To the Question of Comprehensive Treatment in the Patients with Ovarian Cancer III-IV Stages by Autohemochemotherapy Associated with the «Melaxen»

10.12737/5917 ◽  
2014 ◽  
Vol 21 (3) ◽  
pp. 126-131
Author(s):  
Козырева ◽  
S. Kozyreva ◽  
Козырев ◽  
K. Kozyrev ◽  
Карсанов ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Malignant Tumors ◽  
Cancer Recurrence ◽  
Biological Rhythms ◽  
Comprehensive Treatment ◽  
Synthetic Analogue ◽  
Complex Treatment ◽  
Methods Of Treatment ◽  
Positive Effect

This paper presents the positive characteristics of preoperative autohemochemotherapy associated with the drug "Melaxen” as a synthetic analogue of the epiphysial hormone melatonin, produced by Unipharm-USA in the complex treatment of patients with ovarian cancer on the stage III-IV. The authors emphasize that the "Melaxen" has a powerful antioxidant, anticarcinogenic and adaptogenic action, reduces stress response and regulates neuroendocrine function and biological rhythms. The authors believe that neoadjuvant autohemotherapy by the "Melaxen" with a powerful immunomodulatory and lipoic effects, improves general non-specific resistance of the organism, has a positive effect on the immediate and remote results of complex treatment of patients. In comparison with polychemotherapy, the autohemotherapy in combination with the “Melaxen" has the advantages. This therapy is significant in several basic methods of treatment of malignant tumors of the localization. It was found that with autohemochemotherapy by the "Melaxen" improves efficiency polychemotherapy, reduces its toxicity, consequently, clinically warranted and expedient in this connection, can be used as subsidiary means complex treatment of ovarian cancer recurrence in the spread process. The drug allows to improve the quality of life, to increase its duration in critically ill patients.

THE ROLE OF COMPREHENSIVE GERIATRIC ASSESSMENT IN THE TREATMENT OF CANCER PATIENTS IN ELDERLY AND SENILE AGE

2020 ◽  
pp. 65-73
Author(s):  
Ю. В. Алексеева ◽  
Т. Ю. Семиглазова ◽  
Б. С. Каспаров ◽  
Е. В. Ткаченко ◽  
К. И. Прощаев ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Malignant Tumors ◽  
Adverse Outcomes ◽  
Geriatric Syndromes ◽  
Complex Treatment ◽  
Increase Life Expectancy ◽  
Specialized Treatment

Современные подходы к организации диагностики и лечения больных пожилого и старческого возраста со злокачественными новообразованиями позволяют улучшать качество жизни и увеличивать продолжительность жизни. Оценка гериатрического статуса в онкологии позволяет прогнозировать осложнения в процессе комплексного лечения, в том числе лекарственного, модифицировать терапию для уменьшения факторов риска неблагоприятных исходов, осуществлять отбор пациентов на специализированное лечение с использованием стандартных схем. Таким образом, своевременная оценка гериатрических синдромов и их коррекция способна расширить показания к специализированному лечению больных пожилого и старческого возраста. Modern approaches to the organization of diagnosis and treatment of elderly and senile patients with malignant tumors allow to maintain the necessary level of health, improve the quality of life and increase life expectancy. Assessment of geriatric status in Oncology allows: to predict complications during the complex treatment, including drug treatment; to modify treatment to reduce the risk factors of adverse outcomes; to select patients for specialized treatment using standard schemes. So, timely assessment of geriatric syndromes and their correction can expand the indications for specialized treatment of elderly and senile patients.

scholarly journals External genital endometriosis: treatment and rehabilitation

2020 ◽  
Author(s):  
A. G. Solopova ◽  
E. E. Achkasov ◽  
V. S. Moskvichyova ◽  
E. Grigorevskaya ◽  
D. M. Ampilogova
Keyword(s):  
Quality Of Life ◽  
Malignant Tumors ◽  
Pathological Process ◽  
Social Adaptation ◽  
Cochrane Library ◽  
Current View ◽  
Comprehensive Treatment ◽  
Modern Approach ◽  
Rehabilitation Programs

