scholarly journals The Anti-Inflammatory Effect of Zhibaidihuang Decoction on Recurrent Oral Ulcer with Sirt1 as the Key Regulatory Target

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Yajie Shao ◽  
Bin Ding ◽  
Jinjun Ji ◽  
Shanshan Lei ◽  
Yu Dong ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Oral Mucosa ◽  
Causative Factor ◽  
The Body ◽  
Yin Deficiency ◽  
Oral Ulcers ◽  
Fatty Acids Metabolism ◽  
Severity Of The Disease ◽  
Anemarrhena Asphodeloides ◽  
Serum Metabolomics

The syndrome of ROU is generally manifested as obvious pain, redness, and swelling of local ulceration area, accompanied by flushed face, red eyes, sore throat, and swollen gums. Traditional Chinese medicine (TCM) doctors believe that “yin deficiency” is one causative factor of ROU. Zhibaidihuang decoction (ZBDHD) is a prescriptively developed receipt, where Anemarrhena asphodeloides and Phellodendri amurensis Cortex are added in the original Liuweidihuang decoction. It is generally used for “yin deficiency” treatment. It can effectively reduce the recurrence of oral ulcers and release the severity of the disease. However, the mechanism of this activity remains to be elucidated. In this study, we found that ZBDHD has a certain therapeutic effect on the pathological changes of oral mucosa. Furthermore, the results of serum metabolomics showed ZBDHD influenced the synthesis and metabolism of certain fatty acids. The results of western blot, immunochemical, and immunofluorescence staining indicate that ZBDHD could increase the expression of Sirt1 and Foxp3 and suppress the expression and acetylation of NF-κB in oral mucosa cells. By screening active ingredients in ZBDHD, we found berberine, as well as other compounds, presenting high fitness of the Sirt1 reactive centre. Therefore, it is possible that ZBDHD can regulate the Sirt1-NF-κB pathway to improve fatty acids metabolism in the body, thereby achieving the effect of treating ROU.

scholarly journals Changes in Adult Rats’ Testis structure Induced by Hypothyroidism and Alleviating Role of L-Carnitine

2019 ◽  
Vol 1 (4) ◽  
pp. 13-28
Author(s):  
Abdelmonem Awad Hegazy ◽  
Manal Mohammad Morsy ◽  
Rania Said Moawad ◽  
Gehad Mohammad Elsayed
Keyword(s):  
Fatty Acids ◽  
Semen Analysis ◽  
Protective Role ◽  
The Body ◽  
Albino Rats ◽  
Adult Rats ◽  
Fatty Acids Metabolism ◽  
Group 3 ◽  
Group 2

Background Hypothyroidism is a metabolic disorder affecting the functions of many tissues in the body including the testis. Testis is rich in the polyunsaturated fatty acids content and lacks strong intrinsic antioxidant system making it prone to such oxidative stress. L-carnitine (LC) regulates long chain fatty acids metabolism; and is considered a valuable antioxidant factor. Aim It was to evaluate the effect of hypothyroidism induced by propylthiouracil (PTU) on rats’ testes and the possible protective role of LC. Methods Forty-eight adult male albino rats were used in this work. The animals were divided into three groups with sixteen animals in each. Group 1 (Control): Animals were kept without medications. Group 2 (PTU-treated): was subjected to administration of PTU; while group 3 (PTU and LC) received both PTU and LC. By the end of the experiment “30 days”, blood samples were taken for hormonal assay; then animals were anaesthetized and sacrificed. Specimens were homogenized for biochemical analysis; epididymal content of each rat was obtained immediately for semen analysis. Testes’ specimens were harvested, prepared and examined by light microscope examination. Results Induced hypothyroidism was noticed to cause histopathological, morphometric and biochemical changes in rat’s testes. LC protected the testicular specimens against such changes; it also improved the seminal quality and quantity as well as testicular structure and biochemistry. Conclusion Hypothyroidism could result in hazards to the structure of testis. Fortunately co-administration of LC might reduce such hazards.

scholarly journals Oral Lesion Associated with Hypertension: A Mini Review

2020 ◽  
pp. 1-3
Keyword(s):  
Blood Pressure ◽  
Salivary Glands ◽  
Oral Mucosa ◽  
Side Effect ◽  
Oral Lesion ◽  
The Body ◽  
Oral Ulcers ◽  
Hemorrhagic Bullae ◽  
High Level ◽  
Saliva Production

