scholarly journals Study on the Effect of Combination of Prednisone and Vitamin D in the Treatment of Primary Nephrotic Syndrome in Children

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Guoqun Zhou ◽  
Xiangdong Kong
Keyword(s):  
Vitamin D ◽  
Nephrotic Syndrome ◽  
Total Effective Rate ◽  
Combined Treatment ◽  
Effective Rate ◽  
Continuous Treatment ◽  
Treatment Result ◽  
Control Group ◽  
Observation Group ◽  
Primary Nephrotic Syndrome

Objective. To study the effect of prednisone combined with vitamin D in the treatment of primary nephrotic syndrome in children. Method. 73 cases of primary nephrotic syndrome admitted to the nephrology department of our hospital were randomly selected and retrospectively analyzed. 36 cases were treated with prednisone as the control group, and 37 cases were treated with prednisone combined with vitamin D as the observation group. The efficacy was compared after 3 months of continuous treatment. Result. After 3 months of treatment, the blood calcium of the observation group was higher than that of the control group, PTH was lower than that of the control group, and 25-(OH)2D3 and 1,25-(OH)2D3 were higher than those of the control group ( P < 0.05 ). After 1, 2, and 3 months of treatment in the observation group, Scr and 24-h urine protein quantification were lower than those in the control group and eGFR was higher than that in the control group ( P < 0.05 ). CD4+ and CD4+/CD8+ were lower in the observation group than in the control group after 3 months of treatment ( P < 0.05 ). The serum sTfR and TGF-β1 levels were lower in the observation group than in the control group after 3 months of treatment ( P < 0.05 ). The total effective rate of the observation group was 83.78% after 3 months of combined treatment with prednisone and vitamin D, which was significantly higher than the total effective rate of the control group of 61.11% ( P < 0.05 ). The incidence of nausea and vomiting, heartburn, headache, dry cough, hypercalcemia, and constipation during treatment in the observation group was not statistically different from that in the control group ( P > 0.05 ). Conclusion. Combined treatment of primary nephrotic syndrome in children with prednisone and vitamin D can more significantly improve the level of clinical indicators, improve renal function and immune function, and obtain more satisfactory efficacy, without significantly affecting the safety of treatment.

scholarly journals Effect of dexamethasone on TLR4 and MyD88 expression in monocytes of patients with tuberculous meningitis

2017 ◽  
Vol 15 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Jie Zhou ◽  
Jing Wang ◽  
Mei-Ying Gu ◽  
Shu-Qiong Zhang ◽  
Sheng-Li Chen ◽  
...  
Keyword(s):  
Tuberculous Meningitis ◽  
Combined Treatment ◽  
Effective Rate ◽  
Tuberculosis Treatment ◽  
Control Group ◽  
Observation Group ◽  
Blood Monocytes ◽  
Dexamethasone Treatment ◽  
And Control ◽  
Myd88 Pathway

This study aims to analyze the clinical effect of dexamethasone in the treatment of tuberculous meningitis and its effect on MyD88 and TLR4 expression in monocytes. In total, 60 tuberculous meningitis patients were divided into two groups: observation group and control group. Of them, 36 patients were treated with conventional anti-tuberculosis treatment combined with dexamethasone in the observation group, while patients in control group were treated with anti-tuberculosis alone, and the clinical efficacy and expression of TLR4 and MyD88 in peripheral blood monocytes in both the groups were analyzed. The total effective rate in the combined treatment group was 91.67%, which was significantly better than the control group (χ2 = 5.17, P < 0.05). This revealed that dexamethasone treatment can significantly reduce the expression levels of TLR4 and MyD88. Anti-tuberculosis treatment combined with dexamethasone can significantly improve treatment efficacy. Furthermore, the TLR4-MyD88 pathway plays an important role in the dexamethasone treatment of tuberculous meningitis.

