scholarly journals Angiographic Review of Choroidal Involution in Eyes with Retinopathy of Prematurity Treated with Bevacizumab

2020 ◽  
Author(s):  
Yasmin Islam ◽  
Lorick Andersen ◽  
Swati Agarwal-Sinha
Keyword(s):  
Retinopathy Of Prematurity ◽  
Late Phase ◽  
Critical Role ◽  
Intravitreal Bevacizumab ◽  
Retinal Function ◽  
Peripheral Retina ◽  
Phase Imaging ◽  
History Of ◽  
Choroidal Vasculature

Purpose: Retinopathy of prematurity (ROP) is considered a disease of the inner retina; however, there is increasing evidence that demonstrates choroidal vasculature loss in ROP, leading to degeneration of outer retinal function and visual deterioration. Central choroidal thinning is noted in children with history of ROP using optical coherence tomography (OCT) imaging. This study characterizes the presence and persistence of choroidal loss angiographically in eyes of infants treated with intravitreal bevacizumab (IVB) for stage 3 ROP. Methods: Retrospectively reviewed the fluorescein angiography (FA) images of 62 eyes of 31 infants treated with IVB monotherapy. The eyes with good quality early-, mid-, and late-phase imaging were included in this study. The presence of choroidal hypofluoresence involving the central and or peripheral retina were noted. In infants with multiple FAs, serial FAs were analyzed for persistence of choroidal hypofluorescence. Results: The mean age and birth weight of infants was 24.4 weeks PMA and 683 grams, respectively. All infants received IVB monotherapy. 24 of 62 angiography images of sufficient quality reviewed showed the presence of choroidal hypofluorescence involving central and peripheral lobular loss in the early phase and its persistence into mid and late phases. 12 eyes demonstrated persistent choroidal loss on sequential FA until three years chronological age. Conclusions: The study demonstrates the presence of choroidal vascular loss angiographically both central and peripheral fundus in infants with ROP. It highlights the critical role of choroidal involution in outer retinal function that could affect visual outcomes.

Friends of Rose Canyon

2018 ◽  
Vol 95 (3) ◽  
pp. 2-20 ◽  
Author(s):  
Andrew Wiese
Keyword(s):  
Open Space ◽  
Critical Role ◽  
First Century ◽  
Grassroots Politics ◽  
History Of ◽  
University City ◽  
Participant Observer ◽  
The Rose

Place-based activism has played a critical role in the history of urban and environmental politics in California. This article explores the continuing significance of environmental place making to grassroots politics through a case study of Friends of Rose Canyon, an environmental group in San Diego. Based in the fast-growing University City neighborhood, Friends of Rose Canyon waged a long, successful campaign between 2002 and 2018 to prevent construction of a bridge in the Rose Canyon Open Space Park in their community. Using historical and participant observer methodologies, this study reveals how twenty-first-century California urbanites claimed and created meaningful local places and mobilized effective politics around them. It illuminates the critical role of individual activists; suggests practical, replicable strategies for community mobilization; and demonstrates the significant impact of local activism at the urban and metropolitan scales.

scholarly journals CHEK2∗1100delC Mutation and Risk of Prostate Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Victoria Hale ◽  
Maren Weischer ◽  
Jong Y. Park
Keyword(s):  
Prostate Cancer ◽  
Current Knowledge ◽  
Prostate Cancer Screening ◽  
Critical Role ◽  
Prostate Cancer Risk ◽  
Conclusive Evidence ◽  
Increased Risk ◽  
History Of ◽  
Cancer Studies

Although the causes of prostate cancer are largely unknown, previous studies support the role of genetic factors in the development of prostate cancer.CHEK2plays a critical role in DNA replication by responding to double-stranded breaks. In this review, we provide an overview of the current knowledge of the role of a genetic variant, 1100delC, ofCHEK2on prostate cancer risk and discuss the implication for potential translation of this knowledge into clinical practice. Currently, twelve articles that discussedCHEK2∗1100delC and its association with prostate cancer were identified. Of the twelve prostate cancer studies, five studies had independent data to draw conclusive evidence from. The pooled results of OR and 95% CI were 1.98 (1.23–3.18) for unselected cases and 3.39 (1.78–6.47) for familial cases, indicating thatCHEK2∗1100delC mutation is associated with increased risk of prostate cancer. Screening for CHEK2∗1100delC should be considered in men with a familial history of prostate cancer.

