Abstract P220: Exposure to Secondhand Smoke and the Risk of Stroke

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Angela M Malek ◽  
Leslie A McClure ◽  
Mary Cushman ◽  
Daniel T Lackland
Keyword(s):  
African American ◽  
Secondhand Smoke ◽  
Hemorrhagic Stroke ◽  
African American Men ◽  
Health Concern ◽  
White Blood Count ◽  
Inflammation Markers ◽  
Increased Risk ◽  
Shs Exposure ◽  
Exposure To Secondhand Smoke

Background: Stroke is a leading cause of death worldwide, and is a major public health concern in terms of morbidity, mortality, economic costs, and loss of productivity. While exposure to secondhand smoke (SHS) is a risk factor for cardiovascular disease, associations of SHS with risk of stroke have been inconsistent. Hypothesis: We investigated the hypotheses that SHS exposure is associated with increased incidence of stroke and stroke subtypes (ischemic stroke and hemorrhagic stroke) among non-smokers, including never and former smokers. Methods: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) study enrolled a U.S. population sample of 30,239 Caucasian and African-American men and women aged >=45 years in 2003-7 and is following them for stroke outcomes. We calculated the hazard ratio (HR) of stroke among non-smokers with SHS exposure using Cox proportional hazard models. Results: The cohort, without prevalent smoking, stroke and TIA (n=21,743), included 62% Caucasians and 38% African-Americans, with 55% females. Twenty-three percent reported SHS exposure the year prior to enrollment, and these individuals were more likely to be younger, African-American, male (all p<0.001), and have higher C-reactive protein (CRP) and white blood count (WBC) (p<0.05) compared to those not exposed. SHS exposure was associated with a 31% increased risk of any stroke event after adjustment for demographic, socioeconomic, and behavioral factors (Table 1). The association was seen only in ischemic, but not hemorrhagic stroke. Associations were slightly diminished after adjusting for traditional stroke risk factors, and markedly attenuated to the null after further addition of inflammation markers. Conclusions: SHS exposure was not related to stroke after accounting for inflammation markers. Further research is needed to confirm these findings.

scholarly journals Reducing Secondhand Smoke Exposure Among Nonsmoking Pregnant Women: A Systematic Review

2020 ◽  
Vol 22 (12) ◽  
pp. 2127-2133 ◽  
Author(s):  
Chidiogo Nwosu ◽  
Kathryn Angus ◽  
Hazel Cheeseman ◽  
Sean Semple
Keyword(s):  
Pregnant Women ◽  
Secondhand Smoke ◽  
Financial Incentives ◽  
Educational Interventions ◽  
Intervention Delivery ◽  
Effective Interventions ◽  
Increased Risk ◽  
Shs Exposure ◽  
The Uk ◽  
Exposure To Secondhand Smoke

Abstract Introduction Exposure to secondhand smoke (SHS) in pregnancy leads to an increased risk of stillbirths, congenital malformations, and low birth weight. There is a lack of evidence about how best to achieve reductions in SHS exposure among nonsmoking pregnant women. This work systematically reviews individual or household interventions to reduce pregnant women’s exposure to SHS. Methods MEDLINE, EMBASE, and CINAHL databases were searched from their dates of inception to April 17, 2019. Studies were included if: participants were nonsmoking pregnant women; involved an intervention to reduce SHS exposure or encourage partner quitting; and measured SHS exposure of pregnant women and/or recorded quit rates among partners. The UK National Institute for Health & Care Excellence (NICE) Quality Appraisal checklist was used to determine internal and external validity. Results Nine studies met the inclusion criteria. Educational interventions were primarily targeted at the pregnant woman to change her or others’ behavior, with only two studies involving the partner who smoked. Intervention delivery was mixed, spanning brief discussions through to more involving sessions with role play. The effective interventions involved multiple follow-ups. There was no standardized method of assessing exposure to SHS. Many of the included studies had moderate to high risk of bias. Conclusion There is mixed evidence for interventions aimed at reducing pregnant women’s exposure to SHS, though multi-component interventions seem to be more effective. The effectiveness of family-centered approaches involving creating smoke-free homes alongside partner smoking cessation, perhaps involving pharmacological support and/or financial incentives, should be explored. Implications • Measures to protect nonsmoking pregnant women from SHS tend to place the responsibility for “avoidance” on the woman. • There is little work that seeks to involve the smoking partner or other smokers in protecting pregnant women from SHS. • Interventions to create smoke-free homes and/or smoking partner cessation need to be developed: pharmacological and financial support should be explored.

