scholarly journals Features of etiology, pathogenesis, treatment and prophylaxis of periodontal diseases in pregnant women in the context of iron deficiency anemia (review of the literature)

2019 ◽  
Vol 0 (1) ◽  
Author(s):  
O. H. Boichuk-Tovsta ◽  
O. H. Boichuk
2020 ◽  
Vol 25 (4) ◽  
pp. 295-300
Author(s):  
A. T. Yakovlev ◽  
T. F. Danilina ◽  
V. F. Mikhalchenko

Relevance. Modern literature and clinical dental practice do not provide enough information about the value of local immunity parameters for early diagnosis of inflammatory periodontal diseases in pregnant women with iron deficiency anemia. Conventional anti-inflammatory medications used to treat inflammatory periodontal disease are frequently contraindicated during pregnancy. It is important to make a reasonable choice of safe medications, prevention methods, and treatment at early stages of inflammatory periodontal diseases in pregnant women with iron deficiency anemia. The aim of the present study is to determine informative cytokine levels in gingival fluid for early diagnosis of inflammatory periodontal disease and evaluation of effectiveness of “Lysobact” medication in pregnant women with iron deficiency anemia (IDA).Materials and methods. Cytokine levels (IL-8, IL-10; IgA, IgG) in gingival crevicular fluid were investigated in 46 pregnant women aged 18-35: among them 16 (n = 16) had mild IDA (D50), 15 (n = 15) didn't have IDA, 15 (n = 15) were non-pregnant controls. «Lysobact» (Reg. #ПN0179/01-2002) was used in pregnant women with IDA; conventional antiinflammatory therapy was used to treat pregnant women without IDA, before and after drug therapy (8-10 days) according to clinical examinations.Results. There was determined diagnostic value of cytokine levels (IgA, IgG; IL-8, IL-10) that are of great importance for early diagnosis, evaluation of the course of the disease and effectiveness of “Lysobact” immunomodulating drug, and that significantly increase in pregnant women with IDA (IL-10 from 0.010 [1.790] to 3.050 [8.550] ng/ml) versus pregnant women without IDA (from 0.001 [1.259] to 2.900 [18.640] ng/ml) in comparison with controls (4.5 [1.13] ng/ml).Conclusion. Clinical laboratory results in pregnant women with inflammatory periodontal disease allowed to determine diagnostic value of gingival crevicular fluid parameters (sIgA, IgG; IL-8, IL-10) that are related to clinical periodontal index levels, and are informative non-invasive method and are of practical importance for early diagnosis of inflammatory periodontal disease and effectiveness of “Lysobact” drug in pregnant women with iron deficiency anemia.


