Abstract LT014: Extracellular matrix stiffness regulates cellular response to anticancer drugs in breast and lung cancer cells

2021 ◽  
Author(s):  
Atul Bharde ◽  
Snigdha Nadagauda ◽  
Megha Gaur ◽  
Vaishnavi Borade
Keyword(s):  
Lung Cancer ◽  
Extracellular Matrix ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Cellular Response ◽  
Lung Cancer Cells ◽  
Matrix Stiffness ◽  
Extracellular Matrix Stiffness

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

2018 ◽  
Vol 10 (422) ◽  
pp. eaao0475 ◽  
Author(s):  
Marsha C. Lampi ◽  
Cynthia A. Reinhart-King
Keyword(s):  
Extracellular Matrix ◽  
Clinical Trials ◽  
Cellular Response ◽  
Molecular Mechanisms ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Therapeutic Interventions ◽  
Target Tissue ◽  
Matrix Stiffness ◽  
Extracellular Matrix Stiffness

Tissues stiffen during aging and during the pathological progression of cancer, fibrosis, and cardiovascular disease. Extracellular matrix stiffness is emerging as a prominent mechanical cue that precedes disease and drives its progression by altering cellular behaviors. Targeting extracellular matrix mechanics, by preventing or reversing tissue stiffening or interrupting the cellular response, is a therapeutic approach with clinical potential. Major drivers of changes to the mechanical properties of the extracellular matrix include phenotypically converted myofibroblasts, transforming growth factor β (TGFβ), and matrix cross-linking. Potential pharmacological interventions to overcome extracellular matrix stiffening are emerging clinically. Aside from targeting stiffening directly, alternative approaches to mitigate the effects of increased matrix stiffness aim to identify and inhibit the downstream cellular response to matrix stiffness. Therapeutic interventions that target tissue stiffening are discussed in the context of their limitations, preclinical drug development efforts, and clinical trials.

Anti-proliferative activity of the combination of salan Ti(iv) complexes with other organic and inorganic anticancer drugs against HT-29 and NCI-H1229 cells: synergism with cisplatin

RSC Advances ◽  
2015 ◽  
Vol 5 (11) ◽  
pp. 7874-7879 ◽  
Author(s):  
Nitzan Ganot ◽  
Boris Redko ◽  
Gary Gellerman ◽  
Edit Y. Tshuva
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Proliferative Activity ◽  
Human Colon ◽  
Lung Cancer Cells ◽  
Ht 29

Cytotoxic salan Ti(iv) complex demonstrated synergism with cisplatin in vitro toward human colon and lung cancer cells at various ratios.

scholarly journals Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells

2012 ◽  
Vol 42 (2) ◽  
pp. 429-436 ◽  
Author(s):  
RYOHEI TAKAHASHI ◽  
TAKASHI SATO ◽  
DENNIS M. KLINMAN ◽  
TAKESHI SHIMOSATO ◽  
TAKESHI KANEKO ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Antiproliferative Effects ◽  
Human Lung Cancer Cells

scholarly journals Effective combination treatment of lung cancer cells by single vehicular delivery of siRNA and different kinds of anticancer drugs

2016 ◽  
Vol Volume 11 ◽  
pp. 4609-4624 ◽  
Author(s):  
Jin-Ming Li ◽  
Yuanyuan Wang ◽  
Shanshan Xue ◽  
Jinghua Sun ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Combination Treatment ◽  
Lung Cancer Cells ◽  
Effective Combination

Regulation of PD-L1 expression by matrix stiffness in lung cancer cells

2018 ◽  
Vol 495 (3) ◽  
pp. 2344-2349 ◽  
Author(s):  
Ayako Miyazawa ◽  
Satoru Ito ◽  
Shuichi Asano ◽  
Ichidai Tanaka ◽  
Mitsuo Sato ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Matrix Stiffness

CD43 (sialophorin) is involved in the induction of extracellular matrix remodeling and angiogenesis by lung cancer cells

2021 ◽  
Author(s):  
Daniela Vega‐Mendoza ◽  
Alicia Cañas‐Linares ◽  
Angel Flores‐Alcantar ◽  
Roberto Espinosa‐Neira ◽  
Erika Melchy‐Perez ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Extracellular Matrix ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling
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