Arthroscopic Debridement Combined with Rehabilitation Training in the Treatment of Knee Osteoarthritis

2021 ◽  
Vol 7 (5) ◽  
pp. 3384-3388
Author(s):  
Wei Sun ◽  
Wenjie Yu ◽  
Yanhua Wang ◽  
Guangliang Hu
Keyword(s):  
Knee Osteoarthritis ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Arthroscopic Debridement ◽  
Rehabilitation Training ◽  
The Difference ◽  
Score Result ◽  
Better Than

Objective: The clinical effect of arthroscopic debridement combined with rehabilitation training in the treatment of knee arthritis was studied and analyzed. Methods: A total of 90 patients with knee osteoarthritis treated in our hospital from August 2017 to August 2018 were selected as the research objects. All patients were divided into the observation group and the control group by using the random number method. The control group was treated by arthroscopic cleaning operation, and the observation group was treated by combined rehabilitation training on the basis of the treatment in the control group. The total effective rate and simple McGill pain of the two groups were compared Score and lyshoim score. Result: The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05), the difference was statistically significant; after treatment, the simple McGill pain score of the observation group was significantly lower than that of the control group (P < 0.05), the difference was statistically significant, the lyshoim score of the observation group was significantly better than that of the control group (P < 0.05), the difference was statistically significant. Conclusion: In the treatment of knee osteoarthritis, arthroscopic debridement combined with rehabilitation training has a significant effect, which can significantly reduce the pain and improve the prognosis of patients. It is worth popularizing in clinical treatment.

scholarly journals Research on the treatment of Pseudomonas aeruginosa pneumonia in children by macrolide antibiotics

Open Medicine ◽  
2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Xu-qiang Huang ◽  
Li Deng ◽  
Gen Lu ◽  
Chun-hui He ◽  
Pei-qiong Wu ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Reaction Rate ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Macrolide Antibiotics ◽  
Control Group ◽  
Observation Group ◽  
Bacterial Clearance ◽  
Clinical Method ◽  
Combined Application

Abstract To observe a therapeutic effect of macrolide antibiotics in children with Pseudomonas aeruginosa pneumonia. Fifty-four cases of children with Pseudomonas aeruginosa pneumonia were randomly divided into an observation group (n=30) and a control group (n=24). The observation group was treated with macrolide antibiotics and cefoperazone/sulbactam. The control group was treated with cefoperazone/ sulbactam during a course of 10-14 days. The total effective rate was 93.3% in the observation group, and 58.3% in the control group, and results in the observation group were superior to the control group notably (P>0.05). There were no significant differences in bacterial clearance rate, adverse reaction rate between two groups (P>0.05). The combined application of cefoperazone/sulbactam with macrolide antibiotics to treat Pseudomonas aeruginosa pneumonia in children would be a more effective clinical method.

scholarly journals Analysis of Clinical Effect of Treating Arrhythmia with Stable Heart Granules

2013 ◽  
Vol 2 ◽  
pp. 7
Author(s):  
Li Liu
Keyword(s):  
Clinical Practice ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
The Difference ◽  
And Control ◽  
Group Observation

<p><strong>Objective: </strong>To study the clinical effect on the treatment of cardiac arrhythmia, and further guide the clinical treatment. <strong>Method: </strong>From January 2011 to January 2013, 100 patients with arrhythmia were randomly divided into observation group and control group with 50 cases in each group. Observation group patients given oral Stable heart granule treatment, while control group was treated with oral propafenone treatment. The therapeutic effect and adverse reactions of the two groups were observed and compared. <strong>Results: </strong>The total effective rate of the observation group was higher than control group and incidence of adverse reactions was lower than control group, the difference was statistically significant, <em>p</em> &lt; 0.05. The use of stable heart particles in the treatment of arrhythmia produce significant effect. <strong>Conclusion: </strong>Clinical effect for Stable heart granule on arrhythmia was significant and should widely entrenched in clinical practice.</p>

scholarly journals Clinically Studies on Treatment of Pulmonary Arterial Hypertension Induced Right Heart Failure

2015 ◽  
Vol 4 (1) ◽  
pp. 20
Author(s):  
Yudong Wang
Keyword(s):  
Heart Failure ◽  
Pulmonary Arterial Hypertension ◽  
Total Effective Rate ◽  
Right Heart Failure ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Right Heart ◽  
Heart Failure Patients ◽  
Pulmonary Arterial

