scholarly journals Personality Disorders in Alcohol-Dependent Individuals: Relationship with Alcohol Dependence Severity

2009 ◽  
Vol 15 (4) ◽  
pp. 188-195 ◽  
Author(s):  
U.W. Preuss ◽  
M. Johann ◽  
C. Fehr ◽  
G. Koller ◽  
N. Wodarz ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Personality Disorders ◽  
Alcohol Dependent

Comorbidity among alcohol and tobacco dependent patients

2011 ◽  
Vol 26 (S2) ◽  
pp. 132-132
Author(s):  
A. Zoghlami ◽  
D. Blauensteiner ◽  
O. Scheibenbogen ◽  
S. Zadro-Jäger ◽  
M. Musalek
Keyword(s):  
Alcohol Dependence ◽  
Inpatient Treatment ◽  
Preliminary Analysis ◽  
Psychiatric Comorbidity ◽  
Icd 10 ◽  
Withdrawal Therapy ◽  
Clinically Significant ◽  
Drug Use Disorder ◽  
Group Allocation ◽  
Alcohol Dependent

IntroductionPsychiatric concomitant diseases are common with alcohol and tobacco dependent patients. Few studies have compared comorbidities between alcohol dependent smokers and non-smokers.AimsThe aim of this study is to examine the pattern of psychiatric comorbidity among alcohol dependent smokers in an inpatient alcohol therapy unit.Material and methodAfter successfully completing withdrawal therapy, subjects between the ages of 18–65 years who meet the ICD 10 criteria for alcohol dependence and no criteria for other drug use disorder except smoking, and who were participating in an inpatient treatment program for alcohol dependence at Anton Proksch Institut were included.ResultsThis is a preliminary analysis of the survey. In total 81 patients could be examined. 53.1% of the interviewed subjects were female and 46.9% male. The explored samples age ranged from 21–66 years.74.1% of the questioned subjects were smokers, 60% of these patients smoked more than 20 cigarettes per day.Preliminary analysis shows that smoking alcohol dependent patients present a higher comorbidity rate than non-smokers but above all they show a tendency to increased anxiety disorders. Within the population of smokers 48.3% suffer from an anxiety disorder, 48.3% from depression and dysthymia, 12.1% from manic and hypomanic disorder and 5.2% from psychosis. These differences are not clinically significant. This can be explained by the small number of the sample and by the group allocation.ConclusionAlcohol addicted patients exhibit heightened psychiatric comorbidity. Smoking alcohol dependents are more frequently affected and have a disposition to psychiatric disorders.

scholarly journals The efficacy of iCBT added to treatment as usual for alcohol dependent patients in Primary Care: study protocol for a randomized controlled trial.

2019 ◽  
Author(s):  
Karin Hyland ◽  
Anders Hammarberg ◽  
Erik Hedman-Lagerlöf ◽  
Magnus Johansson ◽  
Sven Andreasson
Keyword(s):  
Primary Care ◽  
Randomized Controlled Trial ◽  
Alcohol Dependence ◽  
Controlled Trial ◽  
Alcohol Problems ◽  
Primary Study ◽  
Mixed Effect ◽  
Treatment As Usual ◽  
Randomized Controlled ◽  
Alcohol Dependent

Abstract Introduction Alcohol dependence is a common disorder with a continuum regarding severity. Most alcohol dependent persons have a moderate level of dependence and live under socially orderly conditions. Treatment seeking in this group is low, mainly due to stigma and because treatment options are seen as unappealing. Alcohol is a relevant topic to discuss in many primary care (PC) consultations and PC is less stigmatizing to visit compared to addiction care units for people with alcohol problems. General practitioners (GP) hesitate to engage in treating alcohol problems due to time constraints and lack of knowledge. Screening and brief interventions are effective for high consumers but there are few studies on dependence. Methods This is a two-group, parallel, randomized controlled trial (RCT). The aim is to study whether an Internet based Cognitive Behavioral Treatment (iCBT) when added to treatment as usual (TAU) is more effective than TAU only for alcohol dependence in PC. 260 adults with alcohol dependence will be included. Participants are randomized to iCBT and TAU or TAU only. The primary study outcome is alcohol consumption in grams per week and heavy drinking days. Secondary outcomes include alcohol related problem severity, number of diagnostic criteria for alcohol dependence, depression and anxiety symptoms, health related quality of life and biochemical markers for high consumption and liver pathology. Data will be analyzed using mixed-effect models. Discussion Internet based interventions are attractive to and have been shown to reach people with alcohol problems. Yet there are no studies investigating the efficacy of internet treatment of alcohol dependence in PC. In this study we hypothesize that iCBT when added to TAU will improve treatment outcome for alcohol dependence in PC, compared to TAU only. If effective, iCBT can be distributed to the public to a low cost for a stakeholder and has the opportunity to reduce both short term and long-term public health costs. Trial registration: ISRCTN69957414. Retrospectively registered 07/06/2018. http://www.isrctn.com/ISRCTN69957414

scholarly journals Cortical Glutamate and GABA Changes During Early Abstinence in Alcohol Dependence and Their Associations With Benzodiazepine Medication