scholarly journals Exploring Experiences and Perceptions of Older African American Males Aging With HIV in the Rural Southern United States

2016 ◽  
Vol 11 (2) ◽  
pp. 221-232 ◽  
Author(s):  
Barbara J. Blake ◽  
Gloria A. Jones Taylor ◽  
Richard L. Sowell
Keyword(s):  
United States ◽  
African American ◽  
Rural Communities ◽  
African American Men ◽  
Qualitative Content Analysis ◽  
The United States ◽  
Health Concern ◽  
Treatment And Prevention ◽  
Age Related ◽  
Living With Hiv

The HIV (human immunodeficiency virus) epidemic in the United States remains a serious public health concern. Despite treatment and prevention efforts, approximately 50,000 new HIV cases are transmitted each year. Estimates indicate that 44% of all people diagnosed with HIV are living in the southern region of the United States. African Americans represent 13.2% of the United States population; however, 44% (19,540) of reported new HIV cases in 2014 were diagnosed within this ethnic group. The majority of cases were diagnosed in men (73%, 14,305). In the United States, it is estimated that 21% of adults living with HIV are 50 years or older. There exists limited data regarding how well African American men are aging with HIV disease. The purpose of this study was to explore the perceptions and experiences of older African American men living with HIV in rural Georgia. Data were collected from 35 older African American men living with HIV using focus groups and face-to-face personal interviews. Qualitative content analysis revealed six overlapping themes: (1) Stigma; (2) Doing Fine, Most of the Time; (3) Coping With Age-Related Diseases and HIV; (4) Self-Care; (5) Family Support; and (6) Access to Resources. The findings from this study provide new insights into the lives of rural HIV-infected African American men, expands our understanding of how they manage the disease, and why many return to or remain in rural communities.

ELEVATED SERUM LOW DENSITY LIPOPROTEIN (LDL) IS ASSOCIATED WITH AN INCREASED RISK OF PROSTATE CANCER IN AFRICAN-AMERICAN MEN

2008 ◽  
Vol 179 (4S) ◽  
pp. 150-150
Author(s):  
Kelvin A Moses ◽  
Thura T Abd ◽  
John A Hall ◽  
Michael Goodman ◽  
Muta M Issa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
African American Men ◽  
Low Density Lipoprotein ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Low Density ◽  
Increased Risk

scholarly journals Exposure to Secondhand Smoke: Inconsistency between Self-Response and Urine Cotinine Biomarker Based on Korean National Data during 2009–2018

2021 ◽  
Vol 18 (17) ◽  
pp. 9284
Author(s):  
Boram Sim ◽  
Myung-Bae Park
Keyword(s):  
Secondhand Smoke ◽  
Vulnerable Groups ◽  
Exposure Rate ◽  
Short Term ◽  
The Past ◽  
Health And Nutrition ◽  
Urine Cotinine ◽  
Short Term Exposure ◽  
Shs Exposure ◽  
Exposure To Secondhand Smoke

This study aimed to estimate the secondhand smoke (SHS) exposure using urinary cotinine (UCo) to prove that the SHS exposure could not be properly assessed by self-reporting (SR). In total, 28,574 nonsmokers aged >19 years were selected from the Korean National Health and Nutrition Examination Survey data (2009–2018). First, changes in the annual concentration of UCo were analyzed, and the annual SHS exposure rates were measured based on SR and UCo from 2009 to 2018. Then, the average UCo concentration and UCo-measured SHS exposure rate were confirmed according to the subjects’ characteristics. Finally, factors associated with the UCo-measured SHS exposure rate were identified based on multiple regression analysis. The findings showed that the annual UCo concentrations and self-reported SHS exposure rates dropped significantly over the past decade. In contrast, the UCo-measured SHS exposure rate indicated that >80% of nonsmokers are still exposed to SHS. Moreover, we found vulnerable groups using UCo-measured SHS exposure rate. In particular, the self-reported SHS exposure at home and in workplaces and house type was highly associated with SHS exposure. Thus, these findings indicate that the actual SHS exposure could not be properly assessed by SR and should be verified using a biomarker, such as UCo. Considering that even a short-term exposure can be harmful to health, the goal of the policy should be to keep cotinine concentration as low as possible.

