scholarly journals Особливості поширеності та клінічного перебігу генералізованого пародонтиту початкового та І ступенів у вагітних жінок на тлі залізодефіцитної анемії

2018 ◽  
Author(s):  
O. H. Boychuk-Tovsta
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Comparison Group ◽  
Periodontal Diseases ◽  
Main Group ◽  
The Body ◽  
Deficiency Anemia ◽  
Initial Degree ◽  
Comparison Groups

Summary.The attention of scientists attracts the task of preserving the health of the mother and the fetus in general, as well as studying the oral cavity during pregnancy, in order to prevent the formation of a «dental chroniospermic hearth». The issue of dental morbidity in pregnant women with somatic pathology remains relevant. This is due to many factors, in particular: a significant prevalence of periodontal diseases among the population, an increase in the frequency of extragenital diseases in pregnant women, the influence of infection on the body of the pregnant woman and the fetus. Frequent complications of pregnancy are iron deficiency anemia (IDA), which ranks first among all the complications of the gestation period.The aim of the study – to learn the prevalence and peculiarities of the clinical course of generalized periodontitis of primary and grade I in pregnant women on the background of IDA.Materials and Methods. For solving our tasks, we examined 352 women in the 2nd–3rd trimester of pregnancy at the age of 18–35 years. The original form of generalized periodontitis were observed in 141 individuals with iron deficiency anemia medium and light that formed the core group. The comparison group comprised 98 pregnant women with generalized periodontitis of primary and grade I without concomitant iron deficiency anemia.Results and Discussion. According to research results, the main group generalized periodontitis initial degree met in (43.97±4.18) % of the patients, which was 1.3 times less than in the comparison group. However, the number of cases of generalized periodontitis of the 1st degree in the main group exceeded 1.4 times the similar indicator of the comparison group with values (59.18±4.96) % and (40.82±4.96) % respectively. At the age of 18–26 years, generalized periodontitis of primary level was diagnosed in 1.4 times less than in the surveyed comparison group (48.05±5.69) % vs. (67.92±6.41) %. In the age range of 27–35 years in the main group, generalized periodontitis of initial degree was registered in (39.06±6.10) % of the examined, which was 1.3 times lower than that of the comparison group (48.89±7.45) %. Generalized periodontitis of the degree 1 in patients of the main group aged 18–26 years was recorded in (51.95±5.69)% of the surveyed, which significantly exceeded this index of the comparison group by 1.6 times (32.07±6.41) %. With the increase in age to 27–35 years, the number of cases of generalized periodontitis of the degree 1 in the main group exceeded the similar number of comparison groups in 1.2 times: (60.93±6.10) % and (51.11±7.45) % respectively. In the main group at the age of 18–26, the number of cases of generalized periodontitis degree 1 was insignificantly higher than the number of diagnosed generalized periodontitis of initial degree: (51.95±5.69) % versus (48.05±5.69) %, respectively. However, in the age interval 27–35 years degree generalized periodontitis and generalized periodontitis prevailed entry level 1.6 times. The analysis of objective symptoms of the course of generalized periodontitis in the patients of the study groups showed that in pregnant women with iron deficiency anemia, the clinical picture of GP was significantly more pronounced than in women with uncomplicated pregnancy. In the main group, the expressive (63.12 %) bleeding gums in 1.8 times prevailed in the comparator group (35.71 %). Moderate bleeding in the main group was 1.8 times less (36.88 %) than in the comparison group (64.29 %). 66.67 % of the surveyed main group, against 40.82 % of the comparison group, pointed out the tenderness of the gums. The absence of pain in the gums was noted by 33.33 % of the patients with IDA and 59.18 % of the comparison groups under study. In pregnant women of the main group, severe hyperemia of the gums was 1.5 times more frequent compared to the comparison group (65.25 % versus 43.88 %, respectively). At the same time, a slight redness of gums determined 1.6 times more often in women without pregnancy complications than pregnant women with IDA (56.12 % vs. 34.75 %, respectively).Conclusions. Thus, as a result of the analysis of the parodontium tissue condition found that prevalence, intensity and expressiveness of clinical symptoms of generalized periodontitis were significantly higher in pregnant women compared to women with generalized periodontitis without complications of pregnancy. This fact indicates the negative effect of iron deficiency like physical disease, periodontal status in pregnant women.

scholarly journals The relationship of pregnant women knowledge About iron deficiency Anemia and the role of family In Compliance in consuming Fe tablets in health center

2019 ◽  
Vol 6 (1) ◽  
pp. 49
Author(s):  
Hary Yadi ◽  
Asmarita Jasda
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Health Center ◽  
Iron Deficiency Anemia ◽  
The Body ◽  
Deficiency Anemia ◽  
P Value ◽  
Family Role ◽  
Cross Sectional