Author(s):  
O. H. Boychuk-Tovsta

Summary.The attention of scientists attracts the task of preserving the health of the mother and the fetus in general, as well as studying the oral cavity during pregnancy, in order to prevent the formation of a «dental chroniospermic hearth». The issue of dental morbidity in pregnant women with somatic pathology remains relevant. This is due to many factors, in particular: a significant prevalence of periodontal diseases among the population, an increase in the frequency of extragenital diseases in pregnant women, the influence of infection on the body of the pregnant woman and the fetus. Frequent complications of pregnancy are iron deficiency anemia (IDA), which ranks first among all the complications of the gestation period.The aim of the study – to learn the prevalence and peculiarities of the clinical course of generalized periodontitis of primary and grade I in pregnant women on the background of IDA.Materials and Methods. For solving our tasks, we examined 352 women in the 2nd–3rd trimester of pregnancy at the age of 18–35 years. The original form of generalized periodontitis were observed in 141 individuals with iron deficiency anemia medium and light that formed the core group. The comparison group comprised 98 pregnant women with generalized periodontitis of primary and grade I without concomitant iron deficiency anemia.Results and Discussion. According to research results, the main group generalized periodontitis initial degree met in (43.97±4.18) % of the patients, which was 1.3 times less than in the comparison group. However, the number of cases of generalized periodontitis of the 1st degree in the main group exceeded 1.4 times the similar indicator of the comparison group with values (59.18±4.96) % and (40.82±4.96) % respectively. At the age of 18–26 years, generalized periodontitis of primary level was diagnosed in 1.4 times less than in the surveyed comparison group (48.05±5.69) % vs. (67.92±6.41) %. In the age range of 27–35 years in the main group, generalized periodontitis of initial degree was registered in (39.06±6.10) % of the examined, which was 1.3 times lower than that of the comparison group (48.89±7.45) %. Generalized periodontitis of the degree 1 in patients of the main group aged 18–26 years was recorded in (51.95±5.69)% of the surveyed, which significantly exceeded this index of the comparison group by 1.6 times (32.07±6.41) %. With the increase in age to 27–35 years, the number of cases of generalized periodontitis of the degree 1 in the main group exceeded the similar number of comparison groups in 1.2 times: (60.93±6.10) % and (51.11±7.45) % respectively. In the main group at the age of 18–26, the number of cases of generalized periodontitis degree 1 was insignificantly higher than the number of diagnosed generalized periodontitis of initial degree: (51.95±5.69) % versus (48.05±5.69) %, respectively. However, in the age interval 27–35 years degree generalized periodontitis and generalized periodontitis prevailed entry level 1.6 times. The analysis of objective symptoms of the course of generalized periodontitis in the patients of the study groups showed that in pregnant women with iron deficiency anemia, the clinical picture of GP was significantly more pronounced than in women with uncomplicated pregnancy. In the main group, the expressive (63.12 %) bleeding gums in 1.8 times prevailed in the comparator group (35.71 %). Moderate bleeding in the main group was 1.8 times less (36.88 %) than in the comparison group (64.29 %). 66.67 % of the surveyed main group, against 40.82 % of the comparison group, pointed out the tenderness of the gums. The absence of pain in the gums was noted by 33.33 % of the patients with IDA and 59.18 % of the comparison groups under study. In pregnant women of the main group, severe hyperemia of the gums was 1.5 times more frequent compared to the comparison group (65.25 % versus 43.88 %, respectively). At the same time, a slight redness of gums determined 1.6 times more often in women without pregnancy complications than pregnant women with IDA (56.12 % vs. 34.75 %, respectively).Conclusions. Thus, as a result of the analysis of the parodontium tissue condition found that prevalence, intensity and expressiveness of clinical symptoms of generalized periodontitis were significantly higher in pregnant women compared to women with generalized periodontitis without complications of pregnancy. This fact indicates the negative effect of iron deficiency like physical disease, periodontal status in pregnant women.


2018 ◽  
Vol 3 (3) ◽  
pp. 568
Author(s):  
Ainal Mardiah ◽  
Arni Amir ◽  
Andi Friadi ◽  
Ellyza Nasrul

<p><em>Iron deficiency anemia is anemia caused by iron deficiency in the blood. Maternal iron deficiency affects the low iron reserves in neonates </em><em>and it also influences on </em><em>Brain Derived Neurotropic Factor (BDNF) </em><em> which affects cognitive function.</em><em> </em><em>The purpose of this study was to determine the difference mean of BDNF in neonates from normal pregnant women and pregnant women with iron deficiency. </em><em>The design of this research was Cross Sectional</em><em> </em><em>design. This research was conducted in Community Health Center of Lubuk  Buaya, Ambacang Community Health Center, Community Health Center of Ikur Koto Health Center and Biomedical Laboratory of Andalas University on February 2017 to April 2018. There were 42 pregnant women was selected as sample e of this research. The samples were chosen by Consecutive Sampling. Then, the sample is divided into two groups: normal pregnant women and pregnant women with iron deficiency anemia. BDNF are examined by the ELISA. Next, the data were analyzed by using T test. The levels of BDNF neonates in normal pregnant group was 3.65(ng/ml) and the anemia pregnant group was 1.74(ng/ml) (p &lt;0.05). There was significant difference of BDNF levels in neonates from normal pregnant women and pregnant women with iron deficiency anemia. </em><em>The conclusion of this study is there is a difference of average BDNF in neonates from normal pregnant women and pregnant women with iron deficiency.</em></p><p> </p><p>Anemia defisiensi besi adalah anemia yang disebabkan karena kekurangan zat besi dalam darah. Defisiensi besi  maternal berdampak pada rendahnya cadangan besi pada neonatus dan berdampak terhadap ekspresi Brain Derived Neurotropic Factor (BDNF) yang berpengaruh pada fungsi kognitif. Tujuan penelitian ini adalah untuk mengetahui perbedaan rerata kadar BDNF pada neonatus dari ibu hamil normal dan ibu hamil defisiensi besi. Desain penelitian ini adalah Cross Sectional. Penelitian dilakukan di Puskesmas Lubuk Buaya, Puskesmas Ambacang, Puskesmas Ikur Koto dan Laboratorium Biomedik Universitas Andalas pada bulan Februari 2017 – Juli 2018. Sampel Penelitian adalah ibu hamil sebanyak 42 orang yang dipilih secara Consecutive Sampling, sampel dibagi menjadi dua kelompok yaitu ibu hamil normal dan ibu hamil anemia defisiensi besi. BDNF diperiksa dengan metode ELISA. Data dianalisa menggunakan uji T test. Kadar BDNF neonatus pada ibu kelompok normal adalah 3,65(ng/ml) dan kelompok ibu anemia adalah 1,74(ng/ml) (p&lt;0,05). Terdapat perbedaan bermakna kadar BDNF pada neonatus dari ibu hamil normal dan ibu anemia defisiensi besi. <em></em></p>


