scholarly journals Regulatory Role of Zinc in Allergic Rhinitis through the IL-33/ST2 Pathway

2022 ◽  
Vol 2022 ◽  
pp. 1-6
Author(s):  
Wulin Wen ◽  
Fengxia Yang ◽  
Xueliang Shen ◽  
Ningyu Feng ◽  
Huiyu Ha ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mast Cells ◽  
Serum Zinc ◽  
Zinc Level ◽  
Cell Counting ◽  
Regulatory Role ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Zinc Level ◽  
Cell Supernatant

Objective. We aimed to investigate the expression of serum zinc and cytokines interleukin- (IL-) 13 and IL-33 in patients with allergic rhinitis (AR) and observe the effects of zinc on cytokines and pathway proteins in P815 mast cells stimulated by Artemisia annua allergen (Art.) in the IL-33/suppression of the tumorigenicity 2 (ST2) pathway. We also aimed to explore the possible regulatory role of zinc in AR and provide new ideas to determine the etiology and treatment of AR. Methods. AR patients treated from March to September in 2018 were selected as the research participants, and 50 healthy people in the same period were selected as the control group. Serum samples of all patients were collected, and those of AR patients were tested for the presence of allergens. The expression of IL-13 and IL-33 was detected by performing an enzyme-linked immunosorbent assay, while the serum zinc level was detected by conducting an inductively coupled plasma mass spectrometry. The cell counting kit (CCK-8) was used to detect the proliferation of P815 mast cells, and western blot was used to detect the expression of ST2, p38, and p65 proteins. Results. A total of 92 AR patients were included in the study; of them, 52 had mild AR, while 40 had moderate AR. The primary allergen found in AR patients was Artemisia, and the positivity rate was 53.26%. The serum zinc ion level of AR patients decreased, and the expression of IL-13 and IL-33 increased. After Art. was used to treat P815 mast cells, the expression of IL-33 in the cell supernatant increased in a concentration-dependent manner, the expression of receptor ST2 increased, and the expression of downstream p38 and p65 proteins increased. However, after treatment with ZnSO4, the expression of IL-33 in the cell supernatant decreased, and the expression of ST2, p38, and p65 protein decreased. Conclusion. The serum zinc level of AR patients decreased. In the IL-33/ST2 pathway, ZnSO4 can reduce the hypersensitivity of mast cells induced by Art.

The Role of Serum Zinc Level in Febrile Convulsion Etiology

2012 ◽  
Vol 6 (3) ◽  
pp. 90-93 ◽  
Author(s):  
İhsan Kafadar ◽  
Ayşe Burcu Akıncı ◽  
Fügen Pekün ◽  
Erdal Adal
Keyword(s):  
Serum Zinc ◽  
Febrile Convulsion ◽  
Zinc Level ◽  
Serum Zinc Level

scholarly journals Role of Serum Zinc Level and P300 Event Related Potential in Detection of Minimal Hepatic Encephalopathy

2015 ◽  
Vol 05 (06) ◽  
pp. 58-65
Author(s):  
Ghada M. Galal ◽  
Mahmoud Saif-Al-Islam ◽  
Mohammed Abd Al-Ghafar Abd Al Rahman ◽  
Nagwa S. Ahmed ◽  
Mona M. Abd El Rhman
Keyword(s):  
Hepatic Encephalopathy ◽  
Serum Zinc ◽  
Minimal Hepatic Encephalopathy ◽  
Zinc Level ◽  
Event Related Potential ◽  
Serum Zinc Level ◽  
P300 Event Related Potential

Serum Zinc Levels in Cirrhotic Patients Attending General and Specialty Hospitals, Yangon

2019 ◽  
Vol 31 (3) ◽  
pp. 251-256
Keyword(s):  
Clinical Practice ◽  
Hepatic Encephalopathy ◽  
Zinc Deficiency ◽  
Serum Zinc ◽  
Zinc Level ◽  
The Body ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Cirrhotic Patients ◽  
Cirrhosis Of Liver

Cirrhosis of liver is one of the common medical problem in daily clinical practice and one of the leading causes of morbidity and mortality. Zinc is an essential trace elements for human and plays in many biological roles in the body. Among them, zinc deficiency is thought to be involved in metabolism of ammonia and causes hyperammonia that worsen hepatic encephalopathy. This study aimed to find out the severity of cirrhosis of liver was by Child Turcotte Pugh score and to investigate the associations between serum zinc level and severity of cirrhosis. A hospital-based cross-sectional descriptive study was performed on 78 patients with different underlying causes of cirrhosis of liver at the Medical Units of Yangon General Hospital and Yangon Specialty Hospital. Among the study population, Child grade A was found to be 28.21%, Child grade B was 30.77% and Child grade C was 41.03%. Regarding result of serum zinc level, 62.8% were low level, 28.2% were within normal level and 8.9% were high level. Mean value of serum zinc level in grade A was 0.68 mg/l, grade B was 0.54 mg/l and grade C was 0.48 mg/l (p=0.00). It was found out that there was a high prevalence of zinc deficiency in severe cirrhotic patients. The zinc level was significantly lowest among patients with Child-Pugh C as compare to those with Child-Pugh B and C. Severity of zinc deficiency should be requested for supplementation therapy in cirrhotic patients as to prevent complications such as hepatic encephalopathy, hepatocellular carcinoma and liver failure. Screening for zinc deficiency may need in these patients with more advanced cirrhosis because it seems to be a marker of advanced liver disease and it can be deducted that awareness of serum zinc level among cirrhotic patients is very important in clinical practice.

