scholarly journals Cancer Incidence and Mortality in Chronic Dialysis Population: A Multicenter Cohort Study

2016 ◽  
Vol 43 (3) ◽  
pp. 153-159 ◽  
Author(s):  
Chi Yuen Cheung ◽  
Gary C.W. Chan ◽  
Siu Kim Chan ◽  
Flora Ng ◽  
Man Fai Lam ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kidney Cancer ◽  
Cancer Incidence ◽  
Young Patients ◽  
Chronic Dialysis ◽  
Dialysis Patients ◽  
Multicenter Cohort Study ◽  
Incidence And Mortality ◽  
Individualized Approach ◽  
Risk Of Cancer

Background: Different studies in the past have shown that the risk of cancer development is increased in chronic dialysis patients. However, data concerning the cancer risk in Asian dialysis patients was scarce. More importantly, there was lack of information about the cancer-specific mortality in dialysis patients. Methods: A multicenter retrospective cohort study of 6,254 patients who started either chronic peritoneal dialysis or hemodialysis between 1994 and 2014 in 4 renal units in Hong Kong. Patterns of cancer incidence and mortality in our dialysis patients were compared with those of the general population using standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) respectively. Results: With 14,887 person-years of follow-up, 220 cancers were recorded. The SIR of all cancers was 1.44 (95% CI 1.26-1.65). A trend of an increased SIR was observed in young patients and within the first year of dialysis. Colorectum was the most common site of cancer (20%) while kidney cancer carried the highest risk (SIR 12.28, 95% CI 8.44-17.08). The SMR of all cancers was 0.91 (95% CI 0.72-1.13) and only kidney cancer had higher cancer mortality risk (SMR 4.92, 95% CI 1.80-10.70). SMR was highest in young patients and then decreased with age. Conclusions: The incidence of cancers in our chronic dialysis patients was elevated. Our findings of substantially increased risks in young patients, particularly in relation to kidney cancer, suggest that we can adopt a more individualized approach to cancer screening in chronic dialysis patients.

scholarly journals Increased risk of cancer in chronic dialysis patients: a population-based cohort study in Taiwan

2011 ◽  
Vol 27 (4) ◽  
pp. 1585-1590 ◽  
Author(s):  
H.-F. Lin ◽  
Y.-H. Li ◽  
C.-H. Wang ◽  
C.-L. Chou ◽  
D.-J. Kuo ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Chronic Dialysis ◽  
Dialysis Patients ◽  
Increased Risk ◽  
Risk Of Cancer

scholarly journals Serum uric acid levels and risk of kidney cancer incidence and mortality: A prospective cohort study

2020 ◽  
Vol 9 (15) ◽  
pp. 5655-5661
Author(s):  
Xiao‐Yu Dai ◽  
Qiang‐Sheng He ◽  
Zhong Jing ◽  
Jin‐Qiu Yuan
Keyword(s):  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid ◽  
Kidney Cancer ◽  
Prospective Cohort Study ◽  
Cancer Incidence ◽  
Prospective Cohort ◽  
Incidence And Mortality

scholarly journals Cumulative cancer incidence and mortality after kidney transplantation in Japan: A long‐term multicenter cohort study

2020 ◽  
Author(s):  
Ryoichi Imamura ◽  
Shigeaki Nakazawa ◽  
Kazuaki Yamanaka ◽  
Yoichi Kakuta ◽  
Koichi Tsutahara ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kidney Transplantation ◽  
Cancer Incidence ◽  
Multicenter Cohort Study ◽  
Multicenter Cohort ◽  
Incidence And Mortality

Cardiovascular disease related circulating biomarkers and cancer incidence and mortality: is there an association?

