Vitamin D Status Is Related to Oxidative Stress But Not High-Sensitive C-Reactive Protein in Women with Pre-Eclampsia

Background C-reactive protein is an acute phase response marker and, in an epidemiological context, a predictor of cardiovascular risk. 25-Hydroxy-vitamin D is the best indicator for vitamin D status, but it can be altered by the presence of acute phase response. Our aim was to evaluate the association between serum concentrations of 25-hydroxy-vitamin D and C-reactive protein to assist the interpretation of vitamin D status in a clinical context. Methods We evaluated retrospectively 5076 patients ( n = 4087 women) assessed for 25-hydroxy-vitamin D and C-reactive protein simultaneously. Subjects were classified according to the origin as hospitalized patients ( n = 410) and outpatients ( n = 4666). Outpatients included patients from specialized ( n = 3943) and primary ( n = 723) care. Serum 25-hydroxy-vitamin D was determined by using liquid chromatography and serum C-reactive protein by using immunoturbidimetry. Results Concentrations of 25-hydroxy-vitamin D and C-reactive protein were significantly different between hospitalized subjects and outpatients but not for specialized and primary care settings. Serum concentrations of 25-hydroxy-vitamin D decreased as C-reactive protein increased. Hospitalized patients with C-reactive protein concentrations >30 mg/L showed a significant reduction of 25-hydroxy-vitamin D. In outpatients with C-reactive protein within the reference range (≤10 mg/L), C-reactive protein concentrations were not significantly different for serum 25-hydroxy-vitamin D concentrations >37.5 nmol/L. Conclusions Our data question the reliability and usefulness of assessing 25-hydroxy-vitamin D status as a biomarker of nutritional status in patients displaying acute phase response, especially at concentrations of C-reactive protein >30 mg/L. In addition, the present study shows that in subjects displaying C-reactive protein values within the reference range, serum concentrations of 25-hydroxy-vitamin D >37.5 nmol/L were not associated with lower concentrations of cardiovascular risk (as assessed by C-reactive protein concentrations).

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Vitamin D Deficiency is Associated With Higher Level of High Sensitivity C-reactive Protein (Hs-crp) in Patients Undergoing Elective Coronary Stenting

10.21203/rs.3.rs-73096/v1 ◽

2020 ◽

Author(s):

farzaneh foroughinia ◽

Shaghayegh Mottaghi ◽

Mohammad Reza Alimardani

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Inflammatory Diseases ◽

Inflammatory Marker ◽

Venous Blood ◽

High Sensitivity ◽

Vitamin D Status ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp

Abstract Background: Vitamin D deficiency, a prevalent worldwide concern, has been reported to have a pivotal role in many cardiovascular and inflammatory diseases. Percutaneous coronary intervention (PCI) is a therapeutic approach that may have several short-term and long-term cardiovascular complications, supposing to be mediated with high sensitive C-reactive protein (hs-CRP), an inflammatory marker. This study aimed to investigate the association between vitamin D status and hs-CRP level, as a prognostic marker, in patients undergoing elective PCI. Methods: The study population comprised of 150 patients who underwent elective coronary angioplasty. In order to measure vitamin D and hs-CRP levels, venous blood samples were obtained at baseline and 24 hours after PCI. Results: Our results showed a significant inverse relationship between post-PCI hs-CRP and also pre-post hs-CRP difference levels and vitamin D status. Conclusion: Hs-CRP content is higher in vitamin D deficient patients. Therefore, these patients, especially severely-deficient ones (25(OH)D<10ng/ml), may benefit from supplementation with vitamin D prior to PCI.

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Vitamin D, C-reactive protein, and oxidative stress markers in chronic obstructive pulmonary disease

Tzu Chi Medical Journal ◽

10.4103/tcmj.tcmj_198_19 ◽

2021 ◽

Vol 33 (1) ◽

pp. 80

Author(s):

Sarika Pandey ◽

Rajiv Garg ◽

Surya Kant ◽

Priyanka Gaur

Keyword(s):

Oxidative Stress ◽

Chronic Obstructive Pulmonary Disease ◽

Vitamin D ◽

Chronic Obstructive ◽

Oxidative Stress Markers ◽

C Reactive Protein ◽

Obstructive Pulmonary Disease ◽

Reactive Protein ◽

Stress Markers ◽

And Oxidative Stress

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Plasma 25-Hydroxyvitamin D Concentrations and Serum and Salivary C-Reactive Protein in the Osteoporosis and Periodontal Disease Study

Nutrients ◽

10.3390/nu13041148 ◽

2021 ◽

Vol 13 (4) ◽

pp. 1148

Author(s):

Sarah E. Twardowski ◽

Jean Wactawski-Wende ◽

Kathleen M. Hovey ◽

Christopher A. Andrews ◽

Hailey R. Banack ◽

...