scholarly journals Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2077
Author(s):  
Jiun-Chi Huang ◽  
Ya-Chin Huang ◽  
Pei-Yu Wu ◽  
Wen-Hsien Lee ◽  
Yi-Chun Tsai ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Left Atrial Volume ◽  
Serum Zinc ◽  
Zinc Level ◽  
Volume Index ◽  
Serum Zinc Level ◽  
Lower Serum ◽  
Echocardiographic Parameters ◽  
Zinc Levels ◽  
Serum Zinc Levels

Diastolic dysfunction is an emerging challenge among hemodialysis (HD) patients, and the associations between serum zinc with echocardiographic parameters and diastolic function remain uncertain. A total of 185 maintenance HD patients were stratified by the tertiles of serum zinc level to compare their clinical characteristics and echocardiography. Correlations of serum zinc levels with echocardiographic parameters were examined using Pearson’s analysis. Univariate and multivariate logistic regression analyses were performed to investigate the determinants of E/e’ ratio >15 and left atrial volume index (LAVI) > 34 mL/m2, both indicators of diastolic dysfunction. Patients belonging to the first tertile of serum zinc level had a significantly higher E/e’ ratio and LAVI. Serum zinc levels were negatively correlated with E (r = −0.204, p = 0.005), E/e’ ratio (r = −0.217, p = 0.003), and LAVI (r = −0.197, p = 0.007). In a multivariate analysis, older age, diabetes, coronary artery disease, and lower serum zinc levels (OR = 0.974, 95% CI = 0.950–0.999, p = 0.039) were significantly associated with E/e’ ratio >15. Furthermore, diabetes and lower serum zinc levels (OR = 0.978, 95% CI = 0.958–0.999, p = 0.041) were significantly associated with LAVI >34 mL/m2. Reduced serum zinc level was significantly associated with diastolic dysfunction among HD patients. Further prospective studies are warranted to investigate whether zinc supplementation can attenuate cardiac dysfunction in maintenance HD patients.

scholarly journals Zinc deficiency may play a crucial role in dialysis-associated bacterial infections

2020 ◽  
Vol 11 (1) ◽  
pp. e9-e9
Author(s):  
Zahra Lotfi ◽  
Abbas Ali Zeraati ◽  
Elaheh Dashti ◽  
Tina Zeraati ◽  
Maryam Arghiany ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Bacterial Infections ◽  
Critical Role ◽  
Serum Zinc ◽  
Zinc Level ◽  
Healthy Individuals ◽  
Mortality And Morbidity ◽  
Increased Risk ◽  
The Mean

Introduction: Systemic bacterial infections are a common cause of mortality and morbidity in hemodialysis patients. Zinc has a critical role in several immune system functions. Patients who have enough amounts of zinc are able to better face infections caused by various pathogens in comparison to those with zinc insufficiency Objective We sought to assess the role of zinc deficiency in dialysis-associated bacterial infections. Patients and Methods: Eighty-Three adult patients with end-stage renal disease (ESRD) on hemodialysis including 43 patients with bacterial infectious complications and 40 non-infected patients as well as 41 healthy individuals were enrolled. Clinical data, laboratory values including serum zinc level and imaging findings were collected. SPSS was utilized to analyze the data with a significance cutoff set at P < 0.05. Results: Out of 124 participants, 80 (64.51%) were males and 44 (35.49%) were females. The mean age of infected hemodialysis group, non-infected hemodialysis group, and healthy controls were 50.8 ± 16.25, 49.1 ± 18.1, and 56.3 ± 18.2 years, respectively. Catheter site infection (37.3%) and urinary tract infection (30.2%) were the most common infections. The mean serum zinc concentration was significantly lower in the infected patients, compared to non-infected patients and healthy individuals (P < 0.001). Conclusion: The ESRD patients on hemodialysis have lower serum zinc levels which are associated with increased risk of bacterial infection. The role of screening for zinc deficiency and use of supplemental zinc in these patients need to be studied.

scholarly journals Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals

2020 ◽  
Author(s):  
Zahra Ranjbar ◽  
Maryam Zahed ◽  
Mohammad Ali Ranjbar ◽  
Zahra Shirmardan
Keyword(s):  
Healthy Subjects ◽  
Serum Zinc ◽  
Zinc Level ◽  
Therapeutic Effects ◽  
Herpes Labialis ◽  
Healthy Individuals ◽  
Serum Zinc Level ◽  
Significant Difference ◽  
Recurrent Herpes ◽  
History Of

