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Guangjun Wang ◽  
Shuyong Jia ◽  
Hongyan Li ◽  
Ze Wang ◽  
Yuying Tian ◽  
...  
Keyword(s):  
Blood Perfusion ◽  
Local Area ◽  
Morlet Wavelet ◽  
Coherence Analysis ◽  
Frequency Interval ◽  
Control Points ◽  
Significant Difference ◽  
The Difference ◽  
Different Response ◽  
And Control

Acupuncture (Acup) and moxibustion (Moxi) are commonly used interventions in clinical practice. However, the difference between Acup and moxibustion mechanisms is unclear. In current study, blood perfusion responses resulted from Acup or Moxi at Weishu acupoint (BL21) and control points were explored, respectively. The time series of blood flux signals at BL21 and control points were transformed with Morlet wavelet, and the differences in each frequency interval were observed. The results suggested that acupoint response to different stimulation is a comprehensive process which related to all components of blood perfusion signals. Whereas the different response at control points was not observed, there has been significant difference coherence value between Acup and Moxi stimulation. The results suggested the influence of Acup and Moxi not only on the level of blood perfusion at local area; the intrinsic relevance after stimulation which can be evaluated by coherence analysis is also an appropriate index to distinguish different stimulations.

scholarly journals Optimization of Image Reconstruction Method of Cerebral Blood Flow Perfusion Imaging with Digital CZT SPECT

2021 ◽  
Author(s):  
Yaqian Zhou ◽  
Shen Wang ◽  
Peng Wang ◽  
Ning Li ◽  
Ruixin Wu ◽  
...  
Keyword(s):  
Blood Flow ◽  
Image Reconstruction ◽  
Perfusion Imaging ◽  
Blood Perfusion ◽  
Reconstruction Method ◽  
Sphere Diameter ◽  
Back Projection ◽  
Flow Perfusion ◽  
Image Reconstruction Method ◽  
Czt Spect

Abstract Purpose: To evaluate the effects of filtered back projection (FBP), ordered subset expectation maximisation (OSEM), and different filters on cadmium zinc telluride single photon emission computed tomography (CZT SPECT) cerebral blood perfusion image quality to optimise the image reconstruction method.Methods: Jaszczak phantom and patients with clinical cerebral ischemia were selected as study subjects. Under routine clinical conditions, tomographic imaging was performed on the phantom and patients with clinical cerebral ischemia. Image processing included image reconstruction using filtered back projection with Chang’s attenuation correction (FBPChangAC) and OSEM algorithm with CT-based attenuation correction (CTAC), scatter correction (SC), resolution recovery (RR) (OSEMCTAC-SC-RR), and the filtering method used Butterworth (Bw) and Gauss (Gs) filters. Visual and semi-quantitative parameters (integral uniformity, root mean square noise (RMS noise), and contrast and contrast-to-noise ratio (CNR)) were used to evaluate image quality to optimise image reconstruction parameters. One-way and two-way ANOVA were used to process phantom and clinical data.Results: In the tomographic images of phantom and brain imaging of patients, FBP+Bw had the best uniformity and the lowest noise level, while OSEM+Bw had the best contrast. Semi-quantitative analysis showed that the integral uniformity of FBP+Bw was significantly higher than that of OSEM+Bw and OSEM+Gs (p <0.05), and that the RMS noise of FBP+Bw was significantly lower than that of OSEM+Bw and OSEM+Gs (p <0.001). The contrast of FBP+Bw and OSEM+Bw in the cold sphere diameter ≥ 2 cm group was significantly higher than that of OSEM+Gs (p <0.001), while the CNR of FBP+Bw was significantly higher than that of OSEM+Bw and OSEM+Gs (p <0.001) ; the contrast of OSEM+Bw cold sphere diameter < 2 cm was significantly higher than that of FBP+Bw (p <0.01). The semi-quantitative analysis results of the patient's cerebral perfusion tomography were consistent with the model.Conclusion: In CZT SPECT cerebral blood flow perfusion imaging, images with lesion sizes greater than 2 cm were suitable for FBP+Bw (fc=0.40, n=10), and the image with lesion size less than 2 cm was suitable for OSEM+Bw (EM=60, fc=0.45, n=10). The reconstruction method of OSEM+Gs (EM=80, full width at half maximum [FWHM]=3.25) was not suitable for cerebral blood perfusion imaging.

