Cross-Sectional Positive Association of Serum Lipids and Blood Pressure With Serum Sodium Within the Normal Reference Range of 135–145 mmol/L

Abstract Context: The association between thyroid function and blood pressure is insufficiently studied. Objective: The objective of the investigation was to study the association between TSH within the reference range and blood pressure. Design and Setting: This was a cross-sectional, population-based study. Subjects: A total of 30,728 individuals without previously known thyroid disease were studied. Main Outcome Measures: The main outcome measures were mean systolic and diastolic blood pressure and pulse pressure and odds ratio for hypertension (>140/90 mm Hg or current or previous use of antihypertensive medication), according to categories of TSH. Results: Within the reference range of TSH (0.50–3.5 mU/liter), there was a linear increase in blood pressure with increasing TSH. The average increase in systolic blood pressure was 2.0 mm Hg [95% confidence interval (CI) 1.4–2.6 mm Hg] per milliunit per liter increase in TSH among men, and 1.8 mm Hg (95% CI 1.4–2.3 mm Hg) in women. The corresponding increase in diastolic blood pressure was 1.6 mm Hg (95% CI 1.2–2.0 mm Hg) in men and 1.1 mm Hg (95% CI 0.8–1.3 mm Hg) in women. Comparing TSH of 3.0–3.5 mU/liter (upper part of the reference) with TSH of 0.50–0.99 mU/liter (lower part of the reference), the odds ratio for hypertension was 1.98 (95% CI 1.56–2.53) in men and 1.23 (95% CI 1.04–1.46) in women. Conclusion: Within the reference range of TSH, we found a linear positive association between TSH and systolic and diastolic blood pressure that may have long-term implications for cardiovascular health.

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Assessment of normal reference values for thyroid uptake of technetium-99m pertechnetate in a Saudi population

Annals of Saudi Medicine ◽

10.5144/0256-4947.2021.86 ◽

2021 ◽

Vol 41 (2) ◽

pp. 86-90

Author(s):

Awad Alshahrani ◽

Gulam M. Syed ◽

Altaf H. Khan ◽

Shah P. Numani ◽

Abdulaziz Alnaim ◽

...

Keyword(s):

Reference Range ◽

Care Center ◽

Tertiary Care ◽

Standard Technique ◽

Thyroid Function Tests ◽

Cross Sectional ◽

Normal Reference Range ◽

Technetium 99M ◽

Normal Reference ◽

Thyroid Uptake

BACKGROUND: Thyrotoxicosis is a common medical problem. Thyroid nuclear imaging with either I 123 or technetium-99m (Tc-99m) pertechnetate are used to determine the cause. Although I 123 has been the standard technique, Tc-99m pertechnetate is now commonly used, acceptable and easier to perform. The commonly used normal value of Tc-99m pertechnetate is 1–4%, but lower normal values have been reported in different populations. OBJECTIVE: Determine normal reference range of Tc-99m pertechne-tate thyroid uptake for thyroid scintigraphy in Saudi Arabia. DESIGN: Retrospective, cross-sectional. SETTING: Nuclear medicine service at tertiary care center in Riyadh. PATIENTS AND METHODS: We used data from biochemically euthyroid patients who underwent a thyroid Tc-99m pertechnetate scan while having parathyroid scintigraphy for hyperparathyroidism between April 2009 to April 2019. Medical records and biochemical thyroid function tests were reviewed and Tc-99m pertechnetate thyroid uptake values were determined for each patient. MAIN OUTCOME MEASURES: Thyroid uptake of Tc-99m pertechne-tate in euthyroid patients. SAMPLE SIZE: 167 RESULTS: The mean and median uptake of Tc-99m pertechnetate in euthyroid patients were 0.86% and 1.0%, respectively, and the inter-quartile range was 0.0–1.0%. The normal reference range in the study population was 0.2-2%. Thyroid uptake inversely correlated with age in females (r=−0.37, P <.001), males (r=−0.46, P =.001), and for all patients (r=?0.39, P <.0001). CONCLUSION: The range for normal thyroid Tc-99m pertechnetate was lower than the standard 1-4% range. Moreover, uptake decreased with age. Further studies are needed to establish the normal age-adjusted uptake for the thyroid Tc-99m pertechnetate scan. LIMITATIONS: Single center and retrospective. CONFLICT OF INTEREST: None.

