Sex-Specific Association Between Serum Uric Acid and Elevated Alanine Aminotransferase in a Military Cohort: The CHIEF Study

2019 ◽  
Vol 19 (3) ◽  
pp. 333-340 ◽  
Author(s):  
Jia-Wei Lin ◽  
Kun-Zhe Tsai ◽  
Kai-Wen Chen ◽  
Fang-Ying Su ◽  
Yi-Hwei Li ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Alanine Aminotransferase ◽  
Elevated Serum ◽  
Multivariate Logistic Regression Analysis ◽  
The Other ◽  
Current Cigarette Smoking ◽  
Cross Sectional ◽  
Current Cigarette ◽  
Specific Association

Aim: The study was conducted in order to examine the sex-specific association of serum uric acid (SUA) levels with elevated serum alanine aminotransferase (ALT) in a Taiwanese military cohort. Methods: We made a cross-sectional examination of the sex-specific relationship using 6728 men and 766 women, aged 18-50 years from a large military cohort in Taiwan. SUA levels within the reference range (<7.0 mg/dL for men and <5.7 mg/dL for women respectively) were divided into quartiles and SUA levels greater than the upper reference limits were defined as hyperuricemia. Elevated ALT levels were defined as ≥40 U/L. Multivariate logistic regression analysis was performed to determine the association between each SUA category and elevated ALT levels in men and women, respectively. Results: The prevalence of hyperuricemia and elevated ALT in men were 18.7% and 12.7%, respectively, and in women were 3.3% and 2.1%, respectively. As compared with the lowest SUA quartile, hyperuricemia was associated with elevated ALT in men (odds ratios (OR): 1.62, 95% confidence intervals (CI): 1.19-2.20) after controlling for age, service specialty, body mass index, metabolic syndrome components, current cigarette smoking, alcohol intake status, and weekly exercise times, but the associations for the other SUA quartiles were null. By contrast, the associations of hyperuricemia (OR: 0.81, 95% CI: 0.10-6.64) and the other SUA quartiles with elevated ALT were null in women. Conclusion: Our findings suggest that the relationship between each SUA level and elevated ALT may differ by sex among military young adults. The mechanism for the sex difference requires further investigations.

Serum uric acid levels and risk of prehypertension: a meta-analysis

2017 ◽  
Vol 55 (3) ◽  
Author(s):  
Menglin Jiang ◽  
Dandan Gong ◽  
Yu Fan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Meta Analysis ◽  
Elevated Serum ◽  
China National Knowledge Infrastructure ◽  
Cross Sectional ◽  
Knowledge Infrastructure ◽  
Increased Risk ◽  
Cross Sectional Studies ◽  
The Relationship

AbstractElevated serum uric acid (SUA) levels may increase the risk of prehypertension. However, the findings from these studies remain conflicting. The objective of this study was to determine the relationship between SUA levels and risk of prehypertension by conducting a meta-analysis. We conducted a comprehensive literature search of PubMed, Embase, China National Knowledge Infrastructure, VIP, and the Wangfang database without language restrictions through May 2015. Observational studies assessing the relationship between SUA levels and prevalence of prehypertension were included. Pooled adjust odds ratio (OR) and corresponding 95% confidence intervals (CI) of prehypertension were calculated for the highest vs. lowest SUA levels. Prehypertension was defined as systolic blood pressure (BP) ranging from 120 to 139 mmHg or diastolic BP ranging from 80 to 89 mmHg. Eight cross-sectional studies with a total of 21,832 prehypertensive individuals were included. Meta-analysis showed that elevated SUA levels were associated with increased risk of prehypertension (OR: 1.84; 95% CI: 1.42–2.38) comparing the highest vs. lowest level of SUA levels. Subgroup analyses showed that elevated SUA levels significantly increased the risk of prehypertension among men (OR: 1.60; 95% CI: 1.12–2.21) and women (OR: 1.59; 95% CI: 1.17–2.16). Elevated SUA levels are positively associated with the risk of prehypertension in the general population. However, more well-designed longitudinal studies are needed before a definitive conclusion can be drawn due to the cross-sectional studies included are susceptible to bias.