scholarly journals ROLE OF EFFECTIVE PROJECT MANAGEMENT IN REDUCING DRUG DEVELOPMENT COST

2017 ◽  
Vol 10 (3) ◽  
pp. 53
Author(s):  
Faisal B A Zaidi ◽  
Salma Ahmed ◽  
Munish Makkad
Keyword(s):  
Project Management ◽  
Drug Development ◽  
Site Selection ◽  
Late Phase ◽  
Critical Role ◽  
Project Manager ◽  
Development Cost ◽  
The Cost ◽  
Patient Enrollment

ABSTRACTPharmaceuticals are passing through the difficult phase due to increasing numbers of patents expiry along with increasing cost of drug development.Protocol design, regulatory cycle time, site selection, patient enrollment and monitoring are some of the cost contributing elements for late phaseclinical trials. This paper applies the principles of project management and suggests means to reduce the cost of late phase drug development. It alsothrows light on the critical role that a project manager can play in overall drug development process.Keywords: Cost of drug development, Effective project management, Reduction in cost of drug development.

The Discovery of Retrolental Fibroplasia and the Role of Oxygen: A Historical Review, 1942–1956

2004 ◽  
Vol 23 (2) ◽  
pp. 31-38 ◽  
Author(s):  
Elizabeth Reedy
Keyword(s):  
Premature Infants ◽  
Retinopathy Of Prematurity ◽  
Historical Review ◽  
Retrolental Fibroplasia ◽  
History Of ◽  
To Come ◽  
The 1960S ◽  
Prematurely Born Infants ◽  
The U.S

Nearly 50 years after it was thought to be conquered, retinopathy of prematurity (ROP) continues to cause vision disturbances and blindness among prematurely born infants. During the 1940s and early 1950s, researchers and caregivers first identified and struggled to eliminate this problem, which seemed to come from nowhere and was concentrated among the most advanced premature nurseries in the U.S. Research studies initially identified many potential causes, none of which could be proved conclusively. By the mid-1950s, oxygen was identified as the culprit, and its use was immediately restricted. The rate of blindness among premature infants decreased significantly. ROP was not cured, however. By the 1960s, it had reappeared. The history of ROP serves to remind us that, despite our best intentions, the care and treatment of premature newborns will always carry with it the possibility of iatrogenic disease. This caution is worth remembering as we work to expand the quality and quantity of clinical research.

The Carnegie Uaxactun Project and the Development of Maya Archaeology

1990 ◽  
Vol 1 (2) ◽  
pp. 257-276 ◽  
Author(s):  
Stephen L. Black
Keyword(s):  
Large Scale ◽  
Critical Role ◽  
Carnegie Institution ◽  
Field Methods ◽  
Maya Archaeology ◽  
History Of ◽  
Maya Area

AbstractThe Carnegie Institution of Washington's 1924–1937. Uaxactun Project, one of the first large-scale excavations in the Maya area, established the role of dirt archaeology in Maya studies. The archaeologists who worked on this pioneering project developed many field methods and approaches that remain in use today. A review of the project and of the careers of its participants shows the critical role the Carnegie Uaxactun Project has played in the history of Maya archaeology.

scholarly journals GPIHBP1 C89F Neomutation and Hydrophobic C-Terminal Domain G175R Mutation in Two Pedigrees with Severe Hyperchylomicronemia

2011 ◽  
Vol 96 (10) ◽  
pp. E1675-E1679 ◽  
Author(s):  
Sybil Charrière ◽  
Noël Peretti ◽  
Sophie Bernard ◽  
Mathilde Di Filippo ◽  
Agnès Sassolas ◽  
...  
Keyword(s):  
Critical Role ◽  
Phenotypic Expression ◽  
Missense Mutations ◽  
Terminal Domain ◽  
Apoa5 Gene ◽  
Key Enzyme ◽  
History Of ◽  
Functional Consequences ◽  
Signal Peptide Polymorphism