scholarly journals Vitamin D deficiency increases prostatic megalin expression and globulin-bound testosterone import, increasing prostatic androgens in African American men

2021 ◽  
Author(s):  
Jason Garcia ◽  
Kirsten Krieger ◽  
Candice Loitz ◽  
Lillian M Perez ◽  
Zachary A Richards ◽  
...  
Keyword(s):  
Vitamin D ◽  
African American ◽  
African Americans ◽  
Vitamin D Deficiency ◽  
African American Men ◽  
African Ancestry ◽  
Serum Vitamin ◽  
Vitamin D Metabolites ◽  
Increased Risk ◽  
Vitamin D Levels

Vitamin D deficiency associates with an increased risk of prostate cancer (PCa) mortality and is hypothesized to contribute to PCa aggressiveness and disparities in African Americans. We reported a relationship between African-ancestry, circulating and intraprostatic vitamin D metabolites and prostatic expression of megalin, an endocytic membrane receptor that internalizes globulin-bound hormones. Here, we show that megalin imports sex hormone-binding globulin (SHBG)-bound testosterone, potentially regulating intraprostatic hormone levels. Vitamin D levels regulated megalin expression in cell lines, patient-derived prostate epithelial cells, and prostate tissue explants, and mice with prostatic knockout of Lrp2 (megalin) showed reduced prostatic testosterone. Notably, prostatic 5α-dihydrotestosterone levels were higher in African American men and correlated inversely with serum vitamin D status, while megalin protein levels were reduced in PCa tissue. Our findings highlight the negative impact of vitamin D deficiency on PCa and the potential link to PCa disparities observed in African Americans.

scholarly journals Estimation of lifetime cumulative mortality risk of lung cancer by smoking status in Japan

2020 ◽  
Vol 50 (10) ◽  
pp. 1218-1224
Author(s):  
Megumi Hori ◽  
Eiko Saito ◽  
Kota Katanoda ◽  
Shoichiro Tsugane
Keyword(s):  
Lung Cancer ◽  
Life Table ◽  
Mortality Risk ◽  
Secondhand Smoke ◽  
Smoking Status ◽  
Cumulative Risk ◽  
Cumulative Mortality ◽  
Shs Exposure ◽  
Estimated Risk ◽  
Exposure To Secondhand Smoke

Abstract The main objective of this study was to estimate the cumulative mortality risk for lung cancer according to smoking status and exposure to secondhand smoke (SHS) in Japan. We applied a life-table method to estimate the cumulative risk. Estimated lifetime cumulative risk for 20-year-old non-smokers, former, and current smokers was 3.2%, 7.6%, and 14.9% for men and 1.9%, 5.6%, and 7.2% for women, respectively. For males, the estimated risk was 3.2% for non-smokers not exposed to SHS and 4.1% for non-smokers exposed to SHS. For females, the estimated risk was 1.9% for non-smokers not exposed to SHS and 2.4% for non-smokers exposed to SHS. Lifetime cumulative mortality risk differed greatly according to smoking status. Moreover, SHS exposure resulted in observable differences in lifetime mortality risk. This study may be useful for the development of tailored prevention programs.

scholarly journals Is exposure to secondhand smoke associated with current depression (PHQ-8) among never-smokers? Results from a survey among German adults

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Fabian Erdsiek ◽  
Patrick Brzoska
Keyword(s):  
Secondhand Smoke ◽  
Logistic Regression Model ◽  
German Health ◽  
Potential Association ◽  
Prevalence Of Depression ◽  
Patient Health ◽  
Shs Exposure ◽  
Interaction Term ◽  
Never Smokers ◽  
Exposure To Secondhand Smoke

Abstract Background Findings on the association between exposure to secondhand smoke (SHS) and depression are contradictory. Comparability of existing research is limited due to varied methods and measures. This study examines the potential association between exposure to SHS and depression and a potential moderation by sex using representative data from Germany. Methods For our study, we used data from the German Health Update (GEDA) 2014/2015 on n = 10,274 never-smokers. We calculated a logistic regression model with an interaction term for potential sex-exposure interactions. We used the self-reported duration of exposure to predict current depression of any type as defined by the Patient Health Questionnaire PHQ-8 (score ≥ 10), accounting for a large number of confounders. Results In our sample, prevalence of depression was 8.8% in women and 5.3% in men. 90.4% were never or almost never exposed to SHS, while 7.1% were exposed < 1 h per day and around 2.5% reported being exposed for ≥1 h per day. While SHS exposure for < 1 h per day was not associated with current depression (OR = 1.54; 95%-CI: 0.93–1.61), SHS exposure for at least 1 h per day was associated with increased odds for current depression (OR = 1.59; 95%-CI: 1.08–2.35). No sex-specific differences were found. Conclusions Higher levels of SHS exposure are associated with current depression, although the nature and direction of the association are still unclear. We identified no differences in the association between men and women. More studies, particularly using longitudinal data, are needed to determine the nature of the association.