scholarly journals Lack of Associations between Elevated Serum Uric Acid and Components of Metabolic Syndrome Such as Hypertension, Dyslipidemia, and T2DM in Overweight and Obese Chinese Adults

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Li Li ◽  
Qifa Song ◽  
Xi Yang
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Muscle Mass ◽  
Alanine Aminotransferase ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Elevated Serum ◽  
Chinese Adults

The overweight and obese population experiences a higher occurrence of both hyperuricemia and metabolic syndrome. The present study was to explore the relationship between serum uric acid and metabolic syndrome-related risk factors among 409 obese Chinese adults (254 women and 155 men) with >24 kg/m2 BMI. Based on sex-specific reference ranges, 233 (57%) patients showed elevated serum uric acid. A total of 15 attributes were selected to assess the associations between elevated serum uric acid and components of metabolic syndrome, including serum uric acid, total cholesterol, HDL-C, LDL-C, triglyceride, systolic blood pressure, fasting blood glucose, glycosylated hemoglobin, HOMA-IR, alanine aminotransferase, creatinine, urine microalbumin, muscle mass amount, BMI, and age. Among the participants stratified into three groups of grade I, grade II, and grade III obesity, as well as among the participants stratified into male and female groups, univariate correlation analysis identified a negative association (P<0.01) for age, positive associations (P<0.01) for BMI, muscle mass, alanine aminotransferase, and creatinine. The stepwise multivariate logistic regression proved similar associations for age, BMI, creatinine, and alanine aminotransferase. No significant associations were testified between serum uric acid levels and cholesterol, HDL-C, LDL-C, triglyceride, fasting blood glucose, glycosylated hemoglobin, HOMA-IR, and urine microalbumin. Factor analysis illustrated that 15 attributes could be grouped into two common factors and five individual factors. A common underlying factor was identified among uric acid, muscle mass, creatinine, alanine aminotransferase, and BMI. The results indicate that serum uric acid has no apparent association with metabolic syndromes that are commonly characterized by hypertension, dyslipidemia, and T2DM.

Association of uric acid with metabolic parameters and obesity

2020 ◽  
Vol 50 (6) ◽  
pp. 1241-1254
Author(s):  
Marjan Mahdavi-Roshan ◽  
Mina Movahedian ◽  
Hamed Kord Varkaneh ◽  
Arsalan Salari ◽  
Melahat Sedanur Macit ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Communicable Disease ◽  
Adult Population ◽  
Elevated Serum ◽  
Cross Sectional Study ◽  
Metabolic Parameters ◽  
Cross Sectional ◽  
Content Type ◽  
Non Communicable Disease

Purpose Recent studies have shown that hyperuricemia is a predictor of non-communicable disease and an increment of mortality rate. Also, elevated serum uric acid may be associated with obesity in the adult population. This study aims to evaluate the association between serum uric acid levels with metabolic parameters and risk of obesity in the Iranian population. Design/methodology/approach The cross-sectional study was done on 550 participants, who were referred to a hospital for elective angiography in Rasht, Iran; anthropometric indices (waist circumference (WC) and body mass index (BMI)) and hematological factors were measured using the standard approaches. Based to the angiography results, the severity of atherosclerosis was defined. Findings The mean (SD) concentration of serum uric acid for all participants was 5.15 (1.37) mg/dl. Individuals who were at the highest tertile had higher mean (SD) of weight (p = 0.004), creatinine and blood urea nitrogen (p < 0.001) lower fasting blood sugar (FBS) (p = 0.000) and HbA1c (p = 0.016), and they were mostly men compared with those in the lowest tertile. After adjusting for confounders, FBS (ß = –0.145, p = 0.001) and HbA1c (%) (ß = –0.130, p = 0.019) had inverse and weight (ß = 0.156, p = 0.001) had direct association with serum uric acid. After adjustment for additionally potential confounders subjects in the highest tertile of serum uric acid had 92 per cent higher chance of obesity compared with subjects in the lowest tertile (OR 1.92; 95 per cent CI 1.13, 3.23). Originality/value The present study has concluded that increase serum uric acid related to high risk of obesity and low mean of FBS and HbA1c.