scholarly journals Antagonizing αvβ3 Integrin Improves Ischemia-Mediated Vascular Normalization and Blood Perfusion by Altering Macrophages

2021 ◽  
Vol 12 ◽  
Author(s):  
Yongjie Li ◽  
Qian Gao ◽  
Xin Shu ◽  
Lamei Xiao ◽  
Yan Yang ◽  
...  
Keyword(s):  
Blood Flow ◽  
Low Dose ◽  
Cyclic Peptide ◽  
Blood Perfusion ◽  
Vascular Density ◽  
High Dose ◽  
Αvβ3 Integrin ◽  
Hindlimb Ischemia ◽  
Pericyte Coverage ◽  
Flow Perfusion

Background: αVβ3 integrin has been implicated in the physiological processes and pathophysiology of important angiogenesis-related disorders; however, the preclinical and clinical data on integrin αVβ3 antagonists have not demonstrated improved outcomes. Our goal was to test the hypothesis that inhibition of αVβ3 integrin improves blood flow in a mouse hindlimb ischemia model.Methods: In this study, we examined the effect of cilengitide, an αVβ3/αVβ5 integrin-specific RGD-mimetic cyclic peptide, on blood perfusion and angiogenesis after hindlimb ischemia. Blood flow was measured using Laser Doppler Scanner. Vascular density, and macrophages infiltration were examined by immunofluorescence. Macrophage polarization was measured by quantitative real time PCR.Results: We found that low-dose, not high-dose, cilengitide increased blood flow perfusion, capillary formation, and pericyte coverage, accompanied by an accumulation of macrophages and increased expression of the chemokine (C-C motif) ligand 2 (CCL2) in ischemic muscles. Macrophage depletion using clodronate liposomes resulted in a reduction in low-dose cilengitide-induced blood flow perfusion, macrophage accumulation, pericyte coverage, and CCL2 expression. Finally, in vitro assays showed that low-dose, not high-dose, cilengitide increased macrophage migration.Conclusion: These studies identified a novel role of the inhibition of αVβ3 integrin in modulating ischemia-induced angiogenesis, possibly through effects on macrophage infiltration and polarization, and revealed αVβ3 integrin inhibition to be a promising therapeutic strategy for peripheral artery disease.

scholarly journals Anesthetic Techniques for Fetal Surgery

2013 ◽  
Vol 118 (4) ◽  
pp. 796-808 ◽  
Author(s):  
Pornswan Ngamprasertwong ◽  
Erik C. Michelfelder ◽  
Shahriar Arbabi ◽  
Yun Suk Choi ◽  
Christopher Statile ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Function ◽  
Fetal Surgery ◽  
Left Ventricular ◽  
High Dose ◽  
Anesthetic Techniques ◽  
Uterine Blood Flow ◽  
Fetal Cardiac Function ◽  
Significant Difference ◽  
Fetal Acidosis

Abstract Background: Use of high-dose inhalational anesthesia during open fetal surgery may induce maternal–fetal hemodynamic instability and fetal myocardial depression. The authors’ preliminary human retrospective study demonstrated less fetal bradycardia and left ventricular systolic dysfunction with lower dose desflurane supplemented with propofol and remifentanil IV anesthesia (SIVA). In this animal study, the authors compare maternal–fetal effects of high-dose desflurane anesthesia (HD-DES) and SIVA. Methods: Of 26 instrumented midgestational ewes, data from 11 animals exposed to both SIVA and HD-DES in random sequences and six animals exposed to HD-DES while maternal normotension was maintained were analyzed. Maternal electroencephalography was used to guide comparable depths of anesthesia in both techniques. Hemodynamic parameters, blood gas, and fetal cardiac function from echocardiography were recorded. Results: Compared with SIVA, HD-DES resulted in significant maternal hypotension (mean arterial pressure difference, 19.53 mmHg; 95% CI, 17.6–21.4; P &lt; 0.0001), fetal acidosis (pH 7.11 vs. 7.24 at 150 min, P &lt; 0.001), and decreased uterine blood flow. In the HD-DES group with maternal normotension, uterine blood flow still declined and fetal acidosis persisted, with no statistically significant difference from the group exposed to HD-DES that had maternal hypotension. There was no statistically significant difference in fetal cardiac function. Conclusion: In sheep, SIVA affects maternal hemodynamics less and provides better fetal acid/base status than high-dose desflurane. Fetal echocardiography did not reflect myocardial dysfunction in this model.

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