Serum Zinc Levels in Cirrhotic Patients Attending General and Specialty Hospitals, Yangon

Cirrhosis of liver is one of the common medical problem in daily clinical practice and one of the leading causes of morbidity and mortality. Zinc is an essential trace elements for human and plays in many biological roles in the body. Among them, zinc deficiency is thought to be involved in metabolism of ammonia and causes hyperammonia that worsen hepatic encephalopathy. This study aimed to find out the severity of cirrhosis of liver was by Child Turcotte Pugh score and to investigate the associations between serum zinc level and severity of cirrhosis. A hospital-based cross-sectional descriptive study was performed on 78 patients with different underlying causes of cirrhosis of liver at the Medical Units of Yangon General Hospital and Yangon Specialty Hospital. Among the study population, Child grade A was found to be 28.21%, Child grade B was 30.77% and Child grade C was 41.03%. Regarding result of serum zinc level, 62.8% were low level, 28.2% were within normal level and 8.9% were high level. Mean value of serum zinc level in grade A was 0.68 mg/l, grade B was 0.54 mg/l and grade C was 0.48 mg/l (p=0.00). It was found out that there was a high prevalence of zinc deficiency in severe cirrhotic patients. The zinc level was significantly lowest among patients with Child-Pugh C as compare to those with Child-Pugh B and C. Severity of zinc deficiency should be requested for supplementation therapy in cirrhotic patients as to prevent complications such as hepatic encephalopathy, hepatocellular carcinoma and liver failure. Screening for zinc deficiency may need in these patients with more advanced cirrhosis because it seems to be a marker of advanced liver disease and it can be deducted that awareness of serum zinc level among cirrhotic patients is very important in clinical practice.

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A Study of Serum Zinc level in Cirrhosis of Liver

Bangladesh Journal of Medical Biochemistry ◽

10.3329/bjmb.v5i2.13340 ◽

2013 ◽

Vol 5 (2) ◽

pp. 44-47

Author(s):

F Atia ◽

N Sultana ◽

S Ahmed ◽

S Ferdousi ◽

R Sultana ◽

...

Keyword(s):

Serum Zinc ◽

Cross Sectional Study ◽

Zinc Level ◽

Serum Zinc Level ◽

Cross Sectional ◽

Medical College ◽

Cirrhotic Patients ◽

Cirrhosis Of Liver ◽

Zinc Levels ◽

Age Range

Cirrhosis is a consequence of chronic liver diseases. Zinc is a micronutrient that plays an important role in the function of liver. This cross-sectional study was carried out in the Department of Biochemistry, Dhaka Medical College, from July 2010 to June 2011 to observe the association of serum zinc level with liver cirrhosis. A total of 100 adults, both males and females with age range of 18-60 years, of which 50 were healthy subjects and 50 adult hospitalised cirrhotic patients were selected purposively for the study according to selection crieteria. Fasting serum zinc level was measured with atomic absorption spectrophotometer. Serum zinc level was found to be low in 72% patients. Mean ±SD of serum zinc levels (?g/L) were 610.32 ± 169.60 and 827.66 ± 267.32 in cases and controls respectively. In cirrhotic patients serum zinc level was significantly lower than that of healthy controls (P<0.001). Though, it is difficult to draw any definite conclusion from this study, because of reduced level serum of zinc found in cirrhotics, Zn may be supplemented to them with a hope of better treatment response. DOI: http://dx.doi.org/10.3329/bjmb.v5i2.13340 Bangladesh J Med Biochem 2012; 5(2): 44-47

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Assessment of risk factors of multidrug resistant tuberculosis with emphasis on serum zinc

Bangladesh Medical Journal ◽

10.3329/bmj.v43i1.21368 ◽

2014 ◽

Vol 43 (1) ◽

pp. 3-8 ◽

Cited By ~ 1

Author(s):

Nilima Barman ◽

Debabrata Ghosh ◽

Md Quddusur Rahman ◽

Md Nasir Uddin ◽

Sarmeen Ahmed ◽

...