Sex-specific association between serum uric acid and self-reported snoring in rural China: a cross-sectional study

2017 ◽  
Vol 21 (4) ◽  
pp. 939-947
Author(s):  
Haoyu Wang ◽  
Zhao Li ◽  
Yintao Chen ◽  
Ning Ye ◽  
Pengbo Wang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Rural China ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Specific Association

scholarly journals A study of the association of serum uric acid levels with alanine aminotransferase and gamma-glutamyl transferase levels in non-alcoholic fatty liver disease patients diagnosed by imaging studies

2021 ◽  
Vol 8 (7) ◽  
pp. 934
Author(s):  
Anant Parasher ◽  
Kunal Ranjan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Alanine Aminotransferase ◽  
Cross Sectional Study ◽  
Gamma Glutamyl Transferase ◽  
Sectional Study ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Glutamyl Transferase ◽  
Alcoholic Fatty Liver Disease

Background: Non-alcoholic fatty liver disease (NAFLD) is a condition defined by excessive fat accumulation in the form of triglycerides (steatosis) in the liver. In recent years, an association between elevated serum uric acid concentrations and NAFLD has been reported. The aim of the study was to perform cross-sectional study to determine the association between serum uric acid levels and the levels of serum alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT), in NAFLD patients.Methods: In this hospital-based cross-sectional study, 300 patients with diagnosed NAFLD were included during the one-year period from July 2015 to June 2016.Results: Elevation of alanine aminotransferase levels was seen in a total of 93 cases (31%) and elevation of GGT levels in NAFLD patients was seen in 112 patients out of a total of 300 (37.33%). Hyperuricemia was observed in 99 cases out of a total of 300 cases of NAFLD (33%). A significant association was observed between the two parameters.Conclusions: The prevalence rate of NAFLD was significantly higher in subjects with hyperuricemia than that in those without hyperuricemia (78.19% versus 40.83 %) (p<0.001), and the prevalence rate increased with progressively higher serum uric acid levels (p<0.001). The relationship between rising uric acid levels with rising ALT and GGT levels in these patients was also found to be statistically significant.

scholarly journals Elevated Serum Uric Acid Levels Are Related to Cognitive Deterioration in an Elderly Japanese Population

2016 ◽  
Vol 6 (3) ◽  
pp. 580-588 ◽  
Author(s):  
Kazushi Suzuki ◽  
Daisuke Koide ◽  
Kurumi Fujii ◽  
Tsutomu Yamazaki ◽  
Shoji Tsuji ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cognitive Function ◽  
Serum Uric Acid ◽  
Elevated Serum ◽  
Brain Magnetic Resonance Imaging ◽  
Vascular Pathology ◽  
Cognitive Deterioration ◽  
Imaging Data ◽  
Cross Sectional ◽  
Increased Risk

Aims: The association between serum uric acid (UA) levels and cognitive function is controversial since UA can be a risk factor for cerebral ischemia as well as acting as a neuroprotective antioxidant. Methods: We conducted a cross-sectional analysis of 228 elderly participants and examined neuropsychological test results, clinical data as well as brain magnetic resonance imaging data. Patients: Overall, 64 participants were diagnosed with cognitive deterioration. To control for the effect of sex differences, 2 independent sets of single-variable and multivariate logistic regression analyses were performed with quartiles divided into non-sex-specific and sex-specific cutoff values for UA. Results: In non-sex-specific quartiles, the participants in the highest quartiles of UA levels were found to be at a significantly higher risk of cognitive deterioration than those in the lowest quartiles. In sex-specific quartiles, the highest quartile showed an increased risk of cognitive deterioration, and a greater than fourfold increase in the risk in the highest quartiles was confirmed using multivariate regression models. However, no significant association was observed between serum UA levels and the presence of white matter lesions. Conclusions: Elevated serum UA levels were independently associated with cognitive deterioration. UA might have unknown adverse effects on cognitive function, other than causing vascular pathology.