2021 ◽  
Vol 12 ◽  
Author(s):  
Guoying Wang ◽  
Wolfgang Weber-Fahr ◽  
Ulrich Frischknecht ◽  
Derik Hermann ◽  
Falk Kiefer ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Alcohol Withdrawal ◽  
Withdrawal Symptoms ◽  
Internal Quality ◽  
Treatment Seeking ◽  
Withdrawal Period ◽  
Cross Sectional ◽  
Longitudinal Changes ◽  
Single Voxel ◽  
Alcohol Dependent

In this report, we present cross-sectional and longitudinal findings from single-voxel MEGA-PRESS MRS of GABA as well as Glu, and Glu + glutamine (Glx) concentrations in the ACC of treatment-seeking alcohol-dependent patients (ADPs) during detoxification (first 2 weeks of abstinence). The focus of this study was to examine whether the amount of benzodiazepine administered to treat withdrawal symptoms was associated with longitudinal changes in Glu, Glx, and GABA. The tNAA levels served as an internal quality reference; in agreement with the vast majority of previous reports, these levels were initially decreased and normalized during the course of abstinence in ADPs. Our results on Glu and Glx support hyperglutamatergic functioning during alcohol withdrawal, by showing higher ACC Glu and Glx levels on the first day of detoxification in ADPs. Withdrawal severity is reflected in cumulative benzodiazepine requirements throughout the withdrawal period. The importance of withdrawal severity for the study of GABA and Glu changes in early abstinence is emphasized by the benzodiazepine-dependent Glu, Glx, and GABA changes observed during the course of abstinence.

scholarly journals Psychoeducation as a strategy to improve family support perceived from patient with alcohol dependence and personality disorder

2012 ◽  
Vol 5 (1) ◽  
pp. 18-24
Author(s):  
José Miguel Martínez González ◽  
Natalia Albein Urios ◽  
Pilar Munera ◽  
Antonio Verdejo García
Keyword(s):  
Group Therapy ◽  
Alcohol Dependence ◽  
Personality Disorders ◽  
Relapse Prevention ◽  
Behavioral Therapy ◽  
Individual Therapy ◽  
Psychoeducational Intervention ◽  
Self Report ◽  
Significant Difference ◽  
The Impact

The aim of this study was to prospectively analyze the impact of psychoeducation with relatives of addicted patients with personality disorders. We measured the impact of the psychoeducational intervention using a self-report questionnaire designed to assess perceived familiar support. The sample was composed by 37 patients with alcohol dependence following outpatient treatment. They underwent a cognitive-behavioral therapy relapse prevention program especially tailored for addicted individuals with comorbid personality disorders. 56.8% of patients followed individual therapy, and 43.2% followed group therapy. The relatives of the subgroup patients following group therapy simultaneously received the psychoeducational intervention. The analyses of the familiar support questionnaire across treatment showed a significant difference between groups as a function of treatment modality. Patients whose relatives followed the psychoeducational intervention had greater perception of familiar support throughout the treatment process.

scholarly journals A Prospective Comparison of Bipolar I and II Subjects With and Without Comorbid Alcohol Dependence From the COGA Dataset

2020 ◽  
Vol 11 ◽  
Author(s):  
Ulrich W. Preuss ◽  
M. N. Hesselbrock ◽  
V. M. Hesselbrock
Keyword(s):  
Bipolar Disorder ◽  
Alcohol Use ◽  
Alcohol Dependence ◽  
Collaborative Study ◽  
Structured Interviews ◽  
Prospective Comparison ◽  
Bipolar Ii ◽  
Bipolar Patients ◽  
Alcohol Dependent

