Abstract 608: Molecular features of breast cancer involved in classification and prognosis of a multi-country Latin American cohort: The US-LACRN-MPBCS breast cancer cohort

2021 ◽  
Author(s):  
Andrea S. Llera ◽  
Eliana Abdelhay ◽  
Osvaldo Podhajcer ◽  
Nora Artagaveytia ◽  
Adrián Daneri-Navarro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Latin American ◽  
Molecular Features ◽  
The Us ◽  
Breast Cancer Cohort

scholarly journals The US–Latin America Cancer Research Network

2020 ◽  
Vol 6 (Supplement_1) ◽  
pp. 56-56
Author(s):  
Vidya Vedham ◽  
Marianne K. Henderson ◽  
Osvaldo Podhajcer ◽  
Andrea Llera ◽  
Marisa Dreyer Breitenbach ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Research ◽  
Latin America ◽  
Clinical Research ◽  
Latin American ◽  
Molecular Profiling ◽  
Research Network ◽  
Research Institutions ◽  
Cancer Research Network ◽  
The Us

PURPOSE The National Cancer Institute (NCI) Center for Global Health promotes global oncology research to reduce cancer burden worldwide. In 2009, NCI launched the Latin American Cancer Research Network (LACRN) to support a clinical cancer research network in Latin America. LACRN was started by a coalition of research institutions through bilateral collaborative agreements between the US Department of Health and Human Services and the governments of Argentina, Brazil, Chile, Mexico, and Uruguay. The LACRN is supported through a research contract to a study coordination center and subcontracts to 6 low- and middle-income country sites. The participating countries have a shared goal that meets the specific research needs of the regions. The overarching purpose of this endeavor is to implement high-quality standards for conducting clinical research studies and developing collaborative cancer research projects. METHODS NCI supported a clinical breast cancer project for LACRN, “Molecular profiling of breast cancer (MPBC) in Latin American women with stage II and III breast cancer receiving standard neo-adjuvant chemotherapy.” The molecular profiling of breast cancer study was conducted in 40 hospitals and research institutions across 5 countries with a study population of approximately 1,400 patients. RESULTS AND CONCLUSION Establishing a comprehensive network in Latin America and their research institutions yielded an incredible research resource that can be used in future studies, driven by the network. Throughout the process of developing and implementing studies, LACRN helped identify key elements of the functionality of research networks, such as the pivotal role of institutional and government commitment for sustainability; the importance of building multidisciplinary teams, transparent communications, and training; the ability to combine translational, epidemiology, and clinical research to close research gaps; and the application of new technologies to standard cancer clinical care.

scholarly journals Molecular features of premenopausal breast cancers in Latin American women: pilot results from the PRECAMA study

2018 ◽  
Author(s):  
Magali Olivier ◽  
Liacine Bouaoun ◽  
Stephanie Villar ◽  
Alexis Robitaille ◽  
Vincent Cahais ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Latin American ◽  
P53 Protein ◽  
Premenopausal Women ◽  
Population Based ◽  
Breast Cancers ◽  
Protein Markers ◽  
Mutational Signatures ◽  
Molecular Features ◽  
Incident Cases

AbstractBackgroundIn Latin America (LA), there is a high incidence rate of breast cancer (BC) in premenopausal women, and the genomic features of these BC remain unknown. Here, we aim to characterize the molecular features of BC in young LA women within the framework of the PRECAMA study, a multicenter population-based case-control study on breast cancer in premenopausal women.MethodsPathological tumor tissues were collected from incident cases from four LA countries. Immunohistochemistry (IHC) was performed centrally for ER, PR, HER2, Ki67, EGFR, CK5/6 and p53 protein markers. Targeted deep sequencing was done on genomic DNA extracted from formalin-fixed paraffin-embedded (FFPE) tumour tissues and their paired blood samples to screen for somatic mutations in eight genes frequently mutated in BC. A subset of samples was analyzed by exome sequencing to identify somatic mutational signatures.ResultsThe majority of cases were positive for ER or PR (168/233; 72%) and there were 21% triple negative (TN) cases, mainly of basal type. Most tumors were positive for Ki67 (189/233; 81%). In 126 sequenced cases,TP53andPIK3CAwere the most frequently mutated genes (32.5% and 21.4%, respectively), followed byAKT1(9.5%).TP53mutations were more frequent in HER2-enriched and TN IHC subtypes, whilePIK3CA/AKT1mutations were more frequent in ER positive tumors, as expected. Interestingly, a higher proportion of G:C>T:A mutations was observed inTP53gene in PRECAMA cases compared to TCGA and METABRIC breast cancer series (27% vs 14%). Exome-wide mutational patterns in 10 TN cases revealed alterations in signaling transduction pathways and major contributions of mutational signatures caused by altered DNA repair pathways.ConclusionsThis pilot results on PRECAMA tumors gives a preview of the molecular features of premenopausal BC in LA. Although, the overall mutation burden was as expected from data in other populations, mutational patterns observed inTP53and exome-wide suggested possible differences in mutagenic processes giving rise to these tumors compared to other populations. Further omics analyses of a larger number of cases in the near future will allow investigating relationships between these molecular features and risk factors.