scholarly journals Characteristics of Non-Smokers’ Exposure Using Indirect Smoking Indicators and Time Activity Patterns

2020 ◽  
Vol 12 (21) ◽  
pp. 9099
Author(s):  
Byung Lyul Woo ◽  
Min Kyung Lim ◽  
Eun Young Park ◽  
Jinhyeon Park ◽  
Hyeonsu Ryu ◽  
...  
Keyword(s):  
Exposure Time ◽  
Secondhand Smoke ◽  
Activity Patterns ◽  
Time Activity ◽  
Spatial Characteristics ◽  
Exposure Biomarkers ◽  
Shs Exposure ◽  
Temporal And Spatial ◽  
Temporal And Spatial Characteristics ◽  
Exposure To Secondhand Smoke

Since the global enforcement of smoke-free policies, indoor smoking has decreased significantly, and the characteristics of non-smokers’ exposure to secondhand smoke (SHS) has changed. The purpose of this study was to assess the temporal and spatial characteristics of SHS exposure in non-smokers by combining questionnaires and biomarkers with time activity patterns. To assess SHS exposure, biomarkers such as cotinine and 4-(methylnitrosamino)-1-3-(pyridyl)-1-butanol (NNAL) in urine and nicotine in hair were collected from 100 non-smokers in Seoul. Questionnaires about SHS exposure and time activity patterns were also obtained from the participants. The analysis of biomarker samples indicated that about 10% of participants were exposed to SHS when compared with the criteria from previous studies. However, 97% of the participants reported that they were exposed to SHS at least once weekly. The participants were most exposed to SHS in the outdoor microenvironment, where they spent approximately 1.2 h daily. There was a significant correlation between the participants’ time spent outdoors and self-reported SHS exposure time (r2 = 0.935). In this study, a methodology using time activity patterns to assess temporal and spatial characteristics of SHS exposure was suggested. The results of this study may help develop policies for managing SHS exposure, considering the time activity patterns.

Economic cost of tobacco smoking and secondhand smoke exposure at home in Thailand

2021 ◽  
pp. tobaccocontrol-2020-056147
Author(s):  
Touchanun Komonpaisarn
Keyword(s):  
Public Health ◽  
Secondhand Smoke ◽  
Economic Cost ◽  
Health Concern ◽  
Years Of Life Lost ◽  
Tobacco Exposure ◽  
Public Health Agencies ◽  
Premature Deaths ◽  
Shs Exposure ◽  
At Home

IntroductionSmoking is an important public health concern. This study is the first that attempts to estimate the economic cost of smoking and secondhand smoke (SHS) exposure at home in Thailand.MethodA prevalence-based cost of illness approach following the guideline by WHO is employed.ResultIn 2017, the direct morbidity cost attributable to smoking and SHS exposure at home in Thailand was estimated to be at least US$265.97 million and US$23.66 million, respectively. Indirect morbidity costs from workday loss totalling US$25.04 million can be linked to smoking, while US$1.72 million was the result of SHS exposure at home. Smoking-attributable premature deaths resulted in an opportunity loss to the country equivalent to US$2.48 billion, while the figure was US$181.41 million for SHS exposure at home. Total years of life lost due to smoking and SHS-attributable premature deaths are estimated to have been at least 390 955 years for males and 82 536 years for females. The total economic cost from both types of tobacco exposure amounted to US$2.98 billion, equivalent to 17.41% of Thailand’s current health expenditure or 0.65% of its gross domestic product in 2017.ConclusionSmoking imposed a substantial economic burden on Thailand in 2017. Seven per cent of this cost was imposed on non-smokers sharing a residence with smokers. Females bore 80% of this SHS-related cost. The findings call for prompt responses from public health agencies in Thailand to launch effective tobacco control policies.

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