Aim: to systematize data on rehabilitation methods and management tactics for women with external form of genital endometriosis.Materials and Methods. We searched for publications in international scientific databases: scientific electronic library eLibrary, Scholar, ScienceDirect, Cochrane Library, PubMed/MEDLINE for the last 5 years. The data on the modern approach to the therapy and rehabilitation of women with external genital endometriosis are presented. Search terms in Russian and English were used: “endometriosis”, “rehabilitation”, “gynecology”, “quality of life”.Results. Endometriosis is considered an independent risk factor for the development of malignant tumors not only of the reproductive system, but also of the large intestine, bladder, mammary glands. The review presents a current view of the treatment and rehabilitation of women with external genital endometriosis. Endometriosis is a polyetiological disease that can manifest itself as dysmenorrhea, dyspareunia, chronic pelvic pain, as well as dysuria and dyshesia when involving adjacent organs in the pathological process. Relapses, infertility, emotional and psychosexual disorders, problems with socialization are often detected in these patients.Conclusion. It is necessary not only to conduct comprehensive treatment, but also to develop personalized rehabilitation programs that can improve the quality of life, as well as create comfortable conditions for social adaptation in society.

scholarly journals Electrochemotherapy in Breast Cancer - Discussion of the Method and Literature Review

Breast Care ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. 409-414 ◽  
Author(s):  
Mateusz Wichtowski ◽  
Dawid Murawa ◽  
Katarzyna Kulcenty ◽  
Karolina Zaleska
Keyword(s):  
Breast Cancer ◽  
Cancer Recurrence ◽  
Locoregional Treatment ◽  
Electric Pulses ◽  
Non Invasive ◽  
Life Threatening ◽  
Late Stages ◽  
Methods Of Treatment ◽  
Cause Of Pain

Breast cancer is the most common cause of skin metastases in women. The probability of their occurrence ranges from about 5% in the entire population to as much as 30% in the late stages of the disease. Although rarely life-threatening, they have a major impact on the quality of life of patients with this diagnosis, being the cause of pain, effusion, ulceration, infection, and psychological discomfort. Available methods of treatment, both local and systemic, often fail to provide adequate control of the disease. A particular challenge seems to be the treatment of those patients with cutaneous metastases who, due to the extent of their metastases, are not eligible for resection, in whom the possibility of radiation therapy has already been used, and in whom systemic therapy is ineffective or contraindicated. A new method providing the opportunity for effective treatment is electrochemotherapy (ECT). ECT combines electropulsation of tumor cells (by local application of electric pulses) and administration of antineoplastic drugs such as cisplatin or bleomycin (either intravenous or intratumoral). Several clinical studies have demonstrated that ECT provides safe, efficient, and non-invasive locoregional treatment for chest wall breast cancer recurrence.

scholarly journals THE ROLE OF ORTHODONTIC CARE IN THE COMPLEX REHABILITATION OF GLOSSECTOMY PATIENTS

2021 ◽  
Vol 21 ◽  
pp. 42-45
Author(s):  
Yu. P. Mansur ◽  
◽  
D.V. Verstakov ◽  
L.N. Scherbakov ◽  
◽  
...  
Keyword(s):  
Quality Of Life ◽  
Malignant Tumors ◽  
Tongue Cancer ◽  
Vital Functions ◽  
Surgical Methods ◽  
Jaw Abnormalities ◽  
Orthodontic Devices ◽  
Methods Of Treatment

n recent years, Russia has seen an increase in the incidence of malignant tumors of the mouth and throat, including tongue cancer. Surgical methods of treatment of cancer of such localization have a crippling character and inevitably lead to disruption of a number of vital functions, including the development of tooth-jaw deformities, which further deteriorates the quality of life of such patients. Timely prescription of orthodontic devices for prophylactic and therapeutic purposes allows to prevent the development of tooth jaw abnormalities and deformities, as well as to treat the already developed pathology.