Keyword(s):

Risk Factors ◽

Zinc Deficiency ◽

Serum Zinc ◽

Zinc Level ◽

Immune Defense ◽

The Body ◽

Smoking History ◽

Serum Zinc Level ◽

Resistant Tuberculosis ◽

Mdr Tb

Multi-drug resistant tuberculosis (MDR-TB) is a form of TB resistant to isoniazid and rifampicin and considered as a major threat to TB control worldwide. Limited data are available regarding risk factors and serum zinc status of MDR-TB in Bangladesh. Tuberculosis is a disease which blocks a key part of the bodys immune defense. As zinc deficiency causes immune suppression, we assume that it may play a role in the development of MDR-TB. So, this study was carried out to evaluate and assess the serum zinc level as well as different risk factors in patients of MDR-TB. This case control study was carried out in the Department of Clinical Pathology, in collaboration with Department of Public Health and Informatics, Department of Biochemistry, BSMMU and National tuberculosis referral laboratory (NTRL) in NIDCH, Mohakhali, Dhaka from March 2012 to February 2013.We enrolled 50 newly diagnosed cases of MDR-TB patients from NTRL and 50 age matched healthycontrols from a selective community Sirajdikhan Upazilla, Munshiganj District. The two groups were compared based on various demographic factors, behavioral factors, factors related with personal illness history and also laboratory related factors. Serum zinc deficiency, changing trend of number of family members, presence of smoking history, absence of BCG scar and past history of contact TB were statistically significant risk factors for development of MDR-TB in logistic regression model. In our study, we found the mean (SD) serum zinc level in case group 60.40 (8.91) ?g/dL and 84.00 (13.62) ?g/dL in healthy controls which was significant statistically. The risk factors that we found, specially lower level of serum zinc, are the major concern for the development of MDR-TB and attempt to minimize them might contribute to control TB DOI: http://dx.doi.org/10.3329/bmj.v43i1.21368 Bangladesh Med J. 2014 January; 43 (1): 3-8

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A comparative study of the prevalence of zinc deficiency among children with acute diarrhoea in SouthWestern Nigeria

African Health Sciences ◽

10.4314/ahs.v20i1.47 ◽

2020 ◽

Vol 20 (1) ◽

pp. 406-412

Author(s):

Olufunmilola O Abolurin ◽

Oyeku A Oyelami ◽

Saheed B Oseni

Keyword(s):

Zinc Deficiency ◽

Acute Diarrhoea ◽

Serum Zinc ◽

Cross Sectional Study ◽

Zinc Level ◽

Serum Zinc Level ◽

Southwestern Nigeria ◽

Cross Sectional ◽

Under Five ◽

Under Five Children

Background: Zinc deficiency has been associated with increased incidence, severity and duration of childhood diarrhoea. Objective: The objective of the study was to determine the prevalence of zinc deficiency among under-five children with acute diarrhoea. Methods: The study was a comparative cross-sectional study in which serum zinc levels were determined using atomic absorp- tion spectrometry in under-five children with acute diarrhoea and in apparently healthy contols. Two hundred and fifty children with acute diarrhoea and 250 controls were studied at the Wesley Guild Hospital, Ilesa, Nigeria. Results: The diarrhoea patients had a mean ± SD serum zinc level of 78.8 ± 35.6 µg/dl, while the controls had a mean of 107.3 ± 46.8 µg/dl. The mean serum zinc level was significantly lower in the patients than the controls (t = -7.66; p < 0.001). Furthermore, the prevalence of zinc deficiency was significantly higher among the patients (30.4% versus 12.4% in the controls; OR = 3.09; 95% CI = 1.94 – 4.90; χ2 = 24.08; p < 0.001). Low social class was associated with a significantly higher prevalence of zinc deficiency among the patients (p = 0.013). Conclusion: Zinc deficiency is significantly associated with diarrhoea among under-five children in the study community. Hence, routine zinc supplementation should be encouraged for the treatment of diarrhoea, and availability should be ensured. Keywords: Zinc deficiency; diarrhoea; children; Nigeria.