Objective: Comorbidity of alcohol use disorders in bipolar subjects is high as indicated by epidemiological and clinical studies. Though a more severe course of bipolar disorder in subjects with comorbid alcohol dependence has been reported, fewer studies considered the longitudinal course of alcohol dependence in bipolar subjects and the prospective course of comorbid bipolar II subjects. Beside baseline analysis, longitudinal data of the COGA (Collaborative Study on Genetics in Alcoholism) were used to evaluate the course of bipolar I and II disordered subjects with and without comorbid alcohol dependence over more than 5 years of follow-up.Methods: Characteristics of bipolar disorder, alcohol dependence and comorbid psychiatric disorders were assessed using semi-structured interviews (SSAGA) at baseline and at a 5-year follow-up. Two hundred twenty-eight bipolar I and II patients were subdivided into groups with and without comorbid alcohol dependence.Results: Of the 152 bipolar I and 76 bipolar II patients, 172 (75, 4%) had a comorbid diagnosis of alcohol dependence. Bipolar I patients with alcohol dependence, in particular women, had a more severe course of bipolar disorder, worse social functioning and more suicidal behavior than all other groups of subjects during the 5-year follow-up. In contrast, alcohol dependence improved significantly in both comorbid bipolar I and II individuals during this time.Conclusions: A 5-year prospective evaluation of bipolar patients with and without alcohol dependence confirmed previous investigations suggesting a more severe course of bipolar disorder in comorbid bipolar I individuals, whereas bipolar II individuals were less severely impaired by comorbid alcohol use disorder. While severity of alcohol dependence improved during this time in comorbid alcohol-dependent bipolar I patients, the unfavorable outcome for these individuals might be due to the higher comorbidity with personality and other substance use disorders which, together with alcohol dependence, eventually lead to poorer symptomatic and functional clinical outcomes.

STUDYING ADDICTIVE SPLITTING IN THE PROCESS OF PROVITAL INTERVIEWING OF ALCOHOL-DEPENDENT PATIENTS WITH COMORBID PERSONALITY DISORDERS

2019 ◽  
pp. 38-49
Author(s):  
D.I. Shustov ◽  
A.D. Shustov ◽  
O.D. Tuchina ◽  
T.V. Klimenko ◽  
A.A. Solodov ◽  
...  
Keyword(s):  
Personality Disorders ◽  
Alcohol Dependent

Marital Satisfaction Among Spouses of Male Patients with Alcohol Dependence Syndrome

2019 ◽  
Vol 2 (02) ◽  
pp. 8-13
Author(s):  
Humayoon Akbar ◽  
Sudhakar S. ◽  
Shanthi B. ◽  
Khadeja Bi ◽  
Jayaseelan R. ◽  
...  
Keyword(s):  
Marital Satisfaction ◽  
Alcohol Dependence ◽  
Rural Areas ◽  
Tertiary Care ◽  
College Hospital ◽  
Medical College ◽  
Alcohol Dependence Syndrome ◽  
Male Patients ◽  
The Mean ◽  
Alcohol Dependent

BACKGROUND One third of Indians consume alcohol and there is an alarming annual increase in alcohol consumption. Majority of spouses of alcohol dependent males are also the primary care-takers of their husbands and are at risk of domestic violence. Marital dissatisfaction could reduce their involvement in getting their spouses treated for alcohol dependence. Our aim was to study the marital satisfaction among the spouses of patients with alcohol dependence. METHODOLOGY This study was conducted on spouses of male patients with alcohol dependence syndrome attending the psychiatry department of a tertiary care medical college hospital in Kanchipuram District in Tamilnadu. 200 consecutive male patients with alcohol dependence syndrome using the ICD 10 criteria were recruited. Severity of alcohol dependence was assessed using Short Alcohol Dependence Data (SADD). Marital satisfaction among the spouses was assessed using ENRICH Marital Satisfaction (EMS) Scale. Analysis of the data was done using Statistical Package for the Social Sciences (SPSS) version 22.0. RESULTS The mean age of alcohol dependent men and their spouses were 43.05±9.39 and 37.58±8.86 years respectively. Most of the spouses (83.5%) had done their primary education only and 50% were house-wives (unemployed). Majority of men earned between Rs.5000 to 10,000 and most of them were unskilled workers belonging to the lower socio-economic group in the rural areas. The mean SADD and EMS scores were 25.05 ± 8.891 and 31.76 ± 14.45 respectively. 74% of men in our study population were highly dependent on alcohol. Amongst the spouses of men with severe dependence 68.9% reported moderate and 28.3% reported low marital satisfaction. DISCUSSION and CONCLUSION Majority of alcohol dependent men suffered from severe dependence. An inverse relationship between marital satisfaction scores and severity of alcohol dependence was observed. Alcohol dependence and its severity was noted to have an adverse impact on marital satisfaction among spouses of the dependent patients.

scholarly journals Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala

2020 ◽  
Vol 6 (12) ◽  
pp. eaaz1050
Author(s):  
S. Khom ◽  
T. Steinkellner ◽  
T. S. Hnasko ◽  
M. Roberto
Keyword(s):  
Substance P ◽  
Alcohol Dependence ◽  
Critical Role ◽  
Alcohol Exposure ◽  
Gaba Release ◽  
Central Nucleus ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1 ◽  
Gaba Transmission ◽  
Alcohol Dependent

Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its neuroadaptation following chronic alcohol exposure. In naïve rats, SP increased action potential–dependent GABA release, and the selective NK-1R antagonist L822429 decreased it, demonstrating SP regulation of CeM activity under basal conditions. SP induced a larger GABA release in alcohol-dependent rats accompanied by decreased NK-1R expression compared to naïve controls, suggesting NK-1R hypersensitivity which persisted during protracted alcohol withdrawal. The NK-1R antagonist blocked acute alcohol-induced GABA release in alcohol-dependent and withdrawn but not in naïve rats, indicating that dependence engages the SP/NK-1R system to mediate acute effects of alcohol. Collectively, we report long-lasting CeA NK-1R hypersensitivity corroborating that NK-1Rs are promising targets for the treatment of alcohol use disorder.

