scholarly journals Elevated Serum Uric Acid Levels Are Related to Cognitive Deterioration in an Elderly Japanese Population

2016 ◽  
Vol 6 (3) ◽  
pp. 580-588 ◽  
Author(s):  
Kazushi Suzuki ◽  
Daisuke Koide ◽  
Kurumi Fujii ◽  
Tsutomu Yamazaki ◽  
Shoji Tsuji ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cognitive Function ◽  
Serum Uric Acid ◽  
Elevated Serum ◽  
Brain Magnetic Resonance Imaging ◽  
Vascular Pathology ◽  
Cognitive Deterioration ◽  
Imaging Data ◽  
Cross Sectional ◽  
Increased Risk

Aims: The association between serum uric acid (UA) levels and cognitive function is controversial since UA can be a risk factor for cerebral ischemia as well as acting as a neuroprotective antioxidant. Methods: We conducted a cross-sectional analysis of 228 elderly participants and examined neuropsychological test results, clinical data as well as brain magnetic resonance imaging data. Patients: Overall, 64 participants were diagnosed with cognitive deterioration. To control for the effect of sex differences, 2 independent sets of single-variable and multivariate logistic regression analyses were performed with quartiles divided into non-sex-specific and sex-specific cutoff values for UA. Results: In non-sex-specific quartiles, the participants in the highest quartiles of UA levels were found to be at a significantly higher risk of cognitive deterioration than those in the lowest quartiles. In sex-specific quartiles, the highest quartile showed an increased risk of cognitive deterioration, and a greater than fourfold increase in the risk in the highest quartiles was confirmed using multivariate regression models. However, no significant association was observed between serum UA levels and the presence of white matter lesions. Conclusions: Elevated serum UA levels were independently associated with cognitive deterioration. UA might have unknown adverse effects on cognitive function, other than causing vascular pathology.

Serum uric acid levels and risk of prehypertension: a meta-analysis

2017 ◽  
Vol 55 (3) ◽  
Author(s):  
Menglin Jiang ◽  
Dandan Gong ◽  
Yu Fan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Meta Analysis ◽  
Elevated Serum ◽  
China National Knowledge Infrastructure ◽  
Cross Sectional ◽  
Knowledge Infrastructure ◽  
Increased Risk ◽  
Cross Sectional Studies ◽  
The Relationship

AbstractElevated serum uric acid (SUA) levels may increase the risk of prehypertension. However, the findings from these studies remain conflicting. The objective of this study was to determine the relationship between SUA levels and risk of prehypertension by conducting a meta-analysis. We conducted a comprehensive literature search of PubMed, Embase, China National Knowledge Infrastructure, VIP, and the Wangfang database without language restrictions through May 2015. Observational studies assessing the relationship between SUA levels and prevalence of prehypertension were included. Pooled adjust odds ratio (OR) and corresponding 95% confidence intervals (CI) of prehypertension were calculated for the highest vs. lowest SUA levels. Prehypertension was defined as systolic blood pressure (BP) ranging from 120 to 139 mmHg or diastolic BP ranging from 80 to 89 mmHg. Eight cross-sectional studies with a total of 21,832 prehypertensive individuals were included. Meta-analysis showed that elevated SUA levels were associated with increased risk of prehypertension (OR: 1.84; 95% CI: 1.42–2.38) comparing the highest vs. lowest level of SUA levels. Subgroup analyses showed that elevated SUA levels significantly increased the risk of prehypertension among men (OR: 1.60; 95% CI: 1.12–2.21) and women (OR: 1.59; 95% CI: 1.17–2.16). Elevated SUA levels are positively associated with the risk of prehypertension in the general population. However, more well-designed longitudinal studies are needed before a definitive conclusion can be drawn due to the cross-sectional studies included are susceptible to bias.

Association of uric acid with metabolic parameters and obesity

2020 ◽  
Vol 50 (6) ◽  
pp. 1241-1254
Author(s):  
Marjan Mahdavi-Roshan ◽  
Mina Movahedian ◽  
Hamed Kord Varkaneh ◽  
Arsalan Salari ◽  
Melahat Sedanur Macit ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Communicable Disease ◽  
Adult Population ◽  
Elevated Serum ◽  
Cross Sectional Study ◽  
Metabolic Parameters ◽  
Cross Sectional ◽  
Content Type ◽  
Non Communicable Disease