Reagan and Thatcher's Special Relationship

2015 ◽  
Author(s):  
Sally-Ann Treharne
Keyword(s):  
Latin American ◽  
Special Relationship ◽  
Pivotal Moments ◽  
Political Relationships ◽  
Latin American Region ◽  
The Us ◽  
Anglo American ◽  
Elite Interviews ◽  
Personal Diplomacy ◽  
The Cold War

Reagan and Thatcher’s Special Relationship offers a unique insight into one of the most controversial political relationships in recent history. An insightful and original study, it provides a new regionally focused approach to the study of Anglo-American relations. The Falklands War, the US invasion of Grenada, the Anglo-Guatemalan dispute over Belize and the US involvement in Nicaragua are vividly reconstructed as Latin American crises that threatened to overwhelm a renewal in US-UK relations in the 1980s. Reagan and Thatcher’s efforts to normalise relations, both during and after the crises, reveal a mutual desire to strengthen Anglo-American ties and to safeguard individual foreign policy objectives whilst cultivating a close personal and political bond that was to last well beyond their terms in office. This ground-breaking reappraisal analyses pivotal moments in their shared history by drawing on the extensive analysis of recently declassified documents while elite interviews reveal candid recollections by key protagonists providing an alternative vantage point from which to assess the contentious ‘Special Relationship’. Sally-Ann Treharne offers a compelling look into the role personal diplomacy played in overcoming obstacles to Anglo-American relations emanating from the turbulent Latin American region in the final years of the Cold War.

Geo-Economic Competition in Latin America: Brazil, Venezuela, and Regional Integration in the 21st Century

2018 ◽  
Vol 33 ◽  
Author(s):  
Guilherme Casarões
Keyword(s):  
Latin American ◽  
Regional Integration ◽  
Free Trade Area ◽  
The United States ◽  
Economic Competition ◽  
Integration Model ◽  
Trade Area ◽  
Complex Processes ◽  
The Us ◽  
New Institutions

The institutional framework of Latin American integration saw a period of intense transformation in the 2000s, with the death of the ambitious project of the Free Trade Area of the Americas (FTAA), spearheaded by the United States, and the birth of two new institutions, the Union of South American Nations (UNASUR) and the Community of Latin American and Caribbean States (CELAC). This article offers a historical reconstruction of regional integration structures in the 2000s, with emphasis on the fault lines between Brazil, Venezuela and the US, and how they have shaped the institutional order across the hemisphere. We argue that the shaping of UNASUR and CELAC, launched respectively in 2007 and 2010, is the outcome of three complex processes: (1) Brazil’s struggle to strengthen Mercosur by acting more decisively as a regional paymaster; (2) Washington’s selective engagement with some key regional players, notably Colombia, and (3) Venezuela’s construction of an alternative integration model through the Bolivarian Alliance (ALBA) and oil diplomacy. If UNASUR corresponded to Brazil’s strategy to neutralize the growing role of Caracas in South America and to break apart the emerging alliance between Venezuela, Argentina, and Bolivia, CELAC was at the same time a means to keep the US away from regional decisions, and to weaken the Caracas-Havana axis that sustained ALBA.