Abstract Background: Recurrent herpes labialis (RHL) is one of the most common recurrent infective vesiculoulcerative lesions. Topical and systemic administration of Zinc compounds has been found to have preventive and therapeutic effects. The purpose of this article is to evaluate the serum level of zinc in patients with RHL and healthy individuals. Methods: This cross-sectional study was performed on 43 patients with the history of recurrent herpers labialis and 42 healthy subjects with no history of the lesion. Blood samples were taken and serum zinc level was measured. Chi-Square test was used to compare the qualitative relationships and to compare the quantitative relationships independent T-test was used. To observe the relationship of quantitative factors including serum zinc level, the number of relapses and recovery rates correlation test was taken. Results: The results show that serum zinc level has no significant difference in healthy subjects and patients (p> 0.05). Also, zinc level was not related to age and sex factors and frequency of relapse (P> 0.05). But surprisingly in the patients group, there was a significant relationship between zinc level and recovery period. As the serum zinc level was lower, the duration of recovery was significantly higher (p =0.009). Conclusion: The results of this study indicate that zinc deficiency is a risk factor for increasing the duration of herpes labialis lesions. Therefore, the evaluation of serum zinc level in subjects with recurrent herpes labialis and subsequent administration of zinc is recommended in such patients.

scholarly journals Serum Zinc Level at Term Pregnancy and Newborn Anthropometry

2016 ◽  
Author(s):  
Irma Seriana ◽  
Yusrawati Yusrawati ◽  
Gustina Lubis
Keyword(s):  
Birth Weight ◽  
Head Circumference ◽  
Serum Zinc ◽  
Zinc Level ◽  
Birth Length ◽  
Anthropometric Measurement ◽  
Term Pregnancy ◽  
Serum Zinc Level ◽  
Average Birth Weight ◽  
Newborn Anthropometry

Objective: To determine the relationship between serum zinc level at term pregnancy and newborn anthropometry. Methods: This study is an observational study with cross-sectional design. Serum zinc level at term pregnancy was measured and then anthropometric measurement was done to the newborn, including birth weight, birth length and head circumference at birth. The data were statistically analyzed using regression correlation test. Results: Mean serum zinc level at term pregnancy is 36.01 μg/dl (SD=18.34 μg/dl), the average birth weight is 3158 gr (SD=480.4 gr), the average birth length is 48.42 cm (SD=1.75 cm) and the average head circumference at birth is 33.13 cm (SD=1.14 cm). There was no statistically significant relationship between serum zinc levels at term pregnancy and birth weight (p-value=0.152). Meanwhile, there are statistically significant relationships between serum zinc level at term pregnancy with birth length and head circumference with pvalue 0.026 and 0.012, respectively. Conclusion: Serum zinc level at term pregnancy is correlated with birth length and head circumference, but is not correlated with birth weight. [Indones J Obstet Gynecol 2015; 3-4: 190-195] Keywords: birth length, birth weight, head circumference at birth, serum zinc level, term pregnancy

scholarly journals IS SERUM ZINC LEVEL CORRELATED WITH INSULIN RESISTANCE AMONG LACTATING MOTHERS IN JAKARTA?

2020 ◽  
Vol 3 (2) ◽  
pp. 67
Author(s):  
Dian Araminta Ramadhania ◽  
Diana Sunardi ◽  
Ali Sungkar
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Serum Zinc ◽  
Atomic Absorption Spectrophotometry ◽  
Zinc Level ◽  
Model Assessment ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Correlation Test ◽  
Lactating Mothers

Introduction: Insulin resistance is a condition that underlies the development of diabetes mellitus. The prevalence of diabetes mellitus keeps rising, including in Indonesia. A higher proportion of diabetes was found in women. Physiological changes during pregnancy can cause insulin resistance that may persist until postpartum period. Lactation and nutrient like zinc may improve insulin resistance. This study aimed to measure the correlation between zinc serum level and insulin resistance of lactating mothers in Jakarta.Methods: This study used cross-sectional design, was conducted in Puskesmas Kecamatan Grogol Petamburan, West Jakarta and Puskesmas Kecamatan Cilincing, North Jakarta from February to April 2019. A total of 75 lactating mothers at 3–6 months postpartum were selected using consecutive sampling method. Zinc serum was analyzed using atomic absorption spectrophotometry (AAS) method. Insulin resistance was assessed using the homeostasis model assessment-insulin resistance (HOMA-IR).Results: Approximately 76% (n = 57) subjects had low serum zinc level. Spearman correlation test between serum zinc level and HOMA-IR was done (r = 0.003, p = 0.977). Also, correlation test between BMI and HOMA-IR (r = 0.563, p <0.001).Conclusion: No correlation was found between serum zinc level and HOMA-IR however, there was a significant moderate positive correlation between BMI and HOMA-IR.Keywords: Lactation, zinc, insulin resistance, HOMA-IR, BMI

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