Purpose Recent studies have shown that hyperuricemia is a predictor of non-communicable disease and an increment of mortality rate. Also, elevated serum uric acid may be associated with obesity in the adult population. This study aims to evaluate the association between serum uric acid levels with metabolic parameters and risk of obesity in the Iranian population. Design/methodology/approach The cross-sectional study was done on 550 participants, who were referred to a hospital for elective angiography in Rasht, Iran; anthropometric indices (waist circumference (WC) and body mass index (BMI)) and hematological factors were measured using the standard approaches. Based to the angiography results, the severity of atherosclerosis was defined. Findings The mean (SD) concentration of serum uric acid for all participants was 5.15 (1.37) mg/dl. Individuals who were at the highest tertile had higher mean (SD) of weight (p = 0.004), creatinine and blood urea nitrogen (p < 0.001) lower fasting blood sugar (FBS) (p = 0.000) and HbA1c (p = 0.016), and they were mostly men compared with those in the lowest tertile. After adjusting for confounders, FBS (ß = –0.145, p = 0.001) and HbA1c (%) (ß = –0.130, p = 0.019) had inverse and weight (ß = 0.156, p = 0.001) had direct association with serum uric acid. After adjustment for additionally potential confounders subjects in the highest tertile of serum uric acid had 92 per cent higher chance of obesity compared with subjects in the lowest tertile (OR 1.92; 95 per cent CI 1.13, 3.23). Originality/value The present study has concluded that increase serum uric acid related to high risk of obesity and low mean of FBS and HbA1c.

Association Between Serum Uric Acid and Prediabetes in the Korean General Population

2019 ◽  
Vol 31 (8) ◽  
pp. 719-727
Author(s):  
Ryoung Jin Park ◽  
Min Gu Kang
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Hemoglobin A1c ◽  
Multiple Logistic Regression Analysis ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Activity Level ◽  
Cross Sectional ◽  
Increased Risk

The purpose of this study is to examine the relation of serum uric acid with prediabetes in Korea. We conducted a cross-sectional study in 4633 individuals aged 20 to 81 years who participated in the 2016 Korean National Health and Nutrition Examination Survey. Participants are considered to have prediabetes if they have one or more of the following: impaired fasting glucose (fasting blood glucose levels between 5.6 and 6.9 mmol/L); impaired hemoglobin A1c (hemoglobin A1c ranges of 5.7% to 6.4% [39-46 mmol/mol]). Multiple logistic regression analysis was used to compute odds ratios (ORs) and 95% confidence intervals (CIs). Prediabetes was more prevalent in the hyperuricemia group compared with the normal-range group among men (OR = 1.51; 95% CI = 1.11-2.05; P < .01) and women (OR = 1.84; 95% CI = 1.01-3.37; P = .04) after adjustment for age, body mass index, abdominal obesity, blood pressure, triglyceride, high-density lipoprotein cholesterol, renal function, alcohol consumption, smoking, and physical activity level. For a standard deviation increment in uric acid, the odds of having prediabetes as compared with that of not having prediabetes increased about 114% in men ( P = .05) and 116% in women ( P = .01). Higher levels of uric acid were associated with an increased risk of prediabetes among the general Korean population.

scholarly journals Hyperuricemia and Hypertension, Coronary Artery Disease, Kidney Disease: From Concept to Practice

2020 ◽  
Vol 21 (11) ◽  
pp. 4066 ◽  
Author(s):  
Mélanie Gaubert ◽  
Thomas Bardin ◽  
Alain Cohen-Solal ◽  
François Diévart ◽  
Jean-Pierre Fauvel ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Renal Function ◽  
Uric Acid ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Serum Uric Acid ◽  
Elevated Serum ◽  
Renal Diseases ◽  
Increased Risk ◽  
Artery Disease

Since the publication of the Framingham Heart Study, which suggested that uric acid should no longer be associated with coronary heart disease after additional adjustment for cardiovascular disease risk factors, the number of publications challenging this statement has dramatically increased. The aim of this paper was to review and discuss the most recent studies addressing the possible relation between sustained elevated serum uric acid levels and the onset or worsening of cardiovascular and renal diseases. Original studies involving American teenagers clearly showed that serum uric acid levels were directly correlated with systolic and diastolic pressures, which has been confirmed in adult cohorts revealing a 2.21-fold increased risk of hypertension. Several studies involving patients with coronary artery disease support a role for serum uric acid level as a marker and/or predictor for future cardiovascular mortality and long-term adverse events in patients with coronary artery disease. Retrospective analyses have shown an inverse relationship between serum uric acid levels and renal function, and even a mild hyperuricemia has been shown to be associated with chronic kidney disease in patients with type 2 diabetes. Interventional studies, although of small size, showed that uric acid (UA)-lowering therapies induced a reduction of blood pressure in teenagers and a protective effect on renal function. Taken together, these studies support a role for high serum uric acid levels (>6 mg/dL or 60 mg/L) in hypertension-associated morbidities and should bring awareness to physicians with regards to patients with chronic hyperuricemia.