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IS SERUM ZINC LEVEL CORRELATED WITH INSULIN RESISTANCE AMONG LACTATING MOTHERS IN JAKARTA?

World Nutrition Journal ◽

10.25220/wnj.v03.i2.0009 ◽

2020 ◽

Vol 3 (2) ◽

pp. 67

Author(s):

Dian Araminta Ramadhania ◽

Diana Sunardi ◽

Ali Sungkar

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Serum Zinc ◽

Atomic Absorption Spectrophotometry ◽

Zinc Level ◽

Model Assessment ◽

Serum Zinc Level ◽

Cross Sectional ◽

Correlation Test ◽

Lactating Mothers

Introduction: Insulin resistance is a condition that underlies the development of diabetes mellitus. The prevalence of diabetes mellitus keeps rising, including in Indonesia. A higher proportion of diabetes was found in women. Physiological changes during pregnancy can cause insulin resistance that may persist until postpartum period. Lactation and nutrient like zinc may improve insulin resistance. This study aimed to measure the correlation between zinc serum level and insulin resistance of lactating mothers in Jakarta.Methods: This study used cross-sectional design, was conducted in Puskesmas Kecamatan Grogol Petamburan, West Jakarta and Puskesmas Kecamatan Cilincing, North Jakarta from February to April 2019. A total of 75 lactating mothers at 3–6 months postpartum were selected using consecutive sampling method. Zinc serum was analyzed using atomic absorption spectrophotometry (AAS) method. Insulin resistance was assessed using the homeostasis model assessment-insulin resistance (HOMA-IR).Results: Approximately 76% (n = 57) subjects had low serum zinc level. Spearman correlation test between serum zinc level and HOMA-IR was done (r = 0.003, p = 0.977). Also, correlation test between BMI and HOMA-IR (r = 0.563, p <0.001).Conclusion: No correlation was found between serum zinc level and HOMA-IR however, there was a significant moderate positive correlation between BMI and HOMA-IR.Keywords: Lactation, zinc, insulin resistance, HOMA-IR, BMI

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Serum zinc, copper and ferritin levels in transfusion dependent thalassemia patients with iron chelator therapy

Journal of Bangladesh Society of Physiologist ◽

10.3329/jbsp.v14i1.42000 ◽

2019 ◽

Vol 14 (1) ◽

pp. 38-42

Author(s):

Fatema Tuz Munira ◽

Shelina Begum

Keyword(s):

Ferritin Level ◽

Colorimetric Method ◽

Serum Zinc ◽

Study Groups ◽

Iron Chelator ◽

Zinc Level ◽

Serum Copper ◽

Copper Level ◽

Serum Zinc Level ◽

Cross Sectional

Background: Transfusion dependent thalassemia (TDT) patients require regular blood transfusion and iron chelator therapy to maintain their life. Iron chelator may alter serum zinc and copper level in TDT patients. Objective: To observe serum zinc and copper and ferritin levels in transfusion dependent thalassemic patients treated with iron chelator. Method: The present cross sectional study was carried out in the department of Physiology, BSMMU, Dhaka between September 2017 to February 2019. Thirty cases of TDT, aged 5-40 year were included in the study group. Age and sex matched 30 healthy subjects were also studied as control. All the TDT patients were selected from the outpatient Department of Hematology and Transfusion Medicine, BSMMU, Dhaka. Serum zinc was measured by Spectrophotometric method and serum copper and ferritin levels were measured by colorimetric method. For statistical analysis independent sample t test was used. Result: The mean serum zinc level was significantly (p<0.05) lower and serum ferritin level was significantly (p<0.001) higher in TDT compared to control. Again, mean serum copper level and Zn/Cu ratio were not significantly (p>0.05) different in study groups compared to that of control. In addition, 3.3 % TDT patients had hypozincemia and 13.3% TDT patients had hypercupremia. Conclusion: This study may conclude that low serum zinc level and high copper level may be associated with TDT patients treated by combined deferoxamine (DFO) & deferiprone (DFP) iron chelator. J Bangladesh Soc Physiol. 2019, June; 14(1): 38-42

