scholarly journals Acrolein is involved in the synergistic potential of cigarette smoking- and betel quid chewing-related human oral cancer.

2019 ◽  
pp. cebp.1033.2018 ◽  
Author(s):  
Hsiang-Tsui Wang ◽  
Han-Hsing Tsou ◽  
Chih-Hung Hu ◽  
Jin-Hui Liu ◽  
Chung-Ji Liu ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cigarette Smoking ◽  
Betel Quid ◽  
Betel Quid Chewing

Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan

1995 ◽  
Vol 24 (10) ◽  
pp. 450-453 ◽  
Author(s):  
Ying-Chin Ko ◽  
Yung-Li Huang ◽  
Chien-Hung Lee ◽  
Mei-Ju Chen ◽  
Li-Min Lin ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Oral Cancer ◽  
Cigarette Smoking ◽  
Betel Quid ◽  
Betel Quid Chewing

scholarly journals Determining Potential Target Groups for Oral Cancer Screening by Investigating Risk Behaviors Among Occupations

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 49s-49s
Author(s):  
Y.-T. Huang ◽  
Y.-W. Wang ◽  
R.-C. Chen ◽  
C.-Y. Wu ◽  
Y.-H. Yang
Keyword(s):  
Cluster Analysis ◽  
Cancer Screening ◽  
Oral Cancer ◽  
Cigarette Smoking ◽  
Screening Program ◽  
Smoking Habits ◽  
Betel Quid ◽  
High Prevalence ◽  
Betel Quid Chewing ◽  
Oral Cancer Screening

Background: Oral cancer is a major public health burden in Taiwan. Studies have suggested that habits of betel quid chewing, tobacco smoking and alcohol drinking as well as their interaction effects are important risk factors for oral cancer and oral potentially malignant disorders (OPMD). A population-based oral cancer screening program has been implemented by Health Promotion Administration, Ministry of Health and Welfare, Taiwan. People with betel quid chewing and/or cigarette smoking habits are recommended for biennially screening. Previous studies found that majority of betel quid chewers were in labor intensive occupations. Given the fact that high risk groups of oral cancer are often reluctant to attend screening, targeted approach should be applied to improve the effectiveness of screening program. Aim: The aims of this study are to identify occupations with high prevalence of betel-quid chewing and also to investigate changing trends using the National Health Interview Survey (NHIS) database. Methods: The NHIS database of 2009 and 2013 were used to conduct this study. We identified current users of betel quid and/or cigarette from adults with aged 20-64 years old and working on jobs. Occupations were classified using the International Standard Classification of Occupations (ISCO-88). Statistical analyses included indirect standardized rate ratios and cluster analysis of chewing/smoking habits. Results: From the total survey participants (2009: 19,201, 2013: 17,249), we extracted 11,507 and 10,760 persons for the study. In the year of 2013, using the 2-digit code of ISCO-88, drivers and mobile-plant operators (code 83 in ISCO-88) had the highest prevalence of betel quid chewing habit (30.9%), followed by extraction and building trades workers (code 71 in ISCO-88, 29.6%). These two groups also had the 2 highest smoking prevalence (61.2% and 62.2%). The betel quid chewing prevalence decreased from 2009 to 2013 slightly (32.3%-30.9%). However, the prevalence of smoking increased (60.0%-62.2%). Among the betel quid chewers of the two focused occupations, the corresponding rates of receiving oral cancer screening were rather low (35.47% and 21.52%). The indirect standardized ratios using the total sample as the reference showed 6 occupations (2 digit of ISCO-88) with significantly higher ratios (larger than 2). Cluster analysis demonstrated that the group with high prevalence of betel quid chewing also had high prevalence of cigarette smoking habit. Conclusion: The betel quid chewing prevalence has been decreased in all occupations. While at the same time, prevalence of cigarette smoking did not largely decrease. We analyzed the NHIS databases and found that workers in some occupations tend to have higher prevalence in both betel quid chewing and smoking. The oral cancer screening and cancer awareness need be targeted on certain occupations.