Abstract Context: GPIHBP1 is a new endothelial binding site for lipoprotein lipase (LPL), the key enzyme for intravascular lipolysis of triglyceride-rich lipoproteins (TGRL). We have identified two new missense mutations of the GPIHBP1 gene, C89F and G175R, by systematic sequencing in a cohort of 376 hyperchylomicronemic patients without mutations on the LPL, APOC2, or APOA5 gene. Objective: Phenotypic expression and functional consequences of these two mutations were studied. Design: We performed clinical and genotypic studies of probands and their families. GPIHBP1 functional alterations were studied in CHO pgsA-745 transfected cells. Results: Probands are an adult with a homozygous G175R mutation and a child with a hemizygous C89F neomutation and a deletion of the second allele. C89F mutation was associated with a C14F signal peptide polymorphism on the same haplotype. Both patients had resistant hyperchylomicronemia, low LPL activity, and history of acute pancreatitis. In CHO pgsA-745 cells, both G175R and C14F variants reduce the expression of GPIHBP1 at the cell surface. C89F mutation is responsible for a drastic LPL-binding defect to GPIHBP1. C14F may further potentiate C89F effect. Conclusions: The emergence of hyperchylomicronemia in the generation after a neomutation further establishes a critical role for GPIHBP1 in TGRL physiopathology in humans. Our results highlight the crucial role of C65-C89 disulfide bond in LPL binding by GPIHBP1 Ly6 domain. Furthermore, we first report a mutation of the hydrophobic C-terminal domain that impairs GPIHBP1 membrane targeting.

scholarly journals Dust formation history of galaxies: A critical role of metallicity dust mass growth by accreting materials in the interstellar medium

2013 ◽  
Vol 65 (3) ◽  
pp. 213-222 ◽  
Author(s):  
Ryosuke S. Asano ◽  
Tsutomu T. Takeuchi ◽  
Hiroyuki Hirashita ◽  
Akio K. Inoue
Keyword(s):  
Interstellar Medium ◽  
Critical Role ◽  
Dust Formation ◽  
Mass Growth ◽  
Formation History ◽  
Dust Mass ◽  
History Of

A History of Bodies

2018 ◽  
pp. 237-250
Author(s):  
Annette Rodríguez
Keyword(s):  
Twentieth Century ◽  
Mexican American ◽  
Critical Role ◽  
Historical Analysis ◽  
Mexican American Women ◽  
Pedagogical Choices ◽  
History Of ◽  
Definition Of ◽  
The Continuum

This chapter explores the development of pedagogical choices and historical practice via familial and professional mentorship. Rodríguez argues for the critical role of mentorship for the development of women in the historical profession. Naming her work “a history of the gaps,” she discusses widening the definition of historical actors as well as subjects of historical analysis. As an example, the chapter points to the continuum of women acting against racist violence, documenting, analyzing, and historicizing racist violence—against previously masculinist narratives. Demonstrating a “history of the gaps,” Rodríguez’s chapter concludes with the testimonies of Mexican and Mexican American women whose X marks confirmed anti-Mexican murders at the turn of the twentieth century.

Peripheral Lesions of the Retina in the Premature Newborn

PEDIATRICS ◽  
1984 ◽  
Vol 74 (3) ◽  
pp. 446-447
Author(s):  
D. WILLARD ◽  
J. MESSER ◽  
J. P. GERHARD ◽  
D. TEMPE
Keyword(s):  
At Risk ◽  
Retinopathy Of Prematurity ◽  
Peripheral Retina ◽  
Premature Newborn ◽  
Actual Role

To the Editor.— Lucey and Dangman1 showed why a multifactorial explanation of the retinopathy of prematurity seems likely. However, data on the actual role of oxygen, in carefully matched groups, are still lacking. Our survey may contribute to this investigation. The results of a biomicroscopic investigation of the retina were assessed in two groups of prematurely born children who weighed less than 1,500 g at birth. A Goldman's contact glass made it possible to observe the especially at risk peripheral retina.

Sign in / Sign up

Export Citation Format

Share Document