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CARBONIC ANHYDRASE ACTIVITY AND ZINC DEFICIENCY

International Journal of PIXE ◽

10.1142/s0129083597000072 ◽

1997 ◽

Vol 07 (01n02) ◽

pp. 49-52

Author(s):

TOSHIRO KUMAKAWA ◽

TAKAHITO KONDO

Keyword(s):

Zinc Deficiency ◽

Specific Activity ◽

Laboratory Data ◽

Serum Zinc ◽

Carbonic Anhydrase Activity ◽

Zinc Level ◽

Sweat Glands ◽

Acrodermatitis Enteropathica ◽

Normal Range ◽

Serum Zinc Level

A 60-year-old female was hospitalized because of anemia, edema, and diarrhea. She was diagnosed as having short bowel syndrome. The patient developed acrodermatitis enteropathica and taste impairment. Laboratory data showed that the serum zinc level was 21 μ g/dl and erythrocyte CAI specific activity was 0 units/mg isozyme (normal range 0.37 ± 0.08 units/mg isozyme) and CAII specific activity was 2.99 units/mg isozyme (normal range 3.02 ± 0.05 units/mg isozyme). The patient was diagnosed as being in a zinc deficient status. Zinc supplementation resulted in the disappearance of these complications. The serum zinc level reached 50 μ g/dl and erythrocyte CAI specific activity was recovered to 0.26 units/mg isozyme and CAII specific activity was 1.60 units/mg isozyme. CAI is found in gastrointestinal epithelial cells, in vascular epithelium, corneal, lens, ciliary body epithelium, and in sweat glands. CAII is found in virtually all tissues and is especially abundant in secretory and absorbing epithelia. The tissue distribution of CAI corresponds to clinical and physiologic indicators of zinc deficiency. Thus, the erythrocyte CAI specific activity may reflect the actual tissue zinc deficiency status.

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Association of Serum Zinc Level with Febrile Seizures in Children

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i55b33866 ◽

2021 ◽

pp. 200-203

Author(s):

Maryum Naveed ◽

Rimsha Mohsin ◽

Palwasha Khan

Keyword(s):

Febrile Seizure ◽

Serum Zinc ◽

Febrile Convulsion ◽

Febrile Seizures ◽

Cross Sectional Study ◽

Zinc Level ◽

Control Group ◽

Case Group ◽

Serum Zinc Level ◽

Cross Sectional

Introduction: Febrile seizure (FS), previously known as febrile convulsion, is the most common seizure in children. FS usually occurs between six months and five years of age. Aims and objectives: The main objective of the study is to find the association of serum zinc level with febrile seizures in children of Pakistan. Material and methods: This cross sectional study was conducted at Mayo Hospital, Lahore during June 2020 to January 2021. The data was collected from 164 patients of both genders. Results: The data was collected from 164 patients. In the case group, 46 children were male (53.3%), and 36 children (46.7%) were female. In the control group 44 children were male (43.3%) and 38 children were female (56.7%). The age of all participants was between one months and six years. Conclusion: It is concluded that low serum zinc levels are fairly un-sufficient to support the hypothesis that Zinc deficiency could not be a potential risk factor for febrile seizure in children.