2021 ◽  
Author(s):  
Manol Jovani ◽  
Elizabeth E Liu ◽  
Samantha M Paniagua ◽  
Emily S Lau ◽  
Shawn X Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cardiovascular Disease ◽  
Cohort Study ◽  
Cancer Incidence ◽  
Biological Pathways ◽  
Circulating Biomarkers ◽  
Incident Cancer ◽  
Increased Risk ◽  
Incidence And Mortality ◽  
Risk Of Cancer

Abstract Aims Recent studies suggest an association between cardiovascular disease (CVD) and cancer incidence/mortality, but the pathophysiological mechanisms underlying these associations are unclear. We aimed to examine biomarkers previously associated with CVD and study their association with incident cancer and cancer-related death in a prospective cohort study. Methods and Results We used a proteomic platform to measure 71 cardiovascular biomarkers among 5,032 participants in the Framingham Heart Study who were free of cancer at baseline. We used multivariable-adjusted Cox models to examine the association of circulating protein biomarkers with risk of cancer incidence and mortality. To account for multiple testing, we set a 2-sided false discovery rate (FDR Q-value) <0.05. Growth differentiation factor-15 (GDF15; also known as macrophage inhibitory cytokine-1 [MIC1])) was associated with increased risk of incident cancer (hazards ratio [HR] per 1 standard deviation increment 1.31, 95% CI 1.17-1.47), incident gastrointestinal cancer (HR 1.85, 95% CI 1.37-2.50), incident colorectal cancer (HR 1.94, 95% CI 1.29-2.91) and cancer-related death (HR 2.15, 95% CI 1.72-2.70). Stromal cell-derived factor-1 (SFD1) showed an inverse association with cancer-related death (HR 0.75, 95% CI 0.65-0.86). Fibroblast growth factor-23 (FGF23) showed an association with colorectal cancer (HR 1.55, 95% CI 1.20-2.00), and granulin (GRN) was associated with hematologic cancer (HR 1.61, 95% CI 1.30-1.99). Other circulating biomarkers of inflammation, immune activation, metabolism, and fibrosis showed suggestive associations with future cancer diagnosis. Conclusion We observed several significant associations between circulating CVD biomarkers and cancer, supporting the idea that shared biological pathways underlie both diseases. Further investigations of specific mechanisms that lead to both CVD and cancer are warranted. Translational Perspective In our prospective cohort study, baseline levels of biomarkers previously associated with CVD were found to be associated with future development of cancer. In particular, GDF15 was associated with increased risk of cancer incidence and mortality, including gastrointestinal and colorectal cancers; SDF1 was inversely associated with cancer-related death, and FGF23 and GRN were associated with increased risk of colorectal and hematologic cancers, respectively. Other biomarkers of inflammation, immune activation, metabolism, and fibrosis showed suggestive associations. These results suggest potential shared biological pathways that underlie both development of cancer and CVD.

Relationship between alcohol consumption and cancer in rural Chinese adults: 1 5- year follow-up cohort study

2020 ◽  
Author(s):  
Yue Zhang ◽  
Jingyi Li ◽  
Nannan Cheng ◽  
Jie Yang ◽  
Lijing Ye ◽  
...  
Keyword(s):  
Cohort Study ◽  
Alcohol Consumption ◽  
Cancer Incidence ◽  
Rural China ◽  
Density Lipoprotein ◽  
Estimating Equation ◽  
Chinese Adults ◽  
Increased Risk ◽  
Risk Of Cancer

Abstract Background：We aimed to evaluate the association between alcohol consumption and risk of cancer incidence among rural Chinese adults. Methods: We utilized data from a community-based cohort study in rural China enrolled in 2003 and followed up prospectively up to 2018. Generalized estimating equation models were used to obtain odds ratios (OR) and 95% confidence intervals (CI) to analyze the relationship between alcohol consumption and cancer incidence. Results: After an average of 15 years of follow-up, a total of 9870 adult participants were included in this study. The results of the regression analysis for males showed that former drinkers had a significantly increased risk of cancer compared to never drinkers ([OR]2.46,95%[CI](1.43-4.23)). The cancer risk for current drinkers with heavy alcohol consumption(>400g/week) significantly increased ([OR]1.66,95% [CI] (1.18-2.34))compared to never drinkers. Among current drinkers, for every 100g of alcohol consumed per week, the risk of cancer increased by 15%. Among current drinkers, those aged 53.5 years or older , had a significant increase in the risk of cancer ([OR]1.26,95% [CI](1.12-1.42), for those with triglycerides ≥150 mg/dL, the risk of cancer was even higher ([OR]1.50,95%[CI](1.20-1.88), P for interaction 0.018), and for those with high density lipoprotein cholesterol (HDLC)<40 mg/dL, the risk of cancer increased the greatest ([OR]2.03,95%[CI](1.36-3.04), P for interaction 0.005). Conclusions: Among middle-aged and elderly males in rural China, the risk of cancer significantly increased among former and heavy current drinkers compared with never drinkers. Age, triglycerides, and HDLC may increase the risk of cancer along with alcohol consumption.

