Effects of Bisphosphonates on Osseointegration of Dental Implants in Rabbit Model

This study is to investigate the effect of bisphosphonates on the osseointegration of dental implants in a rabbit model. Twenty female New Zealand White rabbits were equally assigned into control and experiment groups which received saline or zoledronic acid treatment 4 weeks prior to surgery. Titanium dental implant was placed on the calvarial bone. Zoledronic acid or saline treatment continued after surgery for 4 weeks (short-term subgroup) or 8 weeks (long-term subgroup) until sacrifice. Three different fluorochrome labeling solutions were administrated for assessing bone growth rates. Samples of the calvarial bone and mandible were subjected to microcomputed tomography (micro-CT), confocal microscope, and histology analysis. Zoledronic acid treatment significantly reduced bone growth rates in the calvarial bone, but had no significant influence in bone mineral density and trabecular microarchitecture. Significantly lower bone-to-implant contact ratios were found in zoledronic acid-treated animals compared to controls at week 4 but not at week 8. Oncologic dose zoledronic acid suppresses the bone growth rates of the calvarial bone; ZA may have an adverse effect on osseointegration of dental implant in short term, but this effect tends to diminish in long term.

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Significant Improvement of Clinical Symptoms, Bone Lesions, and Bone Turnover after Long-Term Zoledronic Acid Treatment in Patients with a Severe Form of Camurati-Engelmann Disease

Molecular Syndromology ◽

10.1159/000479859 ◽

2017 ◽

Vol 8 (6) ◽

pp. 294-302 ◽

Cited By ~ 1

Author(s):

Giampiero I. Baroncelli ◽

Elena Ferretti ◽

Cecilia M. Pini ◽

Benedetta Toschi ◽

Rita Consolini ◽

...

Keyword(s):

Zoledronic Acid ◽

Bone Turnover ◽

Acid Treatment ◽

Clinical Symptoms ◽

Severe Form ◽

Bone Lesions ◽

Engelmann Disease

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Long-Term Zoledronic Acid Treatment Increases Bone Structure and Mechanical Strength of Long Bones of Ovariectomized Adult Rats

Calcified Tissue International ◽

10.1007/s00223-002-2015-4 ◽

2003 ◽

Vol 72 (4) ◽

pp. 519-527 ◽

Cited By ~ 67

Author(s):

S.B. Hornby ◽

G.P. Evans ◽

S.L. Hornby ◽

A. Pataki ◽

M. Glatt ◽

...

Keyword(s):

Zoledronic Acid ◽

Mechanical Strength ◽

Acid Treatment ◽

Bone Structure ◽

Long Bones ◽

Adult Rats ◽

Ovariectomized Adult Rats

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Dental Implants for Patients with Periodontitis

Primary Dental Journal ◽

10.1308/205016820828463898 ◽

2019 ◽

Vol 8 (4) ◽

pp. 54-61

Author(s):

Rajiv M. Patel

Keyword(s):

Treatment Planning ◽

Dental Implants ◽

Dental Implant ◽

Narrative Review ◽

Professional Support ◽

Implant Therapy ◽

Plaque Control ◽

Partially Dentate ◽

Implant Treatment

This article provides a narrative review of the use of dental implants in patients with periodontitis. Using clinical examples where possible, consideration is given to the survival and success of implants, peri-implantitis, comparison of periodontally compromised teeth to implants and to treatment planning to help achieve favourable outcomes. The challenges associated with restoring an edentulous arch or partially dentate dentition with implants where significant alveolar atrophy has occurred can be considerable. Compromised outcomes may be commonplace. Dental implant treatment is more likely to be successful for those patients who attain and maintain excellent plaque control. Professional support should focus on managing underlying periodontitis prior to commencing implant therapy and providing long term, regular supportive periodontal care upon completion of treatment.

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Short-Term Zoledronic Acid Treatment Increases Bone Mineral Density and Marrow Clonogenic Fibroblast Progenitors after Allogeneic Stem Cell Transplantation

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2004-0509 ◽

2005 ◽

Vol 90 (2) ◽

pp. 627-634 ◽

Cited By ~ 50

Author(s):

Libuse Tauchmanovà ◽

Patrizia Ricci ◽

Bianca Serio ◽

Gaetano Lombardi ◽

Annamaria Colao ◽

...

Keyword(s):

Bone Mineral Density ◽

Stem Cell ◽

Zoledronic Acid ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Allogeneic Stem Cell Transplantation ◽