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Estimation of serum zinc levels in children with febrile convulsions

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20182556 ◽

2018 ◽

Vol 5 (4) ◽

pp. 1518 ◽

Cited By ~ 1

Author(s):

Ubaidur Rehman H. ◽

Shamshad Ahmed Khan ◽

Prakash R. Saldanha

Keyword(s):

Serum Zinc ◽

Febrile Seizures ◽

Cross Sectional Study ◽

Zinc Level ◽

Sectional Study ◽

Serum Zinc Level ◽

Cross Sectional ◽

Significant Difference ◽

Zinc Levels ◽

Serum Zinc Levels

Background: Febrile seizures are the most common form of convulsion in children with the aged between 6 months to 6 years. Diﬀerent studies have shown that reduction of zinc leads to the incidence of febrile seizures in children. This study was conducted with the goal of examination of the zinc level in the patients with Febrile Seizures.Methods: This cross sectional study was conducted on 50 children in two equal groups of children with febrile seizures, febrile children without seizures. In order to examine the zinc level blood samples were taken of all subjects and the zinc level of these patients was determined. The data was analyzed using the SPSS-16 statistical software and by descriptive statistical tests.Results: 31 males (47.2%) and 19 female children (52.8%) with the average age of 27.23±15.3 months were examined. The two groups had no signiﬁcant diﬀerence in terms of age and sex. The average of zinc level in the patients with Febrile Seizures was 57.4 µg/dL and it was 116 µg/dL in the febrile children without FS there was a signiﬁcant diﬀerence between the two groups in terms of the zinc level (P=0.01).Conclusions: The low serum zinc level in the group of patients with Febrile Seizures compared with children without febrile seizures indicate the existence of a relationship between the serum zinc level and development of FS in children aged between 6 months and 6 years.

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Serum Zinc Status During Different Trimesters of Gestation

Journal of Bangladesh Society of Physiologist ◽

10.3329/jbsp.v6i1.8085 ◽

1970 ◽

Vol 6 (1) ◽

pp. 52-57

Author(s):

Nushrat Noor ◽

Nasim Jahan ◽

Nayma Sultana ◽

Rezina Akter

Keyword(s):

Pregnant Women ◽

Rank Correlation ◽

Serum Zinc ◽

Cross Sectional Study ◽

Zinc Level ◽

Serum Zinc Level ◽

Cross Sectional ◽

Mortality And Morbidity ◽

Micronutrient Status ◽

Serum Zn

Background: Hypozincemia may be found in different trimesters of pregnancy. Gradual alteration of this micronutrient status during pregnancy is associated with increased maternal and infant mortality and morbidity. Objective: To measure serum zinc level of pregnant women in different trimesters in order to find out their micronutrient status. Method: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka between 1st January 2010 to 31st December 2010. 90 normal pregnant women, age ranged from 20 to 30 years were included in the study group (Group-B) which was further divided into group B1 consisting of 30 different pregnant women in 1st trimester, group B2 consisting of 30 different pregnant women in 2nd trimester and group B3 consisting of 30 different pregnant women in 3rd trimester. Age matched 30 apparently healthy nonpregnant women (Group A) were also selected by for comparison. Serum zinc level was measured by Spectrophotometric method and serum total protein and albumin levels were estimated by standard laboratory technique. Statistical analysis was done by using ANOVA & Spearman rank Correlation as applicable. Result: In this study, serum Zn level was significantly lower in 1st (p<0.01), 2nd and 3rd trimester (p<0.001) of pregnant women in comparison to that of non-pregnant women. Again, this value was significantly (p<0.001) lower in 3rd trimester than those of 1st and 2nd trimesters of pregnant women. Moreover, serum Zn concentration showed negative correlation (r=-0.621) with different trimesters of gestation and this correlation was statistically significant (p< 0.001). Conclusion: This study reveals that gradual hypozincemia was observed in pregnant women from 1st to 3rd trimester of gestation. Key words: Serum zinc; Trimester; Pregnancy. DOI: http://dx.doi.org/10.3329/jbsp.v6i1.8085 J Bangladesh Soc Physiol. 2011 June; 6(1): 52-57

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