2021 ◽  
pp. 1-10
Author(s):  
Ningzhi Zhang ◽  
Li Mei ◽  
Min Li ◽  
Yanjun Zhang ◽  
Jinliang Xu ◽  
...  

2022 ◽  
Vol 1 (1) ◽  
pp. 114-121
Author(s):  
Dewita Dewita ◽  
Henniwati Henniwati ◽  
Lili Kartika Sari Hrp ◽  
Nora Veri

ABSTRAK  Anemia merupakan masalah global terutama bagi ibu hamil. Penyebab utama anemia pada kehamilan adalah defisiensi besi kemudian diikuti oleh defisiensi folat. WHO memperkirakan angka kejadian anemia sekitar 42 % terjadi pada ibu hamil dengan kondisi ekonomi menengah kebawah. Tujuan Pengabdian ini adalah untuk meningkatkan pengetahuan ibu hamil. tentang anemia defisensi besi dan pemeriksaan kadar hemoglobin sebagai deteksi dini mandiri di Desa Matang Seulimeng wilayah kerja Puskesmas Langsa Barat Kota Langsa. Bentuk kegiatan pengabdian masyarakat adalah dengan metode penyuluhan dengan ceramah dan tanya jawab. Sedangkan deteksi dini resiko tinggi dilakukan dengan pemeriksaan kadar hemoglobin dan setelah 2 minggu intervensi dilakukan evaluasi ibu hamil anemia dengan pemeriksaan kadar Hemoglobin. Terjadi perubahan peningkatan pengetahuan baik sebesar 85 % dan hasil pemeriksaan hemoglobin dari 18 ibu hamil anemia setelah evaluasi menjadi 67,8 %  tidak anemia .Penilaian mengenai pemahaman ibu hamil tentang edukasi anemia Defisiensi besi dan pemeriksaan Hemoglobin sebagai deteksi dini resiko pada ibu hamil adalah 3 (tiga) tahap (tahap pretest, tahap penyuluhan, dan tahap posttest serta evaluasi ibu hamil anemia). Adanya peningkatan pengetahuan setelah diberikan edukasi anemia defisiensi pada ibu hamil, dan mampu melakukan deteksi dini mandiri tanda gejala anemia sehingga mendapat penanganan sesegera mungkin. Kata Kunci : anemia defisiensi zat besi, kadar hemoglobin, deteksi dini, ibu hamil  ABSTRACT  Anemia is a global problem, especially for pregnant women. The main cause of anemia in pregnancy is iron deficiency followed by folate deficiency. WHO estimates that the incidence of anemia is around 42% in pregnant women with middle to lower economic conditions. The purpose of this service is to increase the knowledge of pregnant women. regarding iron deficiency anemia and hemoglobin level examination as an independent early detection in Matang Seulimeng Village, the working area of Langsa Barat Health Center, Langsa City. The form of community service activities is the extension method with lectures and questions and answers. Meanwhile, early detection of high risk is carried out by examining hemoglobin levels and after 2 weeks of intervention, pregnant women with anemia are evaluated by examining hemoglobin levels. There was an increase in knowledge of both 85% and the results of hemoglobin examination from 18 anemic pregnant women after the evaluation became 67.8% not anemic. An assessment of the understanding of pregnant women about iron deficiency anemia education and hemoglobin examination as early detection of risk in pregnant women is 3 (three) stages (pretest stage, counseling stage, and posttest stage and evaluation of anemic pregnant women). There is an increase in knowledge after being given education on deficiency anemia in pregnant women, and being able to independently detect early signs of anemia so that they get treatment as soon as possible. Keywords: iron deficiency anemia, hemoglobin levels, early detection, pregnant women


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