Reduced Serum Levels of Cluster of Differentiation 200 in Alcohol-Dependent Patients

2020 ◽  
Vol 55 (4) ◽  
pp. 391-394
Author(s):  
Abhishek Chaturvedi ◽  
Guruprasad Rao ◽  
Samir Kumar Praharaj ◽  
Kanive Parashiva Guruprasad ◽  
Vivek Pais
Keyword(s):  
Alcohol Dependence ◽  
Alcohol Withdrawal ◽  
Addiction Treatment ◽  
Regulatory Protein ◽  
Serum Levels ◽  
Regulatory Proteins ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
Cluster Of Differentiation ◽  
Alcohol Dependent

Abstract Aim Chronic alcohol consumption can activate and dysregulate the neuroimmune system which leads to neuroinflammation. Neuroimmune regulatory proteins (NIReg) (e.g. Cluster of Differentiation 200 (CD200)) are the regulators of innate immune response and are responsible for silencing the innate immunity and suppression of inflammation. In this study, we explored the changes of serum levels of CD200 in patients with alcohol dependence at baseline, after one-week alcohol withdrawal and after one-month of alcohol abstinence. Methods Seventeen patients with alcohol dependence admitted for de-addiction treatment and 12 healthy controls were enrolled in the study. Blood samples were collected at baseline, after one-week, and after one-month, and CD200 levels were measured using enzyme-linked immunosorbent assay kit and compared with the healthy controls. Results The serum level of the neuroimmune regulatory protein CD200 in alcohol dependent group (at baseline) was significantly lower compared to healthy controls (p=0.003), and increased after one-week, and one-month period. Conclusion The present study indicates that decrease of CD200 serum levels in alcohol dependent patients and its rise during alcohol withdrawal and abstinence may provide a preliminary evidence of the role of neuroimmune regulatory proteins in neuroadaptation during alcohol withdrawal.

scholarly journals Impaired Regulation of ALDH2 Protein Expression Revealing a Yet Unknown Epigenetic Impact of rs886205 on Specific Methylation of a Negative Regulatory Promoter Region in Alcohol-Dependent Patients

2015 ◽  
Vol 22 (2) ◽  
pp. 59-69 ◽  
Author(s):  
Mani Haschemi Nassab ◽  
Mathias Rhein ◽  
Lars Hagemeier ◽  
Marius Kaeser ◽  
Marc Muschler ◽  
...  
Keyword(s):  
Protein Expression ◽  
Alcohol Dependence ◽  
Promoter Region ◽  
Promoter Polymorphism ◽  
Aldehyde Dehydrogenase 2 ◽  
Protein Levels ◽  
Epigenetic Effects ◽  
Carcinogenic Metabolite ◽  
Low Alcohol ◽  
Alcohol Dependent

Acetaldehyde, the carcinogenic metabolite of ethanol known to provoke aversive symptoms of alcohol consumption, is predominantly eliminated by aldehyde dehydrogenase 2 (ALDH2). Reduced ALDH2 activity correlates with low alcohol tolerance and low risk for alcohol dependence. The ALDH2 promoter polymorphism rs886205 (A>G) is associated with decreased promoter activity, but a molecular mechanism and allele-dependent ALDH2 protein expression has not been described yet. On the basis of allele-dependent epigenetic effects, we analyzed the rs886205 genotype, methylation rates of cytosine-phosphatidyl-guanine (CpG)-sites within a regulatory promoter region and ALDH2 protein levels in 82 alcohol-dependent patients during a 2-week withdrawal and compared them to 34 matched controls. Patients without the G-allele of rs886205 showed higher methylation of the promoter region than controls and readily adapted epigenetically as well as on protein level during withdrawal, while patients with the G-allele displayed retarded methylation readjustment and no change in ALDH2 protein levels. Our data provide novel insights into an unknown genetic-epigenetic interaction, revealing impaired ALDH2 protein expression in patients with the G-allele of rs886205. Additionally, we checked for an association between rs886205 and protection against alcohol dependence and found a trend association between the G-allele and protection against alcohol dependence that needs replication in a larger Caucasian cohort.

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