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Changing the “Normal Range” for Blood Pressure from 140/90 to 130/Any Improves Risk Assessment

Journal of Insurance Medicine ◽

10.17849/0743-6661-45.1.28 ◽

2015 ◽

Vol 45 (1) ◽

pp. 28-33

Author(s):

Michael Fulks ◽

Robert L. Stout ◽

Vera F. Dolan

Keyword(s):

Blood Pressure ◽

Risk Assessment ◽

Mortality Risk ◽

Life Insurance ◽

Reference Range ◽

Reference Laboratory ◽

Normal Reference Range ◽

Normal Reference ◽

Blood Pressure Study ◽

Upper Limits

Objective Redefine the “normal” reference range for blood pressure from <140/90 to one that more effectively identifies individuals with increased mortality risk. Method Data from the recently published 2014 CRL blood pressure study was used. It includes 2,472,706 life insurance applicants tested by Clinical Reference Laboratory from 1993 to 2007 with follow-up for vital status using the September 2011 Social Security Death Master File. Various upper limits of blood pressure (BP in mm Hg) were evaluated to determine if any was superior to the current, commonly used limit of 140/90 in identifying individuals with increased mortality risk. Results An alternative reference range using a systolic BP (SBP) <130 with any diastolic BP (DBP) included 84% of life insurance applicants. It had a lower mortality rate and narrower range of relative risk than <140/90, including 89% as many applicants but only 68% as many deaths. This pattern of lives and deaths was consistent across age and sex. Conclusion Switching to a “normal” reference range of SBP <130 offers superior risk assessment relative to using BP <140/90 while still including a sufficient percentage of the population.

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Evaluation of normal reference range for thyroid uptake of technetium-99 m in a single centre UK population

Endocrine Abstracts ◽

10.1530/endoabs.50.p402 ◽

2017 ◽

Author(s):

Mavin Macauley ◽

Mohamed Shagwi ◽

Kim Howe ◽

Andrew Curry ◽

Elizabeth Howell ◽

...

Keyword(s):

Reference Range ◽

Single Centre ◽

Normal Reference Range ◽

Normal Reference ◽

Thyroid Uptake

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The Short Cosyntropin Test Revisited: New Normal Reference Range Using LC-MS/MS

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2017-02602 ◽

2018 ◽

Vol 103 (4) ◽

pp. 1696-1703 ◽

Cited By ~ 13

Author(s):

Grethe Å Ueland ◽

Paal Methlie ◽

Marianne Øksnes ◽

Hrafnkell B Thordarson ◽

Jørn Sagen ◽

...

Keyword(s):

Reference Range ◽

Normal Reference Range ◽

New Normal ◽

Normal Reference

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EP08.08: Ventricular occupying ratio at 18-30 weeks' gestation: normal reference range and ventriculomegaly

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.19893 ◽

2018 ◽

Vol 52 ◽

pp. 224-224

Author(s):

R.K. Pooh ◽

T. Nakamura ◽

M. Machida ◽

K. Uenishi ◽

K. Kusunoki ◽

...

Keyword(s):

Reference Range ◽

Normal Reference Range ◽

Normal Reference

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Normal Reference Range of Lateral Ventricle Parameters in Preterm Neonates by Ultrasonography

Shiraz E-Medical Journal ◽

10.5812/semj.57569 ◽

2017 ◽

Vol 18 (8) ◽

Author(s):

Sina Karamimagham ◽

Maryam Poursadeghfard ◽

Fariba Hemmati

Keyword(s):

Lateral Ventricle ◽

Reference Range ◽

Preterm Neonates ◽

Normal Reference Range ◽

Normal Reference

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Assessing the haematology and serum chemistry of Uda rams fed different Kanwa based mineral licks

Journal of Animal Science and Veterinary Medicine ◽

10.31248/jasvm2021.299 ◽

2021 ◽

Vol 6 (6) ◽

pp. 209-215

Author(s):

A. Abdulkarim ◽

◽

K. M. Aljameel ◽

Keyword(s):