Acid Treatment ◽

Mineral Density ◽

Short Term ◽

Turnover Markers

Although osteoporosis is a relatively common complication after allogeneic stem cell transplantation, the role of bisphosphonates in its management has not yet been completely established. Thirty-two patients who underwent allogeneic stem cell transplantation were prospectively evaluated for bone mineral density (BMD) at the lumbar spine (LS) and femoral neck (FN) after a median period of 12.2 months. Then, 15 of the patients with osteoporosis or rapidly progressing osteopenia (bone loss > 5%/yr) received three monthly doses of 4 mg zoledronic acid iv. Fifteen patients were followed up without treatment, and all 30 patients were reevaluated after 12 months for BMD and bone turnover markers. By using enriched mesenchymal stem cells in the colony-forming units fibroblast (CFU-F) assay, we evaluated the osteogenic stromal lineage. This procedure was performed in both groups of patients at study entry and after 12 months. The average BMD loss was 3.42% at LS and 3.8% at FN during a 1-yr longitudinal evaluation in 32 patients. Subsequently, BMD increased at both LS and FN (9.8 and 6.4%, respectively) in the zoledronic acid-treated cohort. Hydroxyproline excretion decreased, and serum bone-specific alkaline phosphatase increased significantly, whereas serum osteocalcin increase did not reach the limit of significance. A significant increase in CFU-F growth in vitro was induced by in vivo zoledronic acid administration. In the untreated group, no significant change was observed in bone turnover markers, LS BMD (–2.1%), FN BMD (–2.3%), and CFU-F colony number. In conclusion, short-term zoledronic acid treatment consistently improved both LS and FN BMD in transplanted patients who were at high risk for fast and/or persistent bone loss, partly by increasing the osteogenic progenitors in the stromal cell compartment.

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Silicon Contamination in Diatom Nutrient Enrichment Experiments

Canadian Journal of Fisheries and Aquatic Sciences ◽

10.1139/f83-088 ◽

1983 ◽

Vol 40 (5) ◽

pp. 657-664 ◽

Cited By ~ 5

Author(s):

Stephen J. Tarapchak ◽

David R. Slavens ◽

Michael A. Quigley ◽

Judith S. Tarapchak

Keyword(s):

Growth Rates ◽

Nutrient Enrichment ◽

Lake Michigan ◽

Pyrex Glass ◽

Short Term ◽

Photosynthetic Rates ◽

Nutrient Bioassay ◽

Enrichment Experiments ◽

Silicon Contamination

Large amounts of biologically available silicon (Si) were released into solution from the walls of Pyrex glass reagent bottles and Erlenmeyer flasks during nutrient bioassay experiments using Lake Michigan water. Photosynthetic rates in short-term (4–7 h) incubations and diatom growth rates and maximum yields in long-term incubations (~7 d) were affected by these extraneous Si supplies. The results of conventional nutrient enrichment bioassays performed in low-Si environments can be seriously biased unless Si contamination from glass incubation containers is avoided.

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Short-term relative invader growth rate predicts long-term equilibrium proportion in a stable, coexisting microbial community

10.1101/2020.04.24.059097 ◽

2020 ◽

Cited By ~ 1

Author(s):

Daniel Padfield ◽

Meaghan Castledine ◽

Joseph Pennycook ◽

Elze Hesse ◽

Angus Buckling

Keyword(s):

Growth Rate ◽

Microbial Community ◽

Relative Abundance ◽

Growth Rates ◽

Community Dynamics ◽

Species Coexistence ◽

Short Term ◽

Long Term Culture ◽

Modelling Approach

AbstractThe ability of species to mutually invade from rare is the defining measure of species coexistence. However, it is unknown whether invasion growth rates predict any characteristic of long-term community dynamics. Here, we use a model five-species microbial community to investigate the link between short-term growth rate and long-term relative abundance. We manipulated diversity and tested the ability of species to coexist in different combinations. Across all diversity levels and species combinations, populations re-established from rare in 71 of 75 combinations and all combinations were stable in long-term culture. Moreover, short-term relative invader growth rate was positively associated with long-term equilibrium proportion, despite large variation in interactions between species and communities. This finding was confirmed using a modelling approach and suggests that the short-term invasion growth rate can predict long-term relative abundance within that community.

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Vitamin D deficiency as a suspected causative factor in the failure of an immediately placed dental implant: a case report

Journal of The Royal Naval Medical Service ◽

10.1136/jrnms-100-328 ◽

2014 ◽

Vol 100 (3) ◽

pp. 328-332 ◽

Cited By ~ 2

Author(s):

G Bryce ◽

N MacBeth

Keyword(s):

Vitamin D ◽

Case Report ◽

Vitamin D Deficiency ◽

Dental Implants ◽

Dental Implant ◽

Causative Factor ◽

Improvised Explosive Device ◽

Immediate Placement ◽

Improvised Explosive

AbstractAimTo discuss the influence of Vitamin D defi ciency in the osseointegration process of a dental implant by way of a case report.SummaryA 29-year-old soldier attended clinic with a fractured mandibular premolar (tooth 44) that was traumatised following head trauma related to the detonation of an Improvised Explosive Device (IED) whilst serving on operational duty. The tooth was deemed unsalvageable and was extracted with immediate placement of a dental implant. The patient experienced no problems but at assessment, five months post-operatively, no osseo-integration of the implant was found. Concurrent medical investigations revealed that he was severely Vitamin D deficient and that this may have contributed to the implant failure.ConclusionVitamin D deficiency may play a role in the failure of osseointegration in dental implants. The assessment of vitamin D status in patients who have been in long-term hospital care or rehabilitation should be considered, prior to the placement of dental implants.