scholarly journals Prevalence and associated factors of hyperuricemia among urban adults aged 35–79 years in southwestern China: a community-based cross-sectional study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiao-Bo Huang ◽  
Wen-Qiang Zhang ◽  
Wei-Wei Tang ◽  
Ya Liu ◽  
Yuan Ning ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Large Scale ◽  
Cross Sectional Study ◽  
Southwestern China ◽  
Current Cigarette Smoking ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Increased Risk ◽  
Urban Adults

Abstract Hyperuricemia is prevalent throughout the world. However, a well-designed large-scale epidemiological investigation of hyperuricemia in southwestern China is lacking. A regional representative sample of 10,141 participants were included using multistage, stratified sampling in Chengdu and Chongqing from September 2013 to March 2014. Hyperuricemia was defined as the self-reported of the doctor's diagnosis of hyperuricemia, or serum uric acid > 420 μmol/L in men or serum uric acid > 360 μmol/L in women. The overall age- and sex-standardized prevalence of hyperuricemia among adults aged 35–79 years was 13.5%. Compared with women, the prevalence of hyperuricemia in men was higher (17.3% versus 10.0%). Hypertension, hyperlipidemia, overweight or obesity, central obesity were associated with an increased risk for hyperuricemia both in men and in women. Married men and women were not susceptible to hyperuricemia. Current cigarette smoking was an associated risk factor of hyperuricemia only in women. Hyperuricemia has become a major health problem among urban adults aged 35–79 years in southwestern China, and special attention should be paid to men. Comorbidities associated with hyperuricemia and causality worth further investigation.

scholarly journals Gambaran Hiperurisemia pada Subyek Keturunan Hipertensi dan Tidak Keturunan Hipertensi

2021 ◽  
Vol 3 (1) ◽  
pp. 16
Author(s):  
Catrien Berhandus ◽  
Jeffrey A. Ongkowijaya ◽  
Adeodata M. C. Kaparang
Keyword(s):  
Uric Acid ◽  
Family History ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
The Other ◽  
Dominant Male ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
History Of ◽  
Family History Of Hypertension