Quantification of betel quid chewing and cigarette smoking in oral cancer patients

2009 ◽  
Vol 37 (6) ◽  
pp. 555-561 ◽  
Author(s):  
Kuo-Yang Tsai ◽  
Che-Chun Su ◽  
Yo-Yu Lin ◽  
Jian-An Chung ◽  
Ie-Bin Lian
Keyword(s):  
Oral Cancer ◽  
Cigarette Smoking ◽  
Cancer Patients ◽  
Betel Quid ◽  
Betel Quid Chewing ◽  
Oral Cancer Patients

scholarly journals Combined Genetic Biomarkers and Betel Quid Chewing for Identifying High-Risk Group for Oral Cancer Occurrence

2017 ◽  
Vol 10 (6) ◽  
pp. 355-362 ◽  
Author(s):  
Chia-Min Chung ◽  
Chien-Hung Lee ◽  
Mu-Kuan Chen ◽  
Ka-Wo Lee ◽  
Cheng-Che E. Lan ◽  
...  
Keyword(s):  
High Risk ◽  
Oral Cancer ◽  
Risk Group ◽  
High Risk Group ◽  
Betel Quid ◽  
Genetic Biomarkers ◽  
Cancer Occurrence ◽  
Betel Quid Chewing

scholarly journals Effects of alcohol consumption, cigarette smoking, and betel quid chewing on upper digestive diseases: a large cross-sectional study and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 78011-78022 ◽  
Author(s):  
Yun-Shiuan Chuang ◽  
Meng-Chieh Wu ◽  
Fang-Jung Yu ◽  
Yao-Kuang Wang ◽  
Chien-Yu Lu ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Cigarette Smoking ◽  
Meta Analysis ◽  
Cross Sectional Study ◽  
Betel Quid ◽  
Sectional Study ◽  
Cross Sectional ◽  
Digestive Diseases ◽  
Betel Quid Chewing

Impact of HOTAIR Gene Polymorphism and Environmental Risk on Oral Cancer

2018 ◽  
Vol 97 (6) ◽  
pp. 717-724 ◽  
Author(s):  
S.C. Su ◽  
M.J. Hsieh ◽  
C.W. Lin ◽  
C.Y. Chuang ◽  
Y.F. Liu ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Odds Ratio ◽  
Gene Polymorphisms ◽  
Clinical Stage ◽  
Interactive Effect ◽  
Clinical Status ◽  
Betel Quid ◽  
Nucleotide Polymorphisms ◽  
Advanced Clinical Stage ◽  
Betel Quid Chewing

Genetic and acquired factors are thought to be interrelated and imperative to estimate the risk and prognosis of oral squamous cell carcinoma (OSCC). HOX transcript antisense intergenic RNA ( HOTAIR) plays crucial roles in gene regulation and is regulated in a variety of cancers. Polymorphisms in HOTAIR have been recently linked to the predisposition to diverse malignancies. In the present study, we aimed to evaluate the influences of HOTAIR gene polymorphisms, combined with environmental triggers, on the susceptibility to oral tumorigenesis. Four single-nucleotide polymorphisms of the HOTAIR gene— rs920778, rs1899663, rs4759314, and rs12427129—were tested in 1,200 control participants and 907 patients with OSCC. We detected a significant association of rs1899663 with the risk of OSCC (adjusted odds ratio, 2.227; 95% confidence interval [95% CI], 1.197 to 4.146; P = 0.012) after adjustment for 3 potential confounders: smoking, betel quid chewing, and alcohol consumption. In further analyses where habitual exposure to each of 3 environmental factors was excluded, we found that, in addition to rs1899663, non–betel quid users who carried the polymorphic allele of rs920778 were more prone to develop OSCC than were those homozygous for wild-type allele (TC: odds ratio [OR], 1.472; 95% CI, 1.069 to 2.029; P = 0.018; TC+CC: OR, 1.448; 95% CI, 1.060 to 1.977; P = 0.020). Moreover, in exploring the relationship between HOTAIR gene polymorphisms and the clinical status of only patients with OSCC who were non–betel quid chewers (excluding the advanced clinical stage), we found that rs920778 and rs4759314 were correlated with the development of large-size tumors (OR, 1.891; 95% CI, 1.027 to 3.484; P = 0.04) and increased lymph node metastasis (OR, 4.140; 95% CI, 1.785 to 9.602; P = 0.001), respectively. Further functional assessments link rs920778 to the regulation of HOTAIR expression and epigenetic status. Our results reveal an interactive effect of HOTAIR gene polymorphisms and betel quid chewing on the development and progression of oral cancer.

Accumulation of mitochondrial DNA deletions in human oral tissues — effects of betel quid chewing and oral cancer

2001 ◽  
Vol 493 (1-2) ◽  
pp. 67-74 ◽  
Author(s):  
Hsin-Chen Lee ◽  
Pen-Hui Yin ◽  
Tzu-Ning Yu ◽  
Yeong-Dar Chang ◽  
Wen-Chen Hsu ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Oral Cancer ◽  
Betel Quid ◽  
Betel Quid Chewing ◽  
Dna Deletions
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