scholarly journals Lack of association between proton pump inhibitor use and brain aging: a cross-sectional study

2021 ◽  
Author(s):  
Nayeon Ahn ◽  
Stefan Frenzel ◽  
Katharina Wittfeld ◽  
Robin Bülow ◽  
Henry Völzke ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Proton Pump ◽  
Brain Aging ◽  
Verbal Learning ◽  
Brain Magnetic Resonance Imaging ◽  
Primary Analysis ◽  
Cross Sectional ◽  
Brain Volumes ◽  
Increased Risk ◽  
Brain Age

Abstract Purpose Due to conflicting scientific evidence for an increased risk of dementia by intake of proton pump inhibitors (PPIs), this study investigates associations between PPI use and brain volumes, estimated brain age, and cognitive function in the general population. Methods Two surveys of the population-based Study of Health in Pomerania (SHIP) conducted in Northeast Germany were used. In total, 2653 participants underwent brain magnetic resonance imaging (MRI) and were included in the primary analysis. They were divided into two groups according to their PPI intake and compared with regard to their brain volumes (gray matter, white matter, total brain, and hippocampus) and estimated brain age. Multiple regression was used to adjust for confounding factors. Cognitive function was evaluated by the Verbal Learning and Memory Test (VLMT) and the Nuremberg Age Inventory (NAI) and put in relation to PPI use. Results No association was found between PPI use and brain volumes or the estimated brain age. The VLMT score was 1.11 lower (95% confidence interval: − 2.06 to − 0.16) in immediate recall, and 0.72 lower (95% CI: − 1.22 to − 0.22) in delayed recall in PPI users than in non-users. PPI use was unrelated to the NAI score. Conclusions The present study does not support a relationship between PPI use and brain aging.

Pyrazinamide Induced Hyperuricemia in the Induction Phase of Anti-Tuberculosis Therapy

2021 ◽  
Vol 15 (5) ◽  
pp. 1136-1138
Author(s):  
N. Muhammad ◽  
S. Mehboob ◽  
M. Abbas
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Cross Sectional Study ◽  
Health Concern ◽  
Induction Phase ◽  
Global Public Health ◽  
Metabolic Disturbances ◽  
Cross Sectional ◽  
Intensive Phase ◽  
Increased Risk

Background: Tuberculosis (TB) is a global public health concern; although there are several recognized anti-tuberculosis drugs (ATDs) that effectively combat Mycobacterium tuberculosis (MTB), the associated adverse effects lead to frequent discontinuation. Objective: To assess the metabolic disturbances resulting from Pyrazinamide, the altered serum uric acid (SUA) levels among TB patients in District Bunir. Study Design: Cross-sectional study Place and Duration of Study: Department of Medicine, Bilal Medical Trust Hospital, Bunir-KPK from 1st January to 30th September 2019. Methodology: One hundred and nine tuberculosis patients were included in the study. All these patients were on ATD with Pyrazinamide and were regularly followed up, and their SUA levels were determined at weeks 0, 4 and 8. Results: The serum uric acid levels were high in almost 85.3% in the intensive phase of anit-TB Therapy (ATT). Among female TB patients, the incidence rate of hyperuricemia was comparatively higher than males (88.1% vs. 81.0%), but there were no significant gender disparities. Conclusion: The anti-tuberculosis drug with pyrazinamide is associated with an increased risk of hyperuricemia. Therefore, the illness needs to be closely monitored during the intensive phase of therapy. Key words: Pyrazinamide, Tuberculosis, Hyperuricaemia

Sex-Specific Association Between Serum Uric Acid and Elevated Alanine Aminotransferase in a Military Cohort: The CHIEF Study

2019 ◽  
Vol 19 (3) ◽  
pp. 333-340 ◽  
Author(s):  
Jia-Wei Lin ◽  
Kun-Zhe Tsai ◽  
Kai-Wen Chen ◽  
Fang-Ying Su ◽  
Yi-Hwei Li ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Alanine Aminotransferase ◽  
Elevated Serum ◽  
Multivariate Logistic Regression Analysis ◽  
The Other ◽  
Current Cigarette Smoking ◽  
Cross Sectional ◽  
Current Cigarette ◽  
Specific Association