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Effects of Short-Term Zoledronic Acid Treatment on Bone Remodeling and Healing at Surgical Sites in the Maxilla and Mandible of Aged Dogs

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2010.05.062 ◽

2011 ◽

Vol 69 (2) ◽

pp. 418-427 ◽

Cited By ~ 26

Author(s):

Sarandeep S. Huja ◽

Amin Mason ◽

Celia E. Fenell ◽

X. Mo ◽

Sarah Hueni ◽

...

Keyword(s):

Zoledronic Acid ◽

Bone Remodeling ◽

Acid Treatment ◽

Short Term ◽

Maxilla And Mandible

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Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw With Plasma Rich in Growth Factors After Dental Implant Surgery: A Case Report

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-18-00254 ◽

2019 ◽

Vol 45 (4) ◽

pp. 289-296 ◽

Cited By ~ 2

Author(s):

Ignacio García Gil ◽

Barbara Molina Ponte ◽

Sergio Trapote Mateo ◽

Jaime Jiménez García

Keyword(s):

Growth Factors ◽

Dental Implants ◽

Dental Implant ◽

Clinical Case ◽

Scientific Evidence ◽

Osteonecrosis Of The Jaw ◽

Oral Bisphosphonates ◽

Implant Surgery ◽

Dental Implant Surgery

Oral bisphosphonates are commonly used to improve bone density in patients who suffer from a variety of pathologies. However, they have also been known to cause bisphosphonate-related osteonecrosis of the jaws (BRONJ). The aim of this clinical case presentation is to (1) determine whether the currently recommended length of time that oral bisphosphonates should be discontinued, before performing dental implant surgery, is sufficient to prevent BRONJ and (2) to describe an alternative treatment for BRONJ. A 65-year-old female patient developed BRONJ after receiving mandibular dental implants 5 months after discontinuing alendronic acid (Fosamax). The BRONJ was treated by surgical osteotomy and plasma rich in growth factors (PRGF), and the patient was followed up with biweekly examinations, which included 0.2% chlorhexidine mouthwashes and removal of any remaining necrotic bone. The dental implants were loaded 41 weeks after surgery and followed up with periapical radiographs and implant stability quotient measurements at 3, 6, 12, and 24 months postloading. Although the Association of Oral and Maxillofacial Surgeons protocols for suspension of presurgical oral bisphosphonates were followed, this patient still developed BRONJ after implant surgery. While a multitude of treatments have been described in the literature, there is not enough scientific evidence to support any one treatment. Based on this clinical case, it can be concluded that the potential adverse effects of oral bisphosphonates on the jaws could be greater than expected and that treatment with PRGF produces promising results, although more long-term studies are necessary to confirm these findings.

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Safety and Efficacy of Long-Term Zoledronic Acid in Advanced Breast Cancer with Bone Metastasis in South China

Journal of Oncology ◽

10.1155/2020/5670601 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Qianyu Wang ◽

Guifang Guo ◽

Zhaohui Ruan ◽

Huijiao Cao ◽

Ying Guo ◽

...

Keyword(s):

Breast Cancer ◽

Zoledronic Acid ◽

Bone Metastasis ◽

Advanced Breast Cancer ◽

Hearing Impairment ◽

Advanced Breast ◽

Short Term ◽

Short Term Treatment ◽

Cox Regression Analysis

Background. This retrospective study aimed to characterize the long-term (>24 months) safety profile of zoledronic acid (ZA). We aimed to investigate whether long-term ZA treatment had greater benefits than short-term treatment in patients from southern China with advanced breast cancer (ABC) with bone metastasis. Patients and Methods. A total of 566 metastatic breast cancer cases were included and divided into two groups according to the duration of ZA treatment. The included patients had at least one lytic bone lesion and had no skeletal-related events (SREs) prior to ZA therapy. The primary endpoint was to analyze the safety and long-term adverse effects, which covered osteonecrosis of jaws (ONJ), renal impairment, and hearing impairment. The second objective was to determine the efficacy of long-term ZA treatment by the incidence of SREs. Results. Fifteen patients were diagnosed with ONJ (2.7%): nine in the short-term group (3.1%) and six in the long-term group (2.2%, P = 0.606). Five cases (0.9%) had renal function impairment: two in the short-term group (0.7%) and four in the long-term group (1.1%, P = 0.676). One patient (0.2%) in the long-term group had hearing impairment after 23 months of ZA treatment (0.4%, P = 0.482). In total, 103 cases in the short-term group (35.2%) and 138 cases in long-term group (50.5%) developed SREs (P < 0.001). The mean annual SRE rate was 0.3 in the short-term group (range, 0–3.1) versus 0.2 in the long-term group (0–1.0, P = 0.269). Subgroup analysis suggested that cases with non-load-bearing bone involvement and those who received systematic anticancer therapy without chemotherapy might benefit from long-term ZA treatment. Cox regression analysis indicated poor performance status, and nonvisceral organ involvement predicted high risk for SRE. Conclusions. The extension of ZA treatment did not increase the long-term adverse events and reduced the annual incidence of SREs beyond 24 months. Although longer treatment of ZA over 24 months appeared to be safe, further prospective investigation is required.

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