Keyword(s):

Vitamin D ◽

Periodontal Disease ◽

Postmenopausal Women ◽

Inverse Association ◽

Vitamin D Status ◽

C Reactive Protein ◽

Hydroxyvitamin D ◽

Reactive Protein ◽

25 Hydroxyvitamin D ◽

Serum Crp

Vitamin D has been hypothesized to play an important role in preventing the development and progression of periodontal disease, but the underlying immune modulatory mechanisms remain understudied. We examined the cross-sectional association between biomarkers of vitamin D status and C-reactive protein (CRP) among postmenopausal women aged 53–81 years. Linear regression was used to examine the association between plasma 25-hydroxyvitamin D (25[OH]D) concentrations, a biomarker of vitamin D status, and both salivary and serum CRP concentrations in 567 women from the Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) Study (1997–2000). CRP concentrations were measured with multiplex arrays and transformed for normality using the natural log. Concentrations above and below the limit of detection were included in analysis as right- and left-censored observations. An inverse association was observed between 25(OH)D and salivary CRP in a model adjusted for age, smoking status, frequency of tooth brushing and flossing, and hormone therapy use (−7.56% difference in salivary CRP concentrations per 10 nmol/L increase in 25(OH)D, 95% CI: −12.78 to −2.03). Further adjustment for percent body fat attenuated this association (−2.48%, 95% CI: −7.88 to 3.24). No significant associations were found between 25(OH)D and serum CRP. Plasma vitamin D concentrations were not associated with salivary or serum CRP concentrations in this cohort of postmenopausal women.

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Retraction of Vitamin D Supplementation Affects Serum High-Sensitivity C-Reactive Protein, Insulin Resistance, and Biomarkers of Oxidative Stress in Pregnant Women. J Nutr 2013;143(9):1432–38

Journal of Nutrition ◽

10.1093/jn/nxab071 ◽

2021 ◽

Vol 151 (5) ◽

pp. 1359-1359

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Vitamin D ◽

Pregnant Women ◽

High Sensitivity ◽

Vitamin D Supplementation ◽

C Reactive Protein ◽

Reactive Protein ◽

Biomarkers Of Oxidative Stress

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Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with Psoriasis

Acta Dermato Venereologica ◽

10.2340/actadv.v101.359 ◽

2021 ◽

Author(s):

Maria Siekkeri Vandikas ◽

Kerstin Landin-Wilhelmsen ◽

Sam Polesie ◽

Martin Gillstedt ◽

Amra Osmancevic

Keyword(s):

Vitamin D ◽

Binding Protein ◽

Vitamin D Metabolites ◽

Vitamin D Status ◽

Vitamin D Binding Protein ◽

C Reactive Protein ◽

Reactive Protein ◽

Highly Sensitive ◽

Baseline Levels ◽

The Impact

High levels of serum vitamin D-binding protein have been shown previously in patients with psoriasis compared with healthy controls; a possible role in inflammation is implied. The primary objective of this study was to investigate the impact of 24-week etanercept treatment on vitamin D status and vitamin D-binding protein in patients with psoriasis. The secondary aim was to explore whether pre-treatment vitamin D levels could predict the treatment effect. A prospective observational study was performed, including 20 patients with psoriasis and 15 controls. Serum samples i.a. were analysed for vitamin D metabolites, vitamin D-binding protein and highly sensitive C-reactive protein. Baseline levels of vitamin D-binding protein were higher in patients with self-reported arthropathy than in those without. After 24 weeks’ treatment, an improvement in psoriasis was noted, as was a decrease in highly sensitive C-reactive protein. Vitamin D-binding protein decreased in those with self-reported arthropathy. Higher baseline levels of vitamin D were associated with partly faster and greater improvement in psoriasis. Vitamin D-binding protein may have an inflammatory biomarker role.

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