<strong>Objective:</strong> to study a clinical treatment of pulmonary arterial hypertension induced right heart failure. <strong>Method:</strong> A total of 60 cases of pulmonary heart disease right heart failure patients were randomly divided into observation group and control group in which 30 cases for each group. <strong>Results:</strong> In the observation group of 30 cases, 14 cases produce an effect, 15 cases is effective, 2 cases is invalid and the total effective rate is 96.6%. In the control group of 30 cases, 8 cases produce an effect, 17 cases is effective, 5 cases is invalid and the total effective rate is 83.3%. <strong>Conclusion:</strong> Dobutamine can alleviate symptoms of heart failure, reduce heart failure patients’ fatality rate and improve prognosis.

scholarly journals Efficacy of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the Management of Malignant Ascites

2020 ◽  
Author(s):  
Jie Jiao ◽  
Chengzhen Li ◽  
Guanying Yu ◽  
Lei Zhang ◽  
Xiaoyan Shi ◽  
...  
Keyword(s):  
Intraperitoneal Chemotherapy ◽  
Adverse Reactions ◽  
Total Effective Rate ◽  
Malignant Ascites ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Short Term ◽  
Significant Difference ◽  
The Difference

Abstract Objective: The purpose of this study is to compare the difference of clinical efficacy between conventional intraperitoneal chemotherapy and HIPEC, so as to explore the clinical application value and advantages of HIPEC.Design: A retrospective analysis was conducted on 80 patients with malignant ascites admitted to our hospital from June 2017 to June 2019. The general clinical data and qualitative data of the treatment results of 80 patients with malignant ascites were processed by SPSS19.0 using χ2 test and quantitative data were processed by t test. P <0.05, statistical data can be considered statistically significant.Results: 1. There was no significant change in vital signs and temperature in the observation group during the treatment, and the difference was not statistically significant 2. The short-term total effective rate of patients in the observation group was 91.11%, and the short-term total effective rate of the patients in the control group was 40%.3. There was no significant difference in the incidence of adverse reactions between the two groups of patients.Conclusion: Intraperitoneal hyperthermic chemotherapy combined with intravenous chemotherapy can significantly control malignant ascites, and has small adverse reactions, which is worthy of clinical promotion and application.

scholarly journals Apatinib, S-1 Combined with Paclitaxel Perfusion in the Treatment of Malignant Seroperitoneum of Gastric Cancer

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Zhiyu Wang ◽  
Dan Hong ◽  
Zhuoqi Zhang ◽  
Shenyong Su ◽  
Yan Shi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Drug Resistance ◽  
Treatment Effect ◽  
Adverse Reactions ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Good Prognosis ◽  
Control Group ◽  
Observation Group ◽  
And Control

Objective: To analyze the effect of apatinib, S-1 combined with paclitaxel perfusion on malignant seroperitoneum of gastric cancer. Methods: From December 2019 to May 2020, 172 patients with gastric cancer treated in our hospital were randomly divided into two groups: observation group and control group, 86 cases each. The control group adopted the method of S-1 combined with paclitaxel perfusion therapy in the treatment of malignant seroperitoneum of gastric cancer. The observation group was given oral apatinib on the basis of S-1 combined with paclitaxel perfusion therapy, and the dosage was 500 mg/d. Results: The total effective rate of treatment in the control group was 43.02%, while the total effective rate in the observation group was 69.77%; the drug resistance of the two groups of patients increased and the adverse reactions were low. Conclusion: Apatinib and S-1 combined with paclitaxel perfusion therapy can effectively improve the treatment effect, stabilize the patient's condition, increase the patient's drug resistance to adverse reactions, and have a good prognosis.

scholarly journals Clinical Observation of Self-Made Yin-Tonifying Ophiopogonis Decoction Combined with Rehabilitation New Liquid in the Treatment of Reflux Esophagitis with Deficiency of Stomach Yin