Aim: The study was conducted in order to examine the sex-specific association of serum uric acid (SUA) levels with elevated serum alanine aminotransferase (ALT) in a Taiwanese military cohort. Methods: We made a cross-sectional examination of the sex-specific relationship using 6728 men and 766 women, aged 18-50 years from a large military cohort in Taiwan. SUA levels within the reference range (<7.0 mg/dL for men and <5.7 mg/dL for women respectively) were divided into quartiles and SUA levels greater than the upper reference limits were defined as hyperuricemia. Elevated ALT levels were defined as ≥40 U/L. Multivariate logistic regression analysis was performed to determine the association between each SUA category and elevated ALT levels in men and women, respectively. Results: The prevalence of hyperuricemia and elevated ALT in men were 18.7% and 12.7%, respectively, and in women were 3.3% and 2.1%, respectively. As compared with the lowest SUA quartile, hyperuricemia was associated with elevated ALT in men (odds ratios (OR): 1.62, 95% confidence intervals (CI): 1.19-2.20) after controlling for age, service specialty, body mass index, metabolic syndrome components, current cigarette smoking, alcohol intake status, and weekly exercise times, but the associations for the other SUA quartiles were null. By contrast, the associations of hyperuricemia (OR: 0.81, 95% CI: 0.10-6.64) and the other SUA quartiles with elevated ALT were null in women. Conclusion: Our findings suggest that the relationship between each SUA level and elevated ALT may differ by sex among military young adults. The mechanism for the sex difference requires further investigations.

scholarly journals Prevalence and associated factors of hyperuricemia among urban adults aged 35–79 years in southwestern China: a community-based cross-sectional study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiao-Bo Huang ◽  
Wen-Qiang Zhang ◽  
Wei-Wei Tang ◽  
Ya Liu ◽  
Yuan Ning ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Large Scale ◽  
Cross Sectional Study ◽  
Southwestern China ◽  
Current Cigarette Smoking ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Increased Risk ◽  
Urban Adults

Abstract Hyperuricemia is prevalent throughout the world. However, a well-designed large-scale epidemiological investigation of hyperuricemia in southwestern China is lacking. A regional representative sample of 10,141 participants were included using multistage, stratified sampling in Chengdu and Chongqing from September 2013 to March 2014. Hyperuricemia was defined as the self-reported of the doctor's diagnosis of hyperuricemia, or serum uric acid > 420 μmol/L in men or serum uric acid > 360 μmol/L in women. The overall age- and sex-standardized prevalence of hyperuricemia among adults aged 35–79 years was 13.5%. Compared with women, the prevalence of hyperuricemia in men was higher (17.3% versus 10.0%). Hypertension, hyperlipidemia, overweight or obesity, central obesity were associated with an increased risk for hyperuricemia both in men and in women. Married men and women were not susceptible to hyperuricemia. Current cigarette smoking was an associated risk factor of hyperuricemia only in women. Hyperuricemia has become a major health problem among urban adults aged 35–79 years in southwestern China, and special attention should be paid to men. Comorbidities associated with hyperuricemia and causality worth further investigation.

scholarly journals Serum uric acid as a prognostic indicator in acute ischemic stroke

2020 ◽  
Vol 8 (4) ◽  
pp. 1435
Author(s):  
Chandana Kaspa ◽  
Shankar Govindu
Keyword(s):  
Uric Acid ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Uric Acid ◽  
Elevated Serum ◽  
Prognostic Indicator ◽  
Uric Acid Concentration ◽  
Risk Of Death ◽  
Increased Risk ◽  
Serum Uric Acid Concentration

Background: Association between serum uric acid (SUA) and the outcome of acute ischemic stroke is debated and needs to be evaluated. The present study was conducted to study the serum uric acid concentration as an indicator of   outcome among acute ischaemic stroke and to determine the role of serum uric acid as a risk factor for acute ischemic stroke.Methods: An observational study where 50 patients who presented within 48 hours of onset of stroke admitted to medical wards of government general Hospital Guntur were selected for the study.Results: Out of 50 patients included for the study, 6 belonged to the age group of 30-40 years. Majority were male (66%) and 44.5% of the males and 76.5% of females showed raised serum uric acid levels. 25 out of 50 patients were diabetic (i.e. 50%) Among them 16 had serum uric acid >6 mg% (ie.64%), 56% of the patients were hypertensive and among them 71% were found to have uric acid levels greater than 6mgs%, 38 out of 50 patients had bad outcome, with elevated uric acid levels found 30 among them. In the present study, BMI and outcome of Stroke were significantly associated with Serum Uric acid levels.Conclusions: Serum uric acid levels can be used as a prognostic indicator as a marker for increased risk of stroke. Elevated serum urate concentration may stratify risk of death after acute stroke.

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