Reference Range ◽

Health Hazard ◽

Serum Biochemistry ◽

Serum Chemistry ◽

Normal Range ◽

Blood Profile ◽

Normal Reference Range ◽

Normal Reference ◽

Mineral Licks ◽

Sheep Production

This study was conducted at the Department of Animal Science’s Teaching and Research farm of Usmanu Danfodiyo University, Sokoto to evaluate the effect of feeding different kanwa based mineral licks on blood profile of Uda rams. Blood of twenty (20) yearlings Uda rams aged by dentition were used to evaluate the effect of Kanwa¬-based mineral blocks. Four (4) animals were allotted to each treatment (Kanwa block) with each animal serving as a replicate. The Kanwa used were Kanwan Bai-Bai, Kanwan Kolo, Hogga, Balma and conventional mineral lick to represent treatment 1, 2, 3, 4 and 5 respectively. Data was collected at the end of the experiment. The result of haematological analysis showed significant (p<0.05) differences in all the parameters analysed except PCV, MCH, WBC and eosinophil; the result indicated that all the values where within the normal reference range except in MCHC where animals placed in T2 and T3 shows values slightly above the normal range. The result of serum biochemistry showed that all the values measured were within the normal reference range for sheep except the albumin of animals placed in T3 which had values slightly above the normal range. The serum mineral composition showed that Potassium levels were higher in T2 and lower in T4; however, there was no difference between animals placed in treatments 1, 2 and 3, so also between treatments 1, 3 and 4. The study concluded that Kanwa positively affected sheep production with no adverse effect on both haematological and serum chemistry, hence little health hazard is associated with feeding Kanwa-based blocks on growing Uda rams.

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Abstract P334: The Relationship Between Urinary Sodium-to-Potassium Ratio And High Blood Pressure: TMM CommCohort Study

Circulation ◽

10.1161/circ.141.suppl_1.p334 ◽

2020 ◽

Vol 141 (Suppl_1) ◽

Author(s):

Mana Kogure ◽

Tomohiro Nakamura ◽

Naho Tsuchiya ◽

Takumi Hirata ◽

Akira Narita ◽

...

Keyword(s):

Blood Pressure ◽

Alcohol Intake ◽

Positive Association ◽

Cross Sectional Study ◽

Analysis Of Covariance ◽

Cross Sectional ◽

High K ◽

Prevention Of Hypertension ◽

The Relationship ◽

Low K

Introduction: Recently, the balance between sodium and potassium intake, i.e. sodium-to-potassium (Na/K) ratio, has received significant attention for prevention of hypertension. Previous studies reported the positive association between urinary Na/K (uNa/K) ratio and hypertension. However, even the same uNa/K ratio value, there might be high Na/ high K ratio or low Na/ low K ratio. Hypothesis: We assessed the hypothesis that blood pressure (BP) is higher in high Na/ high K group than that in low Na/ low K group even at the same uNa/K ratio in general population in cross-sectional study. Methods: The subjects were 20 to 74 years old who participated in The Tohoku Medical Megabank Project Community-based Cohort Study. Of these participants, we targeted 54,011 subjects (men: 20,505 women: 33,506 mean age: 59.9 years) who had information of BP, urinary Na and K. We estimated 24-h urinary excretion of Na and K using Tanaka formula. Urinary Na and K were each classified into quartiles (Na; Q1~Q4, K; Q1~Q4), and set all 16 groups of uNa/K ratio by combining Na and K respectively. To assess the relationship between casual uNa/K ratio and BP, we performed an analysis of covariance to calculate the adjusted mean systolic BP (SBP). We included covariate factors as age, sex, BMI and alcohol intake. We also assessed the relationship between uNa/K ratio and SBP using multiple regression analyses adjusted for covariate factors. We stratified the participants into two groups: ‘under treatment for hypertension’ (n=17,091) and ‘without treatment for hypertension (n=36,920)’. Results: The mean of uNa/K ratio for each group of Na (Q1)/K(Q1), Na (Q2)/K(Q2), Na (Q3)/K(Q3) and Na (Q4)/K(Q4) was all 4.0. As previous report showed, higher uNa/K ratio group showed higher SBP and lower uNa/K group showed lower BP. When we compared adjusted mean SBP of Na (Q1)/K(Q1) and Na (Q4)/K(Q4) the value were comparable, but the value were significantly higher in Na (Q4)/K(Q4) group (The adjusted mean SBP of Na (Q1)/K(Q1), Na (Q2)/K(Q2), Na (Q3)/K(Q3) and Na (Q4)/K(Q4) was 123.6, 124.9, 124.7 and 125.5 mmHg, respectively). The uNa/K was significantly positively associated with SBP independently of age, sex, BMI, and alcohol intake. The finding was unchanged the results in under treatment group. Conclusions: BP was significantly higher in high Na/ high K group than in low Na/ low K group even at the same uNa/K ratio. We suggested that not only increasing K intake but also reducing salt is important for preventing hypertension.

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