2021 ◽  
Vol 5 (4) ◽  
pp. 112-116
Author(s):  
Liang Wang ◽  
Li Liu ◽  
Zhenghui Liu
Keyword(s):  
Reflux Esophagitis ◽  
Clinical Effect ◽  
Clinical Observation ◽  
Random Number ◽  
Clinical Symptoms ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Random Number Table

Objective: To observe the efficacy of Yin-tonifying Ophiopogonis Decoction combined with Rehabilitation New Liquid in the treatment of reflux esophagitis (RE). Methods: Seventy-four patients with RE were included in the study and they were divided into an observation group and a control group using the random number table method with 37 cases in each group. The patients in the control group were given oral Yin-tonifying Ophiopogonis Decoction whereas the patients in the observation group were additionally treated with the Rehabilitation New Liquid. The clinical efficacy, traditional Chinese medicine (TCM) symptoms, and the efficiency of gastroscopy were compared between the two groups. Results: The total effective rate of clinical symptoms, TCM symptoms, and gastroscopy results between the observation group and the control group were significantly different (P < 0.05) and were statistically significant. Conclusion: The clinical effect of Yin-tonifying Ophiopogonis Decoction combined with the Rehabilitation New Liquid in the treatment of RE is significant.

CT Image Analysis of Large Bone Flap Craniotomy for Severe Traumatic Brain Injury

2019 ◽  
Vol 9 (8) ◽  
pp. 1741-1745
Author(s):  
Lihong Hu ◽  
Bo Yin ◽  
Ning Yin ◽  
Aiping Tan
Keyword(s):  
Therapeutic Effect ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Craniocerebral Injury ◽  
Language Function ◽  
Function Score ◽  
Ct Image Analysis ◽  
Large Bone

Objective: To explore the therapeutic effect of large traumatic craniotomy for severe craniocerebral injury and examine recovery using CT image analysis. Methods: 86 patients with severe craniocerebral injury admitted to our hospital were selected and divided into control group (n = 43) and observation group (n = 43). The observation group was treated with modified large traumatic craniotomy, while the control group was treated with standard large traumatic craniotomy. After the experiment, we analyzed the CT images before and after the operation, as well as the therapeutic effect, including the total effective rate of drugs, the incidence of complications, intracranial pressure, neurological deficit, language function score and motor function score, and analyzed their medical value. Results: The medical total effective rate, language function score and motor function score of the observation group were higher than those of the control group, and the incidence of complications, intracranial pressure and neurological deficits were lower than those of the control group, with statistical significance (P < 0.05). CT images also showed that the patient condition was improved and recovery was good. Conclusion: Compared with standard craniotomy, the craniotomy with large bone flaps can achieve better therapeutic effect. The incidence of complications is reduced and the recovery is good. This type of procedure is beneficial to improve the prognosis and neurological function of patients.

scholarly journals Therapeutic Effect of Chinese Massage Combined with Warm Acupuncture on Knee Osteoarthritis

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Fuli Wang
Keyword(s):  
Knee Osteoarthritis ◽  
Total Effective Rate ◽  
Joint Stiffness ◽  
Womac Score ◽  
Effective Rate ◽  
Control Group ◽  
Joint Mobility ◽  
Observation Group ◽  
Research Subjects ◽  
The Difference

Objective: To investigate the effect of Chinese massage combined with warm acupuncture on knee osteoarthritis. Methods: 60 patients with knee osteoarthritis who were treated in our hospital from January 2017 to October 2019 were selected as the research subjects, and they were randomly divided into 2 groups of 30 patients each. The control group was treated with oral western medicine, and the observation group was treated with massage combined with warm acupuncture. The clinical efficacy and WOMAC index were compared between the two groups. Results: The total effective rate of the observation group was higher than that of the control group, and the WOMAC score was lower than that of the control group. The difference was statistically significant(P<0.05). Conclusion: Chinese massage combined with warm acupuncture is effective in treating knee osteoarthritis It can effectively alleviate the symptoms of pain and joint stiffness in patients, and improve joint mobility, which is worth for clinical promotion.

Sign in / Sign up

Export Citation Format

Share Document