Background: Hypertension is a chronic condition due to the high level of blood pressure. There are 2 types of hypertension. Hypertension patients are usually consumed anti-hypertension medication to prevent the high blood pressure which can affect the damage of blood vessel in the body. The used of anti-hypertension drugs can cause the oral lesion because antihypertension drugs have several effect on oral mucosa until the dysfunction of salivary glands. Objective: to know the oral lesions that associated with hypertension. Problem Statement: The used of anti-hypertension drug in hypertension patients have side effect. The side effect can cause the oral lesion and tissue damage in oral cavity. Discussion: Cardiovascular drugs such as anti-hypertension can cause oral ulcers such as agranulocytosis and thrompositopenia with hemorrhagic bullae, peteki, ecchymosis with bleeding. Terasozin and prasozin which are anti-hypertensive drugs can inhibit the salivary glands of alpha-adrenoreceptors, causing dry mouth due to reduced saliva production. Conclusion: Hypertension has a specific role as a cause of oral lesion. The use of antihypertension drug has shown the associated with oral mucosa damage.

Omega-6 and omega-3 fatty acids metabolism pathways in the body of pigs fed diets with different sources of fatty acids

2014 ◽  
Vol 69 (1) ◽  
pp. 1-16 ◽  
Author(s):  
Grzegorz Skiba ◽  
Ewa Poławska ◽  
Monika Sobol ◽  
Stanisława Raj ◽  
Dagmara Weremko
Keyword(s):  
Fatty Acids ◽  
The Body ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Omega 6 ◽  
Fatty Acids Metabolism ◽  
Different Sources

Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases

2012 ◽  
Vol 403 (1) ◽  
pp. 203-213 ◽  
Author(s):  
Lina Zhou ◽  
Quancai Wang ◽  
Peiyuan Yin ◽  
Wenbin Xing ◽  
Zeming Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acids ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Fatty Acids Metabolism ◽  
Serum Metabolomics

DEVELOPMENT OF AN EXPERIMENTAL MODEL OF AVITAMINOSIS F

2020 ◽  
Vol 20 (2) ◽  
pp. 38-40
Author(s):  
A. Levitsky ◽  
A. Lapinska ◽  
I. Selivanskaya
Keyword(s):  
Fatty Acids ◽  
Experimental Model ◽  
Unsaturated Fatty Acids ◽  
Saturated Fatty Acids ◽  
Coconut Oil ◽  
The Body ◽  
Regulatory Function ◽  
Omega 3 ◽  
White Rats ◽  
Arachidonic Acids

The article analyzes the role of essential polyunsaturated fatty acids (PUFA), especially omega-3 series in humans and animals. The biosynthesis of essential PUFA in humans and animals is very limited, so they must be consumed with food (feed). Тhe ratio of omega-3 and omega-6 PUFA is very important. Biomembranes of animal cells contain about 30% PUFA with a ratio of ω-6/ ω-3 1-2. As this ratio increases, the physicochemical properties of biomembranes and the functional activity of their receptors change. The regulatory function of essential PUFA is that in the body under the action of oxygenase enzymes (cyclooxygenase, lipoxygenase) are formed extremely active hormone-like substances (eicosanoids and docosanoids), which affect a number of physiological processes: inflammation, immunity, metabolism. Moreover, ω-6 PUFA form eicosanoids, which have pro-inflammatory, immunosuppressive properties, and ω-3 PUFAs form eicosanoids and docosanoids, which have anti-inflammatory and immunostimulatory properties. Deficiency of essential PUFA, and especially ω-3 PUFA, leads to impaired development of the body and its state of health, which are manifestations of avitaminosis F. Prevention and treatment of avitaminosis F is carried out with drugs that contain PUFA. To create new, more effective vitamin F preparations, it is necessary to reproduce the model of vitamin F deficiency. An experimental model of vitamin F deficiency in white rats kept on a fat –free diet with the addition of coconut oil, which is almost completely free of unsaturated fatty acids, and saturated fatty acids make up almost 99 % of all fatty acids was developed. The total content of ω-6 PUFA (sum of linoleic and arachidonic acids), the content of ω-3 PUFA (α-linolenic, eicosapentaenoic and docosahexaenoic acids) in neutral lipids (triglycerides and cholesterol esters) defined. Тhe content of ω-6 PUFA under the influence of coconut oil decreased by 3.3 times, and the content of ω-3 PUFA - by 7.5 times. Тhe influence of coconut oil, the content of ω-6 PUFA decreased by 2.1 times, and the content of ω-3 PUFA - by 2.8 times. The most strongly reduces the content of ω-3 PUFA, namely eicosapentaenoic, coconut oil, starting from 5 %. Consumption of FFD with a content of 15 % coconut oil reduces the content of eicosapentaenoic acid to zero, ie we have an absolute deficiency of one of the most important essential PUFAs, which determined the presence of vitamin F deficiency.