Use of magnetotherapy in complex treatment and rehabilitation of patients with osteoarthritis (based on consensus of specialists for therapists and general practitioners of polyclinics)

2021 ◽  
pp. 31-35
Author(s):  
L. I. Alekseeva ◽  
A. M. Lila ◽  
A. L. Vertkin
Keyword(s):  
Quality Of Life ◽  
General Practitioners ◽  
Clinical Studies ◽  
Advanced Age ◽  
Complex Treatment ◽  
Physical Methods ◽  
Rheumatological Diseases ◽  
Methods Of Treatment ◽  
Inflammatory Effect

Difficulties in treating patients with rheumatological diseases are due to the complexity and versatility of pathogenesis, frequent comorbidity and advanced age of the majority of such patients. The use of non-pharmacological methods of treatment, including physical methods, enhances the analgesic and anti-inflammatory effect, improves tissue trophism and promotes the activation of reparative processes, slows down the progression of the disease and generally improves the quality of life of patients. In the complex treatment and rehabilitation of rheumatological patients, the use of magnetotherapy seems to be a method that is well substantiated by the data of numerous fundamental and modern clinical studies.

scholarly journals Incubation qualities of eggs and the level of protein ingredients in the blood of embryos and goslings by optimizing the level of tryptophan in the diet of geese of the parent flock

2021 ◽  
Vol 23 (94) ◽  
pp. 20-24
Author(s):  
V. M. Volovich
Keyword(s):  
Amino Acid ◽  
Total Protein ◽  
Reproductive Period ◽  
Egg Laying ◽  
Control Group ◽  
Synthetic Analogue ◽  
Γ Globulins ◽  
Hatching Eggs ◽  
Positive Effect

The results of studies on the effect of synthetic tryptophan supplements to goose feed during the reproductive period on the incubation qualities of eggs, the level of total protein, albumin and α-, β- and γ-globulins in the blood of embryos and newborn goslings are presented. The study was conducted on four groups of geese-analogues of the Obroshyn gray breed group during the 3-month period (January ‒ March). The control group did not receive synthetic tryptophan supplements. The level of this amino acid in this group of geese in accordance with current regulations in Ukraine was 0.16 g per 100 g of feed. To the diet of birds 2, 3 and 4 experimental groups were additionally administered, respectively, 0.04; 0.09 and 0.14 g of synthetic tryptophan per 100 g of feed. As a result of research it was found that increasing the level of tryptophan from 0.16 g to 0.30 g per 100 g of feed due to its synthetic analogue in the diet of geese during egg-laying significantly improves the incubation quality of eggs and has a positive effect on protein levels. daily embryos and 5-day-old goslings. It is shown that the most pronounced effect on improving the quality of hatching eggs and optimizing the effect on the level of protein in the blood of embryos and goslings reveals the content of tryptophan in feed during intensive laying of geese in the amount of 0.25 g per 100 g of feed. Studies have shown that the quality of hatching eggs and the content of total protein, albumin and α-, β- and γ-globulins in the blood of embryos and newborn goslings has a pronounced positive effect on the level of tryptophan in the diet of geese during intensive laying. In particular, increasing the amount of this essential amino acid in goose feed during the reproductive period from 0.16 to 0.30 g due to its synthetic analogue improves such incubation qualities of eggs as: egg-laying, weight, length, width, egg shape index, strength and thickness eggshells, and increases in the serum of 25-day-old embryos and 5-day-old goslings contents of total protein, albumin and α-, β- and γ-globulins (P < 0.05). It is shown that the most pronounced positive effect on the optimization of protein ingredients in the serum of both embryos and goslings was found for the content of tryptophan in the feed of geese of the parent flock in the amount of 0.25 g per 100 g of feed. The results show that increasing the level of such essential amino acids as tryptophan in goose feed during intensive egg-laying from 0.16 to 0.25 g per 100 g of feed activates the synthesis of egg components in the ovary of birds, improves their quality and has a stimulating effect on the biosynthesis in hepatocytes of embryos and newborn goslings of total protein, its albumin, α-, β-globulin fractions and immune γ-globulins.

scholarly journals A case report of triple primary malignant tumors including breast,cervical and thyroid cancers with CHEK2 and PIK3CA mutation