<p>Pregnancy leads to increased energy metabolism, hence the need for energy and other nutrients increases during pregnancy. Increased energy and nutrients are needed for growth and development of the fetus, the increase in the amount of the uterus, changes in the composition and metabolism of the mother's body. If  levels of iron in the body of pregnant women is less, then there will be a condition called anemia. That's because iron is an essential microelement for the body. This substance is especially needed in hemopoiesis (blood formation), ie in the synthesis of hemoglobin. The purpose of this study was  to determine Knowledge of Pregnant Women About Iron Deficiency Anemia and Family Role With Compliance In Consuming Iron Tablet in health center . This study was a quantitative research, analytical, with cross sectional study subjects all mothers who have antenatal and get a tablet Fe in Tanjungpinang health center  based on data consist of 40 respondents. The result of this study was significat relationship between knowledge of pregnant women to iron deficiency anemia with Compliance Consuming Tablet iron  show the value of p 0814, the p-value is greater than the p value 0:05 was shows that no have correlation between knowledge of pregnant women about iron deficiency anemia with Compliance Consuming Iron Tablets. Family Role in monitoring drinking iron tablet  with Compliance Consuming Iron Tablets shows the value of p 0.00 is smaller than the value of α 0.05. This shows that there is a relationship between family role in monitoring drinking iron tablet with compliance consuming iron tablet. This study  indicated to increase Knowledge Level Of a Person On Iron Deficiency Anemia  Not Consume The Influence Behavior Of Iron Tablet  But Can Improve The Role Of Family In Compliance With Pregnant Women Eat Iron Tablet.</p>

Diagnostic information content of indicators of cytokine profile of gingival fluid in pregnant women with iron deficiency anemia

2020 ◽  
Vol 25 (4) ◽  
pp. 295-300
Author(s):  
A. T. Yakovlev ◽  
T. F. Danilina ◽  
V. F. Mikhalchenko
Keyword(s):  
Iron Deficiency ◽  
Early Diagnosis ◽  
Periodontal Disease ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Gingival Crevicular Fluid ◽  
Periodontal Diseases ◽  
Diagnostic Value ◽  
Deficiency Anemia ◽  
Cytokine Levels

Relevance. Modern literature and clinical dental practice do not provide enough information about the value of local immunity parameters for early diagnosis of inflammatory periodontal diseases in pregnant women with iron deficiency anemia. Conventional anti-inflammatory medications used to treat inflammatory periodontal disease are frequently contraindicated during pregnancy. It is important to make a reasonable choice of safe medications, prevention methods, and treatment at early stages of inflammatory periodontal diseases in pregnant women with iron deficiency anemia. The aim of the present study is to determine informative cytokine levels in gingival fluid for early diagnosis of inflammatory periodontal disease and evaluation of effectiveness of “Lysobact” medication in pregnant women with iron deficiency anemia (IDA).Materials and methods. Cytokine levels (IL-8, IL-10; IgA, IgG) in gingival crevicular fluid were investigated in 46 pregnant women aged 18-35: among them 16 (n = 16) had mild IDA (D50), 15 (n = 15) didn't have IDA, 15 (n = 15) were non-pregnant controls. «Lysobact» (Reg. #ПN0179/01-2002) was used in pregnant women with IDA; conventional antiinflammatory therapy was used to treat pregnant women without IDA, before and after drug therapy (8-10 days) according to clinical examinations.Results. There was determined diagnostic value of cytokine levels (IgA, IgG; IL-8, IL-10) that are of great importance for early diagnosis, evaluation of the course of the disease and effectiveness of “Lysobact” immunomodulating drug, and that significantly increase in pregnant women with IDA (IL-10 from 0.010 [1.790] to 3.050 [8.550] ng/ml) versus pregnant women without IDA (from 0.001 [1.259] to 2.900 [18.640] ng/ml) in comparison with controls (4.5 [1.13] ng/ml).Conclusion. Clinical laboratory results in pregnant women with inflammatory periodontal disease allowed to determine diagnostic value of gingival crevicular fluid parameters (sIgA, IgG; IL-8, IL-10) that are related to clinical periodontal index levels, and are informative non-invasive method and are of practical importance for early diagnosis of inflammatory periodontal disease and effectiveness of “Lysobact” drug in pregnant women with iron deficiency anemia.

scholarly journals The role of erythropoietin in the pathogenesis and treatment of iron deficiency anemia during pregnancy and in the postpartum period

2003 ◽  
Vol 52 (4) ◽  
pp. 17-22
Author(s):  
Eduard K. Ailamazyan ◽  
М. A. Tarasova ◽  
А. А. Zaitsev ◽  
А. V. Samarina
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Postpartum Period ◽  
Pathological Condition ◽  
The Body ◽  
Deficiency Anemia ◽  
Fetoplacental Complex ◽  
Iron Deficient ◽  
Anemia During Pregnancy