USE OF ESSENTIAL FATTY ACIDS AND THEIR ROLE IN THE HUMAN ORGANISM DEVELOPMENT

2018 ◽  
Vol 28 (4) ◽  
pp. 1219-1225
Author(s):  
Filip Jovanovski ◽  
Toni Mitrovski ◽  
Viktorija Bezhovska
Keyword(s):  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
Essential Fatty Acids ◽  
Normal Growth ◽  
The Body ◽  
Human Nutrition ◽  
Human Organism ◽  
Working Ability ◽  
The World ◽  
Growth Development

Food is not just a pleasure in life, it is also an important factor for our health. Human nutrition is a mixture of nutrients, which are the only source of energy needed for survival. Energy-poor diet endangers many life functions, and above all the working ability. In the world, the meaning of the diet is very serious, and hence the demands for a –rational, healthy and safe diet are growing. Human nutrition contains saturated and unsaturated fatty acids. Essential fatty acids (EFAs) must be ingested in everyday diet because the body does not produce it. They are very important for human health. They are present in each cell of the human body and are an important factor for the normal growth, development and functioning of cells, muscles, nerves and organs. They are also used in the production of certain hormones - such as prostaglandins, which are crucial for the performance of certain important processes. The deficit from EFAs is due to a number of health problems, including more serious diseases.

Dose schedule of Rasa Aushadhis

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Dr. Jambla Neha ◽  
Saroch Vikas ◽  
Johar Smita
Keyword(s):  
Particle Size ◽  
Oral Mucosa ◽  
Small Particle ◽  
Dose Schedule ◽  
The Body ◽  
Small Particle Size ◽  
Inherent Property ◽  
Ayurvedic Drugs ◽  
Modern Era

Rasashastra deals with the Rasa Aushadhis, the drugs of metallic and mineral origin. Mercury is used in most of the Rasaaushadhis. The toxicity of Mineral and metallic preparations are reduced to such an extent by various procedures of Shodhana, Marana etc. that Mercury converts its inherent property of toxicity into medicinal property. Rasa Aushadhis works quickly on the body because due to their small particle size, their absorption starts from the oral mucosa itself. The action of drugs depends largely upon the Anupana i.e. the vehicle for the drug. Rasacharayas have mentioned various Rasa preparations like Bhasmas, Parpati, Pottali, Manduras, Karpooras etc. along with their doses, dose schedule and Anupana / Sahapana etc. The principles of Rasaaushadhis when correlated in modern era are found to be scientifically accurate. We may say that Rasacharyas had already mastered the science of nanotechnology, purification, action of metabolic catalysts, biotransformation and preservation of medicines. The Ayurvedic drugs can be harmful for our body when not administered in proper dosage as per mentioned in classic literatures.

scholarly journals VITAL NEED OF THE BODY FOR CERTAIN UNSATURATED FATTY ACIDS

1932 ◽  
Vol 96 (1) ◽  
pp. 143-156
Author(s):  
Herbert M. Evans ◽  
Samuel Lepkovsky
Keyword(s):  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
The Body

scholarly journals VITAL NEED OF THE BODY FOR CERTAIN UNSATURATED FATTY ACIDS

1934 ◽  
Vol 106 (2) ◽  
pp. 445-450a
Author(s):  
Herbert M. Evans ◽  
Samuel Lepkovsky ◽  
Elizabeth A. Murphy
Keyword(s):  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
The Body
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