Uncommon Grounds

2017 ◽  
Author(s):  
Jeffrey Lawrence
Keyword(s):  
American Literature ◽  
Latin American ◽  
Historical Novel ◽  
Latin American Literature ◽  
Historical Account ◽  
American Novel ◽  
Song Of Solomon ◽  
The Past ◽  
The North ◽  
The Us

This chapter turns from a historical account of the development of the US literature of experience and the Latin American literature of reading to a textual analysis of the US and Latin American historical novel. Hemispheric/inter-American scholars often cite William Faulkner’s Absalom, Absalom! (1936), Gabriel García Márquez’s One Hundred Years of Solitude (1967), and Toni Morrison’s Song of Solomon (1977) as exemplifying instances of literary borrowing across the North–South divide. As I demonstrate, however, each of the later texts also realigns its predecessor’s historical imaginary according to the dominant logics of the US and Latin American literary fields. Whereas the American works foreground experiential models of reconstructing the past and conveying knowledge across generations, García Márquez’s Latin American novel presents reading as the fundamental mode of comprehending and transmitting history.

An Inter-American Episode

2017 ◽  
Author(s):  
Jeffrey Lawrence
Keyword(s):  
Latin America ◽  
Latin American ◽  
Pablo Neruda ◽  
Jose Marti ◽  
The South ◽  
American Reader ◽  
The North ◽  
Literary Theories ◽  
The Us

This chapter focuses on a paradigmatic misencounter between an American experiencer and a Latin American reader. Examining an implicit debate about the sources of Walt Whitman’s poetry and vision of the Americas, I argue that Waldo Frank, one of the twentieth century’s main literary ambassadors from the US to Latin America, positioned Whitman as the representative US writer whose antibookish experiential aesthetics could serve as a model for “American” writers both in the North and in the South. I show how Frank’s framework provided a foil for Borges’s idiosyncratic view that Whitman’s poetry about America derived entirely from his readings of European and US writers. Although much of the best scholarship on Whitman’s reception in Latin America has concentrated on poets like José Martí and Pablo Neruda, who adapted Whitman’s naturalism, I contend that Borges’s iconoclastic portrait of Whitman as a reader profoundly influenced a range of anti-experiential literary theories and practices in Latin America.

Anxieties of Experience

2017 ◽  
Author(s):  
Jeffrey Lawrence
Keyword(s):  
American Literature ◽  
Latin American ◽  
World Literature ◽  
Latin American Literature ◽  
First Century ◽  
Comparative Approach ◽  
Leaves Of Grass ◽  
Literary Authority ◽  
The Us ◽  
New Interpretation

Anxieties of Experience: The Literatures of the Americas from Whitman to Bolaño offers a new interpretation of US and Latin American literature from the nineteenth century to the present. Revisiting longstanding debates in the hemisphere about whether the source of authority for New World literature derives from an author’s first-hand contact with American places and peoples or from a creative (mis)reading of existing traditions, the book charts a widening gap in how modern US and Latin American writers defined their literary authority. In the process, it traces the development of two distinct literary strains in the Americas: the “US literature of experience” and the “Latin American literature of the reader.” Reinterpreting a range of canonical works from Walt Whitman’s Leaves of Grass to Roberto Bolaño’s 2666, Anxieties of Experience shows how this hemispheric literary divide fueled a series of anxieties, misunderstandings, and “misencounters” between US and Latin American authors. In the wake of recent calls to rethink the “common grounds” approach to literature across the Americas, the book advocates a comparative approach that highlights the distinct logics of production and legitimation in the US and Latin American literary fields. Anxieties of Experience closes by exploring the convergence of the literature of experience and the literature of the reader in the first decades of the twenty-first century, arguing that the post-Bolaño moment has produced the strongest signs of a truly reciprocal literature of the Americas in more than a hundred years.

Charismatic, Pentecostal, and Evangelical Movements in Europe, the US, and Brazil

2017 ◽  
Author(s):  
Detlef Pollack ◽  
Gergely Rosta
Keyword(s):  
Latin American ◽  
Social Deprivation ◽  
Religious Change ◽  
Evangelical Protestantism ◽  
Secularization Theory ◽  
Explanatory Factors ◽  
Theoretical Approaches ◽  
Healing Rituals ◽  
The Us ◽  
Latin American Countries

The growth of Evangelical Protestantism and Pentecostalism is widely regarded as a potent argument against the validity of secularization theory. To explain this growth, Chapter 12 draws on theoretical approaches to analysing new social movements, which allows an expansion of the repertoire of explanations concerning religious change and a testing of alternatives to the models provided by secularization theory. To explain the worldwide growth and relative resilience of the Evangelical and Pentecostal movements, the chapter identifies a number of conditions and explanatory factors: cultural and social confirmation, religious syncretism, social deprivation, and the widespread magical worldview and broadly accepted spiritistic beliefs in Latin American countries that are conducive to the acceptance of Pentecostal experiences and healing rituals.

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