Socioeconomic Disparities in Cancer Incidence and Mortality

2017 ◽  
Author(s):  
Candyce Kroenke ◽  
Ichiro Kawachi
Keyword(s):  
Health Outcomes ◽  
Cancer Incidence ◽  
Sociodemographic Factors ◽  
Cancer Type ◽  
Socioeconomically Disadvantaged ◽  
The Past ◽  
Socioeconomic Gradient ◽  
Incidence And Mortality ◽  
Risk Of Cancer ◽  
The Relationship

The relationship between socioeconomic status (SES) and cancer is complex, dynamic, and evolving. Associations depend on SES measures, cancer type, sociodemographic factors including race/ethnicity, and historical trends. However, socioeconomic disadvantage is often associated with a higher risk of cancer, particularly cancers diagnosed at a late stage, as well as worse prognosis once diagnosed. Research on secular trends over the past 70 years has shown reversals of the socioeconomic gradient for lung and colorectal cancer consistent with differential trends by SES in patterns of smoking, diet, and obesity. Rates of these cancers are now currently higher in socioeconomically disadvantaged groups. SES is considered to be a “fundamental” determinant of health outcomes, and this appears true throughout the cancer spectrum—from cancer incidence to detection, treatment, and survival. Investigations over the past decade have increasingly considered the simultaneous impact of individual SES and area-level SES (as a contextual influence) on health outcomes.

scholarly journals Effectiveness of one-time endoscopic screening programme in prevention of upper gastrointestinal cancer in China: a multicentre population-based cohort study

Gut ◽  
2020 ◽  
pp. gutjnl-2019-320200 ◽  
Author(s):  
Ru Chen ◽  
Yong Liu ◽  
Guohui Song ◽  
Bianyun Li ◽  
Deli Zhao ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Incidence ◽  
Gastrointestinal Cancer ◽  
Screening Programme ◽  
Population Based ◽  
Control Group ◽  
Endoscopic Screening ◽  
Upper Gastrointestinal Cancer ◽  
Incidence And Mortality ◽  
Upper Gastrointestinal

ObjectivesTo estimate the effectiveness of endoscopic screening programme in reducing incidence and mortality of upper gastrointestinal cancer in high risks areas of China.DesignThis multicentre population-based cohort study was conducted in six areas in China from 2005 to 2015. All permanent residents aged 40 to 69 years were identified as target subjects. We refer to those who were invited for screening collectively as the invited group. Of these, we classify those who were invited and undertook endoscopic screening as the screened group and those who were invited but did not accept screening as the non-screened group. Target subjects who were not invited to the screening were assigned to the control group. The effectiveness of the endoscopic screening and screening programme were evaluated by comparing reductions in incidence and mortality from upper gastrointestinal cancer in the screened and invited group with control group.ResultsOur cohort analysis included 637 500 people: 299 483 in the control group and 338 017 in the invited to screening group, 113 340 (33.53%) of whom were screened eventually. Compared with subjects in the control group, upper gastrointestinal cancer incidence and mortality decreased by 23% (relative risk (RR)=0.77, 95% CI 0.74 to 0.81) and 57% (RR=0.43, 95% CI 0.40 to 0.47) in the screened group, respectively, and by 14% (RR=0.86, 95% CI 0.84 to 0.89) and 31% (RR=0.69, 95% CI 0.66 to 0.72) in the invited group, respectively.ConclusionAmong individuals aged 40 to 69 years in high risk areas of upper gastrointestinal cancer, one-time endoscopic screening programme was associated with a significant decrease in upper gastrointestinal cancer incidence and mortality.

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