Iron deficiency anemia (IDA) is a very common pathological condition during pregnancy and the postpartum period. In the structure of hematological diseases in pregnant women, anemias account for about 90% and in most cases are iron deficient [3, 17, 19]. In the third trimester of pregnancy and in the early postpartum period, almost every woman has a latent iron deficiency, and 3040% develop IDA [4, 15, 16, 20, 26]. According to the Ministry of Health of the Russian Federation, the frequency of IDA in Russia has increased 6.3 times over the past ten years, and in St. Petersburg - almost 2 times. The development of anemia during pregnancy is due to an imbalance of iron in the body and is associated with its increased costs for creating a fetoplacental complex, an increase in iron metabolism and a redistribution of this trace element in favor of the fetus. Iron deficiency in the body of pregnant women and women in childbirth is associated with inadequate replacement of losses due to alimentary and mobilized iron.

scholarly journals COVID-19 and iron deficiency anemia: relationships of pathogenesis and therapy

2020 ◽  
Vol 14 (5) ◽  
pp. 644-655
Author(s):  
O. A. Gromova ◽  
I. Yu. Torshin ◽  
Yu. O. Shapovalova ◽  
M. A. Kurtser ◽  
A. G. Chuchalin
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Acute Inflammation ◽  
Ferritin Level ◽  
Interleukin 1 ◽  
The Body ◽  
Deficiency Anemia ◽  
Cytokine Storm ◽  
Pulmonary Hemosiderosis

During pregnancy, a woman becomes more susceptible to respiratory and viral diseases, including novel coronavirus infection (COVID-19). Pregnancy exacerbates the acute inflammation typical to COVID-19, elevating a risk of developing cytokine storm, characterized by an avalanche-like spike of inflammation marker concentrations (C-reactive protein, interleukin-1 в, interleukin-6, interferon-Y, ferritin, erythrocyte sedimentation rate etc.). Cytokine storm increases a risk of pregnancy loss and contribute to formation of multiple organ dysfunction syndrome in pregnant women and fetus. In particular, erythrocyte degradation due to acute inflammation leads to hypoxia and uncontrolled inter-tissue iron redistribution. As a result, conditions are created simultaneously for developing pulmonary hemosiderosis and hemosiderosis of other tissues in pregnant woman and fetus, as well as for augmenting iron loss from the body, which exacerbates iron deficiency anemia (IDA). It is important to emphasize that a surge of ferritin level distinctive for severe COVID-19, does not indicate iron overload. Therefore, recommendations to cancel IDA correction and even to use iron chelators in COVID-19 may increase hypoxia and harm the health of pregnant women.

scholarly journals Polimorfisme gen ferroportin (FPN1) -1355 G/C sebagai faktor risiko anemia defisiensi besi pada ibu hamil

2013 ◽  
Vol 9 (4) ◽  
pp. 162
Author(s):  
Nor Istiqomah ◽  
Sarah Safira Umarghanies ◽  
Arta Farmawati ◽  
Ahmad Hamim Sadewa ◽  
Yuliana Heri Soesilo ◽  
...  
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Ferritin Level ◽  
Gene Promoter ◽  
The Body ◽  
Deficiency Anemia ◽  
Erythrocyte Indices ◽  
Cellular Iron

Background: According to WHO data, prevalence of anemia pregnancy in Indonesia is 44.3%, it’s higher than world prevalence (41.8%). Ferroportin (FPN1) is one of important iron exsporter for iron absorption, release, and recycle inside the body. The varian of FPN1-1355 G/C in promoter region, leads to increased of ferroportin expression and iron export, increased cellular iron needs, overexpression of soluble transferrin receptor (sTfR), decrease hemoglobin (Hb) and erythrocyte indices that manifest to iron deficiency anemia (IDA).Objective: This research will study the frequency of FPN1-1355 G/C polymorphism as a risk factor of IDA in pregnant women in Indonesia.Method: The research design was a case and control study. Blood samples were taken from 26 pregnant women with anemia and 48 pregnant women without anemia. FPN1-1355G/C polymorphism were determined using PCR-RFLP method. sTfR and ferritin level were measured with ELISA. Hemoglobin, erythrocyte indices, and sTfR level were compared among genotype group, then statistically analyzed using independent sample t-test and one way ANOVA. Bivariat analysis of Pearson test was conducted to analyze correlation between level of blood Hb and ferritin in pregnant women (p<0.05).Results: FPN1-1355 G/C polymorphism with frequency in pregnant women with IDA and in pregnant women with anemia non IDA were 100% and 95.2%, respectively (p=0.710; OR=1.600; 95%CI: 0.296-8.653). The mean of Hb level and erythrocyte indices in subjects carrying C allele were lower than subjects carrying only G allele although Hb level is not significantly different (p>0.05). The sTfR and hepcidin level in subjects carrying C allele were higher than subjects carrying only G allele (p<0.05). Conclusion: In this study the FPN1 gene promoter -1355 G/C polymorphism was not a risk factor for anemia, but it was a risk factor for iron deficiency anemia in pregnant women.

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