2020 ◽  
Author(s):  
Ruoxi Xiao ◽  
Shasha Wang ◽  
Libin Sun ◽  
Yongchun Zhang ◽  
Hui Li ◽  
...  
Keyword(s):  
Tumor Metastasis ◽  
Ductal Carcinoma ◽  
Malignant Tumors ◽  
Pik3ca Mutation ◽  
Cervical Squamous Cell Carcinoma ◽  
Left Breast ◽  
Comprehensive Treatment ◽  
Multiple Primary

Abstract IntroductionTo the best of our knowledge the combination of multiple synchronous primary malignant tumors which involves breast carcinoma, thyroid carcinoma and cervical carcinoma has not been previously reported.Case reportHerein, we report a 47-year-old female who was diagnosed with multiple synchronous primary malignancies: cervical squamous-cell carcinoma, invasive ductal carcinoma of left breast, papillary carcinoma of the left thyroid gland and had a gene mutation of both CHEK2 and PIK3CA. We adopted a comprehensive treatment approach .ConclusionWhen a cancer patient presents with the clinical manifestation of another tumor, the possibility of synchronous occurrence of multiple primary malignant tumors, as well as tumor metastasis should be considered. In addition, the follow-up time of patients with malignant tumors should be extended, because timely detection and treatment of more primary malignancies may extend the survival time of patients and improve their quality of life.

Postoperative mobilisation as an indicator for the quality of surgical nursing care

2021 ◽  
Vol 30 (4) ◽  
pp. S4-S15
Author(s):  
Dorthe Hjort Jakobsen ◽  
Claus Høgdall ◽  
Lene Seibæk
Keyword(s):  
Ovarian Cancer ◽  
Nursing Care ◽  
Data Entry ◽  
Cancer Stage ◽  
Clinical Nurses ◽  
Extent Of Surgery ◽  
Nursing Data ◽  
Positive Effect ◽  
Pathology Data

Background: Postoperative mobilisation is an important part of fundamental care. Increased mobilisation has positive effect on recovery, but immobilisation is still a challenge in postoperative care. Aims: To report how the establishment of a national nursing database was used to measure postoperative mobilisation in patients undergoing surgery for ovarian cancer. Methods: ‘Mobilisation’ was defined as at least 3 hours out of bed on postoperative day 1, with the goal set at achieving this in 60% of patients. Data entry was performed by clinical nurses on 4400 patients with ovarian cancer. Findings: 46.7% of patients met the goal for mobilisation on the first postoperative day, but variations in duration and type of mobilisation were observed. Of those mobilised, 51.8% had been walking in the hallway. Conclusions: A national nursing database creates opportunities to optimise fundamental care. By comparing nursing data with oncological, surgical and pathology data it became possible to study mobilisation in relation to cancer stage, comorbidity, treatment and extent of surgery.

Boilerplate

2012 ◽  
Author(s):  
Margaret Jane Radin
Keyword(s):  
Economic Efficiency ◽  
Analytical Framework ◽  
Daily Basis ◽  
Regulatory Agencies ◽  
Jury Trial ◽  
Comprehensive Treatment ◽  
New Methods ◽  
And Control ◽  
Fine Print

Boilerplate—the fine-print terms and conditions that we become subject to when we click “I agree” online, rent an apartment, or enter an employment contract, for example—pervades all aspects of our modern lives. On a daily basis, most of us accept boilerplate provisions without realizing that should a dispute arise about a purchased good or service, the nonnegotiable boilerplate terms can deprive us of our right to jury trial and relieve providers of responsibility for harm. Boilerplate is the first comprehensive treatment of the problems posed by the increasing use of these terms, demonstrating how their use has degraded traditional notions of consent, agreement, and contract, and sacrificed core rights whose loss threatens the democratic order. This book examines attempts to justify the use of boilerplate provisions by claiming either that recipients freely consent to them or that economic efficiency demands them, and it finds these justifications wanting. It argues that our courts, legislatures, and regulatory agencies have fallen short in their evaluation and oversight of the use of boilerplate clauses. To improve legal evaluation of boilerplate, the book offers a new analytical framework, one that takes into account the nature of the rights affected, the quality of the recipient's consent, and the extent of the use of these terms. It goes on to offer possibilities for new methods of boilerplate evaluation and control, and concludes by discussing positive steps that NGOs, legislators, regulators, courts, and scholars could take to bring about better practices.

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