Abstract: Hypertension is one of the most common cardiovascular diseases worldwide. Hyperuricemia is considered if serum uric acid level >7 mg/dl in men and >6 mg/dl in women. This condition is not only associated with gout but has other associations with various diseases such as cardiovascular disease, systemic inflammation, endothelial dysfunction, and hypertension. This study was aimed to obtain the description of serum uric acid levels among people who had family history of hypertension and those who did not. This was a descriptive and observational study with a cross-sectional design. Samples were obtained at Prof. dr. R. D. Kandou Manado by using consecutive sampling, and then were divided into two groups, with and without family history of hypertension; each of 20 people. Of the group with family history of hypertension, 12 were male (60%) and 8 were female (40%), while of the other group, 10 were male (50%) and 10 were female (50%). Based on serum uric acid levels, 6 (30%) of the group with family history of hypertension had hyperuricemia, while 3 (15%) of the other group had hyperuricemia; all of them were male. In conclusion, people with family history of hypertension had hyperuricemia more frequently compared to those without family history of hypertension, with dominant male sex in both groups.Keywords: uric acid; family history of hypertension; hyperuricemia Abstrak: Hipertensi masih merupakan salah satu penyakit kardiovaskular yang paling umum di seluruh dunia. Hiperurisemia ditetapkan bila kadar serum asam urat >7 mg/dl pada laki-laki dan >6 mg/dl pada perempuan. Hiperurisemia tidak hanya berhubungan dengan gout tetapi memiliki hubungan dengan berbagai penyakit seperti penyakit kardiovaskular, inflamasi sistemik, disfungsi endotel, dan hipertensi. Penelitian ini bertujuan untuk mendapatkan gambaran asam urat pada subyek keturunan hipertensi dan tidak keturunan hipertensi. Jenis penelitian ialah observasional deskriptif dengan desain potong lintang. Sampel diperoleh di RSUP Prof. Dr. R. D. Kandou Manado menggunakan consecutive sampling dan dibagi atas dua kelompok, yaitu keturunan hipertensi dan tidak keturunan hipertensi dari hasil anamnesis; masing-masing terdiri dari 20 orang. Dari kelompok keturunan hipertensi didapatkan 12 subyek laki-laki (60%) dan 8 perempuan (40%), sedangkan dari kelompok lainnya sebanyak 10 subyek laki-laki (50%) dan 10 subyek perempuan (50%). Berdasarkan kadar asam urat, dari kelompok keturunan hipertensi sebanyak 6 orang (30%) mengalami hiperurisemia, sedangkan pada kelompok lainnya sebanyak 3 orang (15%) mengalami hiperurisemia. Semua subyek pada kedua kelompok yang mengalami hiperurisemia berjenis kelamin laki-laki. Simpulan penelitian ini ialah subyek keturunan hipertensi lebih banyak mengalami hiperurisemia dibandingkan subyek tidak keturunan hipertensi, dengan jenis kelamin laki-laki dominan pada kedua kelompok.Kata kunci: asam urat; keturunan hipertensi; hiperurisemia

Elevated serum uric acid, hyperuricaemia and dietary patterns among adolescents in mainland China

2020 ◽  
Vol 33 (4) ◽  
pp. 487-493 ◽  
Author(s):  
Hang Zhou ◽  
Zheng Feei Ma ◽  
Yiming Lu ◽  
Yanyan Du ◽  
Jian Shao ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Dietary Patterns ◽  
Elevated Serum ◽  
Principal Component ◽  
Normal Body Mass Index ◽  
Uric Acid Concentration ◽  
Limited Information ◽  
Cross Sectional ◽  
Serum Uric Acid Concentration

AbstractBackgroundElevated serum uric acid concentrations have been associated with metabolic syndrome. However, only limited information is available on the prevalence of hyperuricaemia in adolescents. Therefore, the aim of our cross-sectional study was to study the prevalence of hyperuricaemia and dietary patterns in adolescents aged 13–16 years living in Yangzhou, China.MethodsAdolescents were asked to complete a 20-item food frequency questionnaire (FFQ) and provide an overnight fasting finger-prick sample. Principal component analysis (PCA) with varimax rotation was used to derive the dietary patterns that might be associated with high uric acid concentrations.ResultsA total of 1070 adolescents were recruited. Of these, 53.6% (n = 574) were females, and 58.5% (n = 625) were within the normal body mass index (BMI) range. The males had a significantly higher serving size and frequency in their weekly food consumption, including meat, poultry, Chinese cereal staple foods and Western-style fast foods, than the females (all p < 0.02). The overall mean serum uric acid concentration and prevalence of hyperuricaemia were 368.6 ± 114.5 μmol/L and 37.9%, respectively. The prevalence of hyperuricaemia was 4.633 times greater among the participants who were overweight and obese than among those who were underweight. On the other hand, the prevalence of hyperuricaemia was 0.694 times lower among the participants who had normal weight than those who were underweight.ConclusionsThe prevalence of hyperuricaemia was relatively high in Chinese adolescents. The prevention of hyperuricaemia measures should be strengthened in adolescents to effectively control for obesity